Advanced search
Publication Cover
Journal of Liposome Research Volume 5, 1995 - Issue 3
Submit an article Journal homepage
54
Views
49
CrossRef citations to date
0
Altmetric
Research Article

Encapsulation of Vincristine in Liposomes Reduces its Toxicity and Improves its Anti-Tumor Efficacy

Nancy L. Boman Inex Pharmaceuticals Corporation, 1779 W. 75th Avenue, Vancouver, British Columbia, Canada, V6P 6P2
,
Marcel B. Bally The British Columbia Cancer Agency, Division of Medical Oncology-Laboratory Operations, 601 W. 10th Avenue, Vancouver, British Columbia, Canada, V5Z 4E6
,
Pieter R. Cullis Inex Pharmaceuticals Corporation, 1779 W. 75th Avenue, Vancouver, British Columbia, Canada, V6P 6P2
,
Lawrence D. Mayer The British Columbia Cancer Agency, Division of Medical Oncology-Laboratory Operations, 601 W. 10th Avenue, Vancouver, British Columbia, Canada, V5Z 4E6
&
Murray S. Webb Inex Pharmaceuticals Corporation, 1779 W. 75th Avenue, Vancouver, British Columbia, Canada, V6P 6P2
Pages 523-541 | Published online: 28 Sep 2008

Citations (49)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Trisha A Soosay Raj, Amanda M Smith & Andrew S Moore. (2013) Vincristine sulfate liposomal injection for acute lymphoblastic leukemia. International Journal of Nanomedicine 8, pages 4361-4369.
Read now
Tyler Davis & Sherif S Farag. (2013) Treating relapsed or refractory Philadelphia chromosome-negative acute lymphoblastic leukemia: liposome-encapsulated vincristine. International Journal of Nanomedicine 8, pages 3479-3488.
Read now
Jing Liu, Jie Tang, Haiyun He, Lu-Lu Cai, YiMei Huang, Xiawei Wei, Min Luo, Bilan Wang, Xiang Gao, Chengli Yang, Tingting Hu, Xiangrong Song, Tao Yi, Li Yang, Yongmei Xie, Aiping Tong, Lantu Gou, Yinglan Zhao & Yu Zheng. (2012) Preparation of the thienopyridine derivatives loaded liposomes and study on the effect of compound-lipid interaction on release behavior. Drug Delivery 19:5, pages 247-254.
Read now
Jerzy Gubernator. (2011) Active methods of drug loading into liposomes: recent strategies for stable drug entrapment and increased in vivo activity. Expert Opinion on Drug Delivery 8:5, pages 565-580.
Read now
Larry Boehlke & Jane N Winter. (2006) Sphingomyelin/cholesterol liposomal vincristine: a new formulation for an old drug. Expert Opinion on Biological Therapy 6:4, pages 409-415.
Read now
Murray S. Webb, Andreas H. Sarris, Fernando Cabanillas, Lawrence D. Mayer, Marcel B. Bally, Clive Burge & Pieter R. Cullis. (2000) Clinical and Preclinical Pharmacology of Liposomal Vincristine. Journal of Liposome Research 10:4, pages 501-512.
Read now
Pieter R. Cullis. (2000) Commentary: Liposomes by Accident. Journal of Liposome Research 10:2-3, pages ix-xxiv.
Read now
Tony L. Whateley. (1996) Literature Alerts. Drug Delivery 3:2, pages 127-136.
Read now

Articles from other publishers (41)

Oluwakemi Ebenezer, Michael Shapi & Jack A. Tuszynski. (2022) A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization. International Journal of Molecular Sciences 23:7, pages 4001.
Crossref
Mansoureh Ganjali, Monireh Ganjali, Alaa A.A. Aljabali & Ahmed Barhoum. 2022. Bionanotechnology : Emerging Applications of Bionanomaterials. Bionanotechnology : Emerging Applications of Bionanomaterials 491 530 .
Nahid S. Awad, Vinod Paul, Nour M. AlSawaftah, Gail ter HaarTheresa M. Allen, William G. Pitt & Ghaleb A. Husseini. (2021) Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review. ACS Pharmacology & Translational Science 4:2, pages 589-612.
Crossref
Ghanshyam R. Parmar & Girish U. Sailor. 2021. Nanocarriers: Drug Delivery System. Nanocarriers: Drug Delivery System 281 301 .
V Poorani VigneswaranG Venkat Kumar. (2020) Nano-Niosomal Formulation of Alkaloids from Vinca rosea for Improved Oral Delivery. Journal of Pharmaceutical and Medicinal Research 5:1, pages 102-105.
Crossref
Hussein O. Ammar, Rehab N. Shamma, Rasha S. E. Elbatanony & Basma Khater. (2020) Antioxidants in Cancer Therapy: Recent Trends in Application of Nanotechnology for Enhanced Delivery. Scientia Pharmaceutica 88:1, pages 5.
Crossref
Roger Gilabert-Oriol, Brent W. Sutherland, Malathi Anantha, Alessia Pallaoro & Marcel B. Bally. (2019) Liposomal OTS964, a TOPK inhibitor: a simple method to estimate OTS964 association with liposomes that relies on enhanced OTS964 fluorescence when bound to albumin. Drug Delivery and Translational Research 9:6, pages 1082-1094.
Crossref
Reena Sheoran, Sukhbir Lal Khokra, Viney Chawla & Harish Dureja. (2019) Recent Patents, Formulation Techniques, Classification and Characterization of Liposomes. Recent Patents on Nanotechnology 13:1, pages 17-27.
Crossref
Kuan-Chieh Liu, Arundhathi Arivajiagane, Shang-Jung Wu, Shey-Cherng Tzou, Chiao-Yun Chen & Yun-Ming Wang. (2019) Development of a novel thermal-sensitive multifunctional liposome with antibody conjugation to target EGFR-expressing tumors. Nanomedicine: Nanotechnology, Biology and Medicine 15:1, pages 285-294.
Crossref
Rahman Ateeq, Uahengo Veikko & Likius Daniel. (2018) Mini review on emerging methods of preparation of liposome and its application as Liposome drug delivery systems. Open Journal of Pharmacology and Pharmacotherapeutics 3:1, pages 005-021.
Crossref
Roger Gilabert-Oriol, Gemma Ryan, Ada Leung, Natalie Firmino, Kevin Bennewith & Marcel Bally. (2018) Liposomal Formulations to Modulate the Tumour Microenvironment and Antitumour Immune Response. International Journal of Molecular Sciences 19:10, pages 2922.
Crossref
Tabassum Khan & Pranav Gurav. (2018) PhytoNanotechnology: Enhancing Delivery of Plant Based Anti-cancer Drugs. Frontiers in Pharmacology 8.
Crossref
Maurizio Roveri, Alice Pfohl, Patricia Jaaks, Nagjie Alijaj, Jean-Christophe Leroux, Paola Luciani & Michele Bernasconi. (2017) Prolonged circulation and increased tumor accumulation of liposomal vincristine in a mouse model of rhabdomyosarcoma. Nanomedicine 12:10, pages 1135-1151.
Crossref
Chien-Hsun Wu, I-Ju Liu, Ruei-Min Lu & Han-Chung Wu. (2016) Advancement and applications of peptide phage display technology in biomedical science. Journal of Biomedical Science 23:1.
Crossref
Phatsapong Yingchoncharoen, Danuta S. Kalinowski & Des R. Richardson. (2016) Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come. Pharmacological Reviews 68:3, pages 701-787.
Crossref
Aharon Ronson, Ariella Tvito & Jacob M. Rowe. (2016) Treatment of Relapsed/Refractory Acute Lymphoblastic Leukemia in Adults. Current Oncology Reports 18:6.
Crossref
Zhenghua Zhong, Xin Wei, Baowen Qi, Wenjing Xiao, Li Yang, Yuquan Wei & Lijuan Chen. (2010) A novel liposomal vaccine improves humoral immunity and prevents tumor pulmonary metastasis in mice. International Journal of Pharmaceutics 399:1-2, pages 156-162.
Crossref
H Maswadeh, C Demetzos, K Dimas, Y L Loukas, A Georgopoulos, T Mavromoustakos & G Th Papaioannou. (2002) In-vitro cytotoxic/cytostatic activity of anionic liposomes containing vinblastine against leukaemic human cell lines. Journal of Pharmacy and Pharmacology 54:2, pages 189-196.
Crossref
Jayati Banerjee, Andrea J. Hanson, Bhushan Gadam, Adekunle I. Elegbede, Shakila Tobwala, Bratati Ganguly, Anil V. Wagh, Wallace W. Muhonen, Benedict Law, John B. Shabb, D. K. Srivastava & Sanku Mallik. (2009) Release of Liposomal Contents by Cell-Secreted Matrix Metalloproteinase-9. Bioconjugate Chemistry 20:7, pages 1332-1339.
Crossref
Sima Jeha. (2009) New Therapeutic Strategies in Acute Lymphoblastic Leukemia. Seminars in Hematology 46:1, pages 76-88.
Crossref
Y. LIU, L. CHEN, X. HE, L. FAN, G. YANG, X. CHEN, X. LIN, L. DU, Z. LI, H. YE, Y. MAO, X. ZHAO & Y. WEI. (2008) Enhancement of therapeutic effectiveness by combining liposomal honokiol with cisplatin in ovarian carcinoma. International Journal of Gynecological Cancer 18:4, pages 652-659.
Crossref
Jia HuLi-juan ChenLi LiuXiang ChenPing ChenGuang-li YangWen-li HouMing-hai TangFan ZhangXian-huo WangXia ZhaoYu-quan Wei. (2008) Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity. Experimental and Molecular Medicine 40:6, pages 617.
Crossref
Azadeh Kheirolomoom, Paul A. Dayton, Aaron F.H. Lum, Erika Little, Eric E. Paoli, Hairong Zheng & Katherine W. Ferrara. (2007) Acoustically-active microbubbles conjugated to liposomes: Characterization of a proposed drug delivery vehicle. Journal of Controlled Release 118:3, pages 275-284.
Crossref
Ching-Hon Pui & Sima Jeha. (2007) New therapeutic strategies for the treatment of acute lymphoblastic leukaemia. Nature Reviews Drug Discovery 6:2, pages 149-165.
Crossref
Zhi-ping Yuan, Li-juan Chen, Lin-yu Fan, Ming-hai Tang, Guang-li Yang, Han-su Yang, Xiao-bo Du, Guo-qing Wang, Wen-xiu Yao, Qu-mei Zhao, Bin Ye, Rui Wang, Peng Diao, Wei Zhang, Hong-bin Wu, Xia Zhao & Yu-Quan Wei. (2006) Liposomal Quercetin Efficiently Suppresses Growth of Solid Tumors in Murine Models. Clinical Cancer Research 12:10, pages 3193-3199.
Crossref
Igor V. Zhigaltsev, Norbert Maurer, Katarina Edwards, Göran Karlsson & Pieter R. Cullis. (2006) Formation of drug–arylsulfonate complexes inside liposomes: A novel approach to improve drug retention. Journal of Controlled Release 110:2, pages 378-386.
Crossref
Ralf-Dieter Hofheinz, Senta Ulrike Gnad-Vogt, Ulrich Beyer & Andreas Hochhaus. (2005) Liposomal encapsulated anti-cancer drugs. Anti-Cancer Drugs 16:7, pages 691-707.
Crossref
Igor V. Zhigaltsev, Norbert Maurer, Quet-Fah Akhong, Robert Leone, Esther Leng, Jinfang Wang, Sean C. Semple & Pieter R. Cullis. (2005) Liposome-encapsulated vincristine, vinblastine and vinorelbine: A comparative study of drug loading and retention. Journal of Controlled Release 104:1, pages 103-111.
Crossref
Lloyd B. Jeffs, Lorne R. Palmer, Ellen G. Ambegia, Cory Giesbrecht, Shannon Ewanick & Ian MacLachlan. (2005) A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA. Pharmaceutical Research 22:3, pages 362-372.
Crossref
Dawn N. Waterhouse, Thomas D. Madden, Pieter R. Cullis, Marcel B. Bally, Lawrence D. Mayer & Murray S. Webb. 2005. Liposomes. Liposomes 40 57 .
Nancy Smyth TempletonGreg Hardee, Eric Swayze, Rahul Mehta, Ching-Leou Teng, Art Levin, C Frank Bennett, Lloyd Tillman & Richard Geary. 2003. Gene and Cell Therapy. Gene and Cell Therapy 347 374 .
Frank Güthlein, Angelika M Burger, Martin Brandl, Heinz-Herbert Fiebig, Rolf Schubert, Clemens Unger & Ulrich Massing. (2002) Pharmacokinetics and antitumor activity of vincristine entrapped in vesicular phospholipid gels. Anti-Cancer Drugs 13:8, pages 797-805.
Crossref
Carlo Leonetti, Annamaria Biroccio, Barbara Benassi, Annarita Stringaro, Antonella Stoppacciaro, Sean C Semple & Gabriella Zupi. (2001) Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line. Cancer Gene Therapy 8:6, pages 459-468.
Crossref
Sandra K. Klimuk, Sean C. Semple, Peter Scherrer & Michael J. Hope. (1999) Contact hypersensitivity: a simple model for the characterization of disease-site targeting by liposomes. Biochimica et Biophysica Acta (BBA) - Biomembranes 1417:2, pages 191-201.
Crossref
K. A. GelmonA. TolcherA. R. DiabM. B. BallyL. EmbreeN. HudonC. DedharD. AyersA. EisenB. MeloskyC. BurgeP. LoganL. D. Mayer. (1999) Phase I Study of Liposomal Vincristine. Journal of Clinical Oncology 17:2, pages 697-697.
Crossref
David B. Fenske, Kim F. Wong, Elisabeth Maurer, Norbert Maurer, Johanna M. Leenhouts, Nancy Boman, Lawrence Amankwa & Pieter R. Cullis. (1998) Ionophore-mediated uptake of ciprofloxacin and vincristine into large unilamellar vesicles exhibiting transmembrane ion gradients. Biochimica et Biophysica Acta (BBA) - Biomembranes 1414:1-2, pages 188-204.
Crossref
Murray S. WebbNancy L. BomanDavid J. WisemanDawn SaxonKym SuttonKim F. Wong, Patricia LoganMichael J. Hope. (1998) Antibacterial Efficacy against an In Vivo Salmonella typhimurium Infection Model and Pharmacokinetics of a Liposomal Ciprofloxacin Formulation . Antimicrobial Agents and Chemotherapy 42:1, pages 45-52.
Crossref
Nancy L. Boman, Pieter R. Cullis, Lawrence D. Mayer, Marcel B. Bally & Murray S. Webb. 1998. Long Circulating Liposomes: Old Drugs, New Therapeutics. Long Circulating Liposomes: Old Drugs, New Therapeutics 29 49 .
Pieter R Cullis, Michael J Hope, Marcel B Bally, Thomas D Madden, Lawrence D Mayer & David B Fenske. (1997) Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 1331:2, pages 187-211.
Crossref
Michael J. Hope. (2016) Gene Therapy: Recent Advances and Applications in Dermatology. Journal of Cutaneous Medicine and Surgery 1:2, pages 109-118.
Crossref
Pieter R. Cullis, David B. Fenske & Michael J. Hope. 1996. Biochemistry of Lipids, Lipoproteins and Membranes. Biochemistry of Lipids, Lipoproteins and Membranes 1 33 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.