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Skin Pharmacology

Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature

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Pages 515-519 | Received 14 Jan 2016, Accepted 27 Feb 2016, Published online: 04 Apr 2016

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Chandra Mauli Jha, Hormaz Dara Dastoor, Natrajan Gopalakrishnan & Stephen Geoffrey Holt. (2022) Obstacles to Early Diagnosis and Treatment of Pruritus in Patients with Chronic Kidney Disease: Current Perspectives. International Journal of Nephrology and Renovascular Disease 15, pages 335-352.
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Rachel Shireen Golpanian & Gil Yosipovitch. (2020) Current and emerging systemic treatments targeting the neural system for chronic pruritus. Expert Opinion on Pharmacotherapy 21:13, pages 1629-1636.
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Articles from other publishers (37)

Shweta Shah, Elizabeth Onugha & Sarah J. Swartz. (2023) Chronic kidney disease–associated pruritus: what is known and its application in children. Pediatric Nephrology 39:1, pages 25-35.
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Mei-Ju Ko, Yu-Sen Peng & Hon-Yen Wu. (2023) Uremic pruritus: pathophysiology, clinical presentation, and treatments. Kidney Research and Clinical Practice 42:1, pages 39-52.
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Jin-Cheol Kim, Won-Sik Shim, In-Suk Kwak, Dong-Hun Lee, Jin-Seo Park, So-Yeon Lee, Seok-Young Kang, Bo-Young Chung, Chun-Wook Park & Hye-One Kim. (2023) Pathogenesis and Treatment of Pruritus Associated with Chronic Kidney Disease and Cholestasis. International Journal of Molecular Sciences 24:2, pages 1559.
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J. Pedro Teixeira, Sara A. Combs, Michael J. Germain & Sara N. Davison. 2022. Evidence‐Based Nephrology. Evidence‐Based Nephrology 551 569 .
Daniel E. Weiner, Marc G. Vervloet, Sebastian Walpen, Thilo Schaufler, Catherine Munera, Frédérique Menzaghi, Warren Wen, Sarbani Bhaduri & Michael J. Germain. (2022) Safety and Effectiveness of Difelikefalin in Patients With Moderate-to-Severe Pruritus Undergoing Hemodialysis: An Open-Label, Multicenter Study. Kidney Medicine 4:10, pages 100542.
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Claire C. Y. Wang, Henry H. L. Wu, Arvind Ponnusamy, Isobel Pye & Alexander Woywodt. (2022) Pruritus in Chronic Kidney Disease: An Update. Allergies 2:3, pages 87-105.
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An-Yu Cheng & Lai-San Wong. (2022) Uremic Pruritus: From Diagnosis to Treatment. Diagnostics 12:5, pages 1108.
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Zoe A Karavolis, Andrew B Su & Alyssa M Peckham. (2022) State-level response to gabapentin misuse in the United States: Implications and future direction. American Journal of Health-System Pharmacy 79:9, pages e143-e148.
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Zoe M Lipman, Vijayakumar Paramasivam, Gil Yosipovitch & Michael J Germain. (2021) Clinical management of chronic kidney disease-associated pruritus: current treatment options and future approaches. Clinical Kidney Journal 14:Supplement_3, pages i16-i22.
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Radomir Reszke, Katarzyna Kiliś-Pstrusińska & Jacek C. Szepietowski. (2021) Chronic Kidney Disease-Associated Itch (CKD-aI) in Children—A Narrative Review. Toxins 13:7, pages 450.
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Seema Rajesh Rao, Nandini Vallath, Vishwanath Siddini, Tukaram Jamale, Divya Bajpai, Nitish Nitin Sancheti & Dharshan Rangaswamy. (2021) Symptom Management among Patients with Chronic Kidney Disease. Indian Journal of Palliative Care 27, pages S14-S29.
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Wei-Wei Feng, Bo Yuan, Fang-Yuan Shen, Wang-Yang Fan, Di-Sen Mei, Bei-Yan Bao & Qi-Jun Chen. (2021) Efficacy of uremic pruritus treatment in patients undergoing hemodialysis, a network meta-analysis for randomized clinical trials. Néphrologie & Thérapeutique 17:1, pages 30-34.
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Jian-Hui Zhao, Qiu-Shuang Zhu, Yi-Wen Li & Li-Li Wang. (2021) Determinants of the intensity of uremic pruritus in patients receiving maintenance hemodialysis: A cross-sectional study. PLOS ONE 16:1, pages e0245370.
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Cheng Teng Yeam, Tiffany Eri Yo, Ying Lin Cheryl Tan, Adrian Liew & Jun Jie Benjamin Seng. (2021) Complementary and alternative medicine therapies for uremic pruritus – A systematic review of randomized controlled trials. Complementary Therapies in Medicine 56, pages 102609.
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Daniel Hercz, Simon H Jiang & Angela C Webster. (2020) Interventions for itch in people with advanced chronic kidney disease. Cochrane Database of Systematic Reviews 2020:12.
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Roger Haber, Julien Bachour, Antoine Salloum, Toni Maacaron, Fares Khoury, Luciana Habr, Alfred Ammoury & Najat Joubran. (2020) Comparison of gabapentin and doxepin in the management of uremic pruritus: A randomized crossover clinical trial. Dermatologic Therapy 33:6.
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Erin P. Westby, Kerri S. Purdy & Karthik K. Tennankore. (2020) A review of the management of uremic pruritus: current perspectives and future directions. Itch 5:3, pages e38-e38.
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Kathleen May V. Eusebio‐Alpapara, Rochelle L. Castillo & Belen L. Dofitas. (2019) Gabapentin for uremic pruritus: a systematic review of randomized controlled trials. International Journal of Dermatology 59:4, pages 412-422.
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Inayat U Rehman, Pauline SM Lai, Lim S Kun, Learn H Lee, Kok G Chan & Tahir M Khan. (2019) Chronic Kidney Disease‐Associated Pruritus and Quality of Life in Malaysian Patients Undergoing Hemodialysis. Therapeutic Apheresis and Dialysis 24:1, pages 17-25.
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Jessica Ragazzo, Annemarie Cesta, S. Vanita Jassal, Nicholas Chiang & Marisa Battistella. (2020) Development and Validation of a Uremic Pruritus Treatment Algorithm and Patient Information Toolkit in Patients With Chronic Kidney Disease and End Stage Kidney Disease. Journal of Pain and Symptom Management 59:2, pages 279-292.e5.
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Daniel Samaha, Trisha Kandiah & Deborah Zimmerman. (2020) Cannabis Use for Restless Legs Syndrome and Uremic Pruritus in in patients treated with maintenance dialysis: A Survey. Canadian Journal of Kidney Health and Disease 7, pages 205435812095494.
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Claire E. Martin, Sergi Clotet-Freixas, Janine F. Farragher & Gregory L. Hundemer. (2020) Have We Just Scratched the Surface? A Narrative Review of Uremic Pruritus in 2020. Canadian Journal of Kidney Health and Disease 7, pages 205435812095402.
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Inayat Ur Rehman, Pauline Siew Mei Lai, Soo Kun Lim, Learn Han Lee & Tahir Mehmood Khan. (2019) Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus. BMC Nephrology 20:1.
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Giovanni Maria Rossi, Mattia Corradini, Valentina Blanco, Silvia Mattei, Enrico Fiaccadori, Augusto Vaglio & Lucio Manenti. (2019) Randomized trial of two after-dialysis gabapentin regimens for severe uremic pruritus in hemodialysis patients. Internal and Emergency Medicine 14:8, pages 1341-1346.
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Inayat Ur Rehman, Tahir Ali Chohan, Allah Bukhsh & Tahir Mehmood Khan. (2019) Impact of Pruritus on Sleep Quality of Hemodialysis Patients: A Systematic Review and Meta-Analysis. Medicina 55:10, pages 699.
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Manuel Pedro Pereira, Asit Mittal & Sonja Ständer. (2019) Current treatment strategies in refractory chronic pruritus. Current Opinion in Pharmacology 46, pages 1-6.
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Julie H. Ishida, Charles E. McCulloch, Michael A. Steinman, Barbara A. Grimes & Kirsten L. Johansen. (2018) Gabapentin and Pregabalin Use and Association with Adverse Outcomes among Hemodialysis Patients. Journal of the American Society of Nephrology 29:7, pages 1970-1978.
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Taige Cao, Hong Liang Tey & Gil Yosipovitch. (2018) Chronic Pruritus in the Geriatric Population. Dermatologic Clinics 36:3, pages 199-211.
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Kristen M. Sanders & Tasuku Akiyama. (2018) The vicious cycle of itch and anxiety. Neuroscience & Biobehavioral Reviews 87, pages 17-26.
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Asit Mittal, Chesta Agarwal, Manisha Balai & Ayush Taneja. (2018) Gabapentin and pregabalin in dermatology. Indian Journal of Dermatology, Venereology and Leprology 84:5, pages 634.
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Asit Mittal & Kapil Vyas. (2018) Drug treatment of pruritus of systemic origin. Indian Journal of Drugs in Dermatology 4:2, pages 52.
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Hugh C. Rayner, Maria Larkina, Mia Wang, Matthew Graham-Brown, Sabine N. van der Veer, Tevfik Ecder, Takeshi Hasegawa, Werner Kleophas, Brian A. Bieber, Francesca Tentori, Bruce M. Robinson & Ronald L. Pisoni. (2017) International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis. Clinical Journal of the American Society of Nephrology 12:12, pages 2000-2007.
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Elizabeth Simonsen, Paul Komenda, Blake Lerner, Nicole Askin, Clara Bohm, James Shaw, Navdeep Tangri & Claudio Rigatto. (2017) Treatment of Uremic Pruritus: A Systematic Review. American Journal of Kidney Diseases 70:5, pages 638-655.
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Sarah L. Sheu & Kevin C. Wang. (2016) Pruritus and Dermatitis in the Elderly. Current Geriatrics Reports 5:4, pages 266-274.
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Xia Jiang, Fen Ji, Zhi-Wei Chen & Qiao-Lin Huang. (2016) Comparison of high-flux hemodialysis with hemodialysis filtration in treatment of uraemic pruritus: a randomized controlled trial. International Urology and Nephrology 48:9, pages 1533-1541.
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C. Zeidler, B. Pfleiderer & S. Ständer. (2016) Neues zur Therapie des chronischen PruritusNew treatment options for chronic pruritus. Der Hautarzt 67:8, pages 627-634.
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Domenico chirchiglia. (2016) Can the Aggravation of Pruritus be a Sign of Worsening Peripheral Neuropathy in Uremic Disease? A Clinical and Neurophysiological Study. International Journal of Neurology and Brain Disorders 3:4, pages 1-4.
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