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Research Article

Development and characterization of liposomal formulations for rapamycin delivery and investigation of their antiproliferative effect on MCF7 cells

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Pages 322-331 | Received 27 Feb 2009, Accepted 12 Apr 2009, Published online: 28 Oct 2009

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Ho Yub Yoon, In Ho Chang, Yoon Tae Goo, Chang Hyun Kim, Tae Hoon Kang, Soo-Yeon Kim, Sang Jin Lee, Seh Hyon Song, Young Mi Whang & Young Wook Choi. (2019) Intravesical delivery of rapamycin via folate-modified liposomes dispersed in thermo-reversible hydrogel. International Journal of Nanomedicine 14, pages 6249-6268.
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Azadeh Haeri, Mahraz Osouli, Fereshteh Bayat, Sonia Alavi & Simin Dadashzadeh. (2018) Nanomedicine approaches for sirolimus delivery: a review of pharmaceutical properties and preclinical studies. Artificial Cells, Nanomedicine, and Biotechnology 46:sup1, pages 1-14.
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Hadi Valizadeh, Saeed Ghanbarzadeh & Parvin Zakeri-Milani. (2015) Fusogenic liposomal formulation of sirolimus: improvement of drug anti-proliferative effect on human T-cells. Drug Development and Industrial Pharmacy 41:9, pages 1558-1565.
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Articles from other publishers (28)

Clara Cortell-Fuster, María Amparo Martínez-Gómez, Ana Cristina Cercós-Lleti & Mónica Climente-Martí. (2023) Optimization, Formulation, and Stability of Topical Rapamycin Used for Rare Tuberous Sclerosis Disease: from Ointment to Liposomes. Journal of Pharmaceutical Innovation.
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Gregor Bordon, Shivaprakash N. Ramakrishna, Sam G. Edalat, Remo Eugster, Andrea Arcifa, Martina Vermathen, Simone Aleandri, Mojca Frank Bertoncelj, Julien Furrer, Peter Vermathen, Lucio Isa, Rowena Crockett, Oliver Distler & Paola Luciani. (2023) Liposomal aggregates sustain the release of rapamycin and protect cartilage from friction. Journal of Colloid and Interface Science 650, pages 1659-1670.
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Muhammed Abdur Rauf. 2023. Liposomal Encapsulation in Food Science and Technology. Liposomal Encapsulation in Food Science and Technology 189 222 .
Uttom Nandi, Ichioma Onyesom & Dennis Douroumis. (2021) Transferrin conjugated Stealth liposomes for sirolimus active targeting in breast cancer. Journal of Drug Delivery Science and Technology 66, pages 102900.
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Tomomitsu Kanaya, Shigeru Miyagawa, Takuji Kawamura, Yoshiki Sakai, Kenta Masada, Nobutoshi Nawa, Hidekazu Ishida, Jun Narita, Koichi Toda, Toru Kuratani & Yoshiki Sawa. (2021) Innovative therapeutic strategy using prostaglandin I2 agonist (ONO1301) combined with nano drug delivery system for pulmonary arterial hypertension. Scientific Reports 11:1.
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Uttom Nandi, Ichioma Onyesom & Dennis Douroumis. (2021) An in vitro evaluation of antitumor activity of sirolimus-encapsulated liposomes in breast cancer cells . Journal of Pharmacy and Pharmacology 73:3, pages 300-309.
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Uttom Nandi, Ichioma Onyesom & Dennis Douroumis. (2021) Anti-cancer activity of sirolimus loaded liposomes in prostate cancer cell lines. Journal of Drug Delivery Science and Technology 61, pages 102200.
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Gabriela Torres-Flores, Azucena Gonzalez-Horta, Yadira I. Vega-Cantu, Ciro Rodriguez & Aida Rodriguez-Garcia. (2020) Preparation and Characterization of Liposomal Everolimus by Thin-Film Hydration Technique. Advances in Polymer Technology 2020, pages 1-9.
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I. M. Le-Deygen, A. A. Skuredina & E. V. Kudryashova. (2020) Experimental Methods to Study the Mechanisms of Interaction of Lipid Membranes with Low-Molecular-Weight Drugs. Russian Journal of Bioorganic Chemistry 46:4, pages 480-497.
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Maria Condello, Giovanna Mancini & Stefania Meschini. (2020) The Exploitation of Liposomes in the Inhibition of Autophagy to Defeat Drug Resistance. Frontiers in Pharmacology 11.
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Carla Garcia-Mazas, Sheila Barrios-Esteban, Noemi Csaba & Marcos Garcia-Fuentes. 2020. Biomaterials for Cancer Therapeutics. Biomaterials for Cancer Therapeutics 365 398 .
Murilo Batista Abud, Ricardo Noguera Louzada, David Leonardo Cruvinel Isaac, Leonardo Gomes Souza, Ricardo Gomes dos Reis, Eliana Martins Lima & Marcos Pereira de Ávila. (2019) In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus. International Journal of Retina and Vitreous 5:1.
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Jarosław Mazuryk, Tobiasz Deptuła, Alice Polchi, Jacek Gapiński, Stefano Giovagnoli, Alessandro Magini, Carla Emiliani, Joachim Kohlbrecher & Adam Patkowski. (2016) Rapamycin-loaded solid lipid nanoparticles: Morphology and impact of the drug loading on the phase transition between lipid polymorphs. Colloids and Surfaces A: Physicochemical and Engineering Aspects 502, pages 54-65.
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Askell Hvid Hinna, Stefan Hupfeld, Judith Kuntsche, Annette Bauer-Brandl & Martin Brandl. (2016) Mechanism and kinetics of the loss of poorly soluble drugs from liposomal carriers studied by a novel flow field-flow fractionation-based drug release −/transfer-assay. Journal of Controlled Release 232, pages 228-237.
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Josimar O. Eloy, Raquel Petrilli, José Fernando Topan, Heriton Marcelo Ribeiro Antonio, Juliana Palma Abriata Barcellos, Deise L. Chesca, Luciano Neder Serafini, Daniel G. Tiezzi, Robert J. Lee & Juliana Maldonado Marchetti. (2016) Co-loaded paclitaxel/rapamycin liposomes: Development, characterization and in vitro and in vivo evaluation for breast cancer therapy. Colloids and Surfaces B: Biointerfaces 141, pages 74-82.
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Ankit K. Rochani, Aswathy Ravindran Girija, Ankita Borah, Toru Maekawa & D. Sakthi Kumar. (2016) Heat-Shock Protein 90–Targeted Nano Anticancer Therapy. Journal of Pharmaceutical Sciences 105:4, pages 1454-1466.
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Gregory Benedetto, C. Greer Vestal & Christine Richardson. (2015) Aptamer-Functionalized Nanoparticles as “Smart Bombs”: The Unrealized Potential for Personalized Medicine and Targeted Cancer Treatment. Targeted Oncology 10:4, pages 467-485.
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Kishore Cholkar, Sriram Gunda, Ravinder Earla, Dhananjay Pal & Ashim K. Mitra. (2014) Nanomicellar Topical Aqueous Drop Formulation of Rapamycin for Back-of-the-Eye Delivery. AAPS PharmSciTech 16:3, pages 610-622.
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A N Ilinskaya & M A Dobrovolskaia. (2014) Immunosuppressive and anti-inflammatory properties of engineered nanomaterials. British Journal of Pharmacology 171:17, pages 3988-4000.
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Saeed Ghanbarzadeh, Sanam Arami, Zhaleh Pourmoazzen & Arash Khorrami. (2014) Improvement of the antiproliferative effect of Rapamycin on tumor cell lines by poly (monomethylitaconate)-based pH-sensitive, plasma stable liposomes. Colloids and Surfaces B: Biointerfaces 115, pages 323-330.
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Ichioma OnyesomDimitrios A. Lamprou, Lamprini Sygellou, Samuel K. Owusu-WareMilan AntonijevicBabur Z. ChowdhryDennis Douroumis. (2013) Sirolimus Encapsulated Liposomes for Cancer Therapy: Physicochemical and Mechanical Characterization of Sirolimus Distribution within Liposome Bilayers. Molecular Pharmaceutics 10:11, pages 4281-4293.
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Janet L. Markman, Arthur Rekechenetskiy, Eggehard Holler & Julia Y. Ljubimova. (2013) Nanomedicine therapeutic approaches to overcome cancer drug resistance. Advanced Drug Delivery Reviews 65:13-14, pages 1866-1879.
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Niravkumar R. Patel, Bhushan S. Pattni, Abraham H. Abouzeid & Vladimir P. Torchilin. (2013) Nanopreparations to overcome multidrug resistance in cancer. Advanced Drug Delivery Reviews 65:13-14, pages 1748-1762.
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Chuang Yang, Hai Z Liu, Zhong X Fu & Wei D Lu. (2011) Oxaliplatin long-circulating liposomes improved therapeutic index of colorectal carcinoma. BMC Biotechnology 11:1.
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Azadeh Haeri, Saeed Sadeghian, Shahram Rabbani, Maryam Sotoudeh Anvari, Mohammad Ali Boroumand & Simin Dadashzadeh. (2011) Use of remote film loading methodology to entrap sirolimus into liposomes: Preparation, characterization and in vivo efficacy for treatment of restenosis. International Journal of Pharmaceutics 414:1-2, pages 16-27.
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Alina Shapira, Yoav D. Livney, Henk J. Broxterman & Yehuda G. Assaraf. (2011) Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance. Drug Resistance Updates 14:3, pages 150-163.
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M. Abdur Rouf, Imran Vural, Erem Bilensoy, Atilla Hincal & Dilek Demir Erol. (2010) Rapamycin-cyclodextrin complexation: improved solubility and dissolution rate. Journal of Inclusion Phenomena and Macrocyclic Chemistry 70:1-2, pages 167-175.
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Giorgia Urbinati, Véronique Marsaud, Vincent Plassat, Elias Fattal, Sylviane Lesieur & Jack-Michel Renoir. (2010) Liposomes loaded with histone deacetylase inhibitors for breast cancer therapy. International Journal of Pharmaceutics 397:1-2, pages 184-193.
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