1,259
Views
48
CrossRef citations to date
0
Altmetric
Investigations and reviews

Mechanisms of action of topical 5-fluorouracil: Review and implications for the treatment of dermatological disorders

Pages 83-89 | Received 14 May 2010, Accepted 26 Jun 2010, Published online: 31 Oct 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Thomas Vazquez & Mercedes Florez-White. (2020) A patient with squamous cell carcinoma in-situ successfully treated with intralesional 5-Fluorouracil and topical trichloroacetic acid. Journal of Dermatological Treatment 31:2, pages 180-182.
Read now
Dan Ma, Yong Huang & Shurong Song. (2019) Inhibiting the HPV16 oncogene-mediated glycolysis sensitizes human cervical carcinoma cells to 5-fluorouracil. OncoTargets and Therapy 12, pages 6711-6720.
Read now
Hande Güçlü, Zeynep Banu Doganlar, Vuslat Pelitli Gürlü, Altan Özal, Ayten Dogan, Meryem Aysenur Turhan & Oguzhan Doganlar. (2018) Effects of cisplatin-5-fluorouracil combination therapy on oxidative stress, DNA damage, mitochondrial apoptosis, and death receptor signalling in retinal pigment epithelium cells. Cutaneous and Ocular Toxicology 37:3, pages 291-304.
Read now
Mohamed A. Safwat, Ghareb M. Soliman, Douaa Sayed & Mohamed A. Attia. (2017) Gold nanoparticles capped with benzalkonium chloride and poly (ethylene imine) for enhanced loading and skin permeability of 5-fluorouracil. Drug Development and Industrial Pharmacy 43:11, pages 1780-1791.
Read now
Elizabeth E Uhlenhake. (2013) Optimal treatment of actinic keratoses. Clinical Interventions in Aging 8, pages 29-35.
Read now

Articles from other publishers (43)

Mona E. Elbanan, Maggie E. Amer, Mohamed A. El‐Missiry, Azza I. Othman & Sameh M. Shabana. (2023) Melatonin protected against kidney impairment induced by 5‐fluorouracil in mice. Journal of Experimental Zoology Part A: Ecological and Integrative Physiology 339:8, pages 777-787.
Crossref
Kevin S. Puerta Durango, Chiamaka L. Okorie, Shabnam Momtahen & Brian J. Simmons. (2023) A case of topical 5-fluorouracil provoked psoriasis. JAAD Case Reports 39, pages 30-33.
Crossref
Ricardo Ferrando, Scott G. Mitchell, Elena Atrián-Blasco & Elena Cerrada. (2023) Antibacterial properties of phosphine gold( i ) complexes with 5-fluorouracil . Dalton Transactions 52:30, pages 10507-10514.
Crossref
Michael J. Pierro, April J. Zhang & Lubna N. Chaudhary. (2023) Worsening Rash in a Patient With Metastatic Breast Cancer. JAMA Oncology 9:4, pages 564.
Crossref
Domenico Arcuri, Brandon Ramchatesingh, François Lagacé, Lisa Iannattone, Elena Netchiporouk, Philippe Lefrançois & Ivan V. Litvinov. (2023) Pharmacological Agents Used in the Prevention and Treatment of Actinic Keratosis: A Review. International Journal of Molecular Sciences 24:5, pages 4989.
Crossref
María Reyes García de la Fuente, Álvaro Rico Morales & Josep Manel Casanova Seuma. (2023) Lesiones premalignas de piel y mucosas y carcinoma escamoso in situ. FMC - Formación Médica Continuada en Atención Primaria 30:3, pages 14-27.
Crossref
Gideon P. Smith & Edwin S.L. Chan. 2023. Clinical Immunology. Clinical Immunology 1072 1079 .
Cristina Wöhlke Vendruscolo, Beatriz Ewert de Oliveira & Gislaine Ricci Leonardi. 2023. Biotechnology Applied to Inflammatory Diseases. Biotechnology Applied to Inflammatory Diseases 305 322 .
Ming-Yee Sun & Sonu M. M. Bhaskar. (2022) When Two Maladies Meet: Disease Burden and Pathophysiology of Stroke in Cancer. International Journal of Molecular Sciences 23:24, pages 15769.
Crossref
Enayat Attwa, Mohamed H. Khater, Heba M. Selim & Reham Essam. (2022) Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis. Dermatologic Therapy 35:11.
Crossref
Whitney T. H. Chow & Matthew Potter. (2022) Fingerprint loss associated with topical 5‐fluorouracil cream. Clinical and Experimental Dermatology 47:7, pages 1371-1372.
Crossref
Lucian G. Scurtu, Marian Petrica, Mariana Grigore, Alina Avram, Ionel Popescu & Olga Simionescu. (2022) A Conservative Combined Laser Cryoimmunotherapy Treatment vs. Surgical Excision for Basal Cell Carcinoma. Journal of Clinical Medicine 11:12, pages 3439.
Crossref
Aline Martins dos Santos, Alberto Gomes Tavares Junior, Suzana Gonçalves Carvalho & Marlus Chorilli. (2022) An Updated Review on Properties, Nanodelivery Systems, and Analytical Methods for the Determination of 5-Fluorouracil in Pharmaceutical and Biological Samples. Current Pharmaceutical Design 28:18, pages 1501-1512.
Crossref
Mohammad Kashif Iqubal, Ashif Iqubal, Hasib Anjum, Madan Mohan Gupta, Javed Ali & Sanjula Baboota. (2021) Determination of in vivo virtue of dermal targeted combinatorial lipid nanocolloidal based formulation of 5-fluorouracil and resveratrol against skin cancer. International Journal of Pharmaceutics 610, pages 121179.
Crossref
Javid Sadri Nahand, Nikta Rabiei, Reza Fathazam, Mohammad Taghizadieh, Mohammad Saeid Ebrahimi, Maryam Mahjoubin-Tehran, Hossein Bannazadeh Baghi, AliReza Khatami, Mohammad Abbasi-Kolli, Hamid Reza Mirzaei, Neda Rahimian, Maryam Darvish & Hamed Mirzaei. (2021) Oncogenic viruses and chemoresistance: What do we know?. Pharmacological Research 170, pages 105730.
Crossref
Xuecheng Shao, Xuehui Zheng, Dan Ma, Yang Liu & Guoyan Liu. (2021) Inhibition of lncRNA-NEAT1 sensitizes 5-Fu resistant cervical cancer cells through de-repressing the microRNA-34a/LDHA axis. Bioscience Reports 41:7.
Crossref
Luigi Bennardo, Francesco Bennardo, Amerigo Giudice, Maria Passante, Stefano Dastoli, Pietro Morrone, Eugenio Provenzano, Cataldo Patruno & Steven Paul Nisticò. (2021) Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?. Current Oncology 28:4, pages 2317-2325.
Crossref
Dea Florensia & Lita Setyowatie. (2021) Effectiveness of 5-Fluorouracil 5% Cream in Perianal Condylomata Accuminata Treatment: A Case Report. Berkala Ilmu Kesehatan Kulit dan Kelamin 33:1, pages 78.
Crossref
Beatriz Ewert de Oliveira, Otávio Henrique Junqueira Amorim, Lonetá Lauro Lima, Rodrigo Alvarenga Rezende, Natalia Cammarosano Mestnik, Ediléia Bagatin & Gislaine Ricci Leonardi. (2021) 5-Fluorouracil, innovative drug delivery systems to enhance bioavailability for topical use. Journal of Drug Delivery Science and Technology 61, pages 102155.
Crossref
Salman Ahmad Mustfa, Eleonora Maurizi, John McGrath & Ciro Chiappini. (2020) Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery. Advanced Therapeutics 4:1, pages 2000160.
Crossref
Surid Mohammad Chowdhury, Md. Nuruzzaman Hossain & Md. Rajdoula Rafe. (2020) In silico design and evaluation of novel 5-fluorouracil analogues as potential anticancer agents. Heliyon 6:9, pages e04978.
Crossref
An Chen, Dong-Liang Wu, Jia Shi, Suresh Narva, Xiao-Yin Zhao, Yan-Ling Wu & Wen Zhang. (2020) Design, synthesis and biological evaluation of 2-methyl-(1,1′-biphenyl)-pyrimidine conjugates. Bioorganic & Medicinal Chemistry Letters 30:16, pages 127328.
Crossref
Xia-Lin Dai, Chao Wu, Jin-Hui Li, Lian-Chao Liu, Xin He, Tong-Bu Lu & Jia-Mei Chen. (2020) Modulating the solubility and pharmacokinetic properties of 5-fluorouracil via cocrystallization . CrystEngComm 22:21, pages 3670-3682.
Crossref
Shaimaa Fayez, Torsten Bruhn, Doris Feineis, Laurent Aké Assi, Suresh Awale & Gerhard Bringmann. (2020) Ancistrosecolines A–F, Unprecedented seco -Naphthylisoquinoline Alkaloids from the Roots of Ancistrocladus abbreviatus , with Apoptosis-Inducing Potential against HeLa Cancer Cells . Journal of Natural Products 83:4, pages 1139-1151.
Crossref
Natalie Kash & Sirunya Silapunt. 2020. Basal Cell Carcinoma. Basal Cell Carcinoma 49 81 .
Charalampos Siotos, Akachimere C. Uzosike, Hwanhee Hong, Stella M. Seal, Gedge D. Rosson, Carisa M. Cooney & Damon S. Cooney. (2019) Keloid Excision and Adjuvant Treatments. Annals of Plastic Surgery 83:2, pages 154-162.
Crossref
Vlad Mihai Voiculescu, Cristina Victoria Lisievici, Mihai Lupu, Cristina Vajaitu, Carmen Cristina Draghici, Alexandra Victoria Popa, Iulia Solomon, Teona Ioana Sebe, Maria Magdalena Constantin & Constantin Caruntu. (2019) Mediators of Inflammation in Topical Therapy of Skin Cancers. Mediators of Inflammation 2019, pages 1-15.
Crossref
Gideon P. Smith & Edwin S.L. Chan. 2019. Clinical Immunology. Clinical Immunology 1177 1184.e1 .
Dmitriy N. Shurpik, Denis A. Sevastyanov, Pavel V. Zelenikhin, Evgenia V. Subakaeva, Vladimir G. Evtugyn, Yuriy N. Osin, Peter J. Cragg & Ivan I. Stoikov. (2018) Hydrazides of glycine-containing decasubstituted pillar[5]arenes: Synthesis and encapsulation of Floxuridine. Tetrahedron Letters 59:50, pages 4410-4415.
Crossref
Yusuf Karakas, Secil Vural, Omer Diker & Omer Dizdar. (2018) When side effect becomes the effect: Efficacy of capecitabine in refractory psoriasis. Dermatologic Therapy 31:6, pages e12629.
Crossref
Garrett T. Prince, Michael C. Cameron, Ramin Fathi & Theodore Alkousakis. (2018) Topical 5-fluorouracil in dermatologic disease. International Journal of Dermatology 57:10, pages 1259-1264.
Crossref
M. Ehret, C. Velter, M. Tebacher, C. Bruant-Rodier & B. Cribier. (2018) Carcinome épidermoïde de croissance rapide après traitement par mébutate d’ingénol. Annales de Dermatologie et de Vénéréologie 145:10, pages 607-612.
Crossref
P. Ishioka, M. Maia, S.B. Rodrigues, R.F. Lellis & S.H. Hirata. (2018) In vivo Confocal Laser Microscopy for monitoring of actinic keratosis treatment: a comparison with histopathologic assessment after treatment with topical 5% 5-fluorouracil. Journal of the European Academy of Dermatology and Venereology 32:7, pages 1155-1163.
Crossref
Kozo Nakai, Junko Moriue, Emiko Ishikawa, Ayako Nishiura, Tetsuya Moriue & Yasuo Kubota. (2018) Clearance and hyperpigmentation of chronic psoriatic plaques by tegafur/gimercil/oteracil potassium (TS-1). Dermatologica Sinica 36:2, pages 101-102.
Crossref
Christina Megill & Timothy Wilkin. (2017) Topical therapies for the treatment of anal high-grade squamous intraepithelial lesions. Seminars in Colon and Rectal Surgery 28:2, pages 86-90.
Crossref
Naseem Akhtar & Riaz A. Khan. (2016) Liposomal systems as viable drug delivery technology for skin cancer sites with an outlook on lipid-based delivery vehicles and diagnostic imaging inputs for skin conditions'. Progress in Lipid Research 64, pages 192-230.
Crossref
Thomas Dirschka & John T. Lear. (2014) Sequential Treatment of Multiple Actinic Keratoses with Solaraze and Actikerall. Case Reports in Dermatology 6:2, pages 164-168.
Crossref
Urspeter Masche. (2014) Aktinische Keratosen. pharma-kritik 36:3.
Crossref
Youssef W. Naguib, Amit Kumar & Zhengrong Cui. (2014) The effect of microneedles on the skin permeability and antitumor activity of topical 5-fluorouracil. Acta Pharmaceutica Sinica B 4:1, pages 94-99.
Crossref
Andrea Hui & Orit Markowitz. (2013) Ingenol Mebutate for the Treatment of Actinic Keratosis. Current Dermatology Reports 2:3, pages 172-176.
Crossref
M. A. Stashkevych. (2013) Distribution of 5-fluorouracil between lymphocytes and blood plasma. The Ukrainian Biochemical Journal 85:4, pages 94-97.
Crossref
Juma A. M. Ali, Darren J. Creek, Karl Burgess, Harriet C. Allison, Mark C. Field, Pascal Mäser & Harry P. De Koning. (2013) Pyrimidine Salvage in Trypanosoma brucei Bloodstream Forms and the Trypanocidal Action of Halogenated Pyrimidines . Molecular Pharmacology 83:2, pages 439-453.
Crossref
Gideon P. Smith & Edwin S.L. Chan. 2013. Clinical Immunology. Clinical Immunology 1077 1084 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.