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Inhalation Toxicology
International Forum for Respiratory Research
Volume 23, 2011 - Issue 12
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Research Article

Heterozygosity in the glutathione synthesis gene Gclm increases sensitivity to diesel exhaust particulate induced lung inflammation in mice

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Pages 724-735 | Received 04 Jun 2011, Accepted 22 Jul 2011, Published online: 03 Oct 2011

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Tyler P. Nicholas, Anoria K. Haick, Tomomi W. Workman, William C. Griffith, James D. Nolin, Terrance J. Kavanagh, Elaine M. Faustman & William A. Altemeier. (2020) The effects of genotype × phenotype interactions on silver nanoparticle toxicity in organotypic cultures of murine tracheal epithelial cells. Nanotoxicology 14:7, pages 908-928.
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David K. Scoville, Collin C. White, Dianne Botta, Dowon An, Zahra Afsharinejad, Theo K. Bammler, Xiaohu Gao, William A. Altemeier & Terrance J. Kavanagh. (2018) Quantum dot induced acute changes in lung mechanics are mouse strain dependent. Inhalation Toxicology 30:9-10, pages 397-403.
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Chad S. Weldy, Ian P. Luttrell, Collin C. White, Vicki Morgan-Stevenson, David P. Cox, Christopher M. Carosino, Timothy V. Larson, James A. Stewart, Joel D. Kaufman, Francis Kim, Kanchan Chitaley & Terrance J. Kavanagh. (2013) Glutathione (GSH) and the GSH synthesis gene Gclm modulate plasma redox and vascular responses to acute diesel exhaust inhalation in mice. Inhalation Toxicology 25:8, pages 444-454.
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Articles from other publishers (23)

Faria Khan, Yuzhi Chen, Hadley J. Hartwell, Jin Yan, Ying-Hsuan Lin, Anastasia Freedman, Zhenfa Zhang, Yue Zhang, Andrew T. Lambe, Barbara J. Turpin, Avram Gold, Andrew P. Ault, Rafal Szmigielski, Rebecca C. Fry & Jason D. Surratt. (2023) Heterogeneous Oxidation Products of Fine Particulate Isoprene Epoxydiol-Derived Methyltetrol Sulfates Increase Oxidative Stress and Inflammatory Gene Responses in Human Lung Cells. Chemical Research in Toxicology 36:11, pages 1814-1825.
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Christopher M. Schaupp, Dianne Botta, Collin C. White, David K. Scoville, Sengkeo Srinouanprachanh, Theo K. Bammler, James MacDonald & Terrance J. Kavanagh. (2022) Persistence of improved glucose homeostasis in Gclm null mice with age and cadmium treatment. Redox Biology 49, pages 102213.
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Ehsanifar Mojtaba, Montazeri Zeinab & Rafati Mehravar. (2022) Neurotoxicity related exposure to ambient nanoparticles. Journal of Neuroscience and Neurological Disorders 6:1, pages 005-010.
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Andrés Valderrama, Maria Isabel Zapata, Juan C. Hernandez & Jaiberth A. Cardona-Arias. (2022) Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020. Heliyon 8:1, pages e08778.
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Tyler P. Nicholas, William K. Boyes, David K. Scoville, Tomomi W. Workman, Terrance J. Kavanagh, William A. Altemeier & Elaine M. Faustman. (2021) The effects of gene × environment interactions on silver nanoparticle toxicity in the respiratory system: An adverse outcome pathway. WIREs Nanomedicine and Nanobiotechnology 13:5.
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David K. Scoville, Cindy Yanfei Li, Dongfang Wang, Joseph L. Dempsey, Daniel Raftery, Sridhar Mani, Haiwei Gu & Julia Yue Cui. (2019) Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome–Related Aqueous Metabolites in Mice. Drug Metabolism and Disposition 47:8, pages 928-940.
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Hui Zhou, Meizhen Wang, Nicole E. Smalley, Maxim Kostylev, Amy L. Schaefer, E. Peter Greenberg, Ajai A. Dandekar & Feng Xu. (2019) Modulation of Pseudomonas aeruginosa Quorum Sensing by Glutathione . Journal of Bacteriology 201:9.
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David K. Scoville, James D. Nolin, H. Luke Ogden, Dowon An, Zahra Afsharinejad, Brian W. Johnson, Theo K. Bammler, Xiaohu Gao, Charles W. Frevert, William A. Altemeier, Teal S. Hallstrand & Terrance J. Kavanagh. (2019) Quantum dots and mouse strain influence house dust mite-induced allergic airway disease. Toxicology and Applied Pharmacology 368, pages 55-62.
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Lucio G. Costa, Yu-Chi Chang & Toby B. Cole. (2017) Developmental Neurotoxicity of Traffic-Related Air Pollution: Focus on Autism. Current Environmental Health Reports 4:2, pages 156-165.
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Jérémie Soeur, Jean-Philippe Belaïdi, Christel Chollet, Laurence Denat, Ariane Dimitrov, Christophe Jones, Philippe Perez, Martine Zanini, Olivia Zobiri, Sakina Mezzache, Dominique Erdmann, Guillaume Lereaux, Joan Eilstein & Laurent Marrot. (2017) Photo-pollution stress in skin: Traces of pollutants (PAH and particulate matter) impair redox homeostasis in keratinocytes exposed to UVA1. Journal of Dermatological Science 86:2, pages 162-169.
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Ulrike Luderer, Meagan B. Myers, Malathi Banda, Karen L. McKim, Laura Ortiz & Barbara L. Parsons. (2017) Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status. Reproductive Toxicology 69, pages 187-195.
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Lucio G. Costa, Toby B. Cole, Jacki Coburn, Yu-Chi Chang, Khoi Dao & Pamela J. Roqué. (2017) Neurotoxicity of traffic-related air pollution. NeuroToxicology 59, pages 133-139.
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Toby B. Cole, Jacki Coburn, Khoi Dao, Pam Roqué, Yu-Chi Chang, Vrinda Kalia, Tomas R. Guilarte, Jennifer Dziedzic & Lucio G. Costa. (2016) Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology 374, pages 1-9.
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Megan M. Cartwright, Stefanie C. Schmuck, Charlie Corredor, Bingbing Wang, David K. Scoville, Claire R. Chisholm, Hui-Wen Wilkerson, Zahra Afsharinejad, Theodor K. Bammler, Jonathan D. Posner, Vaithiyalingam Shutthanandan, Donald R. Baer, Somenath Mitra, William A. Altemeier & Terrance J. Kavanagh. (2016) The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis. Redox Biology 9, pages 264-275.
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Pamela J. Roqué, Khoi Dao & Lucio G. Costa. (2016) Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms. NeuroToxicology 56, pages 204-214.
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David K. Scoville, Collin C. White, Dianne Botta, Lisa A. McConnachie, Megan E. Zadworny, Stefanie C. Schmuck, Xiaoge Hu, Xiaohu Gao, Jianbo Yu, Russell L. Dills, Lianne Sheppard, Martha A. Delaney, William C. Griffith, Richard P. Beyer, Richard C. Zangar, Joel G. Pounds, Elaine M. Faustman & Terrance J. Kavanagh. (2015) Susceptibility to quantum dot induced lung inflammation differs widely among the Collaborative Cross founder mouse strains. Toxicology and Applied Pharmacology 289:2, pages 240-250.
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Neal S. Gould, Elysia Min, Jie Huang, Hong Wei Chu, Jim Good, Richard J. Martin & Brian J. Day. (2015) Glutathione Depletion Accelerates Cigarette Smoke-Induced Inflammation and Airspace Enlargement. Toxicological Sciences 147:2, pages 466-474.
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Lucio G. Costa, Toby B. Cole, Jacki Coburn, Yu-Chi Chang, Khoi Dao & Pamela Roque. (2014) Neurotoxicants Are in the Air: Convergence of Human, Animal, and In Vitro Studies on the Effects of Air Pollution on the Brain . BioMed Research International 2014, pages 1-8.
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David K. Scoville, Christopher M. Schaupp, François Baneyx & Terrance J. Kavanagh. 2014. Quantum Dots: Applications in Biology. Quantum Dots: Applications in Biology 179 190 .
Yonggang Liu, Wei-Ming Chien, Ivan O Medvedev, Chad S Weldy, Daniel L Luchtel, Michael E Rosenfeld & Michael T Chin. (2013) Inhalation of diesel exhaust does not exacerbate cardiac hypertrophy or heart failure in two mouse models of cardiac hypertrophy. Particle and Fibre Toxicology 10:1.
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Lisa A. McConnachie, Dianne Botta, Collin C. White, Chad S. Weldy, Hui-Wen Wilkerson, Jianbo Yu, Russell Dills, Xiaozhong Yu, William C. Griffith, Elaine M. Faustman, Federico M. Farin, Sean E. Gill, William C. Parks, Xiaoge Hu, Xiaohu Gao, David L. Eaton & Terrance J. Kavanagh. (2013) The Glutathione Synthesis Gene Gclm Modulates Amphiphilic Polymer-Coated CdSe/ZnS Quantum Dot–Induced Lung Inflammation in Mice. PLoS ONE 8:5, pages e64165.
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Gennaro Giordano, Terrance J. Kavanagh, Elaine M. Faustman, Collin C. White & Lucio G. Costa. (2013) Low-Level Domoic Acid Protects Mouse Cerebellar Granule Neurons from Acute Neurotoxicity: Role of Glutathione. Toxicological Sciences 132:2, pages 399-408.
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Chad S. Weldy, Ian P. Luttrell, Collin C. White, Vicki Morgan-Stevenson, Theo K. Bammler, Richard P. Beyer, Zahra Afsharinejad, Francis Kim, Kanchan Chitaley & Terrance J. Kavanagh. (2012) Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice. Free Radical Biology and Medicine 53:6, pages 1264-1278.
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