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PCO

The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome

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Pages 635-638 | Received 29 Jan 2015, Accepted 31 Mar 2015, Published online: 04 Aug 2015

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Ara Unanyan, Laura Pivazyan, Ekaterina Krylova, Andrey Eskin, Araksya Zakaryan, Antonina Sarkisova & Anatoly Ishchenko. (2022) Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: systematic review and meta-analysis. Gynecological Endocrinology 38:12, pages 1035-1046.
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Yu Song, Huimin Wang, Hongli Huang & Zhengyan Zhu. (2020) Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis. Gynecological Endocrinology 36:3, pages 204-210.
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Articles from other publishers (20)

Zahra Shahveghar Asl, Karim Parastouei & Eslam Eskandari. (2023) The effects of N-acetylcysteine on ovulation and sex hormones profile in women with polycystic ovary syndrome: a systematic review and meta-analysis. British Journal of Nutrition, pages 1-9.
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Bahare Rafiee, Saied Karbalay-doust, Seyed Mohammad Bagher Tabei, Negar Azarpira, Sanaz Alaee, Parvin Lohrasbi & Soghra Bahmanpour. (2022) Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary. European Journal of Translational Myology 32:2.
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Mahmoud Alalfy, Ahmed S. S. A. Rashwan, Mohamed Hussein, Ahmed Bakry, Ahmed Eid & Marwa M. Eid. (2022) The Use of N-Acetyl Cysteine Versus Chromium Picolinate as an Adjuvant to Clomiphene Citrate and Metformin in PCOS Women to Improve Ovulation Induction and Insulin Resistance: A Pilot Randomized Controlled Trial. Current Women s Health Reviews 18:2.
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Reem Magzoub, Elrasheid A.H. Kheirelseid, Claire Perks & Sarah Lewis. (2022) Does metformin improve reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome? Meta-analysis and systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology 271, pages 38-62.
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Lifang Yuan, Hongbo Wu, Weiyu Huang, Yin Bi, Aiping Qin & Yihua Yang. (2021) The function of metformin in endometrial receptivity (ER) of patients with polycyclic ovary syndrome (PCOS): a systematic review and meta-analysis. Reproductive Biology and Endocrinology 19:1.
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Nagita Devi, Chandrasekhar Boya, Manik Chhabra & Dipika Bansal. (2021) N -acetyl-cysteine as adjuvant therapy in female infertility: a systematic review and meta-analysis . Journal of Basic and Clinical Physiology and Pharmacology 32:5, pages 899-910.
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Jasmine K Sandhu, Ahsan Waqar, Ashish Jain, Christine Joseph, Kosha Srivastava, Olive Ochuba, Tasnim Alkayyali, Sheila W Ruo & Sujan Poudel. (2021) Oxidative Stress in Polycystic Ovarian Syndrome and the Effect of Antioxidant N-Acetylcysteine on Ovulation and Pregnancy Rate. Cureus.
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Nafiseh Mardani, Samaneh Mozafarpoor, Azadeh Goodarzi & Farahnaz Nikkhah. (2021) A systematic review of N‐acetylcysteine for treatment of acne vulgaris and acne‐related associations and consequences: Focus on clinical studies. Dermatologic Therapy 34:3.
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Alexander O. Shpakov. (2021) Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms. Pharmaceuticals 14:1, pages 42.
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Esmee M Bordewijk, Rui Wang, Madelon van Wely, Michael F Costello, Robert J Norman, Helena Teede, Lyle C Gurrin, Ben W Mol & Wentao Li. (2020) To share or not to share data: how valid are trials evaluating first-line ovulation induction for polycystic ovary syndrome?. Human Reproduction Update 26:6, pages 929-941.
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Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan & Roger J Hart. (2020) Antioxidants for female subfertility. Cochrane Database of Systematic Reviews 2020:11.
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Abigail Sharpe, Lara C Morley, Thomas Tang, Robert J Norman & Adam H Balen. (2019) Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews.
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Rui Wang, Wentao Li, Esmée M Bordewijk, Richard S Legro, Heping Zhang, Xiaoke Wu, Jingshu Gao, Laure Morin-Papunen, Roy Homburg, Tamar E König, Etelka Moll, Sujata Kar, Wei Huang, Neil P Johnson, Saad A Amer, Walter Vegetti, Stefano Palomba, Angela Falbo, Ülkü Özmen, Hakan Nazik, Christopher D Williams, Grasso Federica, Jonathan Lord, Yilmaz Sahin, Siladitya Bhattacharya, Robert J Norman, Madelon van Wely & Ben Willem Mol. (2019) First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Human Reproduction Update 25:6, pages 717-732.
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M F Costello, M L Misso, A Balen, J Boyle, L Devoto, R M Garad, R Hart, L Johnson, C Jordan, R S Legro, R J Norman, E Mocanu, J Qiao, R J Rodgers, L Rombauts, E C Tassone, S Thangaratinam, E Vanky & H J Teede. (2019) Evidence summaries and recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome: assessment and treatment of infertility. Human Reproduction Open 2019:1.
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Richard Eugene Frye. 2019. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine 301 330 .
Martin Alcala, Sebastián Gutierrez-Vega, Erica Castro, Enrique Guzman-Gutiérrez, Maria Pilar Ramos-Álvarez & Marta Viana. (2018) Antioxidants and Oxidative Stress: Focus in Obese Pregnancies. Frontiers in Physiology 9.
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M. A. Gadalla, S. Huang, R. Wang, R. J. Norman, S. A. Abdullah, A. M. El Saman, A. M. Ismail, M. van Wely & B. W. J. Mol. (2018) Effect of clomiphene citrate on endometrial thickness, ovulation, pregnancy and live birth in anovulatory women: systematic review and meta-analysis. Ultrasound in Obstetrics & Gynecology 51:1, pages 64-76.
Crossref
Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan & Roger J Hart. (2017) Antioxidants for female subfertility. Cochrane Database of Systematic Reviews.
Crossref
Tahereh Behrouzi Lak, Masoomeh Hajshafiha, Fariba Nanbakhsh & Sima Oshnouei. (2017) N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT. International Journal of Reproductive BioMedicine 15:4, pages 203-208.
Crossref
Rui Wang, Bobae V Kim, Madelon van Wely, Neil P Johnson, Michael F Costello, Hanwang Zhang, Ernest Hung Yu Ng, Richard S Legro, Siladitya Bhattacharya, Robert J Norman & Ben Willem J Mol. (2017) Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis. BMJ, pages j138.
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