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Are infertility treatments a potential risk factor for cancer development? Perspective of 30 years of follow-up

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Pages 809-814 | Received 20 Aug 2011, Accepted 27 Feb 2012, Published online: 05 Apr 2012

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Zohre Momenimovahed, Azita Tiznobaik, Safoura Taheri & Hamid Salehiniya. (2019) Ovarian cancer in the world: epidemiology and risk factors. International Journal of Women's Health 11, pages 287-299.
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Zhipeng Fan, Hongfei Song, Rongli Yuan, Yangzhi Peng & Yong Jiang. (2023) Genetic predisposition to female infertility in relation to epithelial ovarian and endometrial cancers. Postgraduate Medical Journal 99:1168, pages 63-68.
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Liang Yu, Jiafan Sun, Qiqin Wang, Wennian Yu, Anqi Wang, Shu Zhu, Wei Xu & Xiuli Wang. (2023) Ovulation induction drug and ovarian cancer: an updated systematic review and meta-analysis. Journal of Ovarian Research 16:1.
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Lidia A. Klyukina, Elena A. Sosnova & Anton А. Ishchenko. (2022) Assisted reproductive technology and uterine cancer risk. A systematic review and meta-analysis. Journal of obstetrics and women's diseases 71:3, pages 77-86.
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Lidiya A. Klyukina, Elena A. Sosnova & Anton A. Ishchenko. (2022) The stimulation of ovulation and endometrial carcinogenesis: possible relationship and study prospects (literature review). V.F.Snegirev Archives of Obstetrics and Gynecology 9:2, pages 73-81.
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Pulak R. Manna, Ahsen U. Ahmed, Deborah Molehin, Madhusudhanan Narasimhan, Kevin Pruitt & P. Hemachandra Reddy. (2022) Hormonal and Genetic Regulatory Events in Breast Cancer and Its Therapeutics: Importance of the Steroidogenic Acute Regulatory Protein. Biomedicines 10:6, pages 1313.
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R Machtinger, N Fallach, I Goldstein, G Chodick, E Schiff, R Orvieto & R Mashiach. (2022) Ovarian stimulation for fertility treatments and risk of breast cancer: a matched cohort study. Human Reproduction 37:3, pages 577-585.
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V.O. Berestovyi, A. Mahmood, A.M. Martych, A.B. Prylutska, O.O. Berestovyi & D.O. Govsieiev. (2021) Prospective study to estimate the role of different infertility factors in prediction of unsuccessful IVF outcome. REPRODUCTIVE ENDOCRINOLOGY:62, pages 14-21.
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Yusuf Beebeejaun, Abbeyrahmee Athithan, Timothy P. Copeland, Mohan S. Kamath, Ippokratis Sarris & Sesh K. Sunkara. (2021) Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis. Fertility and Sterility 116:1, pages 198-207.
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Jennifer Frances Barcroft, Nicolas Galazis, Benjamin P Jones, Natalie Getreu, Timothy Bracewell-Milnes, Karen J Grewal, Flavia Sorbi, Joseph Yazbek, Kostas Lathouras, J Richard Smith, Paul Hardiman, Meen-Yau Thum, Jara Ben-Nagi, Sadaf Ghaem-Maghami, Jan Verbakel & Srdjan Saso. (2021) Fertility treatment and cancers—the eternal conundrum: a systematic review and meta-analysis. Human Reproduction 36:4, pages 1093-1107.
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Sonia Guleria, Allan Jensen, Vanna Albieri, Bugge Nøhr, Kirsten Frederiksen & Susanne K. Kjær. (2021) Endometrial cancer risk after fertility treatment: a population-based cohort study. Cancer Causes & Control 32:2, pages 181-188.
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Yu‐Ting Jiang, Ting‐Ting Gong, Jia‐Yu Zhang, Xiu‐Qin Li, Song Gao, Yu‐Hong Zhao & Qi‐Jun Wu. (2020) Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies. International Journal of Cancer 147:8, pages 2121-2130.
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J. Raad, L. Rolland, M. Grynberg, B. Courbiere & E. Mathieu d’Argent. (2020) Tumeurs frontières de l’ovaire. Recommandations pour la pratique clinique du CNGOF – Fertilité. Gynécologie Obstétrique Fertilité & Sénologie  48:3, pages 330-336.
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Sonia Guleria, Susanne K. Kjær, Vanna Albieri, Kirsten Frederiksen & Allan Jensen. (2019) A Cohort Study of Breast Cancer Risk after 20 Years of Follow-Up of Women Treated with Fertility Drugs. Cancer Epidemiology, Biomarkers & Prevention 28:12, pages 1986-1992.
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Darja Arko & Iztok Takac. (2019) Inquiry and computer program Onko-Online: 25 years of clinical registry for breast cancer at the University Medical Centre Maribor. Radiology and Oncology 53:3, pages 348-356.
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Ivana Rizzuto, Renee F Behrens & Lesley A Smith. (2019) Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility. Cochrane Database of Systematic Reviews 2019:6.
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Zohre Momenimovahed, Safoura Taheri, Azita Tiznobaik & Hamid Salehiniya. (2019) Do the Fertility Drugs Increase the Risk of Cancer? A Review Study. Frontiers in Endocrinology 10.
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Frida E. Lundberg, Anastasia N. Iliadou, Kenny Rodriguez-Wallberg, Kristina Gemzell-Danielsson & Anna L. V. Johansson. (2019) The risk of breast and gynecological cancer in women with a diagnosis of infertility: a nationwide population-based study. European Journal of Epidemiology 34:5, pages 499-507.
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Shruti Parikh & Christophe Blockeel. 2018. Preventing Age Related Fertility Loss. Preventing Age Related Fertility Loss 125 139 .
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Marte Myhre Reigstad, Ritsa Storeng, Tor Åge Myklebust, Nan Birgitte Oldereid, Anne Katerine Omland, Trude Eid Robsahm, Louise Annette Brinton, Siri Vangen, Kari Furu & Inger Kristin Larsen. (2017) Cancer Risk in Women Treated with Fertility Drugs According to Parity Status—A Registry-based Cohort Study. Cancer Epidemiology, Biomarkers & Prevention 26:6, pages 953-962.
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Allison L. Goetsch, Dana Kimelman & Teresa K. WoodruffAllison L. Goetsch, Dana Kimelman & Teresa K. Woodruff. 2017. Fertility Preservation and Restoration for Patients with Complex Medical Conditions. Fertility Preservation and Restoration for Patients with Complex Medical Conditions 285 300 .
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Ignacio Zapardiel, Maria Cruz, Maria D. Diestro, Antonio Requena & Juan A. Garcia-Velasco. (2016) Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers. Human Reproduction Update 22:3, pages 281-305.
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R. Kessous, E. Davidson, M. Meirovitz, R. Sergienko & E. Sheiner. (2015) The risk of female malignancies after fertility treatments: a cohort study with 25-year follow-up. Journal of Cancer Research and Clinical Oncology 142:1, pages 287-293.
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Srdjan Saso, Louay S. Louis, Farah Doctor, Ali Hassan Hamed, Jayanta Chatterjee, Joseph Yazbek, Shabana Bora, Hossam Abdalla, Sadaf Ghaem-Maghami & Meen-Yau Thum. (2015) Does fertility treatment increase the risk of uterine cancer? A meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology 195, pages 52-60.
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Barbara Luke, Morton B. Brown, Logan G. Spector, Stacey A. Missmer, Richard E. Leach, Melanie Williams, Lori Koch, Yolanda Smith, Judy E. Stern, G. David Ball & Maria J. Schymura. (2015) Cancer in women after assisted reproductive technology. Fertility and Sterility 104:5, pages 1218-1226.
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Jing Zhao, Yanping Li, Qiong Zhang & Yonggang Wang. (2015) RETRACTED: Does ovarian stimulation for IVF increase gynaecological cancer risk? A systematic review and meta-analysis. Reproductive BioMedicine Online 31:1, pages 20-29.
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Tamar Perri, Dror Lifshitz, Siegal Sadetzki, Bernice Oberman, Dror Meirow, Gilad Ben-Baruch, Eitan Friedman & Jacob Korach. (2015) Fertility treatments and invasive epithelial ovarian cancer risk in Jewish Israeli BRCA1 or BRCA2 mutation carriers. Fertility and Sterility 103:5, pages 1305-1312.
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Alessandra Gennari, Mauro Costa, Matteo Puntoni, Laura Paleari, Andrea De Censi, Maria Pia Sormani, Nicoletta Provinciali & Paolo Bruzzi. (2015) Breast cancer incidence after hormonal treatments for infertility: systematic review and meta-analysis of population-based studies. Breast Cancer Research and Treatment 150:2, pages 405-413.
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Marte Myhre Reigstad, Inger Kristin Larsen, Tor Åge Myklebust, Trude Eid Robsahm, Nan Birgitte Oldereid, Anne Katerine Omland, Siri Vangen, Louise Annette Brinton & Ritsa Storeng. (2015) Risk of breast cancer following fertility treatment-A registry based cohort study of parous women in Norway. International Journal of Cancer 136:5, pages 1140-1148.
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Dominic Stoop, Ana Cobo & Sherman Silber. (2014) Fertility preservation for age-related fertility decline. The Lancet 384:9950, pages 1311-1319.
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K. von Horn, M. Depenbusch, A. Schultze-Mosgau & G. Griesinger. (2014) Krebsrisiko nach ovarieller StimulationCancer risk with ovarian stimulation. Gynäkologische Endokrinologie 12:3, pages 162-166.
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Louise A. Brinton, Bert Scoccia, Kamran S. Moghissi, Carolyn L. Westhoff, Shelley Niwa, David Ruggieri, Britton Trabert & Emmet J. Lamb. (2014) Long-term Relationship of Ovulation-Stimulating Drugs to Breast Cancer Risk. Cancer Epidemiology, Biomarkers & Prevention 23:4, pages 584-593.
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Aus Tariq Ali. (2014) Reproductive Factors and the Risk of Endometrial Cancer. International Journal of Gynecologic Cancer 24:3, pages 384-393.
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Bassma Mohamed El Sabaa. (2014) Pathological conditions predisposing to infertility and gynaecological neoplasia. World Journal of Obstetrics and Gynecology 3:2, pages 28.
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Federica Tomao, Giuseppe Lo Russo, Gian Spinelli, Valeria Stati, Alessandra Prete, Natalie Prinzi, Marsela Sinjari, Patrizia Vici, Anselmo Papa, Maria Chiotti, Pierluigi Benedetti Panici & Silverio Tomao. (2014) Fertility drugs, reproductive strategies and ovarian cancer risk. Journal of Ovarian Research 7:1, pages 51.
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Britton Trabert, Emmet J. Lamb, Bert Scoccia, Kamran S. Moghissi, Carolyn L. Westhoff, Shelley Niwa & Louise A. Brinton. (2013) Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort. Fertility and Sterility 100:6, pages 1660-1666.
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L. A. Brinton, C. L. Westhoff, B. Scoccia, E. J. Lamb, B. Trabert, S. Niwa & K. S. Moghissi. (2013) Fertility drugs and endometrial cancer risk: results from an extended follow-up of a large infertility cohort. Human Reproduction 28:10, pages 2813-2821.
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Ivana Rizzuto, Renee F Behrens & Lesley A Smith. (2013) Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility. Cochrane Database of Systematic Reviews.
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Louise A. Brinton, Britton Trabert, Varda Shalev, Eitan Lunenfeld, Tal Sella & Gabriel Chodick. (2013) In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services. Fertility and Sterility 99:5, pages 1189-1196.
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