Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 26, 2014 - Issue 6
587
Views
27
CrossRef citations to date
0
Altmetric
Modeling/Symmetry

A hybrid CFD-PBPK model for naphthalene in rat and human with IVIVE for nasal tissue metabolism and cross-species dosimetry

, &
Pages 333-344 | Received 15 Nov 2013, Accepted 14 Feb 2014, Published online: 25 Mar 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Jean-Marie Heydel, Philippe Faure & Fabrice Neiers. (2019) Nasal odorant metabolism: enzymes, activity and function in olfaction. Drug Metabolism Reviews 51:2, pages 224-245.
Read now
Lisa A. Bailey, Marc A. Nascarella, Laura E. Kerper & Lorenz R. Rhomberg. (2016) Hypothesis-based weight-of-evidence evaluation and risk assessment for naphthalene carcinogenesis. Critical Reviews in Toxicology 46:1, pages 1-42.
Read now

Articles from other publishers (25)

Teresa R. Sterner, Tammie R. Covington & David R. Mattie. (2023) Complex Mixtures: Array PBPK Modeling of Jet Fuel Components. Toxics 11:2, pages 187.
Crossref
Marjory Moreau, Jeff Fisher, Melvin E. Andersen, Asayah Barnwell, Sage Corzine, Aarati Ranade, Patrick D. McMullen & Scott D. Slattery. (2022) NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1,3-dichloropropene. Toxicology 481, pages 153340.
Crossref
Xiaoqing Chang, Yu-Mei Tan, David G. Allen, Shannon Bell, Paul C. Brown, Lauren Browning, Patricia Ceger, Jeffery Gearhart, Pertti J. Hakkinen, Shruti V. Kabadi, Nicole C. Kleinstreuer, Annie Lumen, Joanna Matheson, Alicia Paini, Heather A. Pangburn, Elijah J. Petersen, Emily N. Reinke, Alexandre J. S. Ribeiro, Nisha Sipes, Lisa M. Sweeney, John F. Wambaugh, Ronald Wange, Barbara A. Wetmore & Moiz Mumtaz. (2022) IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making. Toxics 10:5, pages 232.
Crossref
Melvin E. Andersen. (2022) Assessing modes of action, measures of tissue dose and human relevance of rodent toxicity endpoints with octamethylcyclotetrasiloxane (D4). Toxicology Letters 357, pages 57-72.
Crossref
Ali A. Rostami, Jerry L. Campbell, Yezdi B. Pithawalla, Hamideh Pourhashem, Raheema S. Muhammad-Kah, Mohamadi A. Sarkar, Jianmin Liu, Willie J. McKinney, Robinan Gentry & Maria Gogova. (2022) A comprehensive physiologically based pharmacokinetic (PBPK) model for nicotine in humans from using nicotine-containing products with different routes of exposure. Scientific Reports 12:1.
Crossref
Erin E. Yost, Audrey Galizia, Dustin F. Kapraun, Amanda S. Persad, Suryanarayana V. Vulimiri, Michelle Angrish, Janice S. Lee & Ingrid L. Druwe. (2021) Health Effects of Naphthalene Exposure: A Systematic Evidence Map and Analysis of Potential Considerations for Dose–Response Evaluation. Environmental Health Perspectives 129:7.
Crossref
Robert F. Phalen, Mark D. Hoover, Michael J. Oldham & Annie M. Jarabek. (2021) Inhaled aerosol dosimetry: Research-related needs and recommendations. Journal of Aerosol Science 155, pages 105755.
Crossref
Melvin E. Andersen, Pankajini Mallick, Harvey J. ClewellIIIIII, Miyoung Yoon, Geary W. Olsen & Matthew P. Longnecker. (2021) Using quantitative modeling tools to assess pharmacokinetic bias in epidemiological studies showing associations between biomarkers and health outcomes at low exposures. Environmental Research 197, pages 111183.
Crossref
Victor Antontsev, Aditya Jagarapu, Yogesh Bundey, Hypatia Hou, Maksim Khotimchenko, Jason Walsh & Jyotika Varshney. (2021) A hybrid modeling approach for assessing mechanistic models of small molecule partitioning in vivo using a machine learning-integrated modeling platform. Scientific Reports 11:1.
Crossref
Kaushik Chakravarty, Victor G. Antontsev, Maksim Khotimchenko, Nilesh Gupta, Aditya Jagarapu, Yogesh Bundey, Hypatia Hou, Neha Maharao & Jyotika Varshney. (2021) Accelerated Repurposing and Drug Development of Pulmonary Hypertension Therapies for COVID-19 Treatment Using an AI-Integrated Biosimulation Platform. Molecules 26:7, pages 1912.
Crossref
Maksim Khotimchenko, Victor Antontsev, Kaushik Chakravarty, Hypatia Hou & Jyotika Varshney. (2021) In Silico Simulation of the Systemic Drug Exposure Following the Topical Application of Opioid Analgesics in Patients with Cutaneous Lesions. Pharmaceutics 13:2, pages 284.
Crossref
Kendra Shrestha, Ross Walenga, Jinxiang Xi, Yidan Shang, Hana Salati, Jim Bartley & David White. 2021. Clinical and Biomedical Engineering in the Human Nose. Clinical and Biomedical Engineering in the Human Nose 255 291 .
Dustin F Kapraun, Paul M Schlosser, Leena A Nylander-French, David Kim, Erin E Yost & Ingrid L Druwe. (2020) A Physiologically Based Pharmacokinetic Model for Naphthalene With Inhalation and Skin Routes of Exposure. Toxicological Sciences 177:2, pages 377-391.
Crossref
Lisa A. Bailey & Lorenz R. Rhomberg. (2020) Incorporating ToxCast™ data into naphthalene human health risk assessment. Toxicology in Vitro 67, pages 104913.
Crossref
Jeffrey W. Fisher, Jeffery M. Gearhart, Jerry L. CampbellJrJr & Darshan Mehta. 2020. Physiologically Based Pharmacokinetic (PBPK) Modeling. Physiologically Based Pharmacokinetic (PBPK) Modeling 127 138 .
Aline Robert-Hazotte, Rachel Schoumacker, Etienne Semon, Loïc Briand, Elisabeth Guichard, Jean-Luc Le Quéré, Philippe Faure & Jean-Marie Heydel. (2019) Ex vivo real-time monitoring of volatile metabolites resulting from nasal odorant metabolism. Scientific Reports 9:1.
Crossref
Elin BogerMarkus Fridén. (2019) Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:1, pages 1-12.
Crossref
Alain Sewer, Marja Talikka, Florian Martin, Julia Hoeng & Manuel C Peitsch. 2018. Bioinformatics in the Era of Post Genomics and Big Data. Bioinformatics in the Era of Post Genomics and Big Data.
Amy J. Clippinger, David Allen, Annie M. Jarabek, Marco Corvaro, Marianna Gaça, Sean Gehen, Jon A. Hotchkiss, Grace Patlewicz, Jodie Melbourne, Paul Hinderliter, Miyoung Yoon, Dongeun Huh, Anna Lowit, Barbara Buckley, Michael Bartels, Kelly BéruBé, Daniel M. Wilson, Ian Indans & Mathieu Vinken. (2018) Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report. Toxicology in Vitro 48, pages 53-70.
Crossref
Joseph A. Cichocki & John B. Morris. (2017) Inhalation dosimetry modeling provides insights into regional respiratory tract toxicity of inhaled diacetyl. Toxicology 388, pages 30-39.
Crossref
Lei Li, Sarah Carratt, Matthew Hartog, Nataliia Kovalchuk, Kunzhi Jia, Yanan Wang, Qing-Yu Zhang, Patricia Edwards, Laura Van Winkle & Xinxin Ding. (2017) Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice. Environmental Health Perspectives 125:6.
Crossref
E Boger, N Evans, M Chappell, A Lundqvist, P Ewing, A Wigenborg & M Fridén. (2016) Systems Pharmacology Approach for Prediction of Pulmonary and Systemic Pharmacokinetics and Receptor Occupancy of Inhaled Drugs. CPT: Pharmacometrics & Systems Pharmacology 5:4, pages 201-210.
Crossref
Hermann M. Bolt. 2016. Thresholds of Genotoxic Carcinogens. Thresholds of Genotoxic Carcinogens 117 128 .
Joseph A. Cichocki, Gregory J. Smith & John B. Morris. (2014) Tissue Sensitivity of the Rat Upper and Lower Extrapulmonary Airways to the Inhaled Electrophilic Air Pollutants Diacetyl and Acrolein. Toxicological Sciences 142:1, pages 126-136.
Crossref
H.J. Clewell, A. Efremenko, J.L. Campbell, D.E. Dodd & R.S. Thomas. (2014) Transcriptional responses in the rat nasal epithelium following subchronic inhalation of naphthalene vapor. Toxicology and Applied Pharmacology 280:1, pages 78-85.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.