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PCOS

d-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review

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Pages 256-262 | Received 09 Aug 2010, Accepted 25 Oct 2010, Published online: 10 Dec 2010

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Antoaneta Gateva, Vittorio Unfer & Zdravko Kamenov. (2018) The use of inositol(s) isomers in the management of polycystic ovary syndrome: a comprehensive review. Gynecological Endocrinology 34:7, pages 545-550.
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Simona De Cicco, Valentina Immediata, Daniela Romualdi, Caterina Policola, Anna Tropea, Christian Di Florio, Valeria Tagliaferri, Elisa Scarinci, Silvia Della Casa, Antonio Lanzone & Rosanna Apa. (2017) Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. Gynecological Endocrinology 33:9, pages 698-701.
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Özlen Emekçi Özay, Ali Cenk Özay, Erkan Çağlıyan, Recep Emre Okyay & Bülent Gülekli. (2017) Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial. Gynecological Endocrinology 33:7, pages 524-528.
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Giovanni Monastra, Vittorio Unfer, Abdel Halim Harrath & Mariano Bizzarri. (2017) Combining treatment with myo-inositol and D-chiro-inositol (40:1) is effective in restoring ovary function and metabolic balance in PCOS patients. Gynecological Endocrinology 33:1, pages 1-9.
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Ewa M. Milewska, Adam Czyzyk, Blazej Meczekalski & Alessandro D. Genazzani. (2016) Inositol and human reproduction. From cellular metabolism to clinical use. Gynecological Endocrinology 32:9, pages 690-695.
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Antonio La Marca, Valentina Grisendi, Giulia Dondi, Giovanna Sighinolfi & Antonio Cianci. (2015) The menstrual cycle regularization following d-chiro-inositol treatment in PCOS women: a retrospective study. Gynecological Endocrinology 31:1, pages 52-56.
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Alessandro D. Genazzani, Susanna Santagni, Erika Rattighieri, Elisa Chierchia, Giulia Despini, Giulia Marini, Alessia Prati & Tommaso Simoncini. (2014) Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients. Gynecological Endocrinology 30:6, pages 438-443.
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Alessandro D. Genazzani, Alessia Prati, Susanna Santagni, Federica Ricchieri, Elisa Chierchia, Erica Rattighieri, Annalisa Campedelli, Tommaso Simoncini & Paolo G. Artini. (2012) Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. Gynecological Endocrinology 28:12, pages 969-973.
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Articles from other publishers (28)

Elisa SCARINCI, Giovanna NOTARISTEFANO, Anna TROPEA, Simone M. FABOZZI, Ornella ALESIANI, Elisabetta MEUCCI, Andrea SILVESTRINI, Marco CINTONI, Alice DITERLIZZI, Antonio LANZONE & Rosanna APA. (2023) Insulin-sensitizing effect and antioxidant action of alpha lipoic acid in oligomenorrheic women with polycystic ovary syndrome. Minerva Obstetrics and Gynecology 75:2.
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Ekaterina М Riazantceva, Marina A. Tarasova, Natalia N. Tkachenko & Alexander M. Gzgzyan. (2020) Effect of obesity therapy in women of reproductive age on leptin level and hormonal ovarian function. Journal of obstetrics and women's diseases 69:3, pages 17-26.
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Olga A. Gromova, Ivan Yu. Torshin, Elena V. Uvarova, Natalya I. Tapilskaya & Alla G. Kalacheva. (2020) Systematic analysis of the biological roles and pharmacological properties of D-chiro-inositol. Gynecology 22:3, pages 21-28.
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Caitlin Cridland & Glenda Gillaspy. (2020) Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?. Molecules 25:12, pages 2789.
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Arianna Pani, Ilaria Gironi, Giacoma Di Vieste, Elena Mion, Federico Bertuzzi & Basilio Pintaudi. (2020) From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management. International Journal of Endocrinology 2020, pages 1-10.
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Anna Wojciechowska, Adam Osowski, Marcin Jóźwik, Ryszard Górecki, Andrzej Rynkiewicz & Joanna Wojtkiewicz. (2019) Inositols’ Importance in the Improvement of the Endocrine–Metabolic Profile in PCOS. International Journal of Molecular Sciences 20:22, pages 5787.
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Т. Л. Архипкина & Л. П. Любимова. (2019) Efficiency of the D-chiro-inositol for the polycystic ovary syndrome. Reproductive Endocrinology 0:45, pages 57-62.
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Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan, Ruth Hodgson & Cindy Farquhar. (2018) Inositol for subfertile women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2018:12.
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Chau T. Tay, Anju E. Joham, Danielle S. Hiam, Moustafa A. Gadalla, Jyotsna Pundir, Shakila Thangaratinam, Helena J. Teede & Lisa J. Moran. (2018) Pharmacological and surgical treatment of nonreproductive outcomes in polycystic ovary syndrome: An overview of systematic reviews. Clinical Endocrinology 89:5, pages 535-553.
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J Pundir, D Psaroudakis, P Savnur, P Bhide, L Sabatini, H Teede, A Coomarasamy & S Thangaratinam. (2018) Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. BJOG: An International Journal of Obstetrics & Gynaecology 125:3, pages 299-308.
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Anna Rita Maurizi, Marika Menduni, Rossella Del Toro, Shadi Kyanvash, Daria Maggi, Chiara Guglielmi, Angelo Lauria Pantano, Giuseppe Defeudis, Elvira Fioriti, Silvia Manfrini & Paolo Pozzilli. (2016) A pilot study of d-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. Acta Diabetologica 54:4, pages 361-365.
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Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan, Ruth Hodgson, Julie Brown & Cindy Farquhar. (2016) Inositol for subfertile women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews.
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Samer El Hayek, Lynn Bitar, Layal H. Hamdar, Fadi G. Mirza & Georges Daoud. (2016) Poly Cystic Ovarian Syndrome: An Updated Overview. Frontiers in Physiology 7.
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Mark P. Thomas, Stephen J. Mills & Barry V. L. Potter. (2016) The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo -Inositol Chemistry) . Angewandte Chemie International Edition 55:5, pages 1614-1650.
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Mark P. Thomas, Stephen J. Mills & Barry V. L. Potter. (2016) Die “anderen” Inositole und ihre Phosphate: Synthese, Biologie und Medizin (sowie jüngste Fortschritte in der myo -Inositolchemie) . Angewandte Chemie 128:5, pages 1644-1683.
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Ali Cenk Ozay, Ozlen Emekci Ozay, Recep Emre Okyay, Erkan Cagliyan, Tuncay Kume & Bulent Gulekli. (2016) Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women. International Journal of Endocrinology 2016, pages 1-8.
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Antonio Simone Laganà & Alfonsa Pizzo. (2015) Authors’ reply to: “Empiric” inositol supplementation in normal-weight non-insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. Archives of Gynecology and Obstetrics 291:5, pages 959-960.
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Deirdre K. Tobias, Audrey J. Gaskins, Stacey A. Missmer, Frank B. Hu, JoAnn E. Manson, Germaine M. Buck Louis, Cuilin Zhang & Jorge E. Chavarro. (2015) History of infertility and risk of type 2 diabetes mellitus: a prospective cohort study. Diabetologia 58:4, pages 707-715.
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Jorge Chavarro, Audrey Gaskins & Myriam Afeiche. 2015. Nutrition, Fertility, and Human Reproductive Function. Nutrition, Fertility, and Human Reproductive Function 1 26 .
Mohd Ashraf Ganie, Semanti Chakraborty & Hammadur Rehman. (2015) Treatment of polycystic ovary syndrome: recent trial results. Clinical Investigation 5:3, pages 337-350.
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Jorge E. Chavarro, Eden Cardozo & Myriam Afeiche. 2015. Obesity and Fertility. Obesity and Fertility 31 72 .
Alessandro D. Genazzani, Susanna Santagni, Federica Ricchieri, Annalisa Campedelli, Erika Rattighieri, Elisa Chierchia, Giulia Marini, Giulia Despini, Alessia Prati & Tommaso Simoncini. (2014) Myo-inositol modulates insulin and luteinizing hormone secretion in normal weight patients with polycystic ovary syndrome. Journal of Obstetrics and Gynaecology Research 40:5, pages 1353-1360.
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N. Mendoza & M.J. Cancelo. 2014. Handbook of diet and nutrition in the menstrual cycle, periconception and fertility. Handbook of diet and nutrition in the menstrual cycle, periconception and fertility 521 532 .
S. O. Dubrovina. (2014) Polycystic ovary syndrome: the strategy of diagnosis and treatment. Problemy reproduktsii:6, pages 10.
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Alessandro D. Genazzani, Alessia Prati, Giulia Despini, Giulia Marini & Federica Ricchieri. 2014. Frontiers in Gynecological Endocrinology. Frontiers in Gynecological Endocrinology 59 67 .
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Jorge E. Chavarro & Thomas L. Toth. 2012. Maternal Obesity. Maternal Obesity 20 34 .
Glenda E. Gillaspy. (2011) The cellular language of myo‐ inositol signaling . New Phytologist 192:4, pages 823-839.
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