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International Journal of Radiation Biology Volume 88, 2012 - Issue 3
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EVALUATION OF RADIOCHEMOTHERAPY WITH LAROMUSTINE

Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors

Sara RockwellDepartment of Therapeutic Radiology;Department of Pharmacology, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USACorrespondence[email protected]
,
Yanfeng LiuDepartment of Therapeutic Radiology
,
Helen A. SeowDepartment of Pharmacology, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
,
Kimiko IshiguroDepartment of Pharmacology, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
,
Raymond P. BaumannDepartment of Pharmacology, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
,
Philip G. PenkethDepartment of Pharmacology, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
,
Krishnamurthy ShyamDepartment of Pharmacology, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
,
Oluwatoyin M. AkintujoyeDepartment of Therapeutic Radiology
,
Peter M. GlazerDepartment of Therapeutic Radiology
&
Alan C. SartorelliDepartment of Pharmacology, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
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Pages 277-285 | Received 18 Aug 2011, Accepted 02 Nov 2011, Published online: 20 Dec 2011

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Sara Rockwell, Tina A. Grove, Yanfeng Liu, Yung-Chi Cheng, Susan A. Higgins & Carmen J. Booth. (2013) Preclinical studies of the Chinese Herbal Medicine formulation PHY906 (KD018) as a potential adjunct to radiation therapy. International Journal of Radiation Biology 89:1, pages 16-25.
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Articles from other publishers (7)

Hanim Saim, Siti N. M. Yassin, Maheza I. M. Salim, Khairunadwa Jemon, Rania H. AlAshwal, Asnida A. Wahab, Mariaulpa Sahalan, Hum Yan Chai & Lai K. Wee. (2022) Antitumor effect of infrared whole-body hyperthermia with curcumin in breast Cancer. Multimedia Tools and Applications 81:29, pages 41851-41868.
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Philip G. Penketh, Richard A. Finch, Rachel Sauro, Raymond P. Baumann, Elena S. Ratner & Krishnamurthy Shyam. (2018) pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs. Chemical Biology & Drug Design 91:1, pages 62-74.
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Krishnamurthy Shyam, Philip G. Penketh, Raymond P. Baumann, Rick A. Finch, Rui Zhu, Yong-Lian Zhu & Alan C. Sartorelli. (2015) Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility. Journal of Medicinal Chemistry 58:9, pages 3639-3671.
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Philip G. Penketh, Eric Patridge, Krishnamurthy Shyam, Raymond P. Baumann, Rui Zhu, Kimiko Ishiguro & Alan C. Sartorelli. (2014) Influence of Glutathione and Glutathione S -transferases on DNA Interstrand Cross-Link Formation by 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the Active Anticancer Moiety Generated by Laromustine . Chemical Research in Toxicology 27:8, pages 1440-1449.
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Philip G. Penketh, Krishnamurthy Shyam, Rui Zhu, Raymond P. Baumann, Kimiko Ishiguro & Alan C. Sartorelli. (2014) Influence of Phosphate and Phosphoesters on the Decomposition Pathway of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the Active Anticancer Moiety Generated by Laromustine, KS119, and KS119W. Chemical Research in Toxicology 27:5, pages 818-833.
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James E. HansenGrace ChanYanfeng LiuDenise C. HeganShibani DalalEloise DrayYoungho KwonYuanyuan XuXiaohua XuElizabeth Peterson-RothErik GeigerYilun LiuJoseph GeraJoann B. SweasyPatrick SungSara RockwellRobert N. NishimuraRichard H. WeisbartPeter M. Glazer. (2012) Targeting Cancer with a Lupus Autoantibody. Science Translational Medicine 4:157.
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Eugene Y. Kim, Yanfeng Liu, Oluwatoyin M. Akintujoye, Krishnamurthy Shyam, Tina A. Grove, Alan C. Sartorelli & Sara Rockwell. (2012) Preliminary Studies with a New Hypoxia-Selective Cytotoxin, KS119W, In Vitro and In Vivo . Radiation Research 178:3, pages 126-137.
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