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Original Article

Expression of Three Recombinant Homodimeric Isoforms of PDGF in Saccharomyces cerevisiae: Evidence for Difference in Receptor Binding and Functional Activities

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Pages 271-281 | Published online: 11 Jul 2009

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Read on this site (14)

Johanna Andrae, Hans Ehrencrona, Radiosa Gallini, Mark Lal, Hao Ding & Christer Betsholtz. (2013) Analysis of Mice Lacking the Heparin-Binding Splice Isoform of Platelet-Derived Growth Factor A. Molecular and Cellular Biology 33:20, pages 4030-4040.
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Maria Andersson, Arne Östman, Joachim Kreysing, Gudrun Bäckström, Monique van de Poll & Carl-Henrik Heldin. (1995) Involvement of Loop 2 of Platelet-Derived Growth Faetor-AA and-BB in Receptor Binding. Growth Factors 12:2, pages 159-164.
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Milos Pekny, Arne Östman, Annika Hermansson, Monica Nister, Carl-Henrik Heldin & Bengt Westermark. (1994) Differences in Binding to the Solid Substratum and Extracellular Matrix may Explain Isoform-Specific Paracrine Effects of Platelet-Derived Growth Factor. Growth Factors 10:2, pages 77-87.
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K. Forsberg, G. Nilsson, Z. P. Ren, L. Hellman, B. Westermark & M. Nistér. (1993) Constitutive and Inducible Expression of PDGF in the Human Basophilic Cell Line, KU 812. Growth Factors 9:3, pages 231-241.
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Everardus J. J. van Zoelen, Walter van Rotterdam, Rudi A. C. van de Wetering & Carl-Henrik Heldin. (1993) Differential Effects of PDGF Isoforrns on Proliferation of Normal Rat Kidney Cells. Growth Factors 9:4, pages 329-339.
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Werner Risau, Hannes Drexler, Vladimir Mironov, Anja Smits, Agneta Siegbahn, Keiko Funa & Carl-Henrik Heldin. (1992) Platelet-Derived Growth Factor is Angiogenic In Vivo. Growth Factors 7:4, pages 261-266.
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Anders Eriksson, Charlotte Rorsman, Agneta Ernlund, Lena Claesson-Welsh & Carl-Henrik Heldin. (1992) Ligand-Induced Homo-and Hetero-Dimerization of Platelet-Derived Growth Factor α- and β-Receptors in Intact Cells. Growth Factors 6:1, pages 1-14.
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Levon M. Khachigian & Colin N. Chesterman. (1992) Platelet-Derived Growth Factor and Alternative Splicing: A Review. Pathology 24:4, pages 280-290.
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Ltv Severinsson, Bo Ek, Karin Mellström, Lena Claesson-Welsh & Carl-Henrik Heldin. (1990) Deletion of the Kinase Insert Sequence of the Platelet-Derived Growth Factor β-Receptor Affects Receptor Kinase Activity and Signal Transduction. Molecular and Cellular Biology 10:2, pages 801-809.
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Maria Sjölund, Magnus Rahm, Lena Claesson-welsh, Thomas Sejersen, Carl-Henrik Heldin & Johan Thyberg. (1990) Expression of PDGF α- and β-receptors in Rat Arterial Smooth Muscle Cells is Phenotype and Growth State Dependent. Growth Factors 3:3, pages 191-203.
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Articles from other publishers (74)

A.-A. V. Misterova, V. A. Chicherin & A. S. Gerasimov. (2023) Optimization of a Purification Method for the Recombinant Platelet-Derived Growth Factor rhPDGF-BB Expressed in the Methylotrophic Yeast Pichia Pastoris. Applied Biochemistry and Microbiology 59:4, pages 489-496.
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Philip Tannenberg, Ya-Ting Chang, Lars Muhl, Bàrbara Laviña, Hanna Gladh, Guillem Genové, Christer Betsholtz, Erika Folestad & Karin Tran-Lundmark. (2018) Extracellular retention of PDGF-B directs vascular remodeling in mouse hypoxia-induced pulmonary hypertension. American Journal of Physiology-Lung Cellular and Molecular Physiology 314:4, pages L593-L605.
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Thomas F. Deuel & Yunchao Chang. 2014. Principles of Tissue Engineering. Principles of Tissue Engineering 291 308 .
C.S. Young, P.A. Ladd, C.F. Browning, A. Thompson, J. Bonomo, K. Shockley & C.E. Hart. (2009) Release, biological potency, and biochemical integrity of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) combined with AugmentTM Bone Graft or GEM 21S beta-tricalcium phosphate (β-TCP). Journal of Controlled Release 140:3, pages 250-255.
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Thomas F. Deuel & Yunchao Chang. 2007. Principles of Tissue Engineering. Principles of Tissue Engineering 193 206 .
Chang Shin Park, Ian C. Schneider & Jason M. Haugh. (2003) Kinetic Analysis of Platelet-derived Growth Factor Receptor/Phosphoinositide 3-Kinase/Akt Signaling in Fibroblasts. Journal of Biological Chemistry 278:39, pages 37064-37072.
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Per Lindblom, Holger Gerhardt, Stefan Liebner, Alexandra Abramsson, Maria Enge, Mats Hellström, Gudrun Bäckström, Simon Fredriksson, Ulf Landegren, Henrik C. Nyström, Göran Bergström, Elisabetta Dejana, Arne Östman, Per Lindahl & Christer Betsholtz. (2003) Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes & Development 17:15, pages 1835-1840.
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Ola Rollman, Uffe B. Jensen, Arne Östman, Lars Bolund, Sigrún M. Gústafsdóttir & Thomas G. Jensen. (2003) Platelet Derived Growth Factor (PDGF) Responsive Epidermis Formed from Human Keratinocytes Transduced with the PDGFβ Receptor Gene. Journal of Investigative Dermatology 120:5, pages 742-749.
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Xuri Li, Annica Pontén, Karin Aase, Linda Karlsson, Alexandra Abramsson, Marko Uutela, Gudrun Bäckström, Mats Hellström, Hans Boström, Hong Li, Philippe Soriano, Christer Betsholtz, Carl-Henrik Heldin, Kari Alitalo, Arne Östman & Ulf Eriksson. (2000) PDGF-C is a new protease-activated ligand for the PDGF α-receptor. Nature Cell Biology 2:5, pages 302-309.
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Olli Leppänen, Keiji Miyazawa, Gudrun Bäckström, Kristian Pietras, Tobias Sjöblom, Carl-Henrik Heldin & Arne Östman. (2000) Predimerization of Recombinant Platelet-Derived Growth Factor Receptor Extracellular Domains Increases Antagonistic Potency. Biochemistry 39:9, pages 2370-2375.
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Thomas F. Deuel & Nan Zhang. 2000. Principles of Tissue Engineering. Principles of Tissue Engineering 129 141 .
Linda Karlsson, Cecilia Bondjers & Christer Betsholtz. (1999) Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126:12, pages 2611-2621.
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Carl-Henrik Heldin & Bengt Westermark. (1999) Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor. Physiological Reviews 79:4, pages 1283-1316.
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Mikael Ivarsson, Alan McWhirter, Thomas K. Borg & Kristofer Rubin. (1998) Type I collagen synthesis in cultured human fibroblasts: Regulation by cell spreading, platelet-derived growth factor and interactions with collagen fibers. Matrix Biology 16:7, pages 409-425.
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