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Original Articles

Hypoxia-inducible proteins HIF1α and lactate dehydrogenase LDH5, key markers of anaerobic metabolism, relate with stem cell markers and poor post-radiotherapy outcome in bladder cancer

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Pages 353-363 | Received 06 Oct 2015, Accepted 01 Mar 2016, Published online: 24 Mar 2016

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Savita V. Dandapani. 2017. Advances in Radiation Oncology. Advances in Radiation Oncology 223 238 .

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