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Growth Factors Volume 13, 1996 - Issue 3-4

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Original Article

Aberrant Activation of JAK/STAT Pathway Components in Response to G-CSF, Interferon-a/p and Interferon-y in NFS-60 Cells

U. Novak University of Melbourne, Dept. of Medicine, Royal Melbourne Hospital, Parkville, 3050, Australia

A. C. Ward University of Melbourne, Dept. of Medicine, Royal Melbourne Hospital, Parkville, 3050, Australia

P. J. Hertzog Molecular Genetics and Development Laboratory, Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, 3168, Australia

J. A. Hamilton University of Melbourne, Dept. of Medicine, Royal Melbourne Hospital, Parkville, 3050, Australia

L. Paradiso University of Melbourne, Dept. of Medicine, Royal Melbourne Hospital, Parkville, 3050, Australia

Pages 251-260 | Received 04 Jan 1996, Accepted 02 Feb 1996, Published online: 11 Jul 2009

Cite this article
https://doi.org/10.3109/08977199609003226

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Michael Hörtner, Ulrich Nielsch, Lorenz M. Mayr, James A. Johnston, Peter C. Heinrich & Serge Haan. (2002) Suppressor of Cytokine Signaling-3 Is Recruited to the Activated Granulocyte-Colony Stimulating Factor Receptor and Modulates its Signal Transduction. The Journal of Immunology 169:3, pages 1219-1227.
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Diane L. HevehanWilliam M. MillerEleftherios T. Papoutsakis. (2002) Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. Blood 99:5, pages 1627-1637.
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Debbie C. Koay, Tri-Hung Nguyen & Alan C. Sartorelli. (2002) Distinct region of the granulocyte colony-stimulating factor receptor mediates proliferative signaling through activation of Janus kinase 2 and p44/42 mitogen-activated protein kinase. Cellular Signalling 14:3, pages 239-247.
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Yigal Dror, Alister C Ward, Ivo P Touw & Melvin H Freedman. (2000) Combined corticosteroid/granulocyte colony-stimulating factor (G-CSF) therapy in the treatment of severe congenital neutropenia unresponsive to G-CSF. Experimental Hematology 28:12, pages 1381-1389.
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AC Ward, SPMA Oomen, L Smith, J Gits, D van Leeuwen, AA Soede-Bobok, CAJ Erpelinck-Verschueren, T Yi & IP Touw. (2000) The SH2 domain-containing protein tyrosine phosphatase SHP-1 is induced by granulocyte colony-stimulating factor (G-CSF) and modulates signaling from the G-CSF receptor. Leukemia 14:7, pages 1284-1291.
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AC Ward, DM Loeb, AA Soede-Bobok, IP Touw & AD Friedman. (2000) Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia 14:6, pages 973-990.
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Alister C. Ward, Yvette M. van Aesch, Judith Gits, Anita M. Schelen, John P. de Koning, Daphne van Leeuwen, Melvin H. Freedman & Ivo P. Touw. (1999) Novel Point Mutation in the Extracellular Domain of the Granulocyte Colony-Stimulating Factor (G-Csf) Receptor in a Case of Severe Congenital Neutropenia Hyporesponsive to G-Csf Treatment. The Journal of Experimental Medicine 190:4, pages 497-508.
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Alister C. Ward, Louise Smith, John P. de Koning, Yvette van Aesch & Ivo P. Touw. (1999) Multiple Signals Mediate Proliferation, Differentiation, and Survival from the Granulocyte Colony-stimulating Factor Receptor in Myeloid 32D Cells. Journal of Biological Chemistry 274:21, pages 14956-14962.
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Alister C. WardYvette M. van AeschAnita M. SchelenIvo P. Touw. (1999) Defective Internalization and Sustained Activation of Truncated Granulocyte Colony-Stimulating Factor Receptor Found in Severe Congenital Neutropenia/Acute Myeloid Leukemia. Blood 93:2, pages 447-458.
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Alister C. WardMirjam H.A. HermansLouise SmithYvette M. van AeschAnita M. SchelenClaudia AntonissenIvo P. Touw. (1999) Tyrosine-Dependent and -Independent Mechanisms of STAT3 Activation by the Human Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Differentially Utilized Depending on G-CSF Concentration. Blood 93:1, pages 113-124.
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Alister C. Ward, Jennifer L. Monkhouse, John A. Hamilton & Xavier F. Csar. (1998) Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1448:1, pages 70-76.
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Alister C. Ward, Jennifer L. Monkhouse, Xavier F. Csar, Ivo P. Touw & Paul A. Bello. (1998) The Src-like Tyrosine Kinase Hck Is Activated by Granulocyte Colony-Stimulating Factor (G-CSF) and Docks to the Activated G-CSF Receptor. Biochemical and Biophysical Research Communications 251:1, pages 117-123.
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Mark A. Goldsmith, Aki Mikami, Yun You, Kathleen D. Liu, Liza Thomas, Pamela Pharr & Gregory D. Longmore. (1998) Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo . Proceedings of the National Academy of Sciences 95:12, pages 7006-7011.
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Sandra E. Nicholson, Robyn Starr, Ulrike Novak, Douglas J. Hilton & Judith E. Layton. (1996) Tyrosine Residues in the Granulocyte Colony-stimulating Factor (G-CSF) Receptor Mediate G-CSF-induced Differentiation of Murine Myeloid Leukemic (M1) Cells. Journal of Biological Chemistry 271:43, pages 26947-26953.
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Aberrant Activation of JAK/STAT Pathway Components in Response to G-CSF, Interferon-a/p and Interferon-y in NFS-60 Cells

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Aberrant Activation of JAK/STAT Pathway Components in Response to G-CSF, Interferon-a/p and Interferon-y in NFS-60 Cells

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