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International Review of Psychiatry Volume 7, 1995 - Issue 1
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Original Article

Should rational drug development in psychiatry target more than one mechanism of action in a single molecule?

Sheldon H. Preskorn Department of Psychiatry, University of Kansas, School of Medicine-Wichita 1010, Wichita, Kansas, 67214, USA
Pages 17-28 | Published online: 11 Jul 2009

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C. B. Eap, G. Gründer, P. Baumann, N. Ansermot, A. Conca, E. Corruble, S. Crettol, M. L. Dahl, J. de Leon, C. Greiner, O. Howes, E. Kim, R. Lanzenberger, J. H. Meyer, R. Moessner, H. Mulder, D. J. Müller, M. Reis, P. Riederer, H. G. Ruhe, O. Spigset, E. Spina, B. Stegman, W. Steimer, J. Stingl, S. Suzen, H. Uchida, S. Unterecker, F. Vandenberghe & C. Hiemke. (2021) Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants. The World Journal of Biological Psychiatry 22:8, pages 561-628.
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Articles from other publishers (8)

Dee Lochmann & Tara Richardson. 2019. Antidepressants. Antidepressants 135 144 .
Andrei A. Gakh, Andrey V. Sosnov, Mikhail Krasavin, Tam Luong Nguyen & Ernest Hamel. (2013) Identification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: The special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazole. Bioorganic & Medicinal Chemistry Letters 23:5, pages 1262-1268.
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Annette K. Griffith, Jacqueline Huscroft-D’Angelo, Michael H. Epstein, Nirbhay N. Singh, Jonathan C. Huefner & Robert Pick. (2010) Psychotropic Medication Use for Youth in Residential Treatment: A Comparison Between Youth with Monopharmacy Versus Polypharmacy. Journal of Child and Family Studies 19:6, pages 795-802.
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S. H. Preskorn, R. Ross & C. Y. Stanga. 2004. Antidepressants: Past, Present and Future. Antidepressants: Past, Present and Future 241 262 .
S. H. Preskorn & R. Ross. 2004. Antidepressants: Past, Present and Future. Antidepressants: Past, Present and Future 171 183 .
W.Dale Horst & Sheldon H Preskorn. (1998) Mechanisms of action and clinical characteristics of three atypical antidepressants: venlafaxine, nefazodone, bupropion. Journal of Affective Disorders 51:3, pages 237-254.
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S Kasper, M Zivkov, K.C.B Roes & A.G Pols. (1997) Pharmacological treatment of severely depressed patients: a meta-analysis comparing efficacy of mirtazapine and amitriptyline. European Neuropsychopharmacology 7:2, pages 115-124.
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Siegfried Kasper. (1997) Efficacy of Antidepressants in the Treatment of Severe Depression. Journal of Clinical Psychopharmacology 17, pages 19S-28S.
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