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Original Article

Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine

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Pages 203-211 | Received 13 Jul 1998, Published online: 09 Jul 2009

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H. Kano, C. Saito, N. Yamada, T. Fukuuchi, N. Yamaoka, K. Kaneko & Y. Asami. (2020) Species-dependent patterns of incorporation of purine mononucleotides and nucleosides by lactic acid bacteria. Nucleosides, Nucleotides & Nucleic Acids 39:10-12, pages 1440-1448.
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M. Pastor-Anglada, P. Cano-soldado, E. Errasti-murugarren & F. J. Casado. (2008) SLC28 genes and concentrative nucleoside transporter (CNT) proteins. Xenobiotica 38:7-8, pages 972-994.
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George PH Leung & Chung-Ming Tse. (2007) The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity. Expert Opinion on Drug Metabolism & Toxicology 3:5, pages 705-718.
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Kyla M. Smith, Melissa D. Slugoski, Carol E. Cass, Stephen A. Baldwin, Edward Karpinski & James D. Young. (2007) Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. Molecular Membrane Biology 24:1, pages 53-64.
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Mark F. Vickers, James D. Young, Stephen A. Baldwin, Michael J. Ellison & Carol E. Cass. (2001) Functional production of mammalian concentrative nucleoside transporters in Saccharomyces cerevisiae. Molecular Membrane Biology 18:1, pages 73-79.
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Mark F Vickers, James D Young, Stephen A Baldwin, John R Mackey & Carol E Cass. (2000) Nucleoside transporter proteins: emerging targets for drug discovery. Emerging Therapeutic Targets 4:4, pages 515-539.
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Sonia Fernández-Veledo, Isabel Huber-Ruano, Ivette Aymerich, Sylvie Duflot, F. Javier Casado & Marçal Pastor-Anglada. (2006) Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells. Biochemical Journal 395:2, pages 337-344.
Crossref
Jing Zhang, Tracey Tackaberry, Mabel W. L. Ritzel, Taylor Raborn, Gerry Barron, Stephen A. BaldwinJames D. Young & Carol E. Cass. (2006) Cysteine-accessibility analysis of transmembrane domains 11–13 of human concentrative nucleoside transporter 3. Biochemical Journal 394:2, pages 389-398.
Crossref
Ho-Chul Shin, Jin-Suk Kim, Balvinder Singh Vig, Xueqin Song, John Charles Drach & Gordon Lewis Amidon. (2006) Interaction of Intestinal Nucleoside Transporter hCNT2 with Amino Acid Ester Prodrugs of Floxuridine and 2-Bromo-5,6-dichloro-1-β-D-ribofuranosylbenzimidazole. Biological & Pharmaceutical Bulletin 29:2, pages 247-252.
Crossref
Ricardo J.M. Governo, Jim Deuchars, Stephen A. Baldwin & Anne E. King. (2005) Localization of the NBMPR-sensitive equilibrative nucleoside transporter, ENT1, in the rat dorsal root ganglion and lumbar spinal cord. Brain Research 1059:2, pages 129-138.
Crossref
Liang Peng, Rong Huang, Albert C.H. Yu, King Y. Fung, Michel P. Rathbone & Leif Hertz. (2005) Nucleoside transporter expression and function in cultured mouse astrocytes. Glia 52:1, pages 25-35.
Crossref
Jing Zhang, Kyla M. Smith, Tracey Tackaberry, Frank Visser, Morris J. Robins, Lars P. C. Nielsen, Ireneusz Nowak, Edward Karpinski, Stephen A. Baldwin, James D. Young & Carol E. Cass. (2005) Uridine Binding and Transportability Determinants of Human Concentrative Nucleoside Transporters. Molecular Pharmacology 68:3, pages 830-839.
Crossref
Kyla M. Smith, Melissa D. Slugoski, Shaun K. Loewen, Amy M.L. Ng, Sylvia Y.M. Yao, Xing-Zhen Chen, Edward Karpinski, Carol E. Cass, Stephen A. Baldwin & James D. Young. (2005) The Broadly Selective Human Na+/Nucleoside Cotransporter(hCNT3) Exhibits Novel Cation-coupled Nucleoside TransportCharacteristics. Journal of Biological Chemistry 280:27, pages 25436-25449.
Crossref
Zoran Redzic. 2005. The Blood-Cerebrospinal Fluid Barrier. The Blood-Cerebrospinal Fluid Barrier 175 209 .
Sambasivarao Damaraju, Jing Zhang, Frank Visser, Tracey Tackaberry, Jennifer Dufour, Kyla M. Smith, Melissa Slugoski, Mabel W.L. Ritzel, Stephen A. Baldwin, James D. Young & Carol E. Cass. (2005) Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene. Pharmacogenetics and Genomics 15:3, pages 173-182.
Crossref
Ryo Kato, Tomoji Maeda, Toshihiro Akaike & Ikumi Tamai. (2005) Nucleoside Transport at the Blood-Testis Barrier Studied with Primary-Cultured Sertoli Cells. Journal of Pharmacology and Experimental Therapeutics 312:2, pages 601-608.
Crossref
Marçal Pastor-Anglada, Pedro Cano-Soldado, Míriam Molina-Arcas, M. Pilar Lostao, Ignacio Larráyoz, Javier Martínez-Picado & F. Javier Casado. (2005) Cell entry and export of nucleoside analogues. Virus Research 107:2, pages 151-164.
Crossref
Yurong Lai, Eun-Woo Lee, Carl C. Ton, Shashi Vijay, Huixia Zhang & Jashvant D. Unadkat. (2005) Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively. American Journal of Physiology-Cell Physiology 288:1, pages C39-C45.
Crossref
Vijaya L. Damaraju, Frank Visser, Jing Zhang, Delores Mowles, Amy M. L. Ng, James D. Young, Hiremagalur N. Jayaram & Carol E. Cass. (2005) Role of Human Nucleoside Transporters in the Cellular Uptake of Two Inhibitors of IMP Dehydrogenase, Tiazofurin and Benzamide Riboside. Molecular Pharmacology 67:1, pages 273-279.
Crossref
Marloes P. Schaddelee, Kevin D. Read, Cindy G.J. Cleypool, Adriaan P. IJzerman, Meindert Danhof & Albertus G. de Boer. (2005) Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents. European Journal of Pharmaceutical Sciences 24:1, pages 59-66.
Crossref
Ivette Aymerich, Marçal Pastor-Anglada & F. Javier Casado. (2004) Long Term Endocrine Regulation of Nucleoside Transporters in Rat Intestinal Epithelial Cells. The Journal of General Physiology 124:5, pages 505-512.
Crossref
Melissa D. Slugoski, Shaun K. Loewen, Amy M. L. Ng, Stephen A. Baldwin, Carol E. Cass & James D. Young. (2004) Allelic isoforms of the H + /nucleoside co‐transporter (CaCNT) from Candida albicans reveal separate high‐ and low‐affinity transport systems for nucleosides . Yeast 21:15, pages 1269-1277.
Crossref
Kyla M. Smith, Amy M. L. Ng, Sylvia Y. M. Yao, Kathy A. Labedz, Edward E. Knaus, Leonard I. Wiebe, Carol E. Cass, Stephen A. Baldwin, Xing-Zhen Chen, Edward Karpinski & James D. Young. (2004) Electrophysiological characterization of a recombinant human Na + -coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes . The Journal of Physiology 558:3, pages 807-823.
Crossref
Thack T. Lang, James D. Young & Carol E. Cass. (2004) Interactions of Nucleoside Analogs, Caffeine, and Nicotine with Human Concentrative Nucleoside Transporters 1 and 2 Stably Produced in a Transport-Defective Human Cell Line. Molecular Pharmacology 65:4, pages 925-933.
Crossref
M Pastor-Anglada, M Molina-Arcas, F J Casado, B Bellosillo, D Colomer & J Gil. (2004) Nucleoside transporters in chronic lymphocytic leukaemia. Leukemia 18:3, pages 385-393.
Crossref
Jason D Graci & Craig E Cameron. (2016) Challenges for the Development of Ribonucleoside Analogues as Inducers of Error Catastrophe. Antiviral Chemistry and Chemotherapy 15:1, pages 1-13.
Crossref
Antara Banerjee, Jeffrey S. Johnston & Peter W. Swaan. 2004. Cellular Drug Delivery. Cellular Drug Delivery 107 128 .
Jing Zhang, Frank Visser, Mark F. Vickers, Thack Lang, Morris J. Robins, Lars P.C. Nielsen, Ireneusz Nowak, Stephen A. Baldwin, James D. Young & Carol E. Cass. (2003) Uridine Binding Motifs of Human Concentrative Nucleoside Transporters 1 and 3 Produced in Saccharomyces cerevisiae . Molecular Pharmacology 64:6, pages 1512-1520.
Crossref
Vijaya L Damaraju, Sambasivarao Damaraju, James D Young, Stephen A Baldwin, John Mackey, Michael B Sawyer & Carol E Cass. (2003) Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene 22:47, pages 7524-7536.
Crossref
Lara M Mangravite, Ilaria Badagnani & Kathleen M Giacomini. (2003) Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. European Journal of Pharmacology 479:1-3, pages 269-281.
Crossref
Ho-Chul Shin, Christopher P. Landowski, Duxin Sun, Balvinder S. Vig, Insook Kim, Sachin Mittal, Majella Lane, Gustavo Rosania, John C. Drach & Gordon L. Amidon. (2003) Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. Biochemical and Biophysical Research Communications 307:3, pages 696-703.
Crossref
Shaun K. Loewen, Amy M. L. Ng, Nadira N. Mohabir, Stephen A. Baldwin, Carol E. Cass & James D. Young. (2003) Functional characterization of a H+/nucleoside co-transporter (CaCNT) fromCandida albicans, a fungal member of the concentrative nucleoside transporter (CNT) family of membrane proteins. Yeast 20:8, pages 661-675.
Crossref
Shinya Ito & Jane Alcorn. (2003) Xenobiotic transporter expression and function in the human mammary gland. Advanced Drug Delivery Reviews 55:5, pages 653-665.
Crossref
F. J. Casado, M. P. Lostao, I. Aymerich, I. M. Larráyoz, S. Duflot, S. Rodríguez-Mulero & M. Pastor-Anglada. (2002) Nucleoside transporters in absorptive epitheliaTransportadores de nucleósidos en los epitelios absorbentes. Journal of Physiology and Biochemistry 58:4, pages 207-216.
Crossref
J. Alcorn. (2002) Transporter Gene Expression in Lactating and Nonlactating Human Mammary Epithelial Cells Using Real-Time Reverse Transcription-Polymerase Chain Reaction. Journal of Pharmacology and Experimental Therapeutics 303:2, pages 487-496.
Crossref
Miguel A Cabrita, Stephen A Baldwin, James D Young & Carol E Cass. (2002) Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes. Biochemistry and Cell Biology 80:5, pages 623-638.
Crossref
Sylvia Y. Yao, Amy M. Ng, Shaun K. Loewen, Carol E. Cass, Stephen A. Baldwin & James D. Young. (2002) An ancient prevertebrate Na + -nucleoside cotransporter (hfCNT) from the Pacific hagfish ( Eptatretus stouti ) . American Journal of Physiology-Cell Physiology 283:1, pages C155-C168.
Crossref
Sylvia Y.M. Yao, Amy M.L. Ng, Mark F. Vickers, Manickavasagam Sundaram, Carol E. Cass, Stephen A. Baldwin & James D. Young. (2002) Functional and Molecular Characterization of Nucleobase Transport by Recombinant Human and Rat Equilibrative Nucleoside Transporters 1 and 2. Journal of Biological Chemistry 277:28, pages 24938-24948.
Crossref
Imogen Coe, Ying Zhang, Tamara McKenzie & Zlatina Naydenova. (2002) PKC regulation of the human equilibrative nucleoside transporter, hENT1. FEBS Letters 517:1-3, pages 201-205.
Crossref
S.A. Baldwin, C.E. Cass & J.D. Young. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Frank Visser, Mark F. Vickers, Amy M.L. Ng, Stephen A. Baldwin, James D. Young & Carol E. Cass. (2002) Mutation of Residue 33 of Human Equilibrative Nucleoside Transporters 1 and 2 Alters Sensitivity to Inhibition of Transport by Dilazep and Dipyridamole. Journal of Biological Chemistry 277:1, pages 395-401.
Crossref
Marilyn L. Clarke, John R. Mackey, Stephen A. Baldwin, James D. Young & Carol E. Cass. 2002. Clinically Relevant Resistance in Cancer Chemotherapy. Clinically Relevant Resistance in Cancer Chemotherapy 27 47 .
Carol E. Cass, James D. Young, Stephen A. Baldwin, Miguel A. Cabrita, Kathryn A. Graham, Mark Griffiths, Lori L. Jennings, John R. Mackey, Amy M. L. Ng, Mabel W. L. Ritzel, Mark F. Vickers & Sylvia Y. M. Yao. 2002. Membrane Transporters as Drug Targets. Membrane Transporters as Drug Targets 313 352 .
Thack T. Lang, Milada Selner, James D. Young & Carol E. Cass. (2001) Acquisition of Human Concentrative Nucleoside Transporter 2 (hCNT2) Activity by Gene Transfer Confers Sensitivity to Fluoropyrimidine Nucleosides in Drug-Resistant Leukemia Cells. Molecular Pharmacology 60:5, pages 1143-1152.
Crossref
C J D Sinclair, A E Powell, W Xiong, C G LaRivière, S A Baldwin, C E Cass, J D Young & F E Parkinson. (2009) Nucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitors. British Journal of Pharmacology 134:5, pages 1037-1044.
Crossref
Jian Yi Li, Ruben J. Boado & William M. Pardridge. (2016) Cloned Blood–Brain Barrier Adenosine Transporter is Identical to the Rat Concentrative Na + Nucleoside Cotransporter CNT2 . Journal of Cerebral Blood Flow & Metabolism 21:8, pages 929-936.
Crossref
Stephen R. Hamilton, Sylvia Y.M. Yao, Jean C. Ingram, Dawn A. Hadden, Mabel W.L. Ritzel, Maurice P. Gallagher, Peter J.F. Henderson, Carol E. Cass, James D. Young & Stephen A. Baldwin. (2001) Subcellular Distribution and Membrane Topology of the Mammalian Concentrative Na+-Nucleoside Cotransporter rCNT1. Journal of Biological Chemistry 276:30, pages 27981-27988.
Crossref
Lori L Jennings, Chunhai Hao, Miguel A Cabrita, Mark F Vickers, Stephen A Baldwin, James D. Young & Carol E Cass. (2001) Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous system. Neuropharmacology 40:5, pages 722-731.
Crossref
Emma Marshman, Gordon A. Taylor, Huw D. Thomas, David R. Newell & Nicola J. Curtin. (2001) Hypoxanthine transport in human tumour cell lines. Relationship to the inhibition of hypoxanthine rescue by dipyridamole22Abbreviations: ENT, equilibrative nucleoside transporter; CNT, concentrative nucleoside transporter; DP, dipyridamole; HPX, hypoxanthine; NBTI, nitrobenzylthioinosine; TdR, thymidine; Kt, kinetic constant for tansport; and Tmax, maximum velocity for transport.. Biochemical Pharmacology 61:4, pages 477-484.
Crossref
Simon Leung & Reina Bendayan. (2001) Uptake properties of lamivudine (3TC) by a continuous renal epithelial cell line. Canadian Journal of Physiology and Pharmacology 79:1, pages 59-66.
Crossref
Mabel W.L. Ritzel, Amy M.L. Ng, Sylvia Y.M. Yao, Kathryn Graham, Shaun K. Loewen, Kyla M. Smith, R. Gary Ritzel, Delores A. Mowles, Pat Carpenter, Xing-Zhen Chen, Edward Karpinski, Ralph J. Hyde, Stephen A. Baldwin, Carol E. Cass & James D. Young. (2001) Molecular Identification and Characterization of Novel Human and Mouse Concentrative Na+-Nucleoside Cotransporter Proteins (hCNT3 and mCNT3) Broadly Selective for Purine and Pyrimidine Nucleosides (System cib). Journal of Biological Chemistry 276:4, pages 2914-2927.
Crossref
Rémon A. M. H. Van Aubel, Rosalinde Masereeuw & Frans G. M. Russel. (2000) Molecular pharmacology of renal organic anion transporters. American Journal of Physiology-Renal Physiology 279:2, pages F216-F232.
Crossref
Milton H. SaierJrJr. (2002) Families of transmembrane sugar transport proteins. Molecular Microbiology 35:4, pages 699-710.
Crossref
James D. Young, Christopher I. Cheeseman, John R. Mackey, Carol E. Cass & Stephen A. Baldwin. 2000. Gastrointestinal transport molecular physiology. Gastrointestinal transport molecular physiology 329 378 .
J. R. Mackey, S. Y. M. Yao, K. M. Smith, E. Karpinski, S. A. Baldwin, C. E. Cass & J. D. Young. (1999) Gemcitabine Transport in Xenopus Oocytes Expressing Recombinant Plasma Membrane Mammalian Nucleoside Transporters. JNCI Journal of the National Cancer Institute 91:21, pages 1876-1881.
Crossref
Shaun K. Loewen, Amy M.L. Ng, Sylvia Y.M. Yao, Carol E. Cass, Stephen A. Baldwin & James D. Young. (1999) Identification of Amino Acid Residues Responsible for the Pyrimidine and Purine Nucleoside Specificities of Human Concentrative Na+ Nucleoside Cotransporters hCNT1 and hCNT2. Journal of Biological Chemistry 274:35, pages 24475-24484.
Crossref
Stephen A. Baldwin, John R. Mackey, Carol E. Cass & James D. Young. (1999) Nucleoside transporters: molecular biology and implications for therapeutic development. Molecular Medicine Today 5:5, pages 216-224.
Crossref

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