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Inhalation Toxicology
International Forum for Respiratory Research
Volume 25, 2013 - Issue 3
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Research Article

Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts

Jeffry D. SchroeterApplied Research Associates, Inc. Raleigh, NCUSACorrespondence[email protected]
,
Julia S. KimbellDepartment of Otolaryngology/Head and Neck Surgery, University of North Carolina Chapel Hill, NCUSA
,
Bahman AsgharianApplied Research Associates, Inc. Raleigh, NCUSA
,
Earl W. TewksburyThe Hamner Institutes for Health Sciences, Research Triangle Park NCUSA
,
Mark SochaskiThe Hamner Institutes for Health Sciences, Research Triangle Park NCUSA
,
Melanie L. FosterCollege of Veterinary Medicine, North Carolina State University Raleigh, NCUSA
,
David C. DormanCollege of Veterinary Medicine, North Carolina State University Raleigh, NCUSA
,
Brian A. WongSAIC, NAMRU Dayton, Wright Patterson Air Force Base Dayton, OHUSA
&
Melvin E. AndersenThe Hamner Institutes for Health Sciences, Research Triangle Park NCUSA
 show all
Pages 168-177 | Received 29 Nov 2012, Accepted 16 Jan 2013, Published online: 19 Feb 2013

Citations (10)

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Read on this site (2)

Adam V. Wisnewski, Jean Kanyo, Jennifer Asher, James A. Goodrich, Grace Barnett, Lyn Patrylak, Jian Liu, Carrie A. Redlich & Ala F. Nassar. (2018) Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy. Xenobiotica 48:5, pages 488-497.
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Jürgen Pauluhn. (2015) Analysis of the interrelationship of the pulmonary irritation and elicitation thresholds in rats sensitized with 1,6-hexamethylene diisocyanate (HDI). Inhalation Toxicology 27:4, pages 191-206.
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Articles from other publishers (8)

S. Selvakumar, Subbaraj Karunakaran & V. Siva Rama Krishna. (2022) Detection techniques for air-borne isocyanates based on fluorescent derivatizing agents. Environmental Science: Atmospheres 2:6, pages 1249-1258.
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Wolfgang Dekant & Thomas Colnot. (2022) Evaluation of animal toxicity studies with diisocyanates regarding presence of thresholds for induction and elicitation of respiratory allergy by quantitative weight of evidence. Toxicology and Industrial Health 38:9, pages 578-594.
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Adam V. Wisnewski, Jian Liu & Carrie A. Redlich. (2020) Analysis of Lung Gene Expression Reveals a Role for Cl − Channels in Diisocyanate-induced Airway Eosinophilia in a Mouse Model of Asthma Pathology . American Journal of Respiratory Cell and Molecular Biology 63:1, pages 25-35.
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Juergen Pauluhn. (2019) Concentration × time analyses of sensory irritants revisited: Weight of evidence or the toxic load approach. That is the question. Toxicology Letters 316, pages 94-108.
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Adam V. Wisnewski, Ala F. Nassar, Jian Liu & Dhimiter Bello. (2019) Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure?. Chemical Research in Toxicology 32:4, pages 557-565.
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Christie M. SayesMadhuri Singal. (2018) Optimizing a Test Bed System to Assess Human Respiratory Safety After Exposure to Chemical and Particle Aerosolization. Applied In Vitro Toxicology 4:2, pages 193-201.
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Wenjuan Wei, Nathalie Bonvallot, Åsa Gustafsson, Gaëlle Raffy, Philippe Glorennec, Annette Krais, Olivier Ramalho, Barbara Le Bot & Corinne Mandin. (2018) Bioaccessibility and bioavailability of environmental semi-volatile organic compounds via inhalation: A review of methods and models. Environment International 113, pages 202-213.
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Jürgen Pauluhn. (2014) Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level. Toxicology 319, pages 10-22.
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