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Metformin in Pregnant PCO Patients

Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis

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Pages 833-839 | Received 03 Nov 2014, Accepted 14 Apr 2015, Published online: 06 Oct 2015

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Claudia Raperport, Elpiniki Chronopoulou & Roy Homburg. (2021) Effects of metformin treatment on pregnancy outcomes in patients with polycystic ovary syndrome. Expert Review of Endocrinology & Metabolism 16:2, pages 37-47.
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G. Morgante, M. G. Massaro, A. Di Sabatino, V. Cappelli & V. De Leo. (2018) Therapeutic approach for metabolic disorders and infertility in women with PCOS. Gynecological Endocrinology 34:1, pages 4-9.
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Yue Che, Jie Yu, Yu-Shan Li, Yu-Chen Zhu & Tao Tao. (2023) Polycystic Ovary Syndrome: Challenges and Possible Solutions. Journal of Clinical Medicine 12:4, pages 1500.
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Roberto Matorras, Jose Ignacio Pijoan, Lucía Laínz, María Díaz-Nuñez, Héctor Sainz, Silvia Pérez-Fernandez & Dayana Moreira. (2022) Polycystic ovarian syndrome and miscarriage in IVF: systematic revision of the literature and meta-analysis. Archives of Gynecology and Obstetrics 308:2, pages 363-377.
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Ute Schäfer-Graf & Susanne Reger-Tan. (2022) PCOS und SchwangerschaftPolycystic ovary syndrome and pregnancy. Der Gynäkologe 55:2, pages 85-89.
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Jenna L. Racine, Jacquelyn H. Adams, Kathleen M. Antony, Kara K. Hoppe, Jesus I. Iruretagoyena, Katharina S. Stewart, April Eddy & Janine S. Rhoades. (2021) Metformin Exposure and Risk of Hypertensive Disorders of Pregnancy in Patients with Type 2 Diabetes. American Journal of Perinatology 38:11, pages 1103-1108.
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Elżbieta Poniedziałek-Czajkowska, Radzisław Mierzyński, Dominik Dłuski & Bożena Leszczyńska-Gorzelak. (2021) Prevention of Hypertensive Disorders of Pregnancy—Is There a Place for Metformin?. Journal of Clinical Medicine 10:13, pages 2805.
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Shiqiao Hu, Bei Xu, Rui Long & Lei Jin. (2021) The effect of polycystic ovary syndrome without hyperandrogenism on pregnancy‐related outcomes: a retrospective cohort study. BJOG: An International Journal of Obstetrics & Gynaecology 128:6, pages 1003-1010.
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Amy M. Valent & Linda A. Barbour. (2021) Management of Women with Polycystic Ovary Syndrome During Pregnancy. Endocrinology and Metabolism Clinics of North America 50:1, pages 57-69.
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Alexander O. Shpakov. (2021) Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms. Pharmaceuticals 14:1, pages 42.
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Arianna Pani, Ilaria Gironi, Giacoma Di Vieste, Elena Mion, Federico Bertuzzi & Basilio Pintaudi. (2020) From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management. International Journal of Endocrinology 2020, pages 1-10.
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Aya Mousa, Tone Løvvik, Ijäs Hilkka, Sven M Carlsen, Laure Morin-Papunen, Kristiina Tertti, Tapani Rönnemaa, Argyro Syngelaki, Kypros Nicolaides, Hassan Shehata, Christy Burden, Jane E Norman, Janet Rowan, Jodie M Dodd, William Hague, Eszter Vanky & Helena J Teede. (2020) Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis. BMJ Open 10:5, pages e036981.
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Vasantha Lakshmi Ambarapu, Gunapriya Raghunath, Siva Ranjan D & Muralidhar Reddy. (2020) A Study of Placental Changes in Polycystic Ovarian Syndrome Patients with Gestational Diabetic Mellitus. Journal of Evolution of Medical and Dental Sciences 9:14, pages 1171-1174.
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Silvia Sciannimanico, Franco Grimaldi, Fabio Vescini, Giovanni De Pergola, Massimo Iacoviello, Brunella Licchelli, Edoardo Guastamacchia, Vito A. Giagulli & Vincenzo Triggiani. (2020) Metformin: Up to Date. Endocrine, Metabolic & Immune Disorders - Drug Targets 20:2, pages 172-181.
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Suhail A.R. Doi, Luis Furuya‐Kanamori, Egon Toft, Omran A.H. Musa, Nazmul Islam, Justin Clark & Lukman Thalib. (2019) Metformin in pregnancy to avert gestational diabetes in women at high risk: Meta‐analysis of randomized controlled trials. Obesity Reviews 21:1.
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Razieh Bidhendi Yarandi, Samira Behboudi-Gandevani, Mina Amiri & Fahimeh Ramezani Tehrani. (2019) Metformin therapy before conception versus throughout the pregnancy and risk of gestational diabetes mellitus in women with polycystic ovary syndrome: a systemic review, meta-analysis and meta-regression. Diabetology & Metabolic Syndrome 11:1.
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Kathleen M. Brennan, Lindsay L. Kroener, Gregorio D. Chazenbalk & Daniel A. Dumesic. (2019) Polycystic Ovary Syndrome: Impact of Lipotoxicity on Metabolic and Reproductive Health. Obstetrical & Gynecological Survey 74:4, pages 223-231.
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Claudio D. Gonzalez, Jorge Alvariñas, Maria F.G. Bagnes & Guillermo Di Girolamo. (2019) Metformin and Pregnancy Outcomes: Evidence Gaps and Unanswered Questions. Current Clinical Pharmacology 14:1, pages 54-60.
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A. Santamaria, A. Alibrandi, A. Di Benedetto, B. Pintaudi, F. Corrado, F. Facchinetti & R. D’Anna. (2018) Clinical and metabolic outcomes in pregnant women at risk for gestational diabetes mellitus supplemented with myo-inositol: a secondary analysis from 3 RCTs. American Journal of Obstetrics and Gynecology 219:3, pages 300.e1-300.e6.
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Griffith A Bell, Rajeshwari Sundaram, Sunni L Mumford, Hyojun Park, James Mills, Erin M Bell, Miranda Broadney & Edwina H Yeung. (2018) Maternal polycystic ovarian syndrome and early offspring development. Human Reproduction 33:7, pages 1307-1315.
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Ronan Sugrue & Chloe Zera. (2018) Pregestational Diabetes in Pregnancy. Obstetrics and Gynecology Clinics of North America 45:2, pages 315-331.
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Roshni Patel & Gaurang Shah. (2018) Insulin Sensitizers Modulate GnRH Receptor Expression in PCOS Rats. Archives of Medical Research 49:3, pages 154-163.
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Stephen Safe, Vijayalekshmi Nair & Keshav Karki. (2018) Metformin-induced anticancer activities: recent insights. Biological Chemistry 399:4, pages 321-335.
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José Bellver, Luis Rodríguez-Tabernero, Ana Robles, Elkin Muñoz, Francisca Martínez, José Landeras, Juan García-Velasco, Juan Fontes, Mónica Álvarez, Claudio Álvarez & Belén Acevedo. (2017) Polycystic ovary syndrome throughout a woman’s life. Journal of Assisted Reproduction and Genetics 35:1, pages 25-39.
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Stefano Palomba & Bart C. J. M. Fauser. 2018. Infertility in Women with Polycystic Ovary Syndrome. Infertility in Women with Polycystic Ovary Syndrome 305 323 .
Roberto Romero, Offer Erez, Maik Hüttemann, Eli Maymon, Bogdan Panaitescu, Agustin Conde-Agudelo, Percy Pacora, Bo Hyun Yoon & Lawrence I. Grossman. (2017) Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. American Journal of Obstetrics and Gynecology 217:3, pages 282-302.
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Robert S. Lindsay & Mary R. Loeken. (2017) Metformin use in pregnancy: promises and uncertainties. Diabetologia 60:9, pages 1612-1619.
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Yuehui Zhang, Min Hu, Fanci Meng, Xiaoyan Sun, Hongfei Xu, Jiao Zhang, Peng Cui, Njomeza Morina, Xin Li, Wei Li, Xiao-Ke Wu, Mats Brännström, Ruijin Shao & Håkan Billig. (2017) Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome. EBioMedicine 18, pages 157-170.
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Meng H. Tan, Hussain Alquraini, Kara Mizokami-Stout & Mark MacEachern. (2016) Metformin. Endocrinology and Metabolism Clinics of North America 45:4, pages 819-843.
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Jemma Evans, Lois A. Salamonsen, Amy Winship, Ellen Menkhorst, Guiying Nie, Caroline E. Gargett & Eva Dimitriadis. (2016) Fertile ground: human endometrial programming and lessons in health and disease. Nature Reviews Endocrinology 12:11, pages 654-667.
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