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International Journal of Radiation Biology Volume 88, 2012 - Issue 10
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Research Article

Investigation of the mechanisms underpinning IL-6 cytokine release in bystander responses: The roles of radiation dose, radiation quality and specific ROS/RNS scavengers

Luca G MariottiDepartment of Physics, University of Pavia, Pavia, and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pavia, ItalyCorrespondence[email protected] [email protected]
,
Alessia BertolottiDepartment of Physics, University of Pavia, Pavia, and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pavia, Italy
,
Elena RanzaDepartment of Physics, University of Pavia, Pavia, and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pavia, Italy
,
Gabriele BabiniDepartment of Physics, University of Pavia, Pavia, and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pavia, Italy
&
Andrea OttolenghiDepartment of Physics, University of Pavia, Pavia, and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pavia, Italy
Pages 751-762 | Received 04 Jan 2012, Accepted 12 Jun 2012, Published online: 24 Jul 2012

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Manuela Buonanno, Géraldine Gonon, Badri N. Pandey & Edouard I. Azzam. (2023) The intercellular communications mediating radiation-induced bystander effects and their relevance to environmental, occupational, and therapeutic exposures. International Journal of Radiation Biology 99:6, pages 964-982.
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Charles Kirkby. (2022) A model of infection and immune response to low dose radiation. International Journal of Radiation Biology 98:7, pages 1243-1256.
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Emil Mladenov, Fanghua Li, Lihua Zhang, Holger Klammer & George Iliakis. (2018) Intercellular communication of DNA damage and oxidative status underpin bystander effects. International Journal of Radiation Biology 94:8, pages 719-726.
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Dietrich Averbeck, Sisko Salomaa, Simon Bouffler, Andrea Ottolenghi, Vere Smyth & Laure Sabatier. (2018) Progress in low dose health risk research. Mutation Research/Reviews in Mutation Research 776, pages 46-69.
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Joshua Alwood, Luan Tran, Ann-Sofie Schreurs, Yasaman Shirazi-Fard, Akhilesh Kumar, Diane Hilton, Candice Tahimic & Ruth Globus. (2017) Dose- and Ion-Dependent Effects in the Oxidative Stress Response to Space-Like Radiation Exposure in the Skeletal System. International Journal of Molecular Sciences 18:10, pages 2117.
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Elke Decrock, Delphine Hoorelbeke, Raghda Ramadan, Tinneke Delvaeye, Marijke De Bock, Nan Wang, Dmitri V Krysko, Sarah Baatout, Geert Bultynck, An Aerts, Mathieu Vinken & Luc Leybaert. (2017) Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:6, pages 1099-1120.
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Qian Zhang, Linlin Zhu, Gang Wang, Ye Zhao, Na Xiong, Hegang Bao & Wensen Jin. (2017) Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF-α and ROS. Journal of Biochemical and Molecular Toxicology 31:3, pages e21868.
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Ifigeneia V. Mavragani, Danae A. Laskaratou, Benjamin Frey, Serge M. Candéias, Udo S. Gaipl, Katalin Lumniczky & Alexandros G. Georgakilas. (2016) Key mechanisms involved in ionizing radiation-induced systemic effects. A current review. Toxicology Research 5:1, pages 12-33.
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D. Alloni, G. Baiocco, G. Babini, W. Friedland, P. Kundrát, L. Mariotti & A. Ottolenghi. (2015) Energy dependence of the complexity of DNA damage induced by carbon ions. Radiation Protection Dosimetry 166:1-4, pages 86-90.
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L. G. Mariotti, A. B. Abdelrazzak, A. Ottolenghi, P. O'Neill & M. A. Hill. (2015) Stimulation of intercellular induction of apoptosis in transformed cells at very low doses of ionising radiation: spatial and temporal features. Radiation Protection Dosimetry 166:1-4, pages 161-164.
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J. Morini, G. Babini, L. Mariotti, G. Baiocco, L. Nacci, C. Maccario, U. Rößler, A. Minelli, M. Savio, M. Gomolka, U. Kulka, A. Ottolenghi & C. Danesino. (2015) Radiosensitivity in lymphoblastoid cell lines derived from Shwachman–Diamond syndrome patients. Radiation Protection Dosimetry 166:1-4, pages 95-100.
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G. Babini, V. E. Bellinzona, J. Morini, G. Baiocco, L. Mariotti, K. Unger & A. Ottolenghi. (2015) Mechanisms of the induction of apoptosis mediated by radiation-induced cytokine release. Radiation Protection Dosimetry 166:1-4, pages 165-169.
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G. Babini, M. Ugolini, J. Morini, G. Baiocco, L. Mariotti, P. Tabarelli de Fatis, M. Liotta & A. Ottolenghi. (2015) Investigation of radiation-induced multilayered signalling response of the inflammatory pathway. Radiation Protection Dosimetry 166:1-4, pages 157-160.
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Maria Widel, Anna Lalik, Aleksandra Krzywon, Jan Poleszczuk, Krzysztof Fujarewicz & Joanna Rzeszowska-Wolny. (2015) The different radiation response and radiation-induced bystander effects in colorectal carcinoma cells differing in p53 status. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 778, pages 61-70.
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G. Babini, J. Morini, G. Baiocco, L. Mariotti & A. Ottolenghi. (2015) In vitro γ-ray-induced inflammatory response is dominated by culturing conditions rather than radiation exposures. Scientific Reports 5:1.
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Holger Klammer, Emil Mladenov, Fanghua Li & George Iliakis. (2015) Bystander effects as manifestation of intercellular communication of DNA damage and of the cellular oxidative status. Cancer Letters 356:1, pages 58-71.
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Dora Il’yasova, Alexander Kinev, C. David Melton & Faith G. Davis. (2014) Donor-Specific Cell-Based Assays in Studying Sensitivity to Low-Dose Radiation: A Population-Based Perspective. Frontiers in Public Health 2.
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Saravana Kanagavelu, Seema Gupta, Xiaodong Wu, Sakhi Philip, Max M. Wattenberg, James W. Hodge, Mariluz D. Couto, Kristina D. Chung & Mansoor M. Ahmed. (2014) In Vivo Effects of Lattice Radiation Therapy on Local and Distant Lung Cancer: Potential Role of Immunomodulation . Radiation Research 182:2, pages 149-162.
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Marlon R. Veldwijk, Bo Zhang, Frederik Wenz & Carsten Herskind. (2014) The Biological Effect of Large Single Doses: A Possible Role for Non-Targeted Effects in Cell Inactivation. PLoS ONE 9:1, pages e84991.
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D. Alloni, L.G. Mariotti & A. Ottolenghi. 2014. Comprehensive Biomedical Physics. Comprehensive Biomedical Physics 1 22 .
Luca G. Mariotti, Giacomo Pirovano, Kienan I. Savage, Mihaela Ghita, Andrea Ottolenghi, Kevin M. Prise & Giuseppe Schettino. (2013) Use of the γ-H2AX Assay to Investigate DNA Repair Dynamics Following Multiple Radiation Exposures. PLoS ONE 8:11, pages e79541.
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Chao-Pin Hsiao, Maria Araneta, Xiao Wang & Leorey Saligan. (2013) The Association of IFI27 Expression and Fatigue Intensification during Localized Radiation Therapy: Implication of a Para-Inflammatory Bystander Response. International Journal of Molecular Sciences 14:8, pages 16943-16957.
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D. Alloni, A. Campa, W. Friedland, L. Mariotti & A. Ottolenghi. (2013) Integration of Monte Carlo Simulations with PFGE Experimental Data Yields Constant RBE of 2.3 for DNA Double-Strand Break Induction by Nitrogen Ions between 125 and 225 keV/μm LET. Radiation Research 179:6, pages 690-697.
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Francesco Sciacca & Jeremy Jones. 2005. Radiopaedia.org. Radiopaedia.org.

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