Advanced search
Publication Cover
Growth Factors Volume 14, 1997 - Issue 4
Submit an article Journal homepage
110
Views
50
CrossRef citations to date
0
Altmetric
Original Article

Detection of Vascular Endothelial Growth Factor (VEGF) Protein in Vascular and Non-Vascular Cells of the Normal and Oxygen-Injured Rat Retina

Susan G. Robbins Arkansas Center for Eye Research, Jones Eye Institute, University of Arkansas, for Medical Sciences, 4301 West Markham Street, Mail Slot 522, Little Rock, AR, 72205-7199
,
Jeffrey R. Conaway Arkansas Center for Eye Research, Jones Eye Institute, University of Arkansas, for Medical Sciences, 4301 West Markham Street, Mail Slot 522, Little Rock, AR, 72205-7199
,
Barbara L. Ford Arkansas Center for Eye Research, Jones Eye Institute, University of Arkansas, for Medical Sciences, 4301 West Markham Street, Mail Slot 522, Little Rock, AR, 72205-7199
,
Kerrey A. Roberto Arkansas Center for Eye Research, Jones Eye Institute, University of Arkansas, for Medical Sciences, 4301 West Markham Street, Mail Slot 522, Little Rock, AR, 72205-7199
&
John S. Penn Arkansas Center for Eye Research, Jones Eye Institute, University of Arkansas, for Medical Sciences, 4301 West Markham Street, Mail Slot 522, Little Rock, AR, 72205-7199
Pages 229-241 | Received 24 Jul 1996, Accepted 02 Jan 1997, Published online: 11 Jul 2009

Citations (50)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Duygu Cam, Ayse Tulin Berk, Serap Cilaker Micili, Tuncay Kume, Bekir Ugur Ergur & Osman Yilmaz. (2017) Histological and Immunohistochemical Retinal Changes Following the Intravitreal Injection of Aflibercept, Bevacizumab and Ranibizumab in Newborn Rabbits. Current Eye Research 42:2, pages 315-322.
Read now
Michael W Stewart. (2015) The clinical utility of aflibercept for diabetic macular edema. Diabetes, Metabolic Syndrome and Obesity 8, pages 473-482.
Read now
Alberto R. Cervantes-Villagrana, Jonathan Garcia-Román, Claudia González-Espinosa & Monica Lamas. (2010) Pharmacological Inhibition of N-Methyl D-Aspartate Receptor Promotes Secretion of Vascular Endothelial Growth Factor in Müller Cells: Effects of Hyperglycemia and Hypoxia. Current Eye Research 35:8, pages 733-741.
Read now
David A. Leske, Jianmin Wu, Martina Mookadam, Yi Chen, Michael P. Fautsch, Jonathan M. Holmes & William L. Lanier. (2006) The Relationship of Retinal VEGF and Retinal IGF-1 mRNA with Neovascularization in an Acidosis-Induced Model of Retinopathy of Prematurity. Current Eye Research 31:2, pages 163-169.
Read now
Abbot F Clark, David P Bingaman & Michael A Kapin. (2000) Ocular angiostatic agents. Expert Opinion on Therapeutic Patents 10:4, pages 427-448.
Read now
Susan G. Robbins, Veeraramani S. Rajaratnam & John S. Penn. (1998) Evidence for Upregulation and Redistribution of Vascular Endothelial Growth Factor (VEGF) Receptors flt-1 and flk-1 in the Oxygen-Injured Rat Retina. Growth Factors 16:1, pages 1-9.
Read now

Articles from other publishers (44)

Yogapriya Sundaresan, Sam Yacoub, Bindu Kodati, Charles E. Amankwa, Akash Raola & Gulab Zode. (2023) Therapeutic applications of CRISPR /Cas9 gene editing technology for the treatment of ocular diseases . The FEBS Journal 290:22, pages 5248-5269.
Crossref
Jinkyu Park, Gang Cui, Hyundong Lee, Han Jeong, Jay Jiyong Kwak, Junwon Lee & Suk Ho Byeon. (2023) CRISPR/Cas9 mediated specific ablation of vegfa in retinal pigment epithelium efficiently regresses choroidal neovascularization. Scientific Reports 13:1.
Crossref
Raul Carpi-Santos, Ricardo A. de Melo Reis, Flávia Carvalho Alcantara Gomes & Karin C. Calaza. (2022) Contribution of Müller Cells in the Diabetic Retinopathy Development: Focus on Oxidative Stress and Inflammation. Antioxidants 11:4, pages 617.
Crossref
Rong Li, Guomin Yao, Lingxiao Zhou, Min Zhang, Jin Yan, Xiaodi Wang & Ya Li. (2021) Autophagy is required for the promoting effect of angiogenic factor with G patch domain and forkhead-associated domain 1 (AGGF1) in retinal angiogenesis. Microvascular Research 138, pages 104230.
Crossref
Yuan-Yao Fan, Chi-Hsien Liu, An-Lun Wu, Hung-Chi Chen, Yi-Jen Hsueh, Kuan-Jen Chen, Chi-Chun Lai, Chung-Ying Huang & Wei-Chi Wu. (2021) MicroRNA-126 inhibits pathological retinal neovascularization via suppressing vascular endothelial growth factor expression in a rat model of retinopathy of prematurity. European Journal of Pharmacology 900, pages 174035.
Crossref
Sook Hyun Chung, Tzu-Ni Sin, Taylor Ngo & Glenn Yiu. (2020) CRISPR Technology for Ocular Angiogenesis. Frontiers in Genome Editing 2.
Crossref
Nicolas Froger, Frédéric Matonti, Christophe Roubeix, Valérie Forster, Ivana Ivkovic, Nadège Brunel, Christophe Baudouin, José-Alain Sahel & Serge Picaud. (2020) VEGF is an autocrine/paracrine neuroprotective factor for injured retinal ganglion neurons. Scientific Reports 10:1.
Crossref
Hossein Ameri, Christopher Murat, Amirmohsen Arbabi, Wei Jiang, Srikanth R. Janga, Peter Zhifeng Qin & Sarah F. Hamm-Alvarez. (2020) Reduced Expression of VEGF-A in Human Retinal Pigment Epithelial Cells and Human Muller Cells Following CRISPR-Cas9 Ribonucleoprotein-Mediated Gene Disruption. Translational Vision Science & Technology 9:8, pages 23.
Crossref
Bingyuan Guo, Peng Song, Ke Zhou, Lei Liu & Hai-Chen Wu. (2020) Simultaneous Sensing of Multiple Cancer Biomarkers by a Single DNA Nanoprobe in a Nanopore. Analytical Chemistry 92:13, pages 9405-9411.
Crossref
Eliot R. Dow, Jennifer O. Adeghate, Peter G. Coombs, Mrinali Gupta Patel, Donald J. D’Amico & Szilárd Kiss. (2019) Fellow-Eye Conversion and Treatment in Exudative Age-Related Macular Degeneration. Journal of VitreoRetinal Diseases 3:6, pages 438-444.
Crossref
Shira Hagbi-Levi, Michal Abraham, Liran Tiosano, Batya Rinsky, Michelle Grunin, Orly Eizenberg, Amnon Peled & Itay Chowers. (2019) Promiscuous Chemokine Antagonist (BKT130) Suppresses Laser-Induced Choroidal Neovascularization by Inhibition of Monocyte Recruitment. Journal of Immunology Research 2019, pages 1-12.
Crossref
Ingrid Fleming. (2019) New Lipid Mediators in Retinal Angiogenesis and Retinopathy. Frontiers in Pharmacology 10.
Crossref
Yun-Zheng Le. (2017) VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases. Vision Research 139, pages 108-114.
Crossref
Nikolaos Dervenis, Athanasia Maria Mikropoulou, Paris Tranos & Panagiotis Dervenis. (2017) Ranibizumab in the Treatment of Diabetic Macular Edema: A Review of the Current Status, Unmet Needs, and Emerging Challenges. Advances in Therapy 34:6, pages 1270-1282.
Crossref
Md. Imam Uddin, Stephanie M. Evans, Jason R. Craft, Megan E. Capozzi, Gary W. McCollum, Rong Yang, Lawrence J. Marnett, Md. Jashim Uddin, Ashwath Jayagopal & John S. Penn. (2016) In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Scientific Reports 6:1.
Crossref
Sandra Atienzar-Aroca, Miguel Flores-Bellver, Gemma Serrano-Heras, Natalia Martinez-Gil, Jorge M. Barcia, Silvia Aparicio, Daniel Perez-Cremades, Jose M. Garcia-Verdugo, Manuel Diaz-Llopis, Francisco J. Romero & Javier Sancho-Pelluz. (2016) Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells. Journal of Cellular and Molecular Medicine 20:8, pages 1457-1466.
Crossref
Xiao Fu, John Scott Gens, James A. Glazier, Stephen A. Burns & Thomas J. Gast. (2016) Progression of Diabetic Capillary Occlusion: A Model. PLOS Computational Biology 12:6, pages e1004932.
Crossref
Andreas Reichenbach & Andreas Bringmann. (2015) Retinal Glia. Colloquium Series on Neuroglia in Biology and Medicine: from Physiology to Disease 2:1, pages 1-644.
Crossref
Ingrid Fleming. (2014) The Pharmacology of the Cytochrome P450 Epoxygenase/Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease. Pharmacological Reviews 66:4, pages 1106-1140.
Crossref
Yousef Yafai, Ianors Iandiev, Johannes Lange, Jan Darius Unterlauft, Peter Wiedemann, Andreas Bringmann, Andreas Reichenbach & Wolfram Eichler. (2014) Müller glial cells inhibit proliferation of retinal endothelial cells via TGF-β2 and Smad signaling. Glia 62:9, pages 1476-1485.
Crossref
Jiong Hu, Rüdiger Popp, Timo Frömel, Manuel Ehling, Khader Awwad, Ralf H. Adams, Hans-Peter Hammes & Ingrid Fleming. (2014) Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. Journal of Experimental Medicine 211:2, pages 281-295.
Crossref
William M. Watkins, Gary W. McCollum, Sara R. Savage, Megan E. Capozzi, John S. Penn & David G. Morrison. (2013) Hypoxia-induced expression of VEGF splice variants and protein in four retinal cell types. Experimental Eye Research 116, pages 240-246.
Crossref
Xiao Dan YuD. Ware Branch, S. Ananth Karumanchi & Jun Zhang. (2012) Preeclampsia and Retinopathy of Prematurity in Preterm Births. Pediatrics 130:1, pages e101-e107.
Crossref
Kalimuthu Kalishwaralal, Selvaraj BarathManiKanth, Sureshbabu Ram Kumar Pandian, Venkatraman Deepak & Sangiliyandi Gurunathan. (2010) Silver nano — A trove for retinal therapies. Journal of Controlled Release 145:2, pages 76-90.
Crossref
Susan E. Yanni, Gary W. McCollum & John S. Penn. (2010) Genetic deletion of COX-2 diminishes VEGF production in mouse retinal Müller cells. Experimental Eye Research 91:1, pages 34-41.
Crossref
Benjamin P. Nicholson & Andrew P. Schachat. (2010) A review of clinical trials of anti-VEGF agents for diabetic retinopathy. Graefe's Archive for Clinical and Experimental Ophthalmology 248:7, pages 915-930.
Crossref
Minghua L. ChenLei GuoLois E. H. SmithChristiane E. L. Dammann & Olaf Dammann. (2010) High or Low Oxygen Saturation and Severe Retinopathy of Prematurity: A Meta-analysis. Pediatrics 125:6, pages e1483-e1492.
Crossref
Susan E. Yanni, Monika L. Clark, Rong Yang, David P. Bingaman & John S. Penn. (2010) The effects of nepafenac and amfenac on retinal angiogenesis. Brain Research Bulletin 81:2-3, pages 310-319.
Crossref
Bruce A. Berkowitz & Robin Roberts. (2009) Evidence for a critical role of panretinal pathophysiology in experimental ROP. Documenta Ophthalmologica 120:1, pages 13-24.
Crossref
Rahul Bhola, Todd Purkiss, Stephen Hunter, Dan Stewart & Paul J. Rychwalski. (2009) Effect of granulocyte colony-stimulating factor on the incidence of threshold retinopathy of prematurity. Journal of American Association for Pediatric Ophthalmology and Strabismus 13:5, pages 450-453.
Crossref
J.S. Penn, A. Madan, R.B. Caldwell, M. Bartoli, R.W. Caldwell & M.E. Hartnett. (2008) Vascular endothelial growth factor in eye disease. Progress in Retinal and Eye Research 27:4, pages 331-371.
Crossref
Yasutaka Nagisa. (2008) Vascular complication models using stroke-prone spontaneously hypertensive rats. Folia Pharmacologica Japonica 132:4, pages 207-212.
Crossref
Gary W. McCollum & John S. Penn. 2008. Retinal and Choroidal Angiogenesis. Retinal and Choroidal Angiogenesis 241 257 .
Sallie Nash Harrell & Debra Huffman Brandon. (2007) Retinopathy of Prematurity: The Disease Process, Classifications, Screening, Treatment, and Outcomes. Neonatal Network 26:6, pages 371-378.
Crossref
António Travassos, Susana Teixeira, Pinto Ferreira, Isaura Regadas, Ana Sofia Travassos, Florinod Esteves Esperancinha, Isabel Prieto, Graça Pires, Robert van Velze, A. Valido & Maria do Céu Machado. (2007) Intravitreal Bevacizumab in Aggressive Posterior Retinopathy of Prematurity. Ophthalmic Surgery, Lasers and Imaging Retina 38:3, pages 233-237.
Crossref
Ricardo Maliba, Stéphanie Lapointe, Paul-Eduard Neagoe, Alexandre Brkovic & Martin G. Sirois. (2006) Angiopoietins-1 and -2 are both capable of mediating endothelial PAF synthesis: Intracellular signalling pathways. Cellular Signalling 18:11, pages 1947-1957.
Crossref
Jin Chen, Donna Hicks, Dana Brantley-Sieders, Nikki Cheng, Gary W. McCollum, Xiang Qi-Werdich & John Penn. (2006) Inhibition of retinal neovascularization by soluble EphA2 receptor. Experimental Eye Research 82:4, pages 664-673.
Crossref
Rossella Rota, Teresa Riccioni, Marco Zaccarini, Stefania Lamartina, Anna Del Gallo, Angelo Fusco, Imre Kovesdi, Emilio Balestrazzi, Damiano C. Abeni, Robin R. Ali & Maurizio C. Capogrossi. (2004) Marked inhibition of retinal neovascularization in rats following soluble‐flt‐1 gene transfer. The Journal of Gene Medicine 6:9, pages 992-1002.
Crossref
Laura M DeBusk, Dennis E Hallahan & Pengnian Charles Lin. (2004) Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway. Experimental Cell Research 298:1, pages 167-177.
Crossref
Ruth B. Caldwell, Manuela Bartoli, M. Ali Behzadian, Azza E. B. El-Remessy, Mohamed Al-Shabrawey, Daniel H. Platt & R. William Caldwell. (2003) Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes/Metabolism Research and Reviews 19:6, pages 442-455.
Crossref
K Walsh, S Sriprasad, D Hopster, J Codd & D Mulvin. (2002) Distribution of vascular endothelial growth factor (VEGF) in prostate disease. Prostate Cancer and Prostatic Diseases 5:2, pages 119-122.
Crossref
P L Penfold, L Wen, M C Madigan, M C Gillies, N J C King & J M Provis. (2000) Triamcinolone acetonide modulates permeability and intercellular adhesion molecule-1 (ICAM-1) expression of the ECV304 cell line: implications for macular degeneration. Clinical and Experimental Immunology 121:3, pages 458-465.
Crossref
CHUAN-YI SU, MIN-TSONG CHEN, WEN-SHENG WU & WEN-CHUAN WU. (2000) Concentration of Vascular Endothelial Growth Factor in the Subretinal Fluid of Retinal Detachment. Journal of Ocular Pharmacology and Therapeutics 16:5, pages 463-469.
Crossref
K. U. Bartz-Schmidt, A. Psichias, G. Thumann, K. Heimann & G. K. Krieglstein. 1999. Pathogenesis and Risk Factors of Glaucoma. Pathogenesis and Risk Factors of Glaucoma 217 232 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.