Advanced search
Publication Cover
Journal of Liposome Research Volume 8, 1998 - Issue 3
Submit an article Journal homepage
72
Views
35
CrossRef citations to date
0
Altmetric
Research Article

Micellar Delivery System for Dequalinium—A Lipophilic Cationic Drug with Anticarcinoma Activity

Volkmar Weissig Center for Imaging and Pharmaceutical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129Correspondence[email protected]
,
Carmen Lizano Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcala, 28871, Alcala de Henares, Madrid, Spain
&
Vladimir P. Torchilin Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcala, 28871, Alcala de Henares, Madrid, Spain
Pages 391-400 | Published online: 28 Sep 2008

Citations (35)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Rupa R. Sawant & Vladimir P. Torchilin. (2010) Multifunctionality of lipid-core micelles for drug delivery and tumour targeting. Molecular Membrane Biology 27:7, pages 232-246.
Read now
Igor Skidan, Parita Dholakia & Vladimir Torchilin. (2008) Photodynamic therapy of experimental B-16 melanoma in mice with tumor-targeted 5,10,15,20-tetraphenylporphin-loaded PEG-PE micelles. Journal of Drug Targeting 16:6, pages 486-493.
Read now
Junping Wang, Dimitry Mongayt & Vladimir P. Torchilin. (2005) Polymeric micelles for delivery of poorly soluble drugs: Preparation and anticancer activity in vitro of paclitaxel incorporated into mixed micelles based on poly(ethylene glycol)-lipid conjugate and positively charged lipids. Journal of Drug Targeting 13:1, pages 73-80.
Read now
Volkmar Weissig & Vladimir P. Torchilin. (2001) Towards Mitochondrial Gene Therapy: DQAsomes as a Strategy. Journal of Drug Targeting 9:1, pages 1-13.
Read now

Articles from other publishers (31)

Chou-Yi Hsu, Ahmed Mahdi Rheima, Mustafa M. Kadhim, Nada Nadhim Ahmed, Srwa Hashim Mohammed, Fatima Hashim Abbas, Zainab Talib Abed, Zahra Muhammed Mahdi, Zainab Sabri Abbas, Safa K. Hachim, Farah K. Ali, Zaid H Mahmoud & Ehsan Kianfar. (2023) An overview of nanoparticles in drug delivery: Properties and applications. South African Journal of Chemical Engineering 46, pages 233-270.
Crossref
Janina-Miriam Noy, Fan Chen & Martina Stenzel. (2021) Post-functionalization of drug-loaded nanoparticles prepared by polymerization-induced self-assembly (PISA) with mitochondria targeting ligands. Beilstein Journal of Organic Chemistry 17, pages 2302-2314.
Crossref
Christian Bailly. (2021) Medicinal applications and molecular targets of dequalinium chloride. Biochemical Pharmacology 186, pages 114467.
Crossref
Xing Guo, Xiao Wei, Zi Chen, Xiaobin Zhang, Guang Yang & Shaobing Zhou. (2020) Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy. Progress in Materials Science 107, pages 100599.
Crossref
Félix Sauvage, François-Xavier Legrand, Michel Roux, Ivan Rajkovic, Thomas M. Weiss, Zoltán Varga, Luc Augis, Guillaume Nugue, Jean-Claude Debouzy, Juliette Vergnaud-Gauduchon & Gillian Barratt. (2019) Interaction of dequalinium chloride with phosphatidylcholine bilayers: A biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines. Journal of Colloid and Interface Science 537, pages 704-715.
Crossref
Tamarisk K. Horne & Marianne J. Cronjé. (2017) Mechanistics and photo-energetics of macrocycles and photodynamic therapy: An overview of aspects to consider for research. Chemical Biology & Drug Design 89:2, pages 221-242.
Crossref
Ru Wen, Afoma Umeano, Lily Francis, Nivita Sharma, Smanla Tundup & Shanta Dhar. (2016) Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems. Vaccines 4:2, pages 18.
Crossref
Swati Biswas, Preeti Kumari, Prit Manish Lakhani & Balaram Ghosh. (2016) Recent advances in polymeric micelles for anti-cancer drug delivery. European Journal of Pharmaceutical Sciences 83, pages 184-202.
Crossref
Rakesh K. Pathak, Nagesh Kolishetti & Shanta Dhar. (2014) Targeted nanoparticles in mitochondrial medicine. WIREs Nanomedicine and Nanobiotechnology 7:3, pages 315-329.
Crossref
Ana I. García-Pérez, Eva Galeano, Elena Nieto, M. Cristina Estañ & Pilar Sancho. (2014) Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways. Leukemia Research 38:7, pages 795-803.
Crossref
K. Makowska, M. C. Estañ, I. Gañán-Gómez, M. C. Boyano-Adánez, A. I. García-Pérez & P. Sancho. (2014) Changes in mitochondrial function induced by dequalinium precede oxidative stress and apoptosis in the human prostate-cancer cell line PC-3. Molecular Biology 48:3, pages 359-370.
Crossref
Rupa R. Sawant, Aditi M. Jhaveri, Alexander Koshkaryev, Lin Zhu, Farooq Qureshi & Vladimir P. Torchilin. (2013) Targeted Transferrin-Modified Polymeric Micelles: Enhanced Efficacy in Vitro and in Vivo in Ovarian Carcinoma. Molecular Pharmaceutics 11:2, pages 375-381.
Crossref
Swati Biswas, Onkar S. Vaze, Sara Movassaghian & Vladimir P. Torchilin. 2013. Drug Delivery Strategies for Poorly Water‐Soluble Drugs. Drug Delivery Strategies for Poorly Water‐Soluble Drugs 411 476 .
Rupa R. Sawant, Aditi M. Jhaveri & Vladimir P. Torchilin. (2012) Immunomicelles for advancing personalized therapy. Advanced Drug Delivery Reviews 64:13, pages 1436-1446.
Crossref
Pilar Sancho, Eva Galeano, María Cristina Estañ, Irene Gañán-Gómez, María del Carmen Boyano-Adánez & Ana Isabel García-Pérez. (2012) Raf/MEK/ERK signaling inhibition enhances the ability of dequalinium to induce apoptosis in the human leukemic cell line K562. Experimental Biology and Medicine 237:8, pages 933-942.
Crossref
Volkmar Weissig. (2011) From Serendipity to Mitochondria-Targeted Nanocarriers. Pharmaceutical Research 28:11, pages 2657-2668.
Crossref
Ana I. García-Pérez, Eva Galeano, Elena Nieto & Pilar Sancho. (2011) Dequalinium induces human leukemia cell death by affecting the redox balance. Leukemia Research 35:10, pages 1395-1401.
Crossref
Rupa R. Sawant & Vladimir P. Torchilin. 2010. Cancer Nanotechnology. Cancer Nanotechnology 131 149 .
Pilar Sancho, Eva Galeano, Elena Nieto, M. Dolores Delgado & Ana Isabel Garc?a-P?rez. (2007) Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production. Leukemia Research 31:7, pages 969-978.
Crossref
. 2006. Polymers in Drug Delivery. Polymers in Drug Delivery.
Eva Galeano, Elena Nieto, Ana Isabel García-Pérez, M.Dolores Delgado, Montserrat Pinilla & Pilar Sancho. (2005) Effects of the antitumoural dequalinium on NB4 and K562 human leukemia cell lines. Leukemia Research 29:10, pages 1201-1211.
Crossref
Stanislav Rangelov, Mats Almgren, Katarina Edwards & Christo Tsvetanov. (2004) Formation of Normal and Reverse Bilayer Structures by Self-Assembly of Nonionic Block Copolymers Bearing Lipid-Mimetic Units. The Journal of Physical Chemistry B 108:23, pages 7542-7552.
Crossref
Anatoly N. Lukyanov & Vladimir P. Torchilin. (2004) Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Advanced Drug Delivery Reviews 56:9, pages 1273-1289.
Crossref
Doroth??e Le Garrec, Maxime Ranger & Jean-Christophe Leroux. (2004) Micelles in Anticancer Drug Delivery. American Journal of Drug Delivery 2:1, pages 15-42.
Crossref
Vladimir P. Torchilin, Anatoly N. Lukyanov, Zhonggao Gao & Brigitte Papahadjopoulos-Sternberg. (2003) Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs. Proceedings of the National Academy of Sciences 100:10, pages 6039-6044.
Crossref
Janny X. Zhang, Christian B. Hansen, Theresa M. Allen, Anthony Boey & Ron Boch. (2003) Lipid-derivatized poly(ethylene glycol) micellar formulations of benzoporphyrin derivatives. Journal of Controlled Release 86:2-3, pages 323-338.
Crossref
Sarah Herhardt & Jin Zhang. 2002. Interfacial Catalysis. Interfacial Catalysis.
Zhonggao Gao, Anatoly N. Lukyanov, Anurag Singhal & Vladimir P. Torchilin. (2002) Diacyllipid-Polymer Micelles as Nanocarriers for Poorly Soluble Anticancer Drugs. Nano Letters 2:9, pages 979-982.
Crossref
Vladimir P Torchilin. (2002) PEG-based micelles as carriers of contrast agents for different imaging modalities. Advanced Drug Delivery Reviews 54:2, pages 235-252.
Crossref
Volkmar Weissig & Vladimir P Torchilin. (2001) Cationic bolasomes with delocalized charge centers as mitochondria-specific DNA delivery systems. Advanced Drug Delivery Reviews 49:1-2, pages 127-149.
Crossref
Vladimir P. Torchilin. (2001) Structure and design of polymeric surfactant-based drug delivery systems. Journal of Controlled Release 73:2-3, pages 137-172.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.