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Research Article

The Impact of Acemannan on the Generation and Function of Cytotoxic T-Lymphocytes

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Pages 63-77 | Published online: 28 Sep 2008

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Jian-Hua Xie, Ming-Liang Jin, Gordon A. Morris, Xue-Qiang Zha, Han-Qing Chen, Yang Yi, Jing-En Li, Zhi-Jun Wang, Jie Gao, Shao-Ping Nie, Peng Shang & Ming-Yong Xie. (2016) Advances on Bioactive Polysaccharides from Medicinal Plants. Critical Reviews in Food Science and Nutrition 56:sup1, pages S60-S84.
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Jian-Min Xing & Fen-Fang Li. (2009) Purification of aloe polysaccharides by using aqueous two-phase extraction with desalination. Natural Product Research 23:15, pages 1424-1430.
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Paul M Simon. (1994) Section Review: Biologicals & Immunologicals: Complex carbohydrates in development as human pharmaceuticals. Expert Opinion on Investigational Drugs 3:3, pages 223-239.
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Articles from other publishers (28)

Yingjie Bai, Yimeng Niu, Shengao Qin & Guowu Ma. (2023) A New Biomaterial Derived from Aloe vera—Acemannan from Basic Studies to Clinical Application. Pharmaceutics 15:7, pages 1913.
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Jyoti Baranwal, Swastika Singh, Smriti Kushwaha & Archana Jyoti. (2023) Acemannan from Aloe vera Extract: A Catalyst-Free, Approach for the Access of Imidazole-Fused Nitrogen-Bridgehead Heterocycles. Letters in Organic Chemistry 20:5, pages 446-456.
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Mamta Kumari, Rajendar P. Gupta, Preeti Bagri & Renu Singh. (2023) Immunopathological studies on Escherichia coli infected broiler chickens fed on Aloe vera leaf extract. Veterinary Immunology and Immunopathology 258, pages 110562.
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Erica Españo, Jiyeon Kim & Jeong-Ki Kim. (2022) Utilization of Aloe Compounds in Combatting Viral Diseases. Pharmaceuticals 15:5, pages 599.
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Mengxun Zhang, Jiaqing Zhong, Yongai Xiong, Xun Song, Chenyang Li & Zhendan He. (2021) Development of Broad-Spectrum Antiviral Agents—Inspiration from Immunomodulatory Natural Products. Viruses 13:7, pages 1257.
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Meng-Hsin Lee, Chi-Hsein Chao, Yu-Chi Hsu & Mei-Kuang Lu. (2020) Production, characterization, and functions of sulfated polysaccharides from zinc sulfate enriched cultivation of Antrodia cinnamomea. International Journal of Biological Macromolecules 159, pages 1013-1021.
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Kwangmin Na, Enkhmaa Lkhagva‐Yondon, Minha Kim, Yu‐Ree Lim, Eunju Shin, Chong‐Kil Lee & Myung‐Shin Jeon. (2019) Oral treatment with Aloe polysaccharide ameliorates ovalbumin‐induced atopic dermatitis by restoring tight junctions in skin. Scandinavian Journal of Immunology 91:3.
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Eun-Jung Song, Erica Españo, Jeong-Hyun NamJiyeon KimKyu-Suk ShimEunju ShinYoung In ParkChong-Kil Lee & Jeong-Ki Kim. (2020) Adjuvanticity of Processed Aloe vera gel for Influenza Vaccination in Mice . Immune Network 20:4.
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Pasutha Thunyakitpisal, Vithaya Ruangpornvisuti, Pattrawadee Kengkwasing, Jaroenporn Chokboribal & Polkit Sangvanich. (2017) Acemannan increases NF-κB/DNA binding and IL-6/-8 expression by selectively binding Toll-like receptor-5 in human gingival fibroblasts. Carbohydrate Polymers 161, pages 149-157.
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Adrisyanti Baruah, Manobjyoti Bordoloi & Hari Prasanna Deka Baruah. (2016) Aloe vera: A multipurpose industrial crop. Industrial Crops and Products 94, pages 951-963.
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Ahmad Oryan, Adel Mohammadalipour, Ali Moshiri & Mohammad Reza Tabandeh. (2016) Topical Application of Aloe vera Accelerated Wound Healing, Modeling, and Remodeling. Annals of Plastic Surgery 77:1, pages 37-46.
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Kanokporn Bhalang & Kevin Tompkins. 2015. Polysaccharides. Polysaccharides 2137 2150 .
Gerardo Daniel Sierra-García, Rocío Castro-Ríos, Azucena González-Horta, Jorge Lara-Arias & Abelardo Chávez-Montes. (2014) Acemannan, an Extracted Polysaccharide from Aloe vera : A Literature Review . Natural Product Communications 9:8, pages 1934578X1400900.
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Kanokporn Bhalang & Kevin Tompkins. 2021. Polysaccharides. Polysaccharides 1 12 .
Masood Akhtar, Abdul Hai, Mian Muhammad Awais, Zafar Iqbal, Faqir Muhammad, Ahsan ul Haq & Muhammad Irfan Anwar. (2012) Immunostimulatory and protective effects of Aloe vera against coccidiosis in industrial broiler chickens. Veterinary Parasitology 186:3-4, pages 170-177.
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Jian-min Xing & Fen-fang Li. (2009) Separation and purification of aloe polysaccharides by a combination of membrane ultrafiltration and aqueous two-phase extraction. Applied Biochemistry and Biotechnology 158:1, pages 11-19.
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Nari Yun, Chan-Ho Lee & Sun-Mee Lee. (2009) Protective effect of Aloe vera on polymicrobial sepsis in mice. Food and Chemical Toxicology 47:6, pages 1341-1348.
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M.Y.K. Leung, C. Liu, J.C.M. Koon & K.P. Fung. (2006) Polysaccharide biological response modifiers. Immunology Letters 105:2, pages 101-114.
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Chong Kil Lee. 2006. New Perspectives on Aloe. New Perspectives on Aloe 155 167 .
Sun-A Im, Sun-Tack Oh, Sukgil Song, Mi-Ran Kim, Dong-Seon Kim, Sung-Sick Woo, Tae Hyung Jo, Young In Park & Chong-Kil Lee. (2005) Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity. International Immunopharmacology 5:2, pages 271-279.
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James Talmadge, Jennifer Chavez, Lori Jacobs, Corey Munger, Tony Chinnah, Jimmy T. Chow, David Williamson & Kenneth Yates. (2004) Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity. International Immunopharmacology 4:14, pages 1757-1773.
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Seongwon Choi & Myung-Hee Chung. (2003) A review on the relationship between aloe vera components and their biologic effects. Seminars in Integrative Medicine 1:1, pages 53-62.
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Jae Kwon Lee, Myung Koo Lee, Yeo-Pyo Yun, Youngsoo Kim, Jong Sik Kim, Yeong Shik Kim, Kyungjae Kim, Seong Sun Han & Chong-Kil Lee. (2001) Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells. International Immunopharmacology 1:7, pages 1275-1284.
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Nirmal Pugh, Samir A. Ross, Mahmoud A. ElSohly & David S. Pasco. (2000) Characterization of Aloeride, a New High-Molecular-Weight Polysaccharide from Aloe vera with Potent Immunostimulatory Activity . Journal of Agricultural and Food Chemistry 49:2, pages 1030-1034.
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C. J. Gauntt, H. J. Wood, H. R. McDaniel & B. H. McAnalley. (2000) Aloe polymannose enhances anti-coxsackievirus antibody titres in mice. Phytotherapy Research 14:4, pages 261-266.
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A Djeraba & P Quere. (2000) In vivo macrophage activation in chickens with Acemannan, a complex carbohydrate extracted from Aloe vera. International Journal of Immunopharmacology 22:5, pages 365-372.
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T Reynolds & A.C Dweck. (1999) Aloe vera leaf gel: a review update. Journal of Ethnopharmacology 68:1-3, pages 3-37.
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K. Karaca, J.M. Sharma & R. Nordgren. (1995) Nitric oxide production by chicken macrophages activated by acemannan, a complex carbohydrate extracted from Aloe Vera. International Journal of Immunopharmacology 17:3, pages 183-188.
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