Advanced search
Publication Cover
Journal of Investigative Surgery Volume 7, 1994 - Issue 1
Submit an article Journal homepage
74
Views
48
CrossRef citations to date
0
Altmetric
Original Article

A Persistent Hindlimb Ischemia Model in the Rabbit

Li-Qun Pu Cardiovascular Research Laboratory Departments of Nuclear Medicine, Radiology, and Surgery, Royal Victoria Hospital, McGill University Montreal, Quebec, Canada
,
Steven Jackson Cardiovascular Research Laboratory Departments of Nuclear Medicine, Radiology, and Surgery, Royal Victoria Hospital, McGill University Montreal, Quebec, Canada
,
Kevin J. Lachapelle Cardiovascular Research Laboratory Departments of Nuclear Medicine, Radiology, and Surgery, Royal Victoria Hospital, McGill University Montreal, Quebec, Canada
,
Zaid Arekat Cardiovascular Research Laboratory Departments of Nuclear Medicine, Radiology, and Surgery, Royal Victoria Hospital, McGill University Montreal, Quebec, Canada
,
Alan M. Graham Cardiovascular Research Laboratory Departments of Nuclear Medicine, Radiology, and Surgery, Royal Victoria Hospital, McGill University Montreal, Quebec, Canada
,
Robert Lisbona Cardiovascular Research Laboratory Departments of Nuclear Medicine, Radiology, and Surgery, Royal Victoria Hospital, McGill University Montreal, Quebec, Canada
,
Roland Brassard Cardiovascular Research Laboratory Departments of Nuclear Medicine, Radiology, and Surgery, Royal Victoria Hospital, McGill University Montreal, Quebec, Canada
,
Stirling Carpenter Montreal Neurological Hospital McGill University Montreal, Quebec, Canada
&
James F. Symes Department of Surgery, St. Elizabeth's Medical Center of Boston, Boston, MA, 02135
 show all
Pages 49-60 | Published online: 09 Jul 2009

Citations (48)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Soh Nishimoto, Kenichiro Kawai, Tomoko Tsumano, Kenji Fukuda, Toshihiro Fujiwara & Masao Kakibuchi. (2013) Impacts of bone marrow aspirate and peripheral blood derived platelet-rich plasma on the wound healing in chronic ischaemic limb. Journal of Plastic Surgery and Hand Surgery 47:3, pages 169-174.
Read now
Stephan H Schirmer & Niels van Royen. (2004) Stimulation of collateral artery growth: a potential treatment for peripheral artery disease. Expert Review of Cardiovascular Therapy 2:4, pages 581-588.
Read now

Articles from other publishers (46)

Veronika Lovasova, Robert Bem, Jaroslav Chlupac, Michal Dubsky, Jitka Husakova, Andrea Nemcova & Jiri Fronek. (2023) Animal experimental models of ischemic limbs – A systematic review. Vascular Pharmacology 153, pages 107237.
Crossref
Eseelle K. Hendow, Mehran Moazen, Francesco Iacoviello, Laurent Bozec, Caroline Pellet‐Many & Richard M. Day. (2020) Microporous Biodegradable Films Promote Therapeutic Angiogenesis. Advanced Healthcare Materials 9:17, pages 2000806.
Crossref
Smriti Murali Krishna, Safraz Mohamed Omer & Jonathan Golledge. (2015) Evaluation of the clinical relevance and limitations of current pre-clinical models of peripheral artery disease. Clinical Science 130:3, pages 127-150.
Crossref
Ayako Nishiyama, Hiroyuki Koyama, Tetsuro Miyata & Toshiaki Watanabe. (2015) Therapeutic site selection is important for the successful development of collateral vessels. Journal of Vascular Surgery 62:1, pages 190-199.
Crossref
C Duehrkop & R Rieben. (2014) Refinement of tourniquet-induced peripheral ischemia/reperfusion injury in rats: comparison of 2 h vs 24 h reperfusion. Laboratory Animals 48:2, pages 143-154.
Crossref
H Zhang, X Wang, M Guan, C Li & L Luo. (2013) Skeletal muscle evaluation by MRI in a rabbit model of acute ischaemia. The British Journal of Radiology 86:1026, pages 20120042.
Crossref
Jiaqi Xie, Haibin Wang, Yunya Wang, Fangping Ren, Wei Yi, Kun Zhao, Zilin Li, Qiang Zhao, Zhenhua Liu, Hong Wu, Chunhu Gu & Dinghua Yi. (2013) Induction of Angiogenesis by Controlled Delivery of Vascular Endothelial Growth Factor Using Nanoparticles. Cardiovascular Therapeutics 31:3, pages e12-e18.
Crossref
Galina Dragneva, Petra Korpisalo & Seppo Ylä-Herttuala. (2013) Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success. Disease Models & Mechanisms 6:2, pages 312-322.
Crossref
Xue Xia, Joseph P. Babcock, Sachiko I. Blaber, Kathleen M. Harper & Michael Blaber. (2012) Pharmacokinetic Properties of 2nd-Generation Fibroblast Growth Factor-1 Mutants for Therapeutic Application. PLoS ONE 7:11, pages e48210.
Crossref
Tara L. Haas, Pamela G. Lloyd, Hsiao‐Tung Yang & Ronald L. Terjung. 2011. Comprehensive Physiology. Comprehensive Physiology 2933 3017 .
Masatake Katsu, Hiroyuki Koyama, Hiromitsu Maekawa, Hiroki Kurihara, Hiroaki Uchida & Hirohumi Hamada. (2009) Ex vivo gene delivery of ephrin-B2 induces development of functional collateral vessels in a rabbit model of hind limb ischemia. Journal of Vascular Surgery 49:1, pages 192-198.
Crossref
Hye Won Baik, Byung Kook Kwak, Hyung Jin Shim, Yang Soo Kim, Jong Beom Lee & Kun Sang Kim. (2008) A New Ischemic Model Using a Radiofrequency Wire Electrode in a Rabbit Hindlimb. CardioVascular and Interventional Radiology 31:4, pages 790-798.
Crossref
Chun-Ling Fan, Ping-Jin Gao, Yuan-Jun Gu, Xiao-Feng Tang, Jian-Jun Liu, Jian Wei, Kazutomo Inoue & Ding-Liang Zhu. (2006) THERAPEUTIC ANGIOGENESIS BY INTRAMUSCULAR INJECTION OF FIBRIN PARTICLES INTO ISCHAEMIC HINDLIMBS. Clinical and Experimental Pharmacology and Physiology 33:7, pages 617-622.
Crossref
Jae Ung Lee, Jinho Shin, Woohyuk Song, Hyunjoong Kim, Seunghwan Lee, Se Jin Jang, S. Chiu Wong, Jay E. Edelberg, Gene Liau & Mun K. Hong. (2005) A novel adenoviral gutless vector encoding sphingosine kinase promotes arteriogenesis and improves perfusion in a rabbit hindlimb ischemia model. Coronary Artery Disease 16:7, pages 451-456.
Crossref
Chun-ling FAN, Ping-jin GAO, Zai-qian CHE, Jian-jun LIU, Jian WEI & Ding-liang ZHU. (2005) Therapeutic neovascularization by autologous transplantation with expanded endothelial progenitor cells from peripheral blood into ischemic hind limbs1. Acta Pharmacologica Sinica 26:9, pages 1069-1075.
Crossref
Robert P. Liddell, Tarak H. Patel, Clifford R. Weiss, David S. Lee, Toshio Matsuhashi, P. Rand Brown, Kathleen L. Gabrielson, E. Rene Rodriguez, John Eng, Hideo Kimura & Lawrence V. Hofmann. (2005) Endovascular Model of Rabbit Hindlimb Ischemia: A Platform to Evaluate Therapeutic Angiogenesis. Journal of Vascular and Interventional Radiology 16:7, pages 991-998.
Crossref
Gale L. Tang, David S. Chang, Rajabrata Sarkar, Rong Wang & Louis M. Messina. (2005) The effect of gradual or acute arterial occlusion on skeletal muscle blood flow, arteriogenesis, and inflammation in rat hindlimb ischemia. Journal of Vascular Surgery 41:2, pages 312-320.
Crossref
Shinji HARAKAWA, Noboru INOUE, Takuya HORI, Koji TOCHIO, Tatsuya KARIYA, Kunihito TAKAHASHI, Fuyuki DOGE, David E. MARTIN, Atsushi SAITO, Hiroshi SUZUKI & Hideyuki NAGASAWA. (2005) Effects of Exposure to a 50Hz Electric Field on Plasma Levels of Lactate, Glucose, Free Fatty Acids, Triglycerides and Creatine Phosphokinase Activity in Hind-Limb Ischemic Rats. Journal of Veterinary Medical Science 67:10, pages 969-974.
Crossref
Akihiro HosakaHiroyuki KoyamaToshihiro KushibikiYasuhiko TabataNobuhiro NishiyamaTetsuro MiyataHiroshi ShigematsuTsuyoshi TakatoHirokazu Nagawa. (2004) Gelatin Hydrogel Microspheres Enable Pinpoint Delivery of Basic Fibroblast Growth Factor for the Development of Functional Collateral Vessels. Circulation 110:21, pages 3322-3328.
Crossref
Alexis Caron, Sandrine Michelet, Anne Caron, Sylvie Sordello, Marie‐Agnès Ivanov, Pia Delaère, Didier Branellec, Bertrand Schwartz & Florence Emmanuel. (2004) Human FGF‐1 gene transfer promotes the formation of collateral vessels and arterioles in ischemic muscles of hypercholesterolemic hamsters. The Journal of Gene Medicine 6:9, pages 1033-1045.
Crossref
Richard E. Waters, Ronald L. Terjung, Kevin G. Peters & Brian H. Annex. (2004) Preclinical models of human peripheral arterial occlusive disease: implications for investigation of therapeutic agents. Journal of Applied Physiology 97:2, pages 773-780.
Crossref
Shigeyuki Ishii, Hiroyuki Koyama, Tetsuro Miyata, Seiji Nishikage, Hirohumi Hamada, Shin-Ichi Miyatake & Hiroshi Shigematsu. (2004) Appropriate control of ex vivo gene therapy delivering basic fibroblast growth factor promotes successful and safe development of collateral vessels in rabbit model of hind limb ischemia. Journal of Vascular Surgery 39:3, pages 629-638.
Crossref
Stephan Schirmer, Imo Hoefer & Ivo Buschmann. 2004. Methods in Endothelial Cell Biology. Methods in Endothelial Cell Biology 197 206 .
Zenon S. Kyriakides, Pantelis Petinakis, Loukas Kaklamanis, Theodore Lyras, Eftihia Sbarouni, Panagiotis Karayannakos, Dimitrios Iliopoulos & Dimitrios Th. Kremastinos. (2003) Gender does not influence angiogenesis and arteriogenesis in a rabbit model of chronic hind limb ischemia. International Journal of Cardiology 92:1, pages 83-91.
Crossref
Erxiong LuWilliam R. WagnerUte SchellenbergerJudith A. AbrahamAlexander L. KlibanovSteven R. WoulfeMelissa M. CsikariDavid FischerGeorge F. SchreinerGary H. BrandenburgerFlordeliza S. Villanueva. (2003) Targeted In Vivo Labeling of Receptors for Vascular Endothelial Growth Factor. Circulation 108:1, pages 97-103.
Crossref
John B. Buckwalter, Valerie C. Curtis, Zoran Valic, Stephen B. Ruble & Philip S. Clifford. (2003) Endogenous vascular remodeling in ischemic skeletal muscle: a role for nitric oxide. Journal of Applied Physiology 94:3, pages 935-940.
Crossref
Fuwen Luo, David Wariaro, Göran Lundberg, Harald Blegen & Eric Wahlberg. (2002) Vascular Growth Factor Expression in a Rat Model of Severe Limb Ischemia. Journal of Surgical Research 108:2, pages 258-267.
Crossref
Valeri Chekanov, Ramon Rayel, David Krum, Iman Alwan, John Hare, Tanvir Bajwa & Masood Akhtare. (2016) Electrical Stimulation Promotes Angiogenesis in a Rabbit Hind-Limb Ischemia Model. Vascular and Endovascular Surgery 36:5, pages 357-366.
Crossref
Ismo Vajanto, Tuomas T. Rissanen, Juha Rutanen, Mikko O. Hiltunen, Tiina T. Tuomisto, Katja Arve, Outi Närvänen, Hannu Manninen, Heikki Räsänen, Mikko Hippeläinen, Esko Alhava & Seppo Ylä‐Herttuala. (2002) Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ . The Journal of Gene Medicine 4:4, pages 371-380.
Crossref
Issam A. Halaby, Sean P. Lyden, Mark G. Davies, Elisa Roztocil, Linda J. Salamone, Andrew I. Brooks, Richard M. Green, Howard J. Federoff & William J. Bowers. (2002) Glucocorticoid-Regulated VEGF Expression in Ischemic Skeletal Muscle. Molecular Therapy 5:3, pages 300-306.
Crossref
Jeffrey M. Isner & Takayuki Asahara. 2002. The New Angiotherapy. The New Angiotherapy 249 277 .
N Ohara, H Koyama, T Miyata, H Hamada, S-I Miyatake, M Akimoto & H Shigematsu. (2001) Adenovirus-mediated ex vivo gene transfer of basic fibroblast growth factor promotes collateral development in a rabbit model of hind limb ischemia. Gene Therapy 8:11, pages 837-845.
Crossref
Lucy S. Brevetti, Robert Paek, Sandra E. Brady, Julien I.E. Hoffman, Rajabrata Sarkar & Louis M. Messina. (2001) Exercise-Induced Hyperemia Unmasks Regional Blood Flow Deficit in Experimental Hindlimb Ischemia. Journal of Surgical Research 98:1, pages 21-26.
Crossref
D. Hunter Cherwek, M. Benjamin Hopkins, Michael J. ThompsonBrian H. Annex & Doris A. Taylor. (2000) Fiber type-specific differential expression of angiogenic factors in response to chronic hindlimb ischemia. American Journal of Physiology-Heart and Circulatory Physiology 279:3, pages H932-H938.
Crossref
Luis Henrique W. GowdakLioubov PoliakovaXiaotong WangImre KovesdiKenneth W. FishbeinAntonella ZacheoRoberta PalumboStefania StrainoCostanza EmanueliMassimiliano Marrocco-TrischittaEdward G. LakattaPiero AnversaRichard G. S. SpencerMark TalanMaurizio C. Capogrossi. (2000) Adenovirus-Mediated VEGF 121 Gene Transfer Stimulates Angiogenesis in Normoperfused Skeletal Muscle and Preserves Tissue Perfusion After Induction of Ischemia . Circulation 102:5, pages 565-571.
Crossref
Peter Schratzberger, Gabriele Schratzberger, Marcy Silver, Cynthia Curry, Marianne Kearney, Meredith Magner, Joseph Alroy, Lester S. Adelman, David H. Weinberg, Allan H. Ropper & Jeffrey M. Isner. (2000) Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nature Medicine 6:4, pages 405-413.
Crossref
P. Schratzberger & Jeffrey M. Isner. 2000. From Molecule to Men. From Molecule to Men 221 232 .
Bernhard Witzenbichler, Takayuki Asahara, Toyoaki Murohara, Marcy Silver, Ioakim Spyridopoulos, Meredith Magner, Nicole Principe, Marianne Kearney, Jing-Shan Hu & Jeffrey M. Isner. (1998) Vascular Endothelial Growth Factor-C (VEGF-C/VEGF-2) Promotes Angiogenesis in the Setting of Tissue Ischemia. The American Journal of Pathology 153:2, pages 381-394.
Crossref
Alain Rivard & Jeffrey M. Isner. (1998) Angiogenesis and Vasculogenesis in Treatment of Cardiovascular Disease. Molecular Medicine 4:7, pages 429-440.
Crossref
Jeffrey M. Isner, Ken Walsh, James Symes, Ann Pieczek, Satoshi Takeshita, Jason Lowry, Kenneth Rosenfield, Lawrence Weir, Edi Brogi & Dan Jurayj. (1996) Arterial Gene Transfer for Therapeutic Angiogenesis in Patients with Peripheral Artery Disease. St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts. Human Gene Therapy 7:8, pages 959-988.
Crossref
Takayuki AsaharaChristophe BautersLu P. ZhengSatoshi TakeshitaStuart BuntingNapoleone FerraraJames F. SymesJeffrey M. Isner. (1995) Synergistic Effect of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor on Angiogenesis In Vivo. Circulation 92:9, pages 365-371.
Crossref
Christophe BautersTakayuki AsaharaLu P. ZhengSatoshi TakeshitaStuart BuntingNapoleone FerraraJames F. SymesJeffrey M. Isner. (1995) Recovery of Disturbed Endothelium-Dependent Flow in the Collateral-Perfused Rabbit Ischemic Hindlimb After Administration of Vascular Endothelial Growth Factor. Circulation 91:11, pages 2802-2809.
Crossref
Jeffrey M. IsnerKenneth WalshJames SymesAnn PieczekSatoshi TakeshitaJason LowrySusan RossowKenneth RosenfieldLawrence WeirEdi BrogiRobert Schainfeld. (1995) Arterial Gene Therapy for Therapeutic Angiogenesis in Patients With Peripheral Artery Disease. Circulation 91:11, pages 2687-2692.
Crossref
Klaus J. Walgenbach, Catherine Gratas, Kenneth C. Shestak & Dorothea Becker. (1995) Ischaemia-induced expression of bFGF in normal skeletal muscle: A potential paracrine mechanism for mediating angiogenesis in ischaemic skeletal muscle. Nature Medicine 1:5, pages 453-459.
Crossref
Li-Qun Pu, Gregory R. Gadowski, Alan M. Graham, Michael A. Ricci, Roland Brassard, Allan D. Sniderman & James F. Symes. (1995) Enhanced revascularisation after angiogenic stimulation in a rabbit model of bilateral limb ischaemia. European Journal of Vascular and Endovascular Surgery 9:2, pages 189-196.
Crossref
Christophe Bauters, Takayuki Asahara, Lu P. Zheng, Satoshi Takeshita, Stuart Bunting, Napoleone Ferrara, James F. Symes & Jeffrey M. Isner. (1995) Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor. Journal of Vascular Surgery 21:2, pages 314-325.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.