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Original Article

Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma

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Pages 487-492 | Received 01 Jul 2009, Accepted 06 Jul 2009, Published online: 26 Oct 2009

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Read on this site (2)

Nargis Jamila, Naeem Khan, In Min Hwang, Eun Yeong Nho, Ji Yeon Choi, Amir Atlas, Sadiq Noor Khan, Farhat Amin, Fatima Javed & Kyong Su Kim. (2020) Application of Phytochemical and Elemental Profiling, Chemometric Multivariate Analyses, and Biological Activities for Characterization and Discrimination of Fruits of Four Garcinia Species. Analytical Letters 53:1, pages 122-139.
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Nargis Jamila, Ji Yeon Choi, Joon Ho Hong, Eun Yeong Nho, Naeem Khan, Cheon Ho Jo, Hyang Sook Chun & Kyong Su Kim. (2016) Identification and quantification of adulteration in Garcinia cambogia commercial products by chromatographic and spectrometric methods. Food Additives & Contaminants: Part A 33:12, pages 1751-1760.
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Articles from other publishers (41)

TE Ramadwa & S Meddows-Taylor. (2023) Garcinia livingstonei T. Anderson (Clusiaceae): A comprehensive review of traditional uses, phytochemistry, pharmacology and toxicity. South African Journal of Botany 162, pages 767-782.
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Ciro Cannavacciuolo, Antonietta Cerulli, Verena M. Dirsch, Elke H. Heiss, Milena Masullo & Sonia Piacente. (2023) LC-MS- and 1H NMR-Based Metabolomics to Highlight the Impact of Extraction Solvents on Chemical Profile and Antioxidant Activity of Daikon Sprouts (Raphanus sativus L.). Antioxidants 12:8, pages 1542.
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Amrita Thandayamparambil Anilkumar, Suryaa Manoharan, Satheeswaran Balasubramanian & Ekambaram Perumal. (2023) Garcinia gummi‐gutta : Phytochemicals and pharmacological applications . BioFactors 49:3, pages 584-599.
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Mariana Conceição, Fernando Pereira Beserra, Jennyfer Andrea Aldana Mejia, Gabriel Rocha Caldas, Matheus Hikaru Tanimoto, Andréia Marincek Luzenti, Priscyla Daniely Marcato Gaspari, Nicholas David Evans, Jairo Kenupp Bastos & Cláudia Helena Pellizzon. (2023) Guttiferones: An insight into occurrence, biosynthesis, and their broad spectrum of pharmacological activities. Chemico-Biological Interactions 370, pages 110313.
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Milena Masullo, Antonietta Cerulli, Ciro Cannavacciuolo, Hilal Kılınç, Cosimo Pizza & Sonia Piacente. (2022) Garcinia mangostana L. fruits and derived food supplements: Identification and quantitative determination of bioactive xanthones by NMR analysis. Journal of Pharmaceutical and Biomedical Analysis 218, pages 114835.
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Banashree Chetia Phukan, Ankumoni Dutta, Satarupa Deb, Rubul Saikia, Muhammed Khairujjaman Mazumder, Rajib Paul, Pallab Bhattacharya, Rajat Sandhir & Anupom Borah. (2021) Garcinol blocks motor behavioural deficits by providing dopaminergic neuroprotection in MPTP mouse model of Parkinson’s disease: involvement of anti-inflammatory response. Experimental Brain Research 240:1, pages 113-122.
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Sung Ho Lim, Ho Seon Lee, Chang Hoon Lee & Chang-Ik Choi. (2021) Pharmacological Activity of Garcinia indica (Kokum): An Updated Review. Pharmaceuticals 14:12, pages 1338.
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Lavanya Bolla, Pratima Srivastava, Velayutham Ravichandiran & Satheesh Kumar Nanjappan. (2021) Cytochrome P450 and P-gp Mediated Herb-Drug Interactions and Molecular Docking Studies of Garcinol. Membranes 11:12, pages 992.
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Christian Bailly & Gérard Vergoten. (2021) Anticancer Properties and Mechanism of Action of Oblongifolin C, Guttiferone K and Related Polyprenylated Acylphloroglucinols. Natural Products and Bioprospecting 11:6, pages 629-641.
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Joo-Hui Han, Min-Ho Park & Chang-Seon Myung. (2021) Garcinia cambogia Ameliorates Non-Alcoholic Fatty Liver Disease by Inhibiting Oxidative Stress-Mediated Steatosis and Apoptosis through NRF2-ARE Activation. Antioxidants 10:8, pages 1226.
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Rajinder Raina, Pawan K. Verma, Ila Taku, JItendra K. Malik & Ramesh C. Gupta. 2021. Nutraceuticals. Nutraceuticals 975 990 .
Jung-Yeon Kim, Jungmin Jo, Jaechan Leem & Kwan-Kyu Park. (2020) Inhibition of p300 by Garcinol Protects against Cisplatin-Induced Acute Kidney Injury through Suppression of Oxidative Stress, Inflammation, and Tubular Cell Death in Mice. Antioxidants 9:12, pages 1271.
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Basavaraj S. Nainegali, Regupathi Iyyaswami & Prasanna D Belur. (2020) Partitioning of bio-active compounds from rinds of garcinia indica using aqueous two-phase system: Process evaluation and optimization. Separation and Purification Technology 253, pages 117520.
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Vaishali Aggarwal, Hardeep Singh Tuli, Jagjit Kaur, Diwakar Aggarwal, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Samruddhi Kulkarni, Ginpreet Kaur, Katrin Sak, Manoj Kumar & Kwang Seok Ahn. (2020) Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells. Biomedicines 8:5, pages 103.
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Donisha Shani Niharika Keembiya Liyanagamage, Susanthi Jayasinghe, Anoja Priyadarshani Attanayake & Veranja Karunaratne. (2020) Correlation between Antioxidant Activity and the Garcinol Content Released from Fruit Rinds of Endemic Garcinia quaesita Pierre on Different Cooking Conditions . Journal of Food Quality 2020, pages 1-7.
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Simone Di Micco, Milena Masullo, Afif F. Bandak, James M. Berger, Raffaele Riccio, Sonia Piacente & Giuseppe Bifulco. (2019) Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies. Journal of Natural Products 82:10, pages 2768-2779.
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Satarupa Deb, Banashree Chetia Phukan, Muhammed Khairujjaman Mazumder, Ankumoni Dutta, Rajib Paul, Pallab Bhattacharya, Rajat Sandhir & Anupom Borah. (2019) Garcinol, a multifaceted sword for the treatment of Parkinson's disease. Neurochemistry International 128, pages 50-57.
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Hang Cao, Abdulla Al Mamun Bhuyan, Anja T. Umbach, Ke Ma, Oliver Borst, Meinrad Gawaz, Shaqiu Zhang, Bernd Nürnberg & Florian Lang. (2019) Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis. Toxins 11:7, pages 382.
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Timo D. Stark, Josef Ranner, Benedikt Stiglbauer, Patrick Weiss, Sofie Stark, Onesmo B. Balemba & Thomas Hofmann. (2018) Construction and Application of a Database for a Five-Dimensional Identification of Natural Compounds in Garcinia Species by Means of UPLC-ESI-TWIMS-TOF-MS: Introducing Gas Phase Polyphenol Conformer Drift Time Distribution Intensity Ratios . Journal of Agricultural and Food Chemistry 67:3, pages 975-985.
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Hosakatte Niranjana Murthy, Vijayalaxmi S. Dandin, Dayanand Dalawai, So-Young Park & Kee-Yoeup Paek. 2019. Bioactive Molecules in Food. Bioactive Molecules in Food 1643 1670 .
Bhaswati Choudhury, Raghuram Kandimalla, R. Elancheran, Rupjyoti Bharali & Jibon Kotoky. (2018) Garcinia morella fruit, a promising source of antioxidant and anti-inflammatory agents induces breast cancer cell death via triggering apoptotic pathway. Biomedicine & Pharmacotherapy 103, pages 562-573.
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Hosakatte Niranjana Murthy, Vijayalaxmi S. Dandin, Dayanand Dalawai, So-Young Park & Kee-Yoeup Paek. 2017. Sweeteners. Sweeteners 1 28 .
Mahdi Goudarzvand, Sanaz Afraei, Somaye Yaslianifard, Saleh Ghiasy, Ghazal Sadri, Mustafa Kalvandi, Tina Alinia, Ali Mohebbi, Reza Yazdani, ShahinKhadem Azarian, Abbas Mirshafiey & Gholamreza Azizi. (2016) Hydroxycitric acid ameliorates inflammation and oxidative stress in mouse models of multiple sclerosis. Neural Regeneration Research 11:10, pages 1610.
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Rajinder Raina, Dilip M. Mondhe, Jitendra K. Malik & Ramesh C. Gupta. 2016. Nutraceuticals. Nutraceuticals 669 680 .
Timo D. Stark, Sofie Lösch, Mathias Salger, Onesmo B. Balemba, Junichiro Wakamatsu, Oliver Frank & Thomas Hofmann. (2015) A new NMR approach for structure determination of thermally unstable biflavanones and application to phytochemicals from Garcinia buchananii . Magnetic Resonance in Chemistry 53:10, pages 813-820.
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Chaoqun Liu, Paul Chi-Lui Ho, Fang Cheng Wong, Gautam Sethi, Ling Zhi Wang & Boon Cher Goh. (2015) Garcinol: Current status of its anti-oxidative, anti-inflammatory and anti-cancer effects. Cancer Letters 362:1, pages 8-14.
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Ruchi Badoni Semwal, Deepak Kumar Semwal, Ilze Vermaak & Alvaro Viljoen. (2015) A comprehensive scientific overview of Garcinia cambogia. Fitoterapia 102, pages 134-148.
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Mei-Ling Tsai, Yi-Shiou Chiou, Li-Yu Chiou, Chi-Tang Ho & Min-Hsiung Pan. (2014) Garcinol suppresses inflammation-associated colon carcinogenesis in mice. Molecular Nutrition & Food Research 58:9, pages 1820-1829.
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Eun Jung Park, Sang Ho Kim, Kyung Soo Kim & Han Jin Oh. (2013) Effect of Administration Method on Blood Garcinia cambogia Concentration and Antioxidative Activity. Journal of the Korean Society of Food Science and Nutrition 42:6, pages 856-860.
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Wenping Tang, Min-Hsiung Pan, Shengmin Sang, Shiming Li & Chi-Tang Ho. 2013. Tropical and Subtropical Fruits: Flavors, Color, and Health Benefits. Tropical and Subtropical Fruits: Flavors, Color, and Health Benefits 133 145 .
Fadlina Chany Saputri & Ibrahim Jantan. (2012) Inhibitory Activities of Compounds from the Twigs of Garcinia hombroniana Pierre on Human Low-density Lipoprotein (LDL) Oxidation and Platelet Aggregation . Phytotherapy Research 26:12, pages 1845-1850.
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Ibrahim Jantan & Fadlina Chany Saputri. (2012) Benzophenones and xanthones from Garcinia cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein oxidation and platelet aggregation. Phytochemistry 80, pages 58-63.
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Timo D. Stark, Toshiaki Matsutomo, Sofie Lösch, Paul A. Boakye, Onesmo B. Balemba, Sofie P. Pasilis & Thomas Hofmann. (2012) Isolation and Structure Elucidation of Highly Antioxidative 3,8″-Linked Biflavanones and Flavanone- C -glycosides from Garcinia buchananii Bark . Journal of Agricultural and Food Chemistry 60:8, pages 2053-2062.
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T. K. LimT. K. Lim. 2012. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 45 55 .
Ji-Eun Kim, Seon-Min Jeon, Ki Hun Park, Woo Song Lee, Tae-Sook Jeong, Robin A McGregor & Myung-Sook Choi. (2011) Does Glycine max leaves or Garcinia Cambogiapromote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial. Nutrition Journal 10:1.
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M. Hemshekhar, K. Sunitha, M. Sebastin Santhosh, S. Devaraja, K. Kemparaju, B. S. Vishwanath, S. R. Niranjana & K. S. Girish. (2011) An overview on genus garcinia: phytochemical and therapeutical aspects. Phytochemistry Reviews 10:3, pages 325-351.
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Manjeshwar Shrinath Baliga, Harshith P. Bhat, Ramakrishna J. Pai, Rekha Boloor & Princy Louis Palatty. (2011) The chemistry and medicinal uses of the underutilized Indian fruit tree Garcinia indica Choisy (kokum): A review. Food Research International 44:7, pages 1790-1799.
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Nicholas A. McGrath, Joshua R. Binner, Georgios Markopoulos, Matthew Brichacek & Jon T. Njardarson. (2011) An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products. Chem. Commun. 47:1, pages 209-211.
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Ulyana Muñoz Acuña, Mario Figueroa, Adam Kavalier, Nikola Jancovski, Margaret J. Basile & Edward J. Kennelly. (2010) Benzophenones and Biflavonoids from Rheedia edulis . Journal of Natural Products 73:11, pages 1775-1779.
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Nicoleta Alexandru, Doina Popov & Adriana Georgescu. (2010) Intraplatelet Oxidative/Nitrative Stress: Inductors, Consequences, and Control. Trends in Cardiovascular Medicine 20:7, pages 232-238.
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An-Chin Cheng, Mei-Ling Tsai, Chi-Mei Liu, Ming-Fen Lee, Kalyanam Nagabhushanam, Chi-Tang Ho & Min-Hsiung Pan. (2010) Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. Food & Function 1:3, pages 301.
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