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Papers Presented at the 2nd Workshop on Radiation and Multidrug Resistance Mediated via the Tumour-Microenvironment

Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by γH2AX staining

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Pages 1032-1041 | Received 31 Mar 2009, Accepted 20 Jul 2009, Published online: 06 Nov 2009

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Crossref
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Crossref
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