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Shinobu Tsuzuki, Kenji Kitajima, Toru Nakano, Annegret Glasow, Arthur Zelent & Tariq Enver. (2004) Cross Talk between Retinoic Acid Signaling and Transcription Factor GATA-2. Molecular and Cellular Biology 24:15, pages 6824-6836.
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Ludovica Bruno, Reinhard Hoffmann, Fraser McBlane, John Brown, Rajeev Gupta, Chirag Joshi, Stella Pearson, Thomas Seidl, Clare Heyworth & Tariq Enver. (2004) Molecular Signatures of Self-Renewal, Differentiation, and Lineage Choice in Multipotential Hemopoietic Progenitor Cells In Vitro. Molecular and Cellular Biology 24:2, pages 741-756.
Read now
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M. A. Pearson, A.-M Ofarrell, T. M. Dexter, A. D. Whetton, P. J. Owen-Lynch & C. M. Heyworth. (1998) Investigation of the Molecular Mechanisms Underlying Growth Factor Synergy: The Role of ERK 2 Activation in Synergy. Growth Factors 15:4, pages 293-306.
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Birgit M. Reipert, Donald Allan & T. Michael Dexter. (1996) Exposure to Extremely Low Frequency Magnetic Fields Has No Effect on Growth Rate or Clonogenic Potential of Multipotential Haemopoietic Progenitor Cells. Growth Factors 13:3-4, pages 205-217.
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Ursula Just, On Kan, Jan Fennelly, T. Michael Dexter & Elaine Spooncer. (1995) The Hox-2.4 Gene is not Involved in the Generation of IL-3 Dependent Multipotent FDCP-Mix Cell Lines. Growth Factors 12:3, pages 173-177.
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Jim O'Prey, Scot Ramsay, Ian Chambers & Paul R. Harrison. (1993) Transcriptional Up-Regulation of the Mouse Cytosolic Glutathione Peroxidase Gene in Erythroid Cells is Due to a Tissue-Specific 3' Enhancer Containing Functionally Important CACC/GT Motifs and Binding Sites for GATA and Ets Transcription Factors. Molecular and Cellular Biology 13:10, pages 6290-6303.
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Ursula Just, Makoto Katsuno, Carol Stocking, Elaine Spooncer & Michael Dexter. (1993) Targeted In Vivo Infection with a Retroviral Vector Carrying the Interleukin-3 (Multi-CSF) Gene Leads to Immortalization and Leukemic Transformation of Primitive Hematopoietic Progenitor Cells. Growth Factors 9:1, pages 41-55.
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C. M. Heyworth, J. Hampson, T. M. Dexter, F. Walker, A. W. Burgess, O. Kan, N. Cook, S. J. Vallance & A. D. Whetton. (1991) Development of Multipotential Haemopoietic Stem Cells to Neutrophils is Associated with Increased Expression of Receptors for Granulocyte Macrophage Colony-Stimulating Factor: Altered Biological Responses to GM-CSF during Development. Growth Factors 5:2, pages 87-98.
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Articles from other publishers (73)
Nan Hu, Yaling Qiu & Fan Dong. (2015) Role of Erk1/2 Signaling in the Regulation of Neutrophil Versus Monocyte Development in Response to G-CSF and M-CSF. Journal of Biological Chemistry 290:40, pages 24561-24573.
Crossref
Crossref
Geoffrey Brown, Philip J. Hughes, Rhodri Ceredig & Robert H. Michell. (2012) Versatility and nuances of the architecture of haematopoiesis – Implications for the nature of leukaemia. Leukemia Research 36:1, pages 14-22.
Crossref
Crossref
Beate Fuchs, Lydia Schnapka-Hille, Jürgen Schiller & Michael A. Cross. (2011) Oxygen and cytokine-dependent changes in choline phospholipid saturation in hematopoietic progenitor cells detected by MALDI-TOF mass spectrometry. Chemistry and Physics of Lipids 164:7, pages 636-642.
Crossref
Crossref
A V Guitart, C Debeissat, F Hermitte, A Villacreces, Z Ivanovic, H Boeuf & V Praloran. (2010) Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression. Cell Death & Differentiation 18:1, pages 174-182.
Crossref
Crossref
Pernilla Eliasson, Matilda Rehn, Petter Hammar, Peter Larsson, Oksana Sirenko, Lee A. Flippin, Jörg Cammenga & Jan-Ingvar Jönsson. (2010) Hypoxia mediates low cell-cycle activity and increases the proportion of long-term–reconstituting hematopoietic stem cells during in vitro culture. Experimental Hematology 38:4, pages 301-310.e2.
Crossref
Crossref
Glenda J. Dickson, Alexandra Kwasniewska, Ken I. Mills, Terence R.J. Lappin & Alexander Thompson. (2009) Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal. Experimental Hematology 37:3, pages 322-333.e3.
Crossref
Crossref
Jinglong Chen, Jane Olsen, Sally Ford, Shamaruh Mirza, Andrew Walker, James M. Murphy & Ian G. Young. (2009) A New Isoform of Interleukin-3 Receptor α with Novel Differentiation Activity and High Affinity Binding Mode. Journal of Biological Chemistry 284:9, pages 5763-5773.
Crossref
Crossref
Andrew Pierce, Louise Carney, Hajja G. Hamza, John R. Griffiths, Liqun Zhang, Beth A. Whetton, M. Belen Gonzalez Sanchez, Teruko Tamura, David Sternberg & Anthony D. Whetton. (2008) THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. British Journal of Haematology 141:5, pages 641-650.
Crossref
Crossref
Beate Fuchs, Jürgen Schiller & Michael A. Cross. (2007) Apoptosis-associated changes in the glycerophospholipid composition of hematopoietic progenitor cells monitored by 31P NMR spectroscopy and MALDI-TOF mass spectrometry. Chemistry and Physics of Lipids 150:2, pages 229-238.
Crossref
Crossref
Michael A. Cross, Clare M. Heyworth & T. Michael Dexter. 2007. Ciba Foundation Symposium 204 - The Molecular Basis of Cellular Defence Mechanisms. Ciba Foundation Symposium 204 - The Molecular Basis of Cellular Defence Mechanisms
3
18
.
Ingmar Glauche, Michael Cross, Markus Loeffler & Ingo Roeder. (2007) Lineage Specification of Hematopoietic Stem Cells: Mathematical Modeling and Biological Implications. Stem Cells 25:7, pages 1791-1799.
Crossref
Crossref
John H. Carter & Warren G. Tourtellotte. (2007) Early Growth Response Transcriptional Regulators Are Dispensable for Macrophage Differentiation. The Journal of Immunology 178:5, pages 3038-3047.
Crossref
Crossref
Patrick C. Hanington & Miodrag Belosevic. (2007) Interleukin-6 family cytokine M17 induces differentiation and nitric oxide response of goldfish (Carassius auratus L.) macrophages. Developmental & Comparative Immunology 31:8, pages 817-829.
Crossref
Crossref
N. Underhill-Day, A. Pierce, S. E. Thompson, D. Xenaki, A. D. Whetton & P. J. Owen-Lynch. (2006) Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance. British Journal of Haematology 132:6, pages 774-783.
Crossref
Crossref
Richard D. Unwin, Andrew Pierce, Rod B. Watson, David W. Sternberg & Anthony D. Whetton. (2005) Quantitative Proteomic Analysis Using Isobaric Protein Tags Enables Rapid Comparison of Changes in Transcript and Protein Levels in Transformed Cells. Molecular & Cellular Proteomics 4:7, pages 924-935.
Crossref
Crossref
Jutta Friel, Christoph Heberlein, Maren Geldmacher & Wolfram Ostertag. (2005) Diverse isoforms of colony-stimulating factor-1 have different effects on the development of stroma-dependent hematopoietic cells. Journal of Cellular Physiology 204:1, pages 247-259.
Crossref
Crossref
Jennifer AntonchukCraig D. HylandDouglas J. HiltonWarren S. Alexander. (2004) Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors. Blood 104:5, pages 1306-1313.
Crossref
Crossref
Dia Xenaki, Andrew Pierce, Nick Underhill-Day, Anthony D. Whetton & P.Jane Owen-Lynch. (2004) Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCβII. Cellular Signalling 16:2, pages 145-156.
Crossref
Crossref
John L Lewis, Stephen B Marley, Morenike Ojo & Myrtle Y Gordon. (2004) Opposing effects of PI3 kinase pathway activation on human myeloid and erythroid progenitor cell proliferation and differentiation in vitro. Experimental Hematology 32:1, pages 36-44.
Crossref
Crossref
Richard Karlsson, Maria Engström, Maria Jönsson, Peter Karlberg, Cornelis J.H. Pronk, Johan Richter & Jan-Ingvar Jönsson. (2003)
Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic
Bcl-2
family genes
. Journal of Leukocyte Biology 74:5, pages 923-931.
Crossref
Crossref
Stephane Wong, Jami McLaughlin, Donghui Cheng, Kevin Shannon, Lorraine Robb & Owen N. Witte. (2003) IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease. Proceedings of the National Academy of Sciences 100:20, pages 11630-11635.
Crossref
Crossref
Candy Lee, Caroline A. Evans, Elaine Spooncer, Andrew Pierce, Rachel Mottram & Anthony D. Whetton. (2003) Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate. British Journal of Haematology 122:6, pages 985-995.
Crossref
Crossref
Panagiotis D. Kottaridis, Rosemary E. Gale & David C. Linch. (2003) Flt3 mutations and leukaemia. British Journal of Haematology 122:4, pages 523-538.
Crossref
Crossref
Dean McGaughey & Jeffrey Crawford. 2003. Management of Infection in Oncology Patients. Management of Infection in Oncology Patients
345
361
.
Nicholas J. Slater, Masafumi Yamaguchi, Dominic G. Rothwell, Patrick Baker, Clare M. Heyworth & Rajesh Chopra. (2003) The human granulocyte/macrophage colony-stimulating factor receptor α2 isoform influences haemopoietic lineage commitment and divergence. British Journal of Haematology 122:1, pages 150-158.
Crossref
Crossref
Timm Schroeder, Hella Kohlhof, Nikolaus Rieber & Ursula Just. (2003) Notch Signaling Induces Multilineage Myeloid Differentiation and Up-Regulates PU.1 Expression. The Journal of Immunology 170:11, pages 5538-5548.
Crossref
Crossref
Zoe McIvor, Sibyll Hein, Heike Fiegler, Timm Schroeder, Carol Stocking, Ursula Just & Michael Cross. (2003) Transient expression of PU.1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte differentiation. Experimental Hematology 31:1, pages 39-47.
Crossref
Crossref
S. Tsuzuki, J. Brown, K. Gale, C. Heyworth, G. May & T. Enver. 2003. Acute Leukemias IX. Acute Leukemias IX
44
51
.
Caroline A. Evans, Shahrul Ariffin, Andrew Pierce & Anthony D. Whetton. (2002) Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors. Blood 100:9, pages 3164-3174.
Crossref
Crossref
SJ Collins. (2002) The role of retinoids and retinoic acid receptors in normal hematopoiesis. Leukemia 16:10, pages 1896-1905.
Crossref
Crossref
Ling Chen, Jiachang Zhang, Delia C. Tang, Eitan Fibach & Griffin P. Rodgers. (2002) Influence of lineage‐specific cytokines on commitment and asymmetric cell division of haematopoietic progenitor cells. British Journal of Haematology 118:3, pages 847-857.
Crossref
Crossref
Andrew Pierce, Elaine Spooncer, Shaun Ainsworth & Anthony D Whetton. (2002) BCR–ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor. Oncogene 21:19, pages 3068-3075.
Crossref
Crossref
CM Heyworth, D Gagen, KG Edington & LJ Fairbairn. (2002) Retroviral transfer and expression of human MDR-1 in a murine haemopoietic stem cell line does not alter factor dependence, growth or differentiation characteristics. Leukemia 16:1, pages 106-111.
Crossref
Crossref
J. R. Cáceres‐Cortés, F. A. Cantú‐Garza, M. T. Mendoza‐Mata, M. A. Chavez‐González, G. Ramos‐Mandujano & I. R. Zambrano‐Ramírez. (2001)
Cytotoxic activity of
Justicia spicigera
is inhibited by bcl‐2 proto‐oncogene and induces apoptosis in a cell cycle dependent fashion
. Phytotherapy Research 15:8, pages 691-697.
Crossref
Crossref
David B. SykesMark P. Kamps. (2001) Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins. Blood 98:8, pages 2308-2318.
Crossref
Crossref
D. METCALF & Y. LAÂBI. (2006) Lineage Commitment and Maturation Induction in Normal and Leukemic Preprogenitor Cells. Annals of the New York Academy of Sciences 938:1, pages 278-292.
Crossref
Crossref
N GEIJSEN, L KOENDERMAN & P COFFER. (2001) Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. Cytokine & Growth Factor Reviews 12:1, pages 19-25.
Crossref
Crossref
R Henschler, K.E Appel, C.M Heyworth & H Glatt. (2001) Proliferation and differentiation of murine haemopoietic progenitor cells in stroma-free culture in the presence of metabolites of chlorinated pesticides. Toxicology in Vitro 15:1, pages 31-37.
Crossref
Crossref
J. R. Caceres‐Cortes, G. Krosl, N. Tessier, P. Hugo & T. Hoang. (2009)
Steel Factor Sustains SCL Expression and the Survival of Purified CD34
+
Bone Marrow Cells in the Absence of Detectable Cell Differentiation
. STEM CELLS 19:1, pages 59-70.
Crossref
Crossref
Timm Schroeder, Claudia Lange, John Strehl & Ursula Just. (2008) Generation of functionally mature dendritic cells from the multipotential stem cell line FDCP‐mix. British Journal of Haematology 111:3, pages 890-897.
Crossref
Crossref
Y Laâbi, D Metcalf, S Mifsud & LDi Rago. (2000) Differentiation commitment and regulator-specific granulocyte–macrophage maturation in a novel pro-B murine leukemic cell line. Leukemia 14:10, pages 1785-1795.
Crossref
Crossref
P. W. Zandstra, H.-V. Le, G. Q. Daley, L. G. Griffith & D. A. Lauffenburger. (2000) Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation. Biotechnology and Bioengineering 69:6, pages 607-617.
Crossref
Crossref
Zoe J. McIvor, Clare M. Heyworth, Barbra A. Johnson, Stella Pearson, Heike Fiegler, Lynn Hampson, T. Michael Dexter & Michael A. Cross. (2001) A transient assay for regulatory gene function in haemopoietic progenitor cells. British Journal of Haematology 110:3, pages 674-681.
Crossref
Crossref
Monica Pettersson, Marina Bessonova, Harvest Feng Gu, Leif C. Groop & Jan-Ingvar Jönsson. (2000) Characterization, Chromosomal Localization, and Expression during Hematopoietic Differentiation of the Gene Encoding Arl6ip, ADP-Ribosylation-like Factor-6 Interacting Protein (ARL6). Genomics 68:3, pages 351-354.
Crossref
Crossref
Peter W. ZandstraDouglas A. LauffenburgerConnie J. Eaves. (2000) A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis. Blood 96:4, pages 1215-1222.
Crossref
Crossref
Jonathan R White & Kathleen Weston. (2000) Myb is required for self-renewal in a model system of early hematopoiesis. Oncogene 19:9, pages 1196-1205.
Crossref
Crossref
Thalia PapayannopoulouGregory V. PriestleyAlex RohdeKenneth R. PetersonBetty Nakamoto. (2000) Hemopoietic lineage commitment decisions: in vivo evidence from a transgenic mouse model harboring μLCR-βpro-LacZ as a transgene. Blood 95:4, pages 1274-1282.
Crossref
Crossref
Matthew P. McCormackThomas J. Gonda. (2000) Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the GM-CSF receptor β subunit. Blood 95:1, pages 120-127.
Crossref
Crossref
U. Just, D. Boettiger, O. Kan, T. M. Dexter & E. Spooncer. 2000. Lymphoid Organogenesis. Lymphoid Organogenesis
27
34
.
Richard L Darley & Alan K Burnett. (1999) Mutant RAS inhibits neutrophil but not macrophage differentiation and allows continued growth of neutrophil precursors. Experimental Hematology 27:11, pages 1599-1608.
Crossref
Crossref
Caroline A. EvansAndrew PierceSandra A. WinterElaine SpooncerClare M. HeyworthAnthony D. Whetton. (1999) Activation of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Receptor Subunits in a Multipotential Hematopoietic Progenitor Cell Line Leads to Differential Effects on Development. Blood 94:5, pages 1504-1514.
Crossref
Crossref
Marc Hotfilder, Sarah Baxendale, Michael A. Cross & Fred Sablitzky. (2002) Def‐2, ‐3, ‐6 and ‐8, novel mouse genes differentially expressed in the haemopoietic system. British Journal of Haematology 106:2, pages 335-344.
Crossref
Crossref
Zofia DrzeniekGeorg StöckerBarbara SiebertzUrsula JustTimm SchroederWolfram OstertagHans-Dieter Haubeck. (1999) Heparan Sulfate Proteoglycan Expression Is Induced During Early Erythroid Differentiation of Multipotent Hematopoietic Stem Cells. Blood 93:9, pages 2884-2897.
Crossref
Crossref
J M Davies, N Hawe, J Kabarowski, Q-H Huang, J Zhu, N J Brand, D Leprince, P Dhordain, M Cook, G Morriss-Kay & A Zelent. (1999) Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. Oncogene 18:2, pages 365-375.
Crossref
Crossref
J. Milton Gaviria, W. Conrad Liles & David C. Dale. 1999. Clinical Applications of Cytokines and Growth Factors. Clinical Applications of Cytokines and Growth Factors
118
136
.
T. EnverC.M. HeyworthT.M. Dexter. (1998) Do Stem Cells Play Dice?. Blood 92:2, pages 348-351.
Crossref
Crossref
Donald Metcalf. (1998) Lineage Commitment and Maturation in Hematopoietic Cells: The Case for Extrinsic Regulation. Blood 92:2, pages 345-347.
Crossref
Crossref
A. Pierce, A. D. Whetton, P. J. Owen-Lynch, J. Tavernier, E. Spooncer, T. M. Dexter & C. M. Heyworth. (1998) Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line. Journal of Cell Science 111:6, pages 815-823.
Crossref
Crossref
Birgit M. Reipert, Donald Allan, Siegfried Reipert & T.Michael Dexter. (1997) Apoptosis in haemopoietic progenitor cells exposed to extremely low-frequency magnetic fields. Life Sciences 61:16, pages 1571-1582.
Crossref
Crossref
M Hu, D Krause, M Greaves, S Sharkis, M Dexter, C Heyworth & T Enver. (1997) Multilineage gene expression precedes commitment in the hemopoietic system.. Genes & Development 11:6, pages 774-785.
Crossref
Crossref
I.N. HampsonL. HampsonM. PinkoskiM. CrossC.M. HeyworthR.C. BleackleyE. AtkinsonT.M. Dexter. (1997) Identification of a Serpin Specifically Expressed in Multipotent and Bipotent Hematopoietic Progenitor Cells and in Activated T Cells. Blood 89:1, pages 108-118.
Crossref
Crossref
Ursula Just, Norbert Ahlers, Gökhan Arman, Nicholas Hunt, Wolfram Ostertag & Joachim Nowock. 1996. Gene Technology. Gene Technology
203
218
.
A. D. Goddard, J. Q. Yuan, L. Fairbairn, M. Dexter, J. Borrow, C. Kozak & E. Solomon. (1995) Cloning of the murine homolog of the leukemia-associated PML gene. Mammalian Genome 6:10, pages 732-737.
Crossref
Crossref
Clare M. Heyworth, Mazin Alauldin, Michael A. Cross, Leslie J. Fairbairn, T. Michael Dexter & Anthony D. Whetton. (2008) Erythroid development of the FDCP‐Mix A4 multipotent cell line is governed by the relative concentrations of erythropoietin and interleukin 3. British Journal of Haematology 91:1, pages 15-22.
Crossref
Crossref
Donald Metcalf. 1994.
41
91
.
L.J. Fairbairn, G.J. Cowling, B.M. Reipert & T.M. Dexter. (1993) Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74:5, pages 823-832.
Crossref
Crossref
M. S. Shearman, C. M. Heyworth, T. M. Dexter, B. Haefner, P. J. Owen & A. D. Whetton. (1993) Haemopoietic stem cell development to neutrophils is associated with subcellular redistribution and differential expression of protein kinase C subspecies. Journal of Cell Science 104:1, pages 173-180.
Crossref
Crossref
On Kan, Caroline A. Evans & Anthony D. Whetton. (1992) Cellular signalling events stimulated by myeloid haemopoietic growth factors. Baillière's Clinical Haematology 5:3, pages 653-679.
Crossref
Crossref
. (1997) Levels of inositol metabolites within normal myeloid blast cells and changes during their differentiation towards monocytes. Proceedings of the Royal Society of London. Series B: Biological Sciences 247:1318, pages 27-33.
Crossref
Crossref
MICHAEL J.P. LAWMAN, PATRICIA D. LAWMAN & CHARLES E. BAGWELL. (1992)
Ex Vivo
Expansion and Differentiation of Hematopoietic Stem Cells
. Journal of Hematotherapy 1:3, pages 251-259.
Crossref
Crossref
Donald Metcalf. (1991) Control of Granulocytes and Macrophages: Molecular, Cellular, and Clinical Aspects. Science 254:5031, pages 529-533.
Crossref
Crossref
. (1997) The Florey Lecture, 1991. The colony-stimulating factors: discovery to clinical use. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 333:1266, pages 147-173.
Crossref
Crossref
A.D. Whetton. (1990) Regulation of haemopoietic cell development by growth factors. Cellular Signalling 2:4, pages 323-328.
Crossref
Crossref