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Inhalation Toxicology
International Forum for Respiratory Research
Volume 7, 1995 - Issue 7
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Research Article

Sensitivity Analysis and the Design of Gas Uptake Inhalation Studies

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Pages 1075-1094 | Received 15 Aug 1994, Accepted 24 Oct 1994, Published online: 27 Sep 2008

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Marina V. Evans, Christopher R. Eklund, David N. Williams, Yusupha M. Sey & Jane Ellen Simmons. (2020) Global optimization of the Michaelis–Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats. Inhalation Toxicology 32:3, pages 97-109.
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Hisham A. El-Masri, Sean Dowd, Rex A. Pegram, Randy Harrison, Sisouphanh J. Yavanhxay, Jane Ellen Simmons & Marina Evans. (2009) Development of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments. Inhalation Toxicology 21:14, pages 1176-1185.
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Laurel J. Ng, Louise M. Stuhmiller & James H. Stuhmiller. (2007) Incorporation of Acute Dynamic Ventilation Changes into a Standardized Physiologically Based Pharmacokinetic Model. Inhalation Toxicology 19:3, pages 247-263.
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Ginette Truchon, Robert Tardif, Pierre-Olivier Droz, Ginette Charest-Tardif & Guillaume Pierrehumbert. (2006) Biological Exposure Indicators: Quantification of Biological Variability Using Toxicokinetic Modeling. Journal of Occupational and Environmental Hygiene 3:3, pages 137-143.
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Marina Villafañe Evans & Christopher R. Eklund. (2001) A Graphical Application of Sensitivity Analysis for Gas Uptake Experiments Using Chloroform as an Example. Toxicology Methods 11:4, pages 285-297.
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Articles from other publishers (6)

M.V. Evans & J.C. Caldwell. (2010) Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling for in vivo inhalation gas uptake data exposure in female B6C3F1 mice. Toxicology and Applied Pharmacology 244:3, pages 280-290.
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G. Hamelin, S. Haddad, K. Krishnan & R. Tardif. (2010) Physiologically based modeling of p - tert -octylphenol kinetics following intravenous, oral or subcutaneous exposure in male and female Sprague-Dawley rats . Journal of Applied Toxicology, pages n/a-n/a.
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Robert Tardif, Pierre-Olivier Droz, Ginette Charest-Tardif, Guillaume Pierrehumbert & Ginette Truchon. (2002) Impact of human variability on the biological monitoring of exposure to toluene: I. Physiologically based toxicokinetic modelling. Toxicology Letters 134:1-3, pages 155-163.
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Elaina M. KenyonMichael FeaMirek Styblo & Marina V. Evans. (2001) Application of Modelling Techniques to the Planning of In Vitro Arsenic Kinetic Studies . Alternatives to Laboratory Animals 29:1, pages 15-33.
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Hoan-My Do Luu & Joseph C. Hutter. (2000) Pharmacokinetic modeling of 4,4'-methylenedianiline released from reused polyurethane dialyzer potting materials. Journal of Biomedical Materials Research 53:3, pages 276-286.
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John C. Lipscomb, Jeffrey W. Fisher, Patricia D. Confer & Janusz Z. Byczkowski. (1998) In Vitrotoin VivoExtrapolation for Trichloroethylene Metabolism in Humans. Toxicology and Applied Pharmacology 152:2, pages 376-387.
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