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Journal of Dermatological Treatment Volume 27, 2016 - Issue 5
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Eczema

Efficacy of a novel phosphodiesterase inhibitor, E6005, in patients with atopic dermatitis: An investigator-blinded, vehicle-controlled study

Fuminori OhbaEisai Product Creation Systems, Eisai Co Ltd, Tokyo, Japan; Correspondence[email protected]
,
Shunji MatsukiSugioka Memorial Hospital Clinical Research Center, Fukuoka, Japan;
,
Shuhei ImayamaImayama Shuhei Clinic and Laboratory, Fukuoka, Japan
,
Kyoko MatsugumaSugioka Memorial Hospital Clinical Research Center, Fukuoka, Japan;
,
Seiichiro HojoEisai Product Creation Systems, Eisai Co Ltd, Tokyo, Japan;
,
Maiko NomotoEisai Product Creation Systems, Eisai Co Ltd, Tokyo, Japan;
&
Hideto AkamaEisai Product Creation Systems, Eisai Co Ltd, Tokyo, Japan;
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Pages 467-472 | Received 02 Nov 2015, Accepted 14 Jan 2016, Published online: 14 Apr 2016

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Zhihao Liu, Mingjian Liu, Zhenqing Cao, Pengsen Qiu & Gaopeng Song. (2022) Phosphodiesterase‑4 inhibitors: a review of current developments (2013–2021). Expert Opinion on Therapeutic Patents 32:3, pages 261-278.
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Aisleen Diaz & Emma Guttman-Yassky. (2019) Topical agents for the treatment of atopic dermatitis. Expert Review of Clinical Immunology 15:4, pages 369-382.
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Maddalena Napolitano, Claudio Marasca, Gabriella Fabbrocini & Cataldo Patruno. (2018) Adult atopic dermatitis: new and emerging therapies. Expert Review of Clinical Pharmacology 11:9, pages 867-878.
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Kam Lun Hon, Alexander K.C. Leung, Theresa N. H. Leung & Vivian W. Y. Lee. (2018) Investigational drugs for atopic dermatitis. Expert Opinion on Investigational Drugs 27:8, pages 637-647.
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Taylor Edwards, Nupur U. Patel, Amy Blake, Samantha Prabakaran, Danielle Reimer, Steven R. Feldman & Lindsay C. Strowd. (2018) Insights into future therapeutics for atopic dermatitis. Expert Opinion on Pharmacotherapy 19:3, pages 265-278.
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Masutaka Furue, Takafumi Kadono, Gaku Tsuji & Takeshi Nakahara. (2017) Topical E6005/RVT-501, a novel phosphodiesterase 4 inhibitor, for the treatment of atopic dermatitis. Expert Opinion on Investigational Drugs 26:12, pages 1403-1408.
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Alice C. Cheape & Dedee F. Murrell. (2017) 2% Crisaborole topical ointment for the treatment of mild-to-moderate atopic dermatitis. Expert Review of Clinical Immunology 13:5, pages 415-423.
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Markus Joerger, Stephen P. Finn, Sinead Cuffe, Annette T. Byrne & Steven G. Gray. (2016) The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy?. Expert Opinion on Therapeutic Targets 20:11, pages 1339-1356.
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Derek K. Chu, Alexandro W.L. Chu, Daniel G. Rayner, Gordon H. Guyatt, Juan José Yepes-Nuñez, Luis Gomez-Escobar, Lucia C. Pérez-Herrera, Juan Pablo Díaz Martinez, Romina Brignardello-Petersen, Behnam Sadeghirad, Melanie M. Wong, Renata Ceccacci, Irene X. Zhao, John Basmaji, Margaret MacDonald, Xiajing Chu, Nazmul Islam, Ya Gao, Ariel Izcovich, Rachel N. Asiniwasis, Mark Boguniewicz, Anna De Benedetto, Korey Capozza, Lina Chen, Kathy Ellison, Winfred T. Frazier, Matthew Greenhawt, Joey Huynh, Jennifer LeBovidge, Peter A. Lio, Stephen A. Martin, Monica O’Brien, Peck Y. Ong, Jonathan I. Silverberg, Jonathan M. Spergel, Wendy Smith Begolka, Julie Wang, Kathryn E. Wheeler, Donna D. Gardner & Lynda Schneider. (2023) Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials. Journal of Allergy and Clinical Immunology 152:6, pages 1493-1519.
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Nikolaos Sideris, Eleni Paschou, Katerina Bakirtzi, Dimitra Kiritsi, Ilias Papadimitriou, Aikaterini Tsentemeidou, Elena Sotiriou & Efstratios Vakirlis. (2022) New and Upcoming Topical Treatments for Atopic Dermatitis: A Review of the Literature. Journal of Clinical Medicine 11:17, pages 4974.
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Letizia Crocetti, Giuseppe Floresta, Agostino Cilibrizzi & Maria Paola Giovannoni. (2022) An Overview of PDE4 Inhibitors in Clinical Trials: 2010 to Early 2022. Molecules 27:15, pages 4964.
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Muneeb Ilyas, Christopher M. Logas, Brad P. Glick & James Q. Del Rosso. (2022) Advancements in topical therapy. Dermatological Reviews 3:1, pages 9-13.
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Ana Martín-Santiago, Susana Puig, Daniel Arumi & Francisco Jose Rebollo Laserna. (2022) Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis. Current Therapeutic Research 96, pages 100679.
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Chia-Yu Chu. (2020) Treatments for Childhood Atopic Dermatitis: an Update on Emerging Therapies. Clinical Reviews in Allergy & Immunology 61:2, pages 114-127.
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Xiaoliang Yang, Naotomo Kambe, Riko Takimoto-Ito & Kenji Kabashima. (2021) Advances in the pathophysiology of atopic dermatitis revealed by novel therapeutics and clinical trials. Pharmacology & Therapeutics 224, pages 107830.
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A.-S. Darrigade. (2019) Traitements topiques et photothérapie dans la dermatite atopique. Annales de Dermatologie et de Vénéréologie 146:12, pages 12S85-12S95.
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Henry L. Nguyen, Katelyn R. Anderson & Megha M. Tollefson. (2019) New and Emerging Therapies for Pediatric Atopic Dermatitis. Pediatric Drugs 21:4, pages 239-260.
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A. Chiricozzi, A. Belloni Fortina, E. Galli, G. Girolomoni, I. Neri, G. Ricci, M. Romanelli & D. Peroni. (2019) Current therapeutic paradigm in pediatric atopic dermatitis: Practical guidance from a national expert panel. Allergologia et Immunopathologia 47:2, pages 194-206.
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Ayan Kusari, Allison M. Han, David Schairer & Lawrence F. Eichenfield. (2019) Atopic Dermatitis. Dermatologic Clinics 37:1, pages 11-20.
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Emma Guttman‐Yassky, Jon M. Hanifin, Mark Boguniewicz, Andreas Wollenberg, Robert Bissonnette, Vivek Purohit, Iain Kilty, Anna M. Tallman & Michael A. Zielinski. (2018) The role of phosphodiesterase 4 in the pathophysiology of atopic dermatitis and the perspective for its inhibition. Experimental Dermatology.
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Heng Li, Jianping Zuo & Wei Tang. (2018) Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases. Frontiers in Pharmacology 9.
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Eric J. Yang, Sahil SekhonIsabelle M. Sanchez, Kristen M. BeckTina Bhutani. (2018) Recent Developments in Atopic Dermatitis. Pediatrics 142:4.
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E. Serra-Baldrich, J.O. de Frutos, I. Jáuregui, J.C. Armario-Hita, J.F. Silvestre, L. Herraez, A. Martín-Santiago, A. Valero & J. Sastre. (2018) Changing perspectives in atopic dermatitis. Allergologia et Immunopathologia 46:4, pages 397-412.
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A. Wollenberg, S. Barbarot, T. Bieber, S. Christen-Zaech, M. Deleuran, A. Fink-Wagner, U. Gieler, G. Girolomoni, S. Lau, A. Muraro, M. Czarnecka-Operacz, T. Schäfer, P. Schmid-Grendelmeier, D. Simon, Z. Szalai, J.C. Szepietowski, A. Taïeb, A. Torrelo, T. Werfel & J. Ring. (2018) Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. Journal of the European Academy of Dermatology and Venereology 32:5, pages 657-682.
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Rema Zebda & Amy S. Paller. (2018) Phosphodiesterase 4 inhibitors. Journal of the American Academy of Dermatology 78:3, pages S43-S52.
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Pawinee Rerknimitr, Atsushi Otsuka, Chisa Nakashima & Kenji Kabashima. (2017) The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus. Inflammation and Regeneration 37:1.
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Jusleen Ahluwalia, Jeremy Udkoff, Andrea Waldman, Jenna Borok & Lawrence F. Eichenfield. (2017) Phosphodiesterase 4 Inhibitor Therapies for Atopic Dermatitis: Progress and Outlook. Drugs 77:13, pages 1389-1397.
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Atsushi Otsuka, Takashi Nomura, Pawinee Rerknimitr, Judith A. Seidel, Tetsuya Honda & Kenji Kabashima. (2017) The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis. Immunological Reviews 278:1, pages 246-262.
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Jeremy Udkoff, Andrea Waldman, Jusleen Ahluwalia, Jenna Borok & Lawrence F. Eichenfield. (2017) Current and emerging topical therapies for atopic dermatitis. Clinics in Dermatology 35:4, pages 375-382.
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Nupur Patel & Lindsay C. Strowd. 2017. Management of Atopic Dermatitis. Management of Atopic Dermatitis 185 210 .
A. Heratizadeh & T. Werfel. (2016) Anti-inflammatory therapies in atopic dermatitis. Allergy 71:12, pages 1666-1675.
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