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Immunopharmacology and Immunotoxicology Volume 14, 1992 - Issue 1-2
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Research Article

Antiallergic Effect of Epinastine (WAL 801 CL) on Immediate Hypersensitivity Reactions: (I) Elucidation of the Mechanism for Histamine Release Inhibition

Chiaki Kamei Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Masaaki Akagi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Mitsunobu Mio Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Kazuhiro Kitazumi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Keiji Izushi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Shigehiro Masaki Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
&
Kenji Tasaka Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
 show all
Pages 191-205 | Published online: 28 Sep 2008

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Read on this site (3)

Andrea Leonardi & Luigi Quintieri. (2010) Olopatadine: a drug for allergic conjunctivitis targeting the mast cell. Expert Opinion on Pharmacotherapy 11:6, pages 969-981.
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Andrea Leonardi. (2007) New drug treatments for ocular allergies. Expert Review of Ophthalmology 2:3, pages 397-408.
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Francis S. Mah, Lanny J. Rosenwasser, William D. Townsend, Jack V. Greiner & George Bensch. (2007) Efficacy and comfort of olopatadine 0.2% versus epinastine 0.05% ophthalmic solution for treating itching and redness induced by conjunctival allergen challenge. Current Medical Research and Opinion 23:6, pages 1445-1452.
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Articles from other publishers (24)

Yusuf Rizvi & Tahir Husain Ansari. (2020) Role of topical ophthalmic solutions (0.1%) olopatadine hydrochloride and (0.05%) epinastine hydrochlloride in vernal keratoconjuntivitis. Indian Journal of Clinical and Experimental Ophthalmology 6:3, pages 374-378.
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. (2010) Improvement of the Synthetic Route for Epinastine Antihistamine. Journal of the Korean Chemical Society 54:4, pages 447-450.
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Ken-ichi Kanai, Kazuhito Asano, Tadashi Hisamitsu & Harumi Suzaki. (2005) Suppressive activity of epinastine hydrochloride on TARC production from human peripheral blood CD4+ T cells in-vitro. Journal of Pharmacy and Pharmacology 57:8, pages 1027-1035.
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Alessandro Lambiase, Alessandra Micera & Stefano Bonini. (2009) Multiple action agents and the eye: do they really stabilize mast cells?. Current Opinion in Allergy & Clinical Immunology 9:5, pages 454-465.
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Kelly K. Nichols, Scot Morris, Ian B. Gaddie & David Evans. (2009) Epinastine 0.05% Ophthalmic Solution in Contact Lens-Wearing Subjects With a History of Allergic Conjunctivitis. Eye & Contact Lens: Science & Clinical Practice 35:1, pages 26-31.
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K. Asano, A. Furuta, K. Kanai, S. Sakaue, H. Suzaki & T. Hisamitsu. (2008) Inhibition of Angiogenic Factor Production from Murine Mast Cells by an Antiallergic Agent (Epinastine Hydrochloride) In Vitro. Mediators of Inflammation 2008, pages 1-8.
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Grazyna Galatowicz, Yetunde Ajayi, Michael E. Stern & Virginia L. Calder. (2007) Ocular anti-allergic compounds selectively inhibit human mast cell cytokines in vitro and conjunctival cell infiltration in vivo. Clinical & Experimental Allergy 37:11, pages 1648-1656.
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Kazuhiko Hanashiro, Masanori Sunagawa, Toshiyuki Nakasone, Mariko Nakamura & Tadayoshi Kosugi. (2007) Inhibition of IgE-mediated phosphorylation of FcεRIγ protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: A novel action of antiallergic drugs. International Immunopharmacology 7:7, pages 994-1002.
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Kazuhiko Hanashiro, Masanori Sunagawa, Yoshihiro Tokeshi, Toshiyuki Nakasone, Shigeto Ohta, Mariko Nakamura & Tadayoshi Kosugi. (2006) Antiallergic drugs, azelastine hydrochloride and epinastine hydrochloride, inhibit ongoing IgE secretion of rat IgE-producing hybridoma FE-3 cells. European Journal of Pharmacology 547:1-3, pages 174-183.
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Ira Finegold, David B. Granet, Peter A. D'Arienzo & Arthur B. Epstein. (2006) Efficacy and response with olopatadine versus epinastine in ocular allergic symptoms: A post hoc analysis of data from a conjunctival allergen challenge study. Clinical Therapeutics 28:10, pages 1630-1638.
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Su-Ok Yang & Geun-Eog Ji. (2006) Inhibitory Effects of Actinidia chinensis and Zizyphus jujube on Histamine Release from Rat Peritoneal Mast Cells. Preventive Nutrition and Food Science 11:2, pages 89-93.
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William B. Trattler, Jodi Luchs & Parag Majmudar. (2006) Elestat (Epinastine HCl Ophthalmic Solution 0.05%) as a Therapeutic for Allergic Conjunctivitis. International Ophthalmology Clinics 46:4, pages 87-99.
Crossref
Masahiko Toyoda, Motokazu Nakamura, Kaori Nakada, Maki Iida, Masaki Nakamura, Masahiro Otani, Takafumi Etoh, Hidemi Nakagawa & Masaaki Morohashi. (2005) Effect of Epinastine Hydrochloride, a Second-generation Histamine H1-receptor Antagonist, on Sensory Neurons in vitro. Allergology International 54:4, pages 565-572.
Crossref
Mark B. Abelson, Paul Gomes, H.Jerome Crampton, Rhett M. Schiffman, Ron R. Bradford & Scott M. Whitcup. (2004) Efficacy and tolerability of ophthalmic epinastine assessed using the conjunctival antigen challenge model in patients with a history of allergic conjunctivitis. Clinical Therapeutics 26:1, pages 35-47.
Crossref
Scott M. Whitcup, Ron Bradford, John Lue, Rhett M. Schiffman & Mark B. Abelson. (2004) Efficacy and tolerability of ophthalmic epinastine: A randomized, double-masked, parallel-group, active- and vehicle-controlled environmental trial in patients with seasonal allergic conjunctivitis. Clinical Therapeutics 26:1, pages 29-34.
Crossref
Jean Bousquet, Paul van Cauwenberge & Nikolai Khaltaev. (2001) Allergic Rhinitis and Its Impact on Asthma. Journal of Allergy and Clinical Immunology 108:5, pages S147-S334.
Crossref
R. Kanoh, T. Hatano, H. Ito, T. Yoshida & M. Akagi. (2000) Effects of tannins and related polyphenols on superoxide-induced histamine release from rat peritoneal mast cells. Phytomedicine 7:4, pages 297-302.
Crossref
Naoki Inagaki, Masafumi Nagao, Nobuaki Nakamura, Hirokazu Kawasaki, Katsuhiro Igeta, Keiichi Musoh & Hiroichi Nagai. (2000) Evaluation of anti-scratch properties of oxatomide and epinastine in mice. European Journal of Pharmacology 400:1, pages 73-79.
Crossref
Naotsugu Takahashi, Hisamichi Aizawa, Hiromasa Inoue, Koichiro Matsumoto, Hiroyuki Nakano, Takahito Hirose, Sankei Nishima & Nobuyuki Hara. (1998) Effects of epinastine hydrochloride on cholinergic neuro-effector transmission in canine tracheal smooth muscle. European Journal of Pharmacology 358:1, pages 55-61.
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Yukio Sugimoto, Keiko Umakoshi, Nao Nojiri & Chiaki Kamei. (1998) Effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice. European Journal of Pharmacology 351:1, pages 1-5.
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CHRISTOPHER J. MEADE. (1998) The Mechanism by Which Epinastine Stops an Adenosine Analog from Contracting BDE Rat Airways. American Journal of Respiratory and Critical Care Medicine 157:2, pages 522-530.
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Matsushita Nobutoshi, Aritake Kosuke, Takada Ayumi, Hizue Masanori, Hayashi Kumi, Mitsui Kazuhiko, Hayashi Masatoshi, Hirotsu Ichiro, Kimura Yoshiyuki, Tani Tadato & Nakajima Hiromichi. (1998) Pharmacological Studies on the Novel Antiallergic Drug HQL-79: II. Elucidation of Mechanisms for Antiallergic and Antiasthmatic Effects. Japanese Journal of Pharmacology 78:1, pages 11-22.
Crossref
Nobuyuki Fukuishi, Tomoko Kan, Kimihisa Hirose, Reiko Akagi & Masaaki Akagi. (1995) Inhibitory Effect of Epinastine on Superoxide Generation by Rat Neutrophils. Japanese Journal of Pharmacology 68:4, pages 449-452.
Crossref
Kenji TasakaKenji Tasaka. 1994. New Advances in Histamine Research. New Advances in Histamine Research 293 324 .

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