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Growth Factors Volume 18, 2000 - Issue 1
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Original Article

Stoichiometry, Kinetic and Binding Analysis of the Interaction between Epidermal Growth Factor (EGF) and the Extracellular Domain of the EGF Receptor

Teresa Domagala The Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, 3050, Australia; The CRC for Cellular Growth Factors, Australia
,
Nicky Konstantopoulos The Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, 3050, Australia; The CRC for Cellular Growth Factors, Australia
,
Fiona Smyth The Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, 3050, Australia; The CRC for Cellular Growth Factors, Australia
,
Robert N. Jorissen The Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, 3050, Australia; The CRC for Cellular Growth Factors, Australia
,
Louis Fabri The Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, 3050, Australia; The CRC for Cellular Growth Factors, Australia
,
Detlef Geleick The Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, 3050, Australia
,
Irit Lax The Department of Pharmacology, New York University Medical Center, New York, NY, 10016, USA
,
Joseph Schlessinger The Department of Pharmacology, New York University Medical Center, New York, NY, 10016, USA
,
William Sawyer The Department of Biochemistry, University of Melbourne, Parkville, Australia
,
Geoffrey J. Howlett The Department of Biochemistry, University of Melbourne, Parkville, Australia
,
Antony W. Burgess The Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, 3050, Australia; The CRC for Cellular Growth Factors, Australia
&
Edouard C. Nice The Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, 3050, Australia; The CRC for Cellular Growth Factors, AustraliaCorrespondence[email protected]
 show all
Pages 11-29 | Received 19 Apr 1999, Accepted 08 Jul 1999, Published online: 11 Jul 2009

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Francesca Walker, Julie Rothacker, Christine Henderson, Edouard C. Nice, Bruno Catimel, Hui-Hua Zhang, Andrew M. Scott, Michael F. Bailey, Suzanne G. Orchard, Timothy E. Adams, Zhanqi Liu, Thomas P.J. Garrett, Andrew H.A. Clayton & Antony W. Burgess. (2012) Ligand binding induces a conformational change in epidermal growth factor receptor dimers. Growth Factors 30:6, pages 394-409.
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Timothy E. Adams, Eva J. Koziolek, Peter H. Hoyne, John D. Bentley, Louis Lu, George Lovrecz, Colin W. Ward, F. T. Lee, Andrew M. Scott, Andrew D. Nash, Julie Rothacker, Edouard C. Nice, Antony W. Burgess, Terrance G. Johns, Timothy E. Adams, Eva J. Koziolek, Peter H. Hoyne, John D. Bentley, Louis Lu, George Lovrecz, Colin W. Ward, F. T. Lee, Andrew M. Scott, Andrew D. Nash, Julie Rothacker, Edouard C. Nice, Antony W. Burgess & Terrance G. Johns. (2009) A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo. Growth Factors 27:3, pages 141-154.
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Dianne Alewood, Kathy Nielsen, Paul F. Alewood, David J. Craik, Peter Andrews, Maureen Nerrie, Sara White, Teresa Domagala, Francesca Walker, Julie Rothacker, Antony W. Burgess & Edouard C. Nice. (2005) The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF). Growth Factors 23:2, pages 97-110.
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RobertN. Jorissen, HerbertR. Treutlein, V. Chandana Epa & AntonyW. Burgess. (2002) Modeling the Epidermal Growth Factor—Epidermal Growth Factor Receptor L2 Domain Interaction: Implications for the Ligand Binding Process. Journal of Biomolecular Structure and Dynamics 19:6, pages 961-972.
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