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Immunopharmacology and Immunotoxicology Volume 17, 1995 - Issue 4
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Research Article

Concomitant Immunity against Tumor Development is Enhanced by the Oral Administration of a Kampo Medicine, Hochu-Ekki-To (TJ-41: BU-ZHONG-YI-QI-TANG)

Mamoru Harada Department of Virology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
,
Kazumasa Seta Tsumura & Co., Tokyo, Japan
,
Osamu Ito Department of Immunology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
,
Koji Tamada Department of Immunology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
,
Teili Li Department of Immunology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
,
Hiroshi Terao Department of Immunology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
,
Mitsuhiro Takenoyama Department of Immunology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
,
Genki Kimura Department of Virology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
&
Kikuo Nomoto Department of Immunology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
 show all
Pages 687-703 | Published online: 27 Sep 2008

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Chang-Chi Hsieh, Wen-Chang Lin, Miau-Rong Lee, Shih-Lan Hsu, Hsiao-Sheng Liu, Shung-Te Kao & Ming-Tsuen Hsieh. (2003) Dang-Gui-Bu-Xai-Tang Modulated the Immunity of Tumor Bearing Mice. Immunopharmacology and Immunotoxicology 25:2, pages 259-271.
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Shung-Te Kao, Shih-Liang Yang, Chang-Chi Hsieh, Mei-Do Yang, Ting-Fu Wang & Jaung-Geng Lin. (2000) Immunomodulation of Bu-Zhong-Yi-Qi-Tang on In Vitro Granulocyte Colony-Stimulating-Factor and Tumor Necrosis Factor-α Production by Peripheral Blood Mononuclear Cells. Immunopharmacology and Immunotoxicology 22:4, pages 711-720.
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Articles from other publishers (28)

Nehal M. El-Deeb, Omar M. Ibrahim, Mahmoud A. Mohamed, Mohamed M.S. Farag, Ayman A. Farrag & M.R. El-Aassar. (2022) Alginate/κ-carrageenan oral microcapsules loaded with Agaricus bisporus polysaccharides MH751906 for natural killer cells mediated colon cancer immunotherapy. International Journal of Biological Macromolecules 205, pages 385-395.
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Masayuki Shimizu, Shin Takayama, Akiko Kikuchi, Ryutaro Arita, Rie Ono, Kota Ishizawa & Tadashi Ishii. (2021) Kampo Medicine Treatment for Advanced Pancreatic Cancer: A Case Series. Frontiers in Nutrition 8.
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Masayuki Shimizu, Shin Takayama, Akiko Kikuchi, Ryutaro Arita, Rie Ono, Kota Ishizawa & Tadashi Ishii. (2021) Integrative therapy for advanced pancreatic cancer using Kampo and western medicine: A case report. EXPLORE 17:3, pages 255-258.
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Shin Takayama, Akiko Kikuchi, Toshiaki Makino, Mosaburo Kainuma, Takao Namiki & Takashi Ito. (2020) Basic pharmacological mechanisms and clinical evidence of the efficacy of hochuekkito against infectious diseases and its potential for use against COVID‐19. Traditional & Kampo Medicine 8:1, pages 3-21.
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Hao Liu, Zi-Ying Wang, Yu-Cong Zhou, Wei Song, Usman Ali & Daniel M.-Y Sze. (2021) Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review. Journal of Ethnopharmacology 268, pages 113561.
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Yunke Zhang, Junhong Yang, Yingzhe Chen, Jie Lv, Jing Zhang, Yingna Zhang, Xue Zhao, Hua Fang, Chongchong Liu, Qingyong Zhang, Xinzheng Cui, Xiaohan Wang & Feng Gao. (2019) iTRAQ-Based Proteomics Analysis of Plasma of Myasthenia Gravis Patients Treated with Jia Wei Bu Zhong Yi Qi Decoction. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-18.
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Naoki Fukumura, Hitomi Yamamoto, Masakazu Kitahara, Kaichiro Kamakura, Akihiko Ueki & Masao Ushiyama. (2017) Hochuekkito Reduced the Incidence of Inflammatory Complications in Patients with Sequelae of Cerebrovascular Disease in Convalescent Rehabilitation Wards : A Randomized Multicenter Study. The Japanese Journal of Rehabilitation Medicine 54:4, pages 303-314.
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TETSUO SATO, KAZUKO KITA, CHIHOMI SATO & ATSUSHI KANEDA. (2015) Hochu-ekki-to (Bu-zhong-yi-qi-tang), a herbal medicine, enhances cisplatin-induced apoptosis in HeLa cells. Molecular Medicine Reports 12:4, pages 6215-6220.
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Mingzi Ouyang, Yanyan Liu, Wei Tan, Ya Xiao, Keqiang Yu, Xiaomin Sun, Ying Huang, JingRu Cheng, Ren Luo & Xiaoshan Zhao. (2014) Bu-Zhong-Yi-Qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model. BMC Complementary and Alternative Medicine 14:1.
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Te-Hsin Chao, Pin-Kuei Fu, Chiung-Hung Chang, Shih-Ni Chang, Frank Chiahung Mao & Ching-Heng Lin. (2014) Prescription patterns of Chinese herbal products for post-surgery colon cancer patients in Taiwan. Journal of Ethnopharmacology 155:1, pages 702-708.
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Hye-Min Choi, Hui-Hun Kim & Hwa-Dong Lee. (2014) Comparative Study of Bojungikgitang in Korea, Japan and China on the Anti-Inflammatory and Anti-Oxidative Effects. The Korea Journal of Herbology 29:1, pages 53-60.
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HYE-RYUNG PARK, HYUN-SUN LEE, SUN YOUNG CHO, YOON-SOOK KIM & KWANG-SOON SHIN. (2013) Anti-metastatic effect of polysaccharide isolated from Colocasia esculenta is exerted through immunostimulation. International Journal of Molecular Medicine 31:2, pages 361-368.
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Masayuki Nakayama, Yukihiko Sugiyama, Hideaki Yamasawa, Manabu Soda, Naoko Mato, Tatsuya Hosono & Masashi Bando. (2012) Effect of Hochuekkito on Alveolar Macrophage Inflammatory Responses in Hyperglycemic Mice. Inflammation 35:4, pages 1294-1301.
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Ho-Jae Park, Dong-Hyun Kim, Se-Jin Park, Jong-Min Kim & Jong-Hoon Ryu. (2012) Ginseng in Traditional Herbal Prescriptions. Journal of Ginseng Research 36:3, pages 225-241.
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Xin Chen. 2010. Dietary Components and Immune Function. Dietary Components and Immune Function 497 514 .
Sung-Soo Ronald Han, Chong-Kwan Cho, Yeon-Weol Lee & Hwa-Seung Yoo. (2009) Antimetastatic and Immunomodulating Effect of Water Extracts From Various Mushrooms. Journal of Acupuncture and Meridian Studies 2:3, pages 218-227.
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Suresh Volate, Robert Hudson, Desuo Wang, Stephanie Muga & Michael Wargovich. (2009) TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell Lines. Journal of Oncology 2009, pages 1-10.
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Noritsugu Tsuneoka, Yoshitsugu Tajima, Amane Kitasato, Kenzo Fukuda, Tomoo Kitajima, Tomohiko Adachi, Takehiro Mishima, Tamotsu Kuroki, Shinya Onizuka & Takashi Kanematsu. (2009) Chemopreventative Effect of Hochu-ekki-to (TJ-41) on Chemically Induced Biliary Carcinogenesis in Hamsters. Journal of Surgical Research 151:1, pages 22-27.
Crossref
Noritsugu Tsuneoka, Tamotsu Kuroki, Tomoo Kitajima, Kenzo Fukuda, Shinya Onizuka, Yoshitsugu Tajima & Takashi Kanematsu. 2009. Hepatobiliary and Pancreatic Carcinogenesis in the Hamster. Hepatobiliary and Pancreatic Carcinogenesis in the Hamster 139 156 .
F IkegamiM Sumino, Y Fujii, T Akiba & T Satoh. (2016) Pharmacology and Toxicology of Bupleurum Root-Containing Kampo Medicines in Clinical Use. Human & Experimental Toxicology 25:8, pages 481-494.
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Tsugiya Murayama, Nobuo Yamaguchi, Kozo Iwamoto & Yoshito Eizuru. (2016) Inhibition of Ganciclovir-Resistant Human Cytomegalovirus Replication by Kampo (Japanese Herbal Medicine). Antiviral Chemistry and Chemotherapy 17:1, pages 11-16.
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Shigefumi Cho, Tie Hong, Akiyo Kaneko, Gen Yoshino, Noriyuki Sato, Kokichi Kikuchi, Yoshihiro Aikawa, Fumiko Yasuno, Kazumi Inoue & Jong-Chol Cyong. (2012) Evaluation of Immunological Effects of Hochu-ekki-to (TJ-41) Prophylactic Administration in Mice. The American Journal of Chinese Medicine 32:02, pages 235-243.
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Shigeki Nabeshima, Masayuki Murata, Maki Hamada, Yong Chong, Kouzaburo Yamaji & Jun Hayashi. (2004) Maturation of monocyte-derived dendritic cells by Hochu-ekki-to, a traditional Japanese herbal medicine. International Immunopharmacology 4:1, pages 37-45.
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Soo Jin Lee, Ikuo Saiki, Yoshihiro Hayakawa, Shinyu Nunome, Haruki Yamada & Sung-Hoon Kim. (2003) Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang. International Immunopharmacology 3:2, pages 147-157.
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Tieli Li, Koji Tamada, Koichiro Abe, Hitoshi Tada, Yasuhiro Onoe, Katsunori Tatsugami, Mamoru Harada, Chiharu Kubo & Kikuo Nomoto. (1999) The restoration of the antitumor T cell response from stress-induced suppression using a traditional Chinese herbal medicine Hochu-ekki-to (TJ-41:Bu-Zhong-Yi-Qi-Tang). Immunopharmacology 43:1, pages 11-21.
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M.Sohrab Hossain, Hiroaki Takimoto, Shinjiro Hamano, Hiroki Yoshida, Toshiharu Ninomiya, Yoichi Minamishima, Genki Kimura & Kikuo Nomoto. (1999) Protective effects of hochu-ekki-to, a Chinese traditional herbal medicine against murine cytomegalovirus infection. Immunopharmacology 41:3, pages 169-181.
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Yoshiki Tokura, Michiyo Sakurai, Hiroaki Yagi, Fukumi Furukawa & Masahiro Takigawa. (2015) Systemic Administration of Hochu‐ekki‐to (Bu‐Zhong‐Yi‐Qi‐Tang), a Japanese‐Chinese Herbal Medicine, Maintains Interferon‐γ Production by Peripheral Blood Mononuclear Cells in Patients with Mycosis Fungoides. The Journal of Dermatology 25:2, pages 131-133.
Crossref
Howard Moffet. (1996) Acupuncture and Oriental Medicine Update. Alternative and Complementary Therapies 2:3, pages 192-193.
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