140
Views
20
CrossRef citations to date
0
Altmetric
Original Article

The N-Terminus of gp130 is Critical for the Formation of the High-Affinity Interleukin-6 Receptor Complex

, , , , , & show all
Pages 265-278 | Received 21 Dec 1998, Published online: 11 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Takuya Ohtani, Katsuhiko Ishihara, Toru Atsumi, Yuichi Yoshida, Keigo Nishida, Masahiro Narimatsu, Takahiro Shirogane, Masahiko Hibi & Toshio Hirano. (2000) gp130-mediated signalling as a therapeutic target. Emerging Therapeutic Targets 4:4, pages 459-479.
Read now

Articles from other publishers (19)

Jacqueline Georgy, Yvonne Arlt, Jens M. Moll, Meryem Ouzin, Hendrik T. Weitz, Lothar Gremer, Dieter Willbold, Joachim Grötzinger, Felix Thives-Kurenbach, Jürgen Scheller & Doreen M. Floss. (2021) Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction. Journal of Biological Chemistry 297:5, pages 101295.
Crossref
A. Tratselas, M. Simitsopoulou, A. Giannakopoulou, I. Dori, S. Saoulidis, K. Kollios, P. Papaioannidou, S. Pournaras & E. Roilides. (2014) Effect of Ceftriaxone on the Outcome of Murine Pyelonephritis Caused by Extended-Spectrum-β-Lactamase-Producing Escherichia coli. Antimicrobial Agents and Chemotherapy 58:12, pages 7102-7111.
Crossref
Vaclav Veverka, Terry Baker, Nicholas T. Redpath, Bruce Carrington, Frederick W. Muskett, Richard J. Taylor, Alastair D.G. Lawson, Alistair J. Henry & Mark D. Carr. (2012) Conservation of Functional Sites on Interleukin-6 and Implications for Evolution of Signaling Complex Assembly and Therapeutic Intervention. Journal of Biological Chemistry 287:47, pages 40043-40050.
Crossref
Lindsay L. Jones & Dario A. A. Vignali. (2011) Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily. Immunologic Research 51:1, pages 5-14.
Crossref
Chenhong Luo, Akihiro Nawa, Youhei Yamauchi, Shinichi Kohno, Youko Ushijima, Fumi Goshima, Fumitaka Kikkawa & Yukihiro Nishiyama. (2006) Intercellular trafficking and cytotoxicity of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP repeat peptide. Virus Genes 34:3, pages 263-272.
Crossref
Peter J. Richards, Mari A. Nowell, Sankichi Horiuchi, Rachel M. McLoughlin, Ceri A. Fielding, Sandra Grau, Naoki Yamamoto, Michael Ehrmann, Stefan Rose-John, Anwen S. Williams, Nicholas Topley & Simon A. Jones. (2006) Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis & Rheumatism 54:5, pages 1662-1672.
Crossref
David Perret, François Rousseau, Vinh Tran & Hugues Gascan. (2005) Reversal of some viral IL-6 electrostatic properties compared to IL-6 contributes to a loss of alpha receptor component recruitment. Proteins: Structure, Function, and Bioinformatics 60:1, pages 14-26.
Crossref
D. Kamimura, K. Ishihara & T. Hirano. 2004. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 1 38 .
Cécile Ancey, Andrea Küster, Serge Haan, Andreas Herrmann, Peter C. Heinrich & Gerhard Müller-Newen. (2003) A Fusion Protein of the gp130 and Interleukin-6Rα Ligand-binding Domains Acts as a Potent Interleukin-6 Inhibitor. Journal of Biological Chemistry 278:19, pages 16968-16972.
Crossref
Thomas Taverner, Nathan E. Hall, Richard A.J. O'Hair & Richard J. Simpson. (2002) Characterization of an Antagonist Interleukin-6 Dimer by Stable Isotope Labeling, Cross-linking, and Mass Spectrometry. Journal of Biological Chemistry 277:48, pages 46487-46492.
Crossref
Dar-chone Chow, Lena Brevnova, Xiao-lin He, Monika M Martick, Alex Bankovich & K.Christopher Garcia. (2002) A structural template for gp130-cytokine signaling assemblies. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1592:3, pages 225-235.
Crossref
Hong Li & John Nicholas. (2002) Identification of Amino Acid Residues of gp130 Signal Transducer and gp80 α Receptor Subunit That Are Involved in Ligand Binding and Signaling by Human Herpesvirus 8-Encoded Interleukin-6. Journal of Virology 76:11, pages 5627-5636.
Crossref
Sapna K. Deo, Jennifer C. Lewis & Sylvia Daunert. (2001) C-Terminal and N-Terminal Fusions of Aequorin with Small Peptides in Immunoassay Development. Bioconjugate Chemistry 12:3, pages 378-384.
Crossref
Hong Li, Hailin Wang & John Nicholas. (2001) Detection of Direct Binding of Human Herpesvirus 8-Encoded Interleukin-6 (vIL-6) to both gp130 and IL-6 Receptor (IL-6R) and Identification of Amino Acid Residues of vIL-6 Important for IL-6R-Dependent and -Independent Signaling. Journal of Virology 75:7, pages 3325-3334.
Crossref
Robert L. Moritz, Nathan E. Hall, Lisa M. Connolly & Richard J. Simpson. (2001) Determination of the Disulfide Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Signal Transducer gp130. Journal of Biological Chemistry 276:11, pages 8244-8253.
Crossref
Stefan Pflanz, Ingo Kurth, Joachim Grötzinger, Peter C. Heinrich & Gerhard Müller-Newen. (2000) Two Different Epitopes of the Signal Transducer gp130 Sequentially Cooperate on IL-6-Induced Receptor Activation. The Journal of Immunology 165:12, pages 7042-7049.
Crossref
Rebecca L. Rich & David G. Myszka. (2000) Survey of the 1999 surface plasmon resonance biosensor literature. Journal of Molecular Recognition 13:6, pages 388-407.
Crossref
N.G. Kastrinakis, V.G. Gorgoulis, P.G. Foukas, M.A. Dimopoulos & C. Kittas. (2000) Molecular aspects of multiple myeloma. Annals of Oncology 11:10, pages 1217-1228.
Crossref
James M. Cregg, Joan Lin Cereghino, Jianying Shi & David R. Higgins. (2000) Recombinant protein expression in Pichia pastoris. Molecular Biotechnology 16:1, pages 23-52.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.