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Inhalation Toxicology
International Forum for Respiratory Research
Volume 22, 2010 - Issue 7
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Research Article

N-acetylcysteine attenuates phosgene-induced acute lung injury via up-regulation of Nrf2 expression

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Pages 535-542 | Received 10 Aug 2009, Accepted 01 Dec 2009, Published online: 12 Apr 2010

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Read on this site (9)

Kedar N. Prasad & Stephen C. Bondy. (2022) Can a Micronutrient Mixture Delay the Onset and Progression of Symptoms of Single-Point Mutation Diseases?. Journal of the American Nutrition Association 41:5, pages 489-498.
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Jennifer L. Plahovinsak, Mark R. Perry, Katherine A. Knostman, Robert Segal & Michael C. Babin. (2015) Characterization of a nose-only inhaled phosgene acute lung injury mouse model . Inhalation Toxicology 27:14, pages 832-840.
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James P. Kehrer & Lars-Oliver Klotz. (2015) Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health. Critical Reviews in Toxicology 45:9, pages 765-798.
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Majid Shohrati, Iman Karimzadeh, Amin Saburi, Hossein Khalili & Mostafa Ghanei. (2014) The role of N-acetylcysteine in the management of acute and chronic pulmonary complications of sulfur mustard: a literature review. Inhalation Toxicology 26:9, pages 507-523.
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Wen-Li Li, Chun-Xu Hai & Jürgen Pauluhn. (2011) Inhaled nitric oxide aggravates phosgene model of acute lung injury. Inhalation Toxicology 23:13, pages 842-852.
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Christopher Grainge & Paul Rice. (2010) Management of phosgene-induced acute lung injury. Clinical Toxicology 48:6, pages 497-508.
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Siddhee A. Sahasrabudhe, Marcia R. Terluk & Reena V. Kartha. (2023) N-acetylcysteine Pharmacology and Applications in Rare Diseases—Repurposing an Old Antioxidant. Antioxidants 12:7, pages 1316.
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Kedar N. Prasad. (2023) A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer’s disease, and improve its treatment. Mechanisms of Ageing and Development 210, pages 111757.
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Yang Liu, Shujun Zhou, Du Xiang, Lingao Ju, Dexin Shen, Xinghuan Wang & Yanfeng Wang. (2021) Friend or Foe? The Roles of Antioxidants in Acute Lung Injury. Antioxidants 10:12, pages 1956.
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Qianying Lu, Siyu Huang, Xiangyan Meng, Jianfeng Zhang, Sifan Yu, Junfeng Li, Mingyu Shi, Haojun Fan & Yanmei Zhao. (2021) Mechanism of Phosgene-Induced Acute Lung Injury and Treatment Strategy. International Journal of Molecular Sciences 22:20, pages 10933.
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G. Morris, A. J. Walker, K. Walder, M. Berk, W. Marx, A. F. Carvalho, M. Maes & B. K. Puri. (2021) Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry. Molecular Neurobiology 58:5, pages 2158-2182.
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Thomas W. Sawyer. (2020) N-Acetylcysteine as a treatment for sulphur mustard poisoning. Free Radical Biology and Medicine 161, pages 305-320.
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Jared Radbel, Debra L. Laskin, Jeffrey D. Laskin & Howard M. Kipen. (2020) Disease‐modifying treatment of chemical threat agent–induced acute lung injury. Annals of the New York Academy of Sciences 1480:1, pages 14-29.
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S. Chiang, M.L.H. Huang & D.R. Richardson. (2020) Treatment of dilated cardiomyopathy in a mouse model of Friedreich’s ataxia using N-acetylcysteine and identification of alterations in microRNA expression that could be involved in its pathogenesis. Pharmacological Research 159, pages 104994.
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G. Morris, K. R. Walder, M. Berk, W. Marx, A. J. Walker, M. Maes & B. K. Puri. (2020) The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?. Molecular Biology Reports 47:7, pages 5587-5620.
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Shannon Chiang, Danuta S. Kalinowski, Patric J. Jansson, Des R. Richardson & Michael L.-H. Huang. (2018) Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia. Neurochemistry International 117, pages 35-48.
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A Nadeem, N O Al-Harbi, S F Ahmad, K E Ibrahim, N Siddiqui & M M Al-Harbi. (2018) Glucose-6-phosphate dehydrogenase inhibition attenuates acute lung injury through reduction in NADPH oxidase-derived reactive oxygen species. Clinical and Experimental Immunology 191:3, pages 279-287.
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Amy Anzovino, Shannon Chiang, Bronwyn E. Brown, Clare L. Hawkins, Des R. Richardson & Michael L.-H. Huang. (2017) Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia. The American Journal of Pathology 187:12, pages 2858-2875.
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KN Prasad. (2017) Micronutrient-Induced Activation of Nrf2 and -Elevation of Intracellular Antioxidants for Reducing Oxidative Stress and Chronic Infl ammation in Diabetes. Annals of Molecular and Genetic Medicine 1:1, pages 001-007.
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Leopoldo C. Cancio, Robert L. Sheridan, Rob Dent, Sarah Gene Hjalmarson, Emmie Gardner, Annette F. Matherly, Vikhyat S. Bebarta & Tina Palmieri. (2017) Guidelines for Burn Care Under Austere Conditions. Journal of Burn Care & Research 38:1, pages e482-e496.
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Shannon Chiang, Zaklina Kovacevic, Sumit Sahni, Darius J.R. Lane, Angelica M. Merlot, Danuta S. Kalinowski, Michael L.-H. Huang & Des R. Richardson. (2016) Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia. Clinical Science 130:11, pages 853-870.
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Biao Wang, Lin Feng, Gang-Fu Chen, Wei-Dan Jiang, Yang Liu, Sheng-Yao Kuang, Jun Jiang, Ling Tang, Pei Wu, Wu-Neng Tang, Yong-An Zhang, Juan Zhao & Xiao-Qiu Zhou. (2016) Jian carp ( Cyprinus carpio var. Jian) intestinal immune responses, antioxidant status and tight junction protein mRNA expression are modulated via Nrf2 and PKC in response to dietary arginine deficiency. Fish & Shellfish Immunology 51, pages 116-124.
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Ting Dong, Weilong Liu, Zhirong Shen, Lin Li, She Chen & Xiaoguang Lei. (2016) Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain. Scientific Reports 6:1.
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Elise M. Messier, Brian J. Day, Steven R. Kleeberger, Rubin M. Tuder, Russell P. Bowler, Hong Wei Chu, Robert J. Mason & Beata Kosmider. (2013) N -Acetylcysteine Protects Murine Alveolar Type II Cells from Cigarette Smoke Injury in a Nuclear Erythroid 2–Related Factor–2–Independent Manner . American Journal of Respiratory Cell and Molecular Biology 48:5, pages 559-567.
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Wenli Li, Fangfang Liu, Chen Wang, Hubert Truebel & Juergen Pauluhn. (2013) Novel Insights Into Phosgene-Induced Acute Lung Injury in Rats: Role of Dysregulated Cardiopulmonary Reflexes and Nitric Oxide in Lung Edema Pathogenesis. Toxicological Sciences 131:2, pages 612-628.
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