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Inhalation Toxicology
International Forum for Respiratory Research
Volume 8, 1996 - Issue 3
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Research Article

Pathologic Changes in Rat Lungs Following Acute Sulfur Mustard Inhalation

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Pages 285-297 | Published online: 27 Sep 2008

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Read on this site (8)

Mark R. Perry, Matthew Neal, Roger Hawks, David Pressburger, Jan Satola, Cheryl Triplett, Beth Reed, Meredith Andrews, Jill A. Harvilchuck, Michael S. Nealy, Gennady E. Platoff$suffix/text()$suffix/text() & David T. Yeung. (2021) A novel sulfur mustard (HD) vapor inhalation exposure model of pulmonary toxicity for the efficacy evaluation of candidate medical countermeasures. Inhalation Toxicology 33:6-8, pages 221-233.
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Mohammad Reza Khazdair, Mohammad Hossein Boskabady & Vahideh Ghorani. (2015) Respiratory effects of sulfur mustard exposure, similarities and differences with asthma and COPD. Inhalation Toxicology 27:14, pages 731-744.
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Mohammad Hossein Boskabady, Sediqa Amery, Nassim Vahedi & Mohammad Reza Khakzad. (2011) The effect of vitamin E on tracheal responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. Inhalation Toxicology 23:3, pages 157-165.
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JeanClare Seagrave, Waylon M. Weber & Gary R. Grotendorst. (2010) Sulfur mustard vapor effects on differentiated human lung cells. Inhalation Toxicology 22:11, pages 896-902.
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Waylon M. Weber, Dean A. Kracko, Mericka R. Lehman, Clinton M. Irvin, Lee F. Blair, Richard K. White, Janet M. Benson, Gary R. Grotendorst, Yung-Sung Cheng & Jacob D. McDonald. (2010) Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury. Toxicology Mechanisms and Methods 20:1, pages 14-24.
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Annetta Watson, Dennis Opresko, Robert Young & Veronique Hauschild. (2006) Development and Application of Acute Exposure Guideline Levels (AEGLs) for Chemical Warfare Nerve and Sulfur Mustard Agents. Journal of Toxicology and Environmental Health, Part B 9:3, pages 173-263.
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Fred M. Cowan Dana R. Anderson Clarence A. Broomfield Susan L. Byers William J. Smith. (1997) BIOCHEMICAL ALTERATIONS IN RAT LUNG LAVAGE FLUID FOLLOWING ACUTE SULFUR MUSTARD INHALATION: II. INCREASES IN PROTEOLYTIC ACTIVITY. Inhalation Toxicology 9:1, pages 53-61.
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D. R. Anderson, S. L. Byers, C. R. Clark, J. A. Schlehr. (1997) BIOCHEMICAL ALTERATIONS IN RAT LUNG LAVAGE FLUID FOLLOWING ACUTE SULFUR MUSTARD INHALATION. Inhalation Toxicology 9:1, pages 43-52.
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Articles from other publishers (30)

Rama Malaviya, Jeffrey D. Laskin, Rita Businaro & Debra L. Laskin. (2023) Targeting Tumor Necrosis Factor Alpha to Mitigate Lung Injury Induced by Mustard Vesicants and Radiation. Disaster Medicine and Public Health Preparedness 17.
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Mohammad Reza Khazdair & Mohammad Hossein Boskabady. (2022) Possible Treatment Approaches of Sulfur Mustard-Induced Lung Disorders, Experimental and Clinical Evidence, an Updated Review. Frontiers in Medicine 9.
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Mohammad Reza Khazdair & Mohammad Hossein Boskabady. (2021) Possible treatment with medicinal herbs and their ingredients of lung disorders induced by sulfur mustard exposures: a review. Environmental Science and Pollution Research 28:39, pages 54191-54208.
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Alfred M. Sciuto & Urmila P. Kodavanti. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 515 544 .
Matthew D. McGraw, Marilyn M. Dysart, Tara B. Hendry-Hofer, Paul R. Houin, Jaqueline S. Rioux, Rhonda B. Garlick, Joan E. Loader, Russell Smith, Danielle C. Paradiso, Wesley W. Holmes, Dana R. Anderson, Carl W. White & Livia A. Veress. (2018) Bronchiolitis Obliterans and Pulmonary Fibrosis after Sulfur Mustard Inhalation in Rats. American Journal of Respiratory Cell and Molecular Biology 58:6, pages 696-705.
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Devon K. Andres, Brian M. Keyser, Ashley A. Melber, Betty J. Benton, Tracey A. Hamilton, Denise M. Kniffin, Margaret E. Martens & Radharaman Ray. (2017) Apoptotic cell death in rat lung following mustard gas inhalation. American Journal of Physiology-Lung Cellular and Molecular Physiology 312:6, pages L959-L968.
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Zahra Gholamnezhad, Mohammad Hossein Boskabady, Sediqa Amery, Nassim Vahedi, Abass Tabatabaei, Morteza Boskabady & Alireza Shahriary. (2016) The effect of vitamin E on lung pathology in sulfur mustard-exposed guinea pigs. Toxicology and Industrial Health 32:12, pages 1971-1977.
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Cameron S. McElroy, Elysia Min, Jie Huang, Joan E. Loader, Tara B. Hendry-Hofer, Rhonda B. Garlick, Jackie S. Rioux, Livia A. Veress, Russell Smith, Chris Osborne, Dana R. Anderson, Wesley W. Holmes, Danielle C. Paradiso, Carl W. White & Brian J. Day. (2016) From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity. Toxicological Sciences 154:2, pages 341-353.
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Zhu Xiaoji, Meng Xiao, Xu Rui, Chu Haibo, Zhao Chao, Lian Chengjin, Wang Tao, Guo Wenjun & Zhang Shengming. (2014) Mechanism underlying acute lung injury due to sulfur mustard exposure in rats. Toxicology and Industrial Health 32:8, pages 1345-1357.
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Paul R. Houin, Livia A. Veress, Raymond C. Rancourt, Tara B. Hendry-Hofer, Joan E. Loader, Jacqueline S. Rioux, Rhonda B. Garlick & Carl W. White. (2015) Intratracheal heparin improves plastic bronchitis due to sulfur mustard analog. Pediatric Pulmonology 50:2, pages 118-126.
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Livia A. Veress, Dana R. Anderson, Tara B. Hendry-Hofer, Paul R. Houin, Jacqueline S. Rioux, Rhonda B. Garlick, Joan E. Loader, Danielle C. Paradiso, Russell W. Smith, Raymond C. Rancourt, Wesley W. Holmes & Carl W. White. (2015) Airway Tissue Plasminogen Activator Prevents Acute Mortality Due to Lethal Sulfur Mustard Inhalation. Toxicological Sciences 143:1, pages 178-184.
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Mark R. Perry, Eric M. Benson, Jonathon W. Kohne, Jennifer L. Plahovinsak, Michael C. Babin, Gennady E. PlatoffJr.Jr. & David T. Yeung. (2015) A novel sulfur mustard (HD) vapor inhalation exposure system for accurate inhaled dose delivery. Journal of Pharmacological and Toxicological Methods 71, pages 120-128.
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Alfred M. Sciuto & Urmila P. Kodavanti. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 489 518 .
Mostafa Ghanei & Amin Saburi. 2015. Basic and Clinical Toxicology of Mustard Compounds. Basic and Clinical Toxicology of Mustard Compounds 171 212 .
Ramin Zojaji & Morteza Mazloum Farsi Baf. 2015. Basic and Clinical Toxicology of Mustard Compounds. Basic and Clinical Toxicology of Mustard Compounds 135 170 .
Raymond C. Rancourt, Aftab Ahmad, Livia A. Veress, Jacqueline S. Rioux, Rhonda B. Garlick & Carl W. White. (2014) Antifibrinolytic Mechanisms in Acute Airway Injury after Sulfur Mustard Analog Inhalation. American Journal of Respiratory Cell and Molecular Biology 51:4, pages 559-567.
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Brian M. Keyser, Devon K. Andres, Wesley W. Holmes, Danielle Paradiso, Ashley Appell, Valerie A. Letukas, Betty Benton, Offie E. Clark, Xiugong Gao, Prabhati Ray, Dana R. Anderson & Radharaman Ray. (2014) Mustard Gas Inhalation Injury. International Journal of Toxicology 33:4, pages 271-281.
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Brian M. Keyser, Devon K. Andres, Eric Nealley, Wesley W. Holmes, Betty Benton, Danielle Paradiso, Ashley Appell, Chris Carpin, Dana R. Anderson, William J. Smith & Radharaman Ray. (2013) Postexposure Application of Fas Receptor Small-Interfering RNA to Suppress Sulfur Mustard–Induced Apoptosis in Human Airway Epithelial Cells: Implication for a Therapeutic Approach. Journal of Pharmacology and Experimental Therapeutics 344:1, pages 308-316.
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Mohammad Hossein Boskabady, Abbas Tabatabayee, Sediqa Amiri & Nasim Vahedi. (2011) The effect of vitamin E on pathological changes in kidney and liver of sulphur mustard-exposed guinea pigs. Toxicology and Industrial Health 28:3, pages 216-221.
Crossref
Xiugong Gao, Dana R. Anderson, Ammon W. Brown, Hsiuling Lin, Jack Amnuaysirikul, Aileen L. Chua, Wesley W. Holmes & Prabhati Ray. (2011) Pathological Studies on the Protective Effect of a Macrolide Antibiotic, Roxithromycin, against Sulfur Mustard Inhalation Toxicity in a Rat Model. Toxicologic Pathology 39:7, pages 1056-1064.
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Barry Weinberger, Jeffrey D. Laskin, Vasanthi R. Sunil, Patrick J. Sinko, Diane E. Heck & Debra L. Laskin. (2011) Sulfur mustard-induced pulmonary injury: Therapeutic approaches to mitigating toxicity. Pulmonary Pharmacology & Therapeutics 24:1, pages 92-99.
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Yi-Hua Jan, Diane E. Heck, Joshua P. Gray, Haiyan Zheng, Robert P. Casillas, Debra L. Laskin & Jeffrey D. Laskin. (2010) Selective Targeting of Selenocysteine in Thioredoxin Reductase by the Half Mustard 2-Chloroethyl Ethyl Sulfide in Lung Epithelial Cells. Chemical Research in Toxicology 23:6, pages 1045-1053.
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Radharaman Ray, Cynthia M. Simbulan-Rosenthal, Brian M. Keyser, Betty Benton, Dana Anderson, Wesley Holmes, Valerie A. Trabosh, Ahmad Daher & Dean S. Rosenthal. (2010) Sulfur mustard induces apoptosis in lung epithelial cells via a caspase amplification loop. Toxicology 271:3, pages 94-99.
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Marie J. Hammer-Wilson, Vi Nguyen, Woong-Gyu Jung, Yehchen Ahn, Zhongping Chen & Petra Wilder-Smith. (2010) Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence tomography. Journal of Biomedical Optics 15:1, pages 016017.
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Robert L. Maynard & Robert P. Chilcott. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Dana R. Anderson, Stephanie L. Taylor, David P. Fetterer & Wesley W. Holmes. (2009) Evaluation of protease inhibitors and an antioxidant for treatment of sulfur mustard-induced toxic lung injury. Toxicology 263:1, pages 41-46.
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Mohammad H. BoskabadyJavad Farhadi. (2008) The Possible Prophylactic Effect of Nigella sativa Seed Aqueous Extract on Respiratory Symptoms and Pulmonary Function Tests on Chemical War Victims: A Randomized, Double-Blind, Placebo-Controlled Trial . The Journal of Alternative and Complementary Medicine 14:9, pages 1137-1144.
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Jennifer Sekowski & James Dillman Iii. 2007. Chemical Warfare Agents. Chemical Warfare Agents.
Dana R. Anderson, Susan L. Byers & Keith R. Vesely. (2001) Treatment of sulfur mustard (HD)-induced lung injury†. Journal of Applied Toxicology 20:S1, pages S129-S132.
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J.-H. Calvet, M. Feuermann, B. Llorente, F. Loison, A. Harf & F. Marano. (1999) Comparative toxicity of sulfur mustard and nitrogen mustard on tracheal epithelial cells in primary culture. Toxicology in Vitro 13:6, pages 859-866.
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