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Research Article

Mild and moderate hypothermia increases platelet aggregation induced by various agonists: a whole blood in vitro study

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Pages 44-48 | Received 19 Jun 2009, Accepted 16 Oct 2009, Published online: 03 Dec 2009

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Anni Nørgaard Jeppesen, Anne-Mette Hvas, Anders Morten Grejs, Christophe Duez, Susanne Ilkjær & Hans Kirkegaard. (2018) Platelet aggregation during targeted temperature management after out-of-hospital cardiac arrest: A randomised clinical trial. Platelets 29:5, pages 504-511.
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Thomas Kander, Jens Brokopp, David Erlinge, Christian Lood & Ulf Schött. (2015) Temperature effects on haemostasis in whole blood from ticagrelor- and aspirin-treated patients with acute coronary syndrome. Scandinavian Journal of Clinical and Laboratory Investigation 75:1, pages 27-35.
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Andreas Friedrich Christoph Kaiser, Horst Neubauer, Cora Christina Franken, Jan-Christoph Krüger, Andreas Mügge & Saskia Hannah Meves. (2012) Which is the best anticoagulant for whole blood aggregometry platelet function testing? Comparison of six anticoagulants and diverse storage conditions. Platelets 23:5, pages 359-367.
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Igor Mindukshev, Ekaterina Fock, Irina Dobrylko, Julia Sudnitsyna, Stepan Gambaryan & Mikhail A. Panteleev. (2022) Platelet Hemostasis Reactions at Different Temperatures Correlate with Intracellular Calcium Concentration. International Journal of Molecular Sciences 23:18, pages 10667.
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Adnan Haider, Irfan Azmatullah Khwaja, Abdul Basit Qureshi, Imran Khan, Khalid Abdul Majeed, Muhammad Shahbaz Yousaf, Hafsa Zaneb, Abdul Rehman, Imtiaz Rabbani, Sajid Khan Tahir & Habib Rehman. (2022) Effectiveness of Mild to Moderate Hypothermic Cardiopulmonary Bypass on Early Clinical Outcomes. Journal of Cardiovascular Development and Disease 9:5, pages 151.
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Torstein Schanche, Ole Magnus Filseth, Bjarne Østerud, Timofei V. Kondratiev, Gary C. Sieck & Torkjel Tveita. (2022) Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model. Frontiers in Physiology 13.
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Bernd Wallner, Bettina Schenk, Peter Paal, Markus Falk, Giacomo Strapazzon, Wenjun Z. Martini, Hermann Brugger & Dietmar Fries. (2022) Hypothermia Induced Impairment of Platelets: Assessment With Multiplate vs. ROTEM—An In Vitro Study. Frontiers in Physiology 13.
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Lars J. Bjertnæs, Torvind O. Næsheim, Eirik Reierth, Evgeny V. Suborov, Mikhail Y. Kirov, Konstantin M. Lebedinskii & Torkjel Tveita. (2022) Physiological Changes in Subjects Exposed to Accidental Hypothermia: An Update. Frontiers in Medicine 9.
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Thomas Scherz, Thomas M. Hofbauer, Anna S. Ondracek, Daniel Simon, Fritz Sterz, Christoph Testori, Irene M. Lang & Andreas Mangold. (2021) Mild Therapeutic Hypothermia Alters Hemostasis in ST Elevation Myocardial Infarction Patients. Frontiers in Cardiovascular Medicine 8.
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Bernd Wallner, Bettina Schenk, Martin Hermann, Peter Paal, Markus Falk, Giacomo Strapazzon, Wenjun Z. Martini, Hermann Brugger & Dietmar Fries. (2020) Hypothermia-Associated Coagulopathy: A Comparison of Viscoelastic Monitoring, Platelet Function, and Real Time Live Confocal Microscopy at Low Blood Temperatures, an in vitro Experimental Study. Frontiers in Physiology 11.
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Brittney Williams, Jessica Neder, Ping Cui, Andrew Suen, Kenichi Tanaka, Lin Zou & Wei Chao. (2019) Toll‐like receptors 2 and 7 mediate coagulation activation and coagulopathy in murine sepsis. Journal of Thrombosis and Haemostasis 17:10, pages 1683-1693.
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Thomas Kander & Ulf Schött. (2019) Effect of hypothermia on haemostasis and bleeding risk: a narrative review. Journal of International Medical Research 47:8, pages 3559-3568.
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Yu Chen & Xijing Zhang. 2019. Severe Trauma and Sepsis. Severe Trauma and Sepsis 15 22 .
Hunter B. Moore & Ernest E. Moore. 2019. Intensive Care for Emergency Surgeons. Intensive Care for Emergency Surgeons 195 218 .
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Ulf Schött & Thomas Kander. (2017) Prolonged TTM – enhanced hypocoagulation and bleeding?. Resuscitation 118, pages A3-A4.
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Marko Noc, David Erlinge, Aleksandar Neskovic, Srdjan Kafedzic, Béla Merkely, Endre Zima, Misa Fister, Milovan Petrović, Milenko Čanković, Gábor Veress, Peep Laanmets, Teele Pern, Vladan Vukcevic, Vladimir Dedovic, Beata Średniawa, Andrzej Świątkowski, Thomas Keeble, John Davies, Alexandra-Maria Warenits, Göran Olivecrona, Jan Peruga, Michal Ciszewski, Ivan Horvath, Istvan Edes, Gergely Nagy, Daniel Aradi & Michael Holzer. (2017) COOL AMI EU pilot trial: a multicentre, prospective, randomised controlled trial to assess cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction. EuroIntervention 13:5, pages e531-e539.
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J.W. Simmons & M.F. Powell. (2016) Acute traumatic coagulopathy: pathophysiology and resuscitation. British Journal of Anaesthesia 117, pages iii31-iii43.
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M. Giannoudi & P. Harwood. (2016) Damage control resuscitation: lessons learned. European Journal of Trauma and Emergency Surgery 42:3, pages 273-282.
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Frantisek Bednar, Josef Kroupa, Martina Ondrakova, Pavel Osmancik, Milos Kopa & Zuzana Motovska. (2015) Antiplatelet efficacy of P2Y12 inhibitors (prasugrel, ticagrelor, clopidogrel) in patients treated with mild therapeutic hypothermia after cardiac arrest due to acute myocardial infarction. Journal of Thrombosis and Thrombolysis 41:4, pages 549-555.
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Klemen Steblovnik, Ales Blinc, Mojca Bozic-Mijovski, Igor Kranjec, Enver Melkic & Marko Noc. (2015) Platelet reactivity in comatose survivors of cardiac arrest undergoing percutaneous coronary intervention and hypothermia. EuroIntervention 10:12, pages 1418-1424.
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M. C. Reade & M. Lumsden-Steel. 2015. Annual Update in Intensive Care and Emergency Medicine 2015. Annual Update in Intensive Care and Emergency Medicine 2015 481 493 .
Dag Winstedt, Owain D Thomas, Fredrik Nilsson, Knut Olanders & Ulf Schött. (2014) Correction of hypothermic and dilutional coagulopathy with concentrates of fibrinogen and factor XIII: an in vitro study with ROTEM. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 22:1.
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Nicholas S. Tedesco, Frederick P. Korpi, Vanessa K. Pazdernik & Jeffrey M. Cochran. (2014) Relationship Between Hypothermia and Blood Loss in Adult Patients Undergoing Open Lumbar Spine Surgery. Journal of Osteopathic Medicine 114:11, pages 828-838.
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Thomas Kander, Josef Dankiewicz, Hans Friberg & Ulf Schött. (2014) Platelet aggregation and clot formation in comatose survivors of cardiac arrest treated with induced hypothermia and dual platelet inhibition with aspirin and ticagrelor; a prospective observational study. Critical Care 18:5.
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Thomas KanderJens BrokoppHans FribergUlf Schött. (2014) Wide Temperature Range Testing with ROTEM Coagulation Analyses. Therapeutic Hypothermia and Temperature Management 4:3, pages 125-130.
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José Luis Ferreiro, José Carlos Sánchez-Salado, Montserrat Gracida, Ana Lucrecia Marcano, Gerard Roura, Albert Ariza, Josep Gómez-Lara, Victoria Lorente, Rafael Romaguera, Sílvia Homs, Guillermo Sánchez-Elvira, Luis Teruel, Kristian Rivera, Silvia Gabriela Sosa, Joan Antoni Gómez-Hospital, Dominick J. Angiolillo & Ángel Cequier. (2013) Impact of Mild Hypothermia on Platelet Responsiveness to Aspirin and Clopidogrel: an In Vitro Pharmacodynamic Investigation. Journal of Cardiovascular Translational Research 7:1, pages 39-46.
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Alexander Y. Mitrophanov, Frits R. Rosendaal & Jaques Reifman. (2013) Computational Analysis of the Effects of Reduced Temperature on Thrombin Generation. Anesthesia & Analgesia 117:3, pages 565-574.
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Juliane Mohr, Steffen Ruchholtz, Frank Hildebrand, Sascha Flohé, Michael Frink, Ingo Witte, Matthias Weuster, Matthias Fröhlich, Martijn van Griensven, Claudia Keibl & Philipp Mommsen. (2013) Induced hypothermia does not impair coagulation system in a swine multiple trauma model. Journal of Trauma and Acute Care Surgery 74:4, pages 1014-1020.
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Daniel Dirkmann, Julia Radü-Berlemann, Klaus Görlinger & Jürgen Peters. (2013) Recombinant tissue-type plasminogen activator–evoked hyperfibrinolysis is enhanced by acidosis and inhibited by hypothermia but still can be blocked by tranexamic acid. Journal of Trauma and Acute Care Surgery 74:2, pages 482-488.
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