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Inhalation Toxicology
International Forum for Respiratory Research
Volume 23, 2011 - Issue 14
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Research Article

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling

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Pages 927-937 | Received 27 Jun 2011, Accepted 19 Sep 2011, Published online: 16 Nov 2011

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Ye Zhang, Michael Story, Samrawit Yeshitla, Xiaoyu Wang, Robert R. Scully, Corey Theriot, Honglu Wu, Valerie E. Ryder & Chiu-wing Lam. (2023) Persistent changes in expression of genes involved in inflammation and fibrosis in the lungs of rats exposed to airborne lunar dust. Inhalation Toxicology 35:5-6, pages 139-156.
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Christina Umbright, Rajendran Sellamuthu, Jenny R. Roberts, Shih-Houng Young, Diana Richardson, Diane Schwegler-Berry, Walter McKinney, Bean Chen, Ja Kook Gu, Michael Kashon & Pius Joseph. (2017) Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in rats. Journal of Toxicology and Environmental Health, Part A 80:23-24, pages 1349-1368.
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Breanne Y. Farris, James M. Antonini, Jeffrey S. Fedan, Robert R. Mercer, Katherine A. Roach, Bean T. Chen, Diane Schwegler-Berry, Michael L. Kashon, Mark W. Barger & Jenny R. Roberts. (2017) Pulmonary toxicity following acute coexposures to diesel particulate matter and α-quartz crystalline silica in the Sprague-Dawley rat. Inhalation Toxicology 29:7, pages 322-339.
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Rajendran Sellamuthu, Christina Umbright, Jenny R. Roberts, Shih-Houng Young, Diana Richardson, Walter McKinney, Bean T. Chen, Shengqiao Li, Michael Kashon & Pius Joseph. (2017) Molecular mechanisms of pulmonary response progression in crystalline silica exposed rats. Inhalation Toxicology 29:2, pages 53-64.
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Rajendran Sellamuthu, Christina Umbright, Jenny R. Roberts, Rebecca Chapman, Shih-Houng Young, Diana Richardson, Jared Cumpston, Walter McKinney, Bean T. Chen, David Frazer, Shengqiao Li, Michael Kashon & Pius Joseph. (2012) Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats. Inhalation Toxicology 24:9, pages 570-579.
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Articles from other publishers (16)

Pius Joseph. 2023. Impact of Engineered Nanomaterials in Genomics and Epigenomics. Impact of Engineered Nanomaterials in Genomics and Epigenomics 187 215 .
Roger M. Pallares, Erin Jarvis, Dahlia D. An, Cindy H. Wu, Polly Y. Chang & Rebecca J. Abergel. (2022) Toxicogenomic assessment of organ-specific responses following plutonium internal contamination. Environmental Advances 8, pages 100245.
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Pius Joseph. 2022. Genomic and Epigenomic Biomarkers of Toxicology and Disease. Genomic and Epigenomic Biomarkers of Toxicology and Disease 133 161 .
Katharine L. Korunes, Jie Liu, Ruili Huang, Menghang Xia, Keith A. Houck & J. Christopher Corton. (2022) A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB. PLOS ONE 17:2, pages e0261854.
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Laura Aliisa Saarimäki, Antonio Federico, Iseult Lynch, Anastasios G. Papadiamantis, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis, Angela Serra & Dario Greco. (2021) Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials. Scientific Data 8:1.
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J. K. Choudhari, M. K. Verma, J. Choubey & B. P. Sahariah. (2021) Investigation of MicroRNA and transcription factor mediated regulatory network for silicosis using systems biology approach. Scientific Reports 11:1.
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Andy H. Vo, Terry R. Van Vleet, Rishi R. Gupta, Michael J. Liguori & Mohan S. Rao. (2019) An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation. Chemical Research in Toxicology 33:1, pages 20-37.
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Yke Arnoldussen, Torunn Kringlen Ervik, Mina Baarnes Eriksen, Ida Kero, Vidar Skaug & Shanbeh Zienolddiny. (2019) Cellular Responses of Industrially Relevant Silica Dust on Human Glial Cells In Vitro. International Journal of Molecular Sciences 20:2, pages 358.
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Benjamin Alexander-Dann, Lavinia Lorena Pruteanu, Erin Oerton, Nitin Sharma, Ioana Berindan-Neagoe, Dezső Módos & Andreas Bender. (2018) Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data. Molecular Omics 14:4, pages 218-236.
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Pius Joseph. (2017) Transcriptomics in toxicology. Food and Chemical Toxicology 109, pages 650-662.
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Ngoc Q. Vuong, Patrick Goegan, Francesco De Rose, Dalibor Breznan, Errol M. Thomson, Julie S. O'Brien, Subramanian Karthikeyan, Andrew Williams, Renaud Vincent & Premkumari Kumarathasan. (2017) Responses of A549 human lung epithelial cells to cristobalite and α-quartz exposures assessed by toxicoproteomics and gene expression analysis. Journal of Applied Toxicology 37:6, pages 721-731.
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Pritha Bhattacharjee, Somnath Paul & Pritha Bhattacharjee. (2016) Risk of occupational exposure to asbestos, silicon and arsenic on pulmonary disorders: Understanding the genetic-epigenetic interplay and future prospects. Environmental Research 147, pages 425-434.
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Yali Zeng, Jianjun Deng, Tingting Huo, Faqin Dong & Limin Wang. (2016) Assessment of genetic toxicity with major inhalable mineral granules in A549 cells. Applied Clay Science 119, pages 175-182.
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Bouchra Bakhiyi, France Labrèche & Joseph Zayed. (2014) The photovoltaic industry on the path to a sustainable future — Environmental and occupational health issues. Environment International 73, pages 224-234.
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Pius Joseph, Christina Umbright & Rajendran Sellamuthu. (2013) Blood transcriptomics: applications in toxicology. Journal of Applied Toxicology 33:11, pages 1193-1202.
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Rasmus Foldbjerg, Jing Wang, Christiane Beer, Kasper Thorsen, Duncan S. Sutherland & Herman Autrup. (2013) Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines. Chemico-Biological Interactions 204:1, pages 28-38.
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