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Original Article

The pharmacological profile of a novel norpregnane progestin (trimegestone)

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Pages 316-326 | Published online: 05 Aug 2009

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Read on this site (19)

Matthew D. Overturf, Jordan C. Anderson, Zacharias Pandelides, Lindsay Beyger & Douglas A. Holdway. (2015) Pharmaceuticals and personal care products: A critical review of the impacts on fish reproduction. Critical Reviews in Toxicology 45:6, pages 469-491.
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Gian Benedetto Melis, Marisa Orrù, Maria Francesca Marotto, Monica Pilloni, Mariagrazia Perseu, Stefano Lello & Anna Maria Paoletti. (2011) Use of oral contraceptives in the management of acne. Open Access Journal of Contraception 2, pages 151-159.
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Regine Sitruk-Ware, Ronald Bossemeyer & Phillipe Bouchard. (2007) Preclinical and clinical properties of trimegestone: A potent and selective progestin. Gynecological Endocrinology 23:6, pages 310-319.
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R. Sitruk-Ware. (2005) Pharmacology of different progestogens: the special case of drospirenone. Climacteric 8:sup3, pages 4-12.
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P. Bouchard, F. De Cicco-Nardone, D. Spielmann, N. Garcea & The Trimegestone 301 Study Group. (2005) Bleeding profile and endometrial safety of continuous combined regimens 1 mg 17beta-estradiol/trimegestone versus 1 or 2 mg 17beta-estradiol/norethisterone acetate in postmenopausal women. Gynecological Endocrinology 21:3, pages 142-148.
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R Sitruk-Ware, F Husmann, JHH Thijssen, SO Skouby, F Fruzzetti, J Hanker, J Huber & R Druckmann. (2004) Role of progestins with partial antiandrogenic effects. Climacteric 7:3, pages 238-254.
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Puwen Zhang, Andrew Fensome, Jay Wrobel, Richard Winneker & Zhiming Zhang. (2003) Non-steroidal progesterone receptor modulators. Expert Opinion on Therapeutic Patents 13:12, pages 1839-1847.
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J. H. J. M. Meuwissen, L. Beijers-De Bie, T. Vihtamaki, R. Tuimala, N. Siseles, C. Magaril, H. S. The, P. W. H. Houben, M. Murga, D. Spielmann & T. J. de Villiers. (2002) Assessment of the metabolic tolerance in postmenopausal women over a 1-year period of two hormone replacement therapies containing estradiol in combination with either norgestrel or trimegestone. Gynecological Endocrinology 16:2, pages 155-162.
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Farook Al-Azzawi & May Wahab. (2001) Trimegestone: expanding therapeutic choices for the treatment of the menopause. Expert Opinion on Investigational Drugs 10:9, pages 1737-1744.
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M. Oettel, W. Elger, T. Gräser, C. Holz, P. Lähteenmäki & V. Patchev. (2001) What is past is prologue: estrogen/progestin replacement tomorrow. Gynecological Endocrinology 15:sup4, pages 68-90.
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J. H. J. M. Meuwissen, L. Beijers-De Bie, T. Vihtamaki, R. Tuimala, N. Siseles, C. Magaril, H. S. The, P. W. H. Houben, M. Murga, D. Spielmann & T. J. De Villiers. (2001) A 1-year comparison of the efficacy and clinical tolerance in postmenopausal women of two hormone replacement therapies containing estradiol in combination with either norgestrel or trimegestone. Gynecological Endocrinology 15:5, pages 349-358.
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L. Lepescheux, J. Secchi, M. Gaillard-Kelly & P. Miller. (2001) Effects of 17β-estradiol and trimegestone alone ,and in combination ,on the bone and uterus of ovariectomized rats. Gynecological Endocrinology 15:4, pages 312-320.
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Y. Bouali, M. Gaillard-Kelly & P. J. Marie. (2001) Effect of trimegestone alone or in combination with estradiol on bone mass and bone turnover in an adult rat model of osteopenia. Gynecological Endocrinology 15:1, pages 48-55.
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F. Al-Azzawi, M. Wahab, J. Thompson, B. Pornel, E. Hirvonen, O. Ylikorkala, M. J. van der Mooren, J. Dillon & C. Magaril. (2001) Acceptability and patterns of endometrial bleeding in estradiol-based HRT regimens: a comparative study of cyclical sequential combinations of trimegestone or norethisterone acetate. Climacteric 4:4, pages 343-354.
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Lene H. Petersen, David Hala, Dennis Carty, Mark Cantu, Dalma Martinović & Duane B. Huggett. (2015) Effects of progesterone and norethindrone on female fathead minnow ( Pimephales promelas ) steroidogenesis . Environmental Toxicology and Chemistry 34:2, pages 379-390.
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A.O. Mueck, X. Ruan, H. Seeger, T. Fehm & H. Neubauer. (2014) Genomic and non-genomic actions of progestogens in the breast. The Journal of Steroid Biochemistry and Molecular Biology 142, pages 62-67.
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Frank Z. StanczykJanet P. Hapgood, Sharon Winer & Daniel R. MishellJr.Jr.. (2013) Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects. Endocrine Reviews 34:2, pages 171-208.
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May WahabFarook Al-Azzawi. (2016) Current State of Hormone Replacement Therapy: The Case for Using Trimegestone. Women's Health 2:4, pages 539-550.
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M. Birkhäuser. (2006) Klinische Bedeutung von gestagenen PartialwirkungenClinical significance of partial gestagen effects. Gynäkologische Endokrinologie 4:1, pages 52-64.
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Rebecca A. Shirk, Zhiming Zhang & Richard C. Winneker. (2005) Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat. The Journal of Steroid Biochemistry and Molecular Biology 94:4, pages 361-368.
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Richard C Winneker, Daniel Bitran & Zhiming Zhang. (2003) The preclinical biology of a new potent and selective progestin: trimegestone. Steroids 68:10-13, pages 915-920.
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Regine Sitruk-Ware, Margaret Small, Narender Kumar, Yun-Yen Tsong, Kalyan Sundaram & Theodore Jackanicz. (2003) Nestorone®: clinical applications for contraception and HRT. Steroids 68:10-13, pages 907-913.
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May Wahab, John Thompson & Farook Al-Azzawi. (2000) The effect of submucous fibroids on the dose-dependent modulation of uterine bleeding by trimegestone in postmenopausal women treated with hormone replacement therapy. BJOG: An International Journal of Obstetrics and Gynaecology 107:3, pages 329-334.
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