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Molecular Membrane Biology Volume 12, 1995 - Issue 2
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Original Article

Partitioning of 1, 4-benzodiazepines into natural membranes

Maria A. Perillof Cátedra de Química Biológica, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Av. Velez Sarsfield 299, 5000, Córdoba, Argentina
,
Daniel A. Garcia Cátedra de Química Biológica, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Av. Velez Sarsfield 299, 5000, Córdoba, Argentina
&
Augusto Arce Cátedra de Química Biológica, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Av. Velez Sarsfield 299, 5000, Córdoba, Argentina
Pages 217-224 | Received 26 Sep 1994, Published online: 09 Jul 2009

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Mohammad Hossein Fatemi & Masoomeh Raei Moghaddam. (2012) Prediction of water-phosphatidylcholine membrane partition coefficient of some drugs from their molecular structures. Drug and Chemical Toxicology 35:4, pages 381-388.
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Articles from other publishers (22)

Mokhtar Ganjali Koli & Khaled Azizi. (2019) Investigation of benzodiazepines (BZDs) in a DPPC lipid bilayer: Insights from molecular dynamics simulation and DFT calculations. Journal of Molecular Graphics and Modelling 90, pages 171-179.
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Anahí V. Turina, Pedro D. Clop & María A. Perillo. (2015) Synaptosomal Membrane-Based Langmuir–Blodgett Films: A Platform for Studies on γ-Aminobutyric Acid Type A Receptor Binding Properties. Langmuir 31:5, pages 1792-1801.
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Benjam?n Caruso, Julieta M. S?nchez, Daniel A. Garc?a, Eneida Paula & Mar?a A. Perillo. (2012) Probing the Combined Effect of Flunitrazepam and Lidocaine on the Stability and Organization of Bilayer Lipid Membranes. A Differential Scanning Calorimetry and Dynamic Light Scattering Study. Cell Biochemistry and Biophysics 66:3, pages 461-475.
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A. V. Turina, G. J. Quinteros, B. Caruso, E. L. Moyano & M. A. Perillo. (2011) Surface active benzodiazepine-bromo-alkyl conjugate for potential GABAA-receptor purification. Organic & Biomolecular Chemistry 9:16, pages 5737.
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Alessandra Pagliara, Marianne Reist, Sandrine Geinoz, Pierre-Alain Carrupt & Bernard Testa. (1999) Evaluation and Prediction of Drug Permeation. Journal of Pharmacy and Pharmacology 51:12, pages 1339-1357.
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Gabriela N. Reiner, Diana O. Labuckas & Daniel A. García. (2009) Lipophilicity of some GABAergic phenols and related compounds determined by HPLC and partition coefficients in different systems. Journal of Pharmaceutical and Biomedical Analysis 49:3, pages 686-691.
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Mónica A. Raviolo, Julieta M. Sanchez, Margarita C. Briñón & María A. Perillo. (2008) Determination of liposome permeability of ionizable carbamates of zidovudine by steady state fluorescence spectroscopy. Colloids and Surfaces B: Biointerfaces 61:2, pages 188-198.
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A.del V. Turina, M.V. Nolan, J.A. Zygadlo & M.A. Perillo. (2006) Natural terpenes: Self-assembly and membrane partitioning. Biophysical Chemistry 122:2, pages 101-113.
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Julieta M. Sánchez, Iván Ciklic & María A. Perillo. (2005) Effect of partitioning equilibria on the activity of β-galactosidase in heterogeneous media. Biophysical Chemistry 118:2-3, pages 69-77.
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Daniel A. Garcı́a & Marı́a A. Perillo. (2004) Effects of flunitrazepam on the Lα-HII phase transition of phosphatidylethanolamine using merocyanine 540 as a fluorescent indicator. Colloids and Surfaces B: Biointerfaces 37:1-2, pages 61-69.
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Amnart Poapolathep, Yoshiko Sugita-Konishi, Kunio Doi & Susumu Kumagai. (2003) The fates of trichothecene mycotoxins, nivalenol and fusarenon-X, in mice. Toxicon 41:8, pages 1047-1054.
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Daniel A Garcı́a & Marı́a A Perillo. (2002) Flunitrazepam-membrane non-specific binding and unbinding: two pathways with different energy barriers. Biophysical Chemistry 95:2, pages 157-164.
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Ahmed Ahmed Omran, Keisuke Kitamura, Shigehiko Takegami, Tatsuya Kitade, Abdel-Aziz Youssef El-Sayed, Mahmoud Hamed Mohamed & Mohamed Abdel-Mottaleb. (2002) Effect of Phosphatidylserine Content on the Partition Coefficients of Diazepam and Flurazepam between Phosphatidylcholine–Phosphatidylserine Bilayer of Small Unilamellar Vesicles and Water Studied by Second Derivative Spectrophotometry. CHEMICAL & PHARMACEUTICAL BULLETIN 50:3, pages 312-315.
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Ahmed A. Omran, Keisuke Kitamura, Shigehiko Takegami, Abdel-Aziz Y. El-Sayed & Mohamed Abdel-Mottaleb. (2001) Determination of partition coefficients of diazepam and flurazepam between phosphatidylcholine bilayer vesicles and water by second derivative spectrophotometric method. Journal of Pharmaceutical and Biomedical Analysis 25:2, pages 319-324.
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Marı́a A Perillo & Daniel A Garcia. (2001) Flunitrazepam induces geometrical changes at the lipid–water interface. Colloids and Surfaces B: Biointerfaces 20:1, pages 63-72.
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Daniel A Garcı́a, Santiago Quiroga & Marı́a A Perillo. (2000) Flunitrazepam partitioning into natural membranes increases surface curvature and alters cellular morphology. Chemico-Biological Interactions 129:3, pages 263-277.
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Daniel A Garcı́a & Marı́a A Perillo. (1999) Benzodiazepine localisation at the lipid-water interface: effect of membrane composition and drug chemical structure. Biochimica et Biophysica Acta (BBA) - Biomembranes 1418:1, pages 221-231.
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N. G. Kolosova, G. M. Petrakova & M. A. Gilinskii. (1998) Effect of diazepam on the transmembrane potential and physicochemical state of the thymocyte membrane in rats during exposure to cold. Bulletin of Experimental Biology and Medicine 126:6, pages 1207-1209.
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Daniel A. Gasrc�a & Mar�a A. Perillo. (1997) Partitioning of flunitrazepam into model membranes studied by temperature controlled gel filtration chromatography. Biomedical Chromatography 11:6, pages 343-347.
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Daniel A. García & María A. Perillo. (1997) Supramolecular events modulate flunitrazepam partitioning into natural and model membranes. Colloids and Surfaces B: Biointerfaces 9:1-2, pages 49-57.
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Frédéric Reymond, Guillaume Steyaert, Alessandra Pagliara, Pierre‐Alain Carrupt, Bernard Testa & Hubert Girault. (2004) Transfer Mechanism of Ionic Drugs: Piroxicam as an agent facilitating proton transfer. Helvetica Chimica Acta 79:6, pages 1651-1669.
Crossref
M.A. Perillo & A. Arce. (1996) Estimation of the binding affinity constants of soluble ligand-receptor complexes by a rapid filtration technique: [3H]-flunitrazepam-bovine serum albumin as an example. Journal of Pharmacological and Toxicological Methods 35:2, pages 69-76.
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