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International Journal of Radiation Biology Volume 87, 2011 - Issue 6
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Honokiol and the HIF-1α Pathway

Honokiol inhibits hypoxia-inducible factor-1 pathway

Keng-li LanCancer Center, Taipei Veterans General Hospital, TaipeiCorrespondence[email protected]
,
Keng-hsin Lan
,
Meei-ling SheuInstitute of Medical Technology, National Chung Hsing University, Taichung
,
Ming-yuan ChenCancer Center, Taipei Veterans General Hospital, Taipei
,
Yi-sheng ShihDivision of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei
,
Fu-chih HsuCancer Center, Taipei Veterans General Hospital, Taipei
,
Hong-Ming WangCancer Center, Taipei Veterans General Hospital, Taipei
,
Ren-shyan Liu
&
Sang-hue Yen
 show all
Pages 579-590 | Received 18 Jun 2010, Published online: 07 Apr 2011

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Fatima Khatoon, Sabeeha Ali, Vijay Kumar, Abdelbaset Mohamed Elasbali, Hassan H. Alhassan, Salem Hussain Alharethi, Asimul Islam & Md. Imtaiyaz Hassan. (2023) Pharmacological features, health benefits and clinical implications of honokiol. Journal of Biomolecular Structure and Dynamics 41:15, pages 7511-7533.
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John E. Moulder. (2019) Chemical radiosensitizers: the Journal history. International Journal of Radiation Biology 95:7, pages 940-944.
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Articles from other publishers (22)

Ekaterina I. MikhaevichDanila V. SorokinAlexander M. Scherbakov. (2023) Honokiol inhibits the growth of hormone-resistant breast cancer cells: its promising effect in combination with metformin. Research in Pharmaceutical Sciences 18:5, pages 580-591.
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Xi Wang, Gang Shao, Xiangyu Hong, Yue Shi, Yiting Zheng, Yucheng Yu & Caiyun Fu. (2023) Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway. Pharmaceuticals 16:1, pages 70.
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Yao Li, Chenglin Liang & Xiyuan Zhou. (2022) The application prospects of honokiol in dermatology. Dermatologic Therapy 35:8.
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Zhaowu Ma, Xiaoqiang Xiang, Shiya Li, Peng Xie, Quan Gong, Boon-Cher Goh & Lingzhi Wang. (2022) Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds. Seminars in Cancer Biology 80, pages 379-390.
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Xianglan Yi, Mengxin Qi, Mingxiang Huang, Sheng Zhou & Jing Xiong. (2022) Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth. Frontiers in Pharmacology 13.
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Fabrizio Fontana, Michela Raimondi, Alessandro Di Domizio, Roberta M. Moretti, Marina Montagnani Marelli & Patrizia Limonta. (2019) Unraveling the molecular mechanisms and the potential chemopreventive/therapeutic properties of natural compounds in melanoma. Seminars in Cancer Biology 59, pages 266-282.
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Nethaji Muniraj, Sumit Siddharth & Dipali Sharma. (2019) Bioactive Compounds: Multi-Targeting Silver Bullets for Preventing and Treating Breast Cancer. Cancers 11:10, pages 1563.
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Kishore Banik, Abhishek Manoj Ranaware, Vishwas Deshpande, Savita Pravin Nalawade, Ganesan Padmavathi, Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Muthu K. Shanmugam, Lu Fan, Frank Arfuso, Gautam Sethi & Ajaikumar B. Kunnumakkara. (2019) Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets. Pharmacological Research 144, pages 192-209.
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Abdur Rauf, Seema Patel, Muhammad Imran, Aneela Maalik, Muhammad Umair Arshad, Farhan Saeed, Yahia N. Mabkhot, Salim S. Al-Showiman, Nazir Ahmad & Eman Elsharkawy. (2018) Honokiol: An anticancer lignan. Biomedicine & Pharmacotherapy 107, pages 555-562.
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Chitra Rajagopal, Manendra Babu Lankadasari, Jesil Mathew Aranjani & K.B. Harikumar. (2018) Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy. Pharmacological Research 130, pages 273-291.
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Saima Subhani, Divya Teja Vavilala & Mridul Mukherji. (2016) HIF inhibitors for ischemic retinopathies and cancers: options beyond anti-VEGF therapies. Angiogenesis 19:3, pages 257-273.
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XIAOFANG XU, SHENGFANG GE, RENBING JIA, YIXIONG ZHOU, XIN SONG, HE ZHANG & XIANQUN FAN. (2015) Hypoxia-induced miR-181b enhances angiogenesis of retinoblastoma cells by targeting PDCD10 and GATA6. Oncology Reports 33:6, pages 2789-2796.
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Eun-Ryeong Hahm, Kozue Sakao & Shivendra V. Singh. (2014) Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells. The Prostate 74:12, pages 1209-1221.
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Ines Batinic-HaberleArtak TovmasyanEmily R. H. RobertsZeljko VujaskovicKam W. LeongIvan Spasojevic. (2014) SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways. Antioxidants & Redox Signaling 20:15, pages 2372-2415.
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RONGXIN QI, WENWEN JIN, JUAN WANG, QIYI YI, MAOHU YU, SHIGUO XU & WENSEN JIN. (2014) Oleanolic acid enhances the radiosensitivity of tumor cells under mimetic hypoxia through the reduction in intracellular GSH content and HIF-1α expression. Oncology Reports 31:5, pages 2399-2406.
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Ailin Qu, Lutao Du, Yongmei Yang, Hui Liu, Juan Li, Lili Wang, Yimin Liu, Zhaogang Dong, Xin Zhang, Xiumei Jiang, Haiyan Wang, Zewu Li, Guixi Zheng & Chuanxin Wang. (2014) Hypoxia-Inducible MiR-210 Is an Independent Prognostic Factor and Contributes to Metastasis in Colorectal Cancer. PLoS ONE 9:3, pages e90952.
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Courey Averett, Sumit Arora, Haseeb Zubair, Seema Singh, Arun Bhardwaj & Ajay P. Singh. 2014. Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids. Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids 175 193 .
Wei Yang, Jing Wei, Ting Sun & Fenju Liu. (2013) Effects of knockdown of miR-210 in combination with ionizing radiation on human hepatoma xenograft in nude mice. Radiation Oncology 8:1.
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Keng‐Hsin Lan, Ying‐Wen Wang, Wei‐Ping Lee, Keng‐Li Lan, Szu‐Han Tseng, Li‐Rong Hung, Sang‐Hue Yen, Han‐Chieh Lin & Shou‐Dong Lee. (2011) Multiple effects of honokiol on the life cycle of hepatitis C virus. Liver International 32:6, pages 989-997.
Crossref
Wei Yang, Ting Sun, Jianping Cao, Fenju Liu, Ye Tian & Wei Zhu. (2012) Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro. Experimental Cell Research 318:8, pages 944-954.
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Eric YarnellKathy Abascal. (2012) Botanical Medicines and Ionizing Radiation: Part 2—Radiosensitizing Herbs. Alternative and Complementary Therapies 18:1, pages 35-40.
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Francisco Javier Rodríguez-Jiménez & Victoria Moreno-Manzano. (2011) Modulation of hypoxia-inducible factors (HIF) from an integrative pharmacological perspective. Cellular and Molecular Life Sciences 69:4, pages 519-534.
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