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Growth Factors Volume 11, 1994 - Issue 2
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Original Article

LIF and OM Directly Interact with a Soluble Form of gp130, the IL-6 Receptor Signal Transducing Subunit

Brett Modrell Bristol-Myers Squibb Pharmaceutical Research Institute, 3005 First Avenue, Seattle, WA, 98121, USA
,
Jingwen Liu Veterans Affairs Medical Center, 500 West Fort Street, Boise, ID, 83702-4598, USA
,
Howard Miller Bristol-Myers Squibb Pharmaceutical Research Institute, 3005 First Avenue, Seattle, WA, 98121, USA
&
Mohammed Shoyab Department of Pathobiology, F-167 Health Sciences, SC-38, University of Washington, Seattle, WA, 98195, USA
Pages 81-91 | Received 28 Mar 1994, Accepted 06 Jun 1994, Published online: 11 Jul 2009

Citations (16)

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Robert L. Moritz, Larry D. Ward, Guo-Fen Tu, Louis J. Fabri, Hong Ji, Kiyoshi Yasukawa & Richard J. Simpson. (1999) The N-Terminus of gp130 is Critical for the Formation of the High-Affinity Interleukin-6 Receptor Complex. Growth Factors 16:4, pages 265-278.
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Articles from other publishers (15)

Benjamin Ng, Stuart A. Cook & Sebastian Schafer. (2020) Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway. Experimental & Molecular Medicine 52:12, pages 1871-1878.
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Michael D Burton, Nathan L Sparkman & Rodney W Johnson. (2011) Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior. Journal of Neuroinflammation 8:1.
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Silke Metz, Gudrun Naeth, Peter C. Heinrich & Gerhard Müller-Newen. (2008) Novel Inhibitors for Murine and Human Leukemia Inhibitory Factor Based on Fused Soluble Receptors. Journal of Biological Chemistry 283:10, pages 5985-5995.
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Annelie Tjernlund, Babilonia Barqasho, Piotr Nowak, Sabine Kinloch, Daren Thorborn, Luc Perrin, Anders Sönnerborg, Lilian Walther-Jallow & Jan Andersson. (2006) Early induction of leukemia inhibitor factor (LIF) in acute HIV-1 infection. AIDS 20:1, pages 11-19.
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Wei He, Ke Gong, David K. Smith & Nancy Y. Ip. (2005) The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling. FEBS Letters 579:20, pages 4317-4323.
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Simon A. Jones, Peter J. Richards, Jürgen Scheller & Stefan Rose-John. (2005) Review: IL-6 Transsignaling: The In Vivo Consequences . Journal of Interferon & Cytokine Research 25:5, pages 241-253.
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SIMON A. JONESSANKICHI HORIUCHI, NICHOLAS TOPLEYNAOKI YAMAMOTO & GERALD M. FULLER. (2001) The soluble interleukin 6 receptor: mechanisms of production and implications in disease. The FASEB Journal 15:1, pages 43-58.
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Thomas Jostock, Jürgen Müllberg, Suat Özbek, Raja Atreya, Guido Blinn, Nicole Voltz, Martina Fischer, Markus F. Neurath & Stefan Rose‐John. (2001) Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses. European Journal of Biochemistry 268:1, pages 160-167.
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C. J. Auernhammer & S. Melmed. (2000) Leukemia-Inhibitory Factor—Neuroimmune Modulator of Endocrine Function*. Endocrine Reviews 21:3, pages 313-345.
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Wang Hui, Michael Bell & Graeme Carroll. (2000) SOLUBLE GLYCOPROTEIN 130 (gp130) ATTENUATES OSM- AND LIF-INDUCED CARTILAGE PROTEOGLYCAN CATABOLISM. Cytokine 12:2, pages 151-155.
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Christoph J. Auernhammer & Shlomo Melmed. 2000. Principles of Molecular Regulation. Principles of Molecular Regulation 115 132 .
Jian-Guo Zhang, Yu Zhang, Catherine M. Owczarek, Larry D. Ward, Robert L. Moritz, Richard J. Simpson, Kiyoshi Yasukawa & Nicos A. Nicola. (1998) Identification and Characterization of Two Distinct Truncated Forms of gp130 and a Soluble Form of Leukemia Inhibitory Factor Receptor α-Chain in Normal Human Urine and Plasma. Journal of Biological Chemistry 273:17, pages 10798-10805.
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Kapil Dhingra, Aysegul Sahin, Kamal Emami, Gabriel N. Hortobagyi & Zeev Estrov. (1998) Expression of leukemia inhibitory factor and its receptor in breast cancer: A potential autocrine and paracrine growth regulatory mechanism. Breast Cancer Research and Treatment 48:2, pages 165-174.
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LINDA O. NARHI, ROBERT ROSENFELD, GRANT SHIMAMOTO, RICHARD LEE, NESSA HAWKINS, TIANSHENG LI, JOHN PHILO, JIE WEN & TSUTOMU ARAKAWA. (2009) Comparison of solution properties of human and rat ciliary neurotrophic factor. The Journal of Peptide Research 50:4, pages 300-309.
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Tetsuo Yamamori. 1996. Chemical Factors in Neural Growth, Degeneration and Repair. Chemical Factors in Neural Growth, Degeneration and Repair 265 292 .

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