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Inhalation Toxicology
International Forum for Respiratory Research
Volume 23, 2011 - Issue 6
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Research Article

EGFR upregulates inflammatory and proliferative responses in human lung adenocarcinoma cell line (A549), induced by lower dose of cadmium chloride

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Pages 339-348 | Received 06 Oct 2010, Accepted 14 Mar 2011, Published online: 24 May 2011

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Nikoo Hossein-Khannazer, Gholamreza Azizi, Solat Eslami, Hussaini Alhassan Mohammed, Farimah Fayyaz, Ramin Hosseinzadeh, Abubakar B. Usman, Ali N. Kamali, Hamed Mohammadi, Farhad Jadidi-Niaragh, Emad Dehghanifard & Mohammad Noorisepehr. (2020) The effects of cadmium exposure in the induction of inflammation. Immunopharmacology and Immunotoxicology 42:1, pages 1-8.
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Shun-Dong Dai, Shuang Wang, Ya-Nan Qin & Jin-Chao Zhu. (2021) Multiomics Landscape Uncovers the Molecular Mechanism of the Malignant Evolution of Lung Adenocarcinoma Cells to Chronic Low Dose Cadmium Exposure. Frontiers in Oncology 11.
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Ananya Das, Gazala Habib, Perumal Vivekanandan & Arun Kumar. (2021) Reactive oxygen species production and inflammatory effects of ambient PM2.5 -associated metals on human lung epithelial A549 cells “one year-long study”: The Delhi chapter. Chemosphere 262, pages 128305.
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Sun Jiaxin, Wang Shengchen, Cao Yirong, Wang Shuting & Li Shu. (2020) Cadmium exposure induces apoptosis, inflammation and immunosuppression through CYPs activation and antioxidant dysfunction in common carp neutrophils. Fish & Shellfish Immunology 99, pages 284-290.
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Wageh Sobhy Darwish, Zhen Chen, Yonghan Li, Yue Wu, Hitoshi Chiba & Shu-Ping Hui. (2019) Identification of cadmium-produced lipid hydroperoxides, transcriptomic changes in antioxidant enzymes, xenobiotic transporters, and pro-inflammatory markers in human breast cancer cells (MCF7) and protection with fat-soluble vitamins. Environmental Science and Pollution Research 27:2, pages 1978-1990.
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Wageh Sobhy Darwish, Hitoshi Chiba, Abdelazim Elsayed Elhelaly & Shu-Ping Hui. (2019) Estimation of cadmium content in Egyptian foodstuffs: health risk assessment, biological responses of human HepG2 cells to food-relevant concentrations of cadmium, and protection trials using rosmarinic and ascorbic acids. Environmental Science and Pollution Research 26:15, pages 15443-15457.
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Wei Lv, Linlin Sui, Xiaona Yan, Huaying Xie, Liping Jiang, Chengyan Geng, Qiujuan Li, Xiaofeng Yao, Ying Kong & Jun Cao. (2018) ROS-dependent Atg4 upregulation mediated autophagy plays an important role in Cd-induced proliferation and invasion in A549 cells. Chemico-Biological Interactions 279, pages 136-144.
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Akiko Honda, Pratiti Home Chowdhury, Sho Ito, Hitoshi Okano, Toshinori Onishi, Yusuke Kawaryu, Kayo Ueda & Hirohisa Takano. (2017) Synergic effects of 9,10-phenanthrenequinone and cadmium on pro-inflammatory responses in airway epithelial cells. Environmental Toxicology and Pharmacology 52, pages 276-279.
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Jianqiao Chen, Tingru Pan, Na Wan, Zhepeng Sun, Ziwei Zhang & Shu Li. (2017) Cadmium-induced endoplasmic reticulum stress in chicken neutrophils is alleviated by selenium. Journal of Inorganic Biochemistry 170, pages 169-177.
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Helmut PopperHelmut Popper. 2017. Pathology of Lung Disease. Pathology of Lung Disease 291 320 .
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Huabin Cao, Feiyan Gao, Bing Xia, Qingyang Xiao, Xiaoquan Guo, Guoliang Hu & Caiying Zhang. (2016) The co-induced effects of molybdenum and cadmium on the mRNA expression of inflammatory cytokines and trace element contents in duck kidneys. Ecotoxicology and Environmental Safety 133, pages 157-163.
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Caroline O. Odewumi, Lekan M. Latinwo, Michael L. Ruden, Veera L. D. Badisa, Sheila Fils-Aime & Ramesh B. Badisa. (2016) Modulation of cytokines and chemokines expression by NAC in cadmium chloride treated human lung cells. Environmental Toxicology 31:11, pages 1612-1619.
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Huaying Xie, Jiayue Wang, Liping Jiang, Chengyan Geng, Qiujuan Li, Dan Mei, Lian Zhao & Jun Cao. (2016) ROS-dependent HMGA2 upregulation mediates Cd-induced proliferation in MRC-5 cells. Toxicology in Vitro 34, pages 146-152.
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Mary O. Huff, Sarah L. Todd, Aaron L. Smith, Julie T. Elpers, Alexander P. Smith, Robert D. Murphy, Allison S. Bleser-Shartzer, Jacob E. Hoerter, Brandie N. Radde & Carolyn M. Klinge. (2016) Arsenite and Cadmium Activate MAPK/ERK via Membrane Estrogen Receptors and G-Protein Coupled Estrogen Receptor Signaling in Human Lung Adenocarcinoma Cells. Toxicological Sciences 152:1, pages 62-71.
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CAROLINE ODEWUMI, LEKAN M. LATINWO, ANDRE SINCLAIR, VEERA L.D. BADISA, AHKINYALA ABDULLAH & RAMESH B. BADISA. (2015) Effect of cadmium on the expression levels of interleukin-1α and interleukin-10 cytokines in human lung cells. Molecular Medicine Reports 12:5, pages 6422-6426.
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Zhengxi Wei, Xiulong Song & Zahir A. Shaikh. (2015) Cadmium promotes the proliferation of triple-negative breast cancer cells through EGFR-mediated cell cycle regulation. Toxicology and Applied Pharmacology 289:1, pages 98-108.
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Fuhong Liu, Bei Wang, Liqun Li, Fengyun Dong, Xiaocui Chen, Yan Li, Xiuzhen Dong, Youichiro Wada, Carolyn Kapron & Ju Liu. (2015) Low-Dose Cadmium Upregulates VEGF Expression in Lung Adenocarcinoma Cells. International Journal of Environmental Research and Public Health 12:9, pages 10508-10521.
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Caroline O. Odewumi, Shiela Fils‐Aime, Veera L. D. Badisa, Lekan M. Latinwo, Michael L. Ruden, Christopher Ikediobi & Ramesh B. Badisa. (2014) Chemoprotective effect of monoisoamyl 2, 3‐dimercaptosuccinate (MiADMS) on cytokines expression in cadmium chloride treated human lung cells. Environmental Toxicology 30:6, pages 704-711.
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Xiaohua GaoLinda YuAlicia B. MooreGrace E. Kissling, Michael P. Waalkes & Darlene Dixon. (2015) Cadmium and Proliferation in Human Uterine Leiomyoma Cells: Evidence of a Role for EGFR/MAPK Pathways but Not Classical Estrogen Receptor Pathways. Environmental Health Perspectives 123:4, pages 331-336.
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Imran Ali, Pauliina Damdimopoulou, Ulla Stenius & Krister Halldin. (2015) Cadmium at nanomolar concentrations activates Raf–MEK–ERK1/2 MAPKs signaling via EGFR in human cancer cell lines. Chemico-Biological Interactions 231, pages 44-52.
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Ying Ying Chen, Jin Yong Zhu & King Ming Chan. (2014) Effects of cadmium on cell proliferation, apoptosis, and proto-oncogene expression in zebrafish liver cells. Aquatic Toxicology 157, pages 196-206.
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Alessandro Castorina & Salvatore Giunta. (2014) Mucin 1 (MUC1) signalling contributes to increase the resistance to cell death in human bronchial epithelial cells exposed to nickel acetate. BioMetals 27:6, pages 1149-1158.
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Young-Mi Go, Michael Orr & Dean P. Jones. (2013) Actin cytoskeleton redox proteome oxidation by cadmium. American Journal of Physiology-Lung Cellular and Molecular Physiology 305:11, pages L831-L843.
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Frank Thévenod & Wing-Kee Lee. 2013. Cadmium: From Toxicity to Essentiality. Cadmium: From Toxicity to Essentiality 415 490 .
S. Giunta, A. Castorina, S. Scuderi, C. Patti & V. D’Agata. (2012) Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate. Toxicology in Vitro 26:2, pages 280-287.
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