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Immunopharmacology and Immunotoxicology Volume 37, 2015 - Issue 2

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Research Article

Osthole inhibits inflammatory cytokine release through PPARα/γ-mediated mechanisms in LPS-stimulated 3T3-L1 adipocytes

Xiao-li WangDepartment of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province, China and

Xiang ShangDepartment of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province, China and

Yan CuiDepartment of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province, China and

Xi ZhaoDepartment of Pharmaceutical Laboratory, Medical College of Nantong University, Nantong, Jiangsu Province, China

Yan ZhangDepartment of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province, China and

Mei-lin XieDepartment of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province, China and Correspondence[email protected]

Pages 185-192 | Received 05 Aug 2014, Accepted 16 Jan 2015, Published online: 18 Feb 2015

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https://doi.org/10.3109/08923973.2015.1009997
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Gurdeep Singh & Mukesh Kr. Singh. (2023) An Overview on Sources, Biosynthesis and Bioactivities of Osthole: A Potential Bioactive Compound. Current Bioactive Compounds 19:8.
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Ki-Man Kim, Se-Eun Park & Seung Kim. (2023) Effect of extract from Maclura tricuspidata twig fermented with Ganoderma lucidum mycelium on adipocyte differentiation and inflammation in 3T3-L1 cells. Korean Journal of Food Preservation 30:3, pages 502-513.
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Batoul Rostom, Racha Karaky, Issam Kassab & Maité Sylla-Iyarreta Veitía. (2022) Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways. European Journal of Pharmacology 922, pages 174867.
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Qing Dai, Deqiong Xie, Chenli Zhang, Lei Zhu, Ying Xu, Kui Li, Wen Hao & Hefei Yin. (2021) Osthole Blocks HMGB1 Release From the Nucleus and Confers Protective Effects Against Renal Ischemia-Reperfusion Injury. Frontiers in Physiology 12.
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Guanghao Niu, Mi Zhou, Feng Wang, Jingxing Yang, Jie Huang & Zengyan Zhu. (2020) Marein ameliorates Ang II /hypoxia‐induced abnormal glucolipid metabolism by modulating the HIF ‐1α/ PPARα /γ pathway in H9c2 cells . Drug Development Research 82:4, pages 523-532.
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Fan Wu, Yan Zhao, Qingqing Shao, Ke Fang, Ruolan Dong, Shujun Jiang, Fuer Lu, Jinlong Luo & Guang Chen. (2021) Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling. Frontiers in Pharmacology 12.
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Junping Zhan & Guang Zheng. (2019) Anti-rheumatoid Arthritis Mechanisms of Angelicae Pubescentis Radix. Anti-rheumatoid Arthritis Mechanisms of Angelicae Pubescentis Radix.

Yingjia Yao, Yameng Wang, Liang Kong, Yuqing Chen & Jingxian Yang. (2019) Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease. Life Sciences 217, pages 16-24.
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Ming Yang, Gaopeng Teng, Guangjian Li, Tao Huang & Renguo Xu. (2018) Effectiveness of Osthole on Uric Acid Crystal-induced Acute Gouty Arthritis Through the Inhibition of NLRP3 Inflammasome. International Journal of Pharmacology 14:8, pages 1169-1178.
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Jia Wang, Chang-Hao Jia, Feng Wang & Mei-Lin Xie. (2018) Stevioside inhibits transforming growth factor-β1-induced cardiac fibroblast differentiation and collagen synthesis by modulation of Smad signaling pathway. Journal of Functional Foods 49, pages 384-390.
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Zong-chao Liu, Zhen-long Wang, Chen-yi Huang, Zhi-jiang Fu, Yong Liu, Zhang-chao Wei, Shi-gui Liu, Chuan Ma, Jie-liang Shen & Dayue Darrel Duan. (2018) Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway. Acta Pharmacologica Sinica 39:6, pages 912-922.
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Pei-Ying Liu, Dun-Cheng Chang, Yu-Sheng Lo, Yi-Ting Hsi, Chia-Chieh Lin, Yi-Ching Chuang, Shu-Hui Lin, Ming-Ju Hsieh & Mu-Kuan Chen. (2018) Osthole induces human nasopharyngeal cancer cells apoptosis through Fas-Fas ligand and mitochondrial pathway. Environmental Toxicology 33:4, pages 446-453.
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Feng Wang, Rui-Jun Zhou, Xi Zhao, Hua Ye & Mei-Lin Xie. (2018) Apigenin inhibits ethanol-induced oxidative stress and LPS-induced inflammatory cytokine production in cultured rat hepatocytes. Journal of Applied Biomedicine 16:1, pages 75-80.
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Yuxin Bao, Xiaolin Meng, Fangning Liu, Fei Wang, Jinhui Yang, Haiyu Wang & Guanghong Xie. (2018) Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells. Molecular Medicine Reports.
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Yeli Li, Yingwan Wang, Yiqi Li, Zhiqiang Qian, Ling Zhu & Danli Yang. (2017) Osthole attenuates pulmonary arterial hypertension in monocrotaline-treated rats. Molecular Medicine Reports 16:3, pages 2823-2829.
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Shumin Lv, Yun Zhang, Ming Yan, Hongjiao Mao, Cailing Pan, Mingxiao Gan, Jiawen Fan & Guoxia Wang. (2015) Inhibition of osteolysis after local administration of osthole in a TCP particles-induced osteolysis model. International Orthopaedics 40:7, pages 1545-1552.
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Yan Chen, Jinlong Li, Qiang Li, Tengteng Wang, Lianping Xing, Hao Xu, Yongjun Wang, Qi Shi, Quan Zhou & Qianqian Liang. (2016) Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function. Evidence-Based Complementary and Alternative Medicine 2016, pages 1-12.
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Osthole inhibits inflammatory cytokine release through PPARα/γ-mediated mechanisms in LPS-stimulated 3T3-L1 adipocytes

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Osthole inhibits inflammatory cytokine release through PPARα/γ-mediated mechanisms in LPS-stimulated 3T3-L1 adipocytes

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