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Growth Factors Volume 28, 2010 - Issue 5
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Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases

Kim K. Ia Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, 3010, Australia
,
Ryan D. Mills Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, 3010, Australia
,
Mohammed I. Hossain Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, 3010, Australia
,
Khai-Chew Chan Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, 3010, Australia
,
Boonyarin Jarasrassamee Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, 3010, Australia
,
Robert N. Jorissen Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, P.O. Box 2008, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia
&
Heung-Chin Cheng Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, 3010, AustraliaCorrespondence[email protected]
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Pages 329-350 | Received 20 Jan 2010, Accepted 07 Apr 2010, Published online: 17 May 2010

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Matthew Ku, Meaghan Wall, Ruth N. MacKinnon, Carl R. Walkley, Louise E. Purton, Constantine Tam, David Izon, Lynda Campbell, Heung-Chin Cheng & Harshal Nandurkar. (2015) Src family kinases and their role in hematological malignancies. Leukemia & Lymphoma 56:3, pages 577-586.
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Articles from other publishers (26)

Horacio Maldonado & Lisette Leyton. (2023) CSK-mediated signalling by integrins in cancer. Frontiers in Cell and Developmental Biology 11.
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Adam S. Potter, Mohit M. Hulsurkar, Lingling Wu, Bharat Narasimhan, Kaveh Karimzad, Efstratios Koutroumpakis, Nicolas Palaskas, Anita Deswal, Bharat K. Kantharia & Xander H.T. Wehrens. (2023) Kinase Inhibitors and Atrial Fibrillation. JACC: Clinical Electrophysiology 9:4, pages 591-602.
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Juan Luo, Hailin Zou, Yibo Guo, Tongyu Tong, Liping Ye, Chengming Zhu, Liang Deng, Bo Wang, Yihang Pan & Peng Li. (2022) SRC kinase-mediated signaling pathways and targeted therapies in breast cancer. Breast Cancer Research 24:1.
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Andra Fortner, Alexandra Chera, Antoanela Tanca & Octavian Bucur. (2022) Apoptosis regulation by the tyrosine-protein kinase CSK. Frontiers in Cell and Developmental Biology 10.
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Yuki Ishikawa & Chikashi Terao. (2020) Genetics of systemic sclerosis. Journal of Scleroderma and Related Disorders 5:3, pages 192-201.
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Neha AmatyaDavid Yin-wei LinAmy H. Andreotti. (2019) Dynamic regulatory features of the protein tyrosine kinases. Biochemical Society Transactions 47:4, pages 1101-1116.
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Julhash U. Kazi & Lars Rönnstrand. (2019) The role of SRC family kinases in FLT3 signaling. The International Journal of Biochemistry & Cell Biology 107, pages 32-37.
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G. D. N. Gayathri Samarasekera & Vanessa Jane Auld. (2018) C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src. Molecular Biology of the Cell 29:2, pages 123-136.
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Heung-Chin Cheng, Gahana Advani, Mohammed Iqbal Hossain, Nadia L. Y. Ng, Ya Chee Lim, Anderly C. Chüeh, Mohd Aizuddin Kamaruddin & Yuh-Ping Chong. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1215 1230 .
Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia L. Y. Ng, Anderly C. Chüeh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E. Turk, Thomas E. Smithgall, Ching-Seng Ang, Michael Griffin & Heung-Chin Cheng. (2017) Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine. Cell Communication and Signaling 15:1.
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Elizabeth Foxall, Aikaterini Pipili, Gareth E. Jones & Claire M. Wells. (2016) Significance of kinase activity in the dynamic invadosome. European Journal of Cell Biology 95:11, pages 483-492.
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Dongsheng Liu & David Cowburn. (2016) Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophysics Reports 2:1, pages 33-43.
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Heung-Chin Cheng, Gahana Advani, Mohammed Iqbal Hossain, Nadia LY Ng, Ya Chee Lim, Anderly C. Chüeh, Mohd Aizuddin Kamaruddin & Yuh-Ping Chong. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 17 .
Tae-Hwan Kim, Naser Monsefi, Je-Hoon Song, Alex von Kriegsheim, Drieke Vandamme, Olivier Pertz, Boris N. Kholodenko, Walter Kolch & Kwang-Hyun Cho. (2015) Network-based identification of feedback modules that control RhoA activity and cell migration. Journal of Molecular Cell Biology 7:3, pages 242-252.
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Gahana Advani, Anderly C. Chueh, Ya Chee Lim, Amardeep Dhillon & Heung-Chin Cheng. (2015) Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression. Frontiers in Biology 10:3, pages 195-202.
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Sulyman Barkho, Levi C. T. Pierce, Maria L. McGlone, Sheng Li, Virgil L. Woods, Ross C. Walker, Joseph A. Adams & Patricia A. Jennings. (2013) Distal Loop Flexibility of a Regulatory Domain Modulates Dynamics and Activity of C-Terminal Src Kinase (Csk). PLoS Computational Biology 9:9, pages e1003188.
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Philip J. Hogg. (2013) Targeting allosteric disulphide bonds in cancer. Nature Reviews Cancer 13:6, pages 425-431.
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Hiroaki Tanaka, Ken-ichi Akagi, Chitose Oneyama, Masakazu Tanaka, Yuichi Sasaki, Takashi Kanou, Young-Ho Lee, Daisuke Yokogawa, Marc-Werner Dobenecker, Atsushi Nakagawa, Masato Okada & Takahisa Ikegami. (2013) Identification of a New Interaction Mode between the Src Homology 2 Domain of C-terminal Src Kinase (Csk) and Csk-binding Protein/Phosphoprotein Associated with Glycosphingolipid Microdomains. Journal of Biological Chemistry 288:21, pages 15240-15254.
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Wei-Lan Yeh, Keiko Shioda, Kathryn R. Coser, Danielle Rivizzigno, Kristen R. McSweeney & Toshi Shioda. (2013) Fulvestrant-Induced Cell Death and Proteasomal Degradation of Estrogen Receptor α Protein in MCF-7 Cells Require the CSK c-Src Tyrosine Kinase. PLoS ONE 8:4, pages e60889.
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Daniele Repetto, Simona Aramu, Elisabetta Boeri Erba, Nanaocha Sharma, Silvia Grasso, Isabella Russo, Ole N. Jensen, Sara Cabodi, Emilia Turco, Paola Di Stefano & Paola Defilippi. (2013) Mapping of p140Cap Phosphorylation Sites: The EPLYA and EGLYA Motifs Have a Key Role in Tyrosine Phosphorylation and Csk Binding, and Are Substrates of the Abl Kinase. PLoS ONE 8:1, pages e54931.
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Xiang Xiao, Dolores D. Mruk, Faith L. Cheng & C. Yan Cheng. 2013. Biology and Regulation of Blood-Tissue Barriers. Biology and Regulation of Blood-Tissue Barriers 295 317 .
Lindsy R. Boateng & Anna Huttenlocher. (2012) Spatiotemporal regulation of Src and its substrates at invadosomes. European Journal of Cell Biology 91:11-12, pages 878-888.
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Mohammed I Hossain, Mohd A Kamaruddin & Heung-Chin Cheng. (2012) Aberrant regulation and function of Src family tyrosine kinases: Their potential contributions to glutamate-induced neurotoxicity. Clinical and Experimental Pharmacology and Physiology 39:8, pages 684-691.
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Benjamin C. Montgomery, Herman D. Cortes, Deborah N. Burshtyn & James L. Stafford. (2012) Channel catfish leukocyte immune-type receptor mediated inhibition of cellular cytotoxicity is facilitated by SHP-1-dependent and -independent mechanisms. Developmental & Comparative Immunology 37:1, pages 151-163.
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Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin & Yuh-Ping Chong. 2012. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 463 472 .
Kim K. Ia, Grace R. Jeschke, Yang Deng, Mohd Aizuddin Kamaruddin, Nicholas A. Williamson, Denis B. Scanlon, Janetta G. Culvenor, Mohammed Iqbal Hossain, Anthony W. Purcell, Sheng Liu, Hong-Jian Zhu, Bruno Catimel, Benjamin E. Turk & Heung-Chin Cheng. (2011) Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of β-Synuclein as a Potential CHK Physiological Substrate. Biochemistry 50:31, pages 6667-6677.
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