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Original Article

Cofactor Regeneration in Biocatalysis in Organic Media

Pages 1-30 | Received 15 Mar 1996, Published online: 11 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Frank Hollmann & Andreas Schmid. (2004) Electrochemical Regeneration of Oxidoreductases for Cell-free Biocatalytic Redox Reactions. Biocatalysis and Biotransformation 22:2, pages 63-88.
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Marrit Eckstein, Thomas Daußmann & Udo Kragl. (2004) Recent Developments in NAD(P)H Regeneration for Enzymatic Reductions in One- and Two-Phase Systems. Biocatalysis and Biotransformation 22:2, pages 89-96.
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Mats Andersson, Ralf Otto, Hans Holmberg & Patrick Adlercreutz. (1997) Alcaligenes Eutrophus Cells Containing Hydrogenase, a Coenzyme Regenerating Catalyst for Nadh-Dependent Oxidoreductases. Biocatalysis and Biotransformation 15:4, pages 281-296.
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Articles from other publishers (37)

Thilak Reddy Enugala, Marina Corbella Morató, Shina C. L. Kamerlin & Mikael Widersten. (2020) The Role of Substrate-Coenzyme Crosstalk in Determining Turnover Rates in Rhodococcus ruber Alcohol Dehydrogenase . ACS Catalysis 10:16, pages 9115-9128.
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Teng-Yun Wei, Jia-Wei Tang, Guo-Wei Ni, Hong-Yi Wang, Dong Yi, Fu-Li Zhang & Shao-Xin Chen. (2019) Development of an Enzymatic Process for the Synthesis of ( S )-2-Chloro-1-(2,4-dichlorophenyl) Ethanol . Organic Process Research & Development 23:9, pages 1822-1828.
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Lei Huang, Friso S. Aalbers, Wei Tang, Robert Röllig, Marco W. Fraaije & Selin Kara. (2019) Convergent Cascade Catalyzed by Monooxygenase–Alcohol Dehydrogenase Fusion Applied in Organic Media. ChemBioChem 20:13, pages 1653-1658.
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Kurt FaberKurt Faber. 2018. Biotransformations in Organic Chemistry. Biotransformations in Organic Chemistry 315 405 .
Gustav Rehn, Asbjørn Toftgaard Pedersen & John M. Woodley. (2016) Application of NAD(P)H oxidase for cofactor regeneration in dehydrogenase catalyzed oxidations. Journal of Molecular Catalysis B: Enzymatic 134, pages 331-339.
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Valerie Spieler, Bernhard Valldorf, Franziska Maaß, Alexander Kleinschek, Stefan H. Hüttenhain & Harald Kolmar. (2016) Coupled reactions on bioparticles: Stereoselective reduction with cofactor regeneration on PhaC inclusion bodies. Biotechnology Journal 11:7, pages 890-898.
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Dharmalingam Sivanesan & Sungho Yoon. (2013) Functionalized bipyridyl rhodium complex capable of electrode attachment for regeneration of NADH. Polyhedron 57, pages 52-56.
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Vanja Kaswurm, Wouter Van Hecke, Klaus Dieter Kulbe & Roland Ludwig. (2013) Guidelines for the Application of NAD(P)H Regenerating Glucose Dehydrogenase in Synthetic Processes. Advanced Synthesis & Catalysis 355:9, pages 1709-1714.
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Karl Fisher, Stephan Mohr, David Mansell, Nicholas J. Goddard, Peter R. Fielden & Nigel S. Scrutton. (2013) Electro-enzymatic viologen-mediated substrate reduction using pentaerythritol tetranitrate reductase and a parallel, segmented fluid flow system. Catalysis Science & Technology 3:6, pages 1505.
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Svenja Kochius, Anders O. Magnusson, Frank Hollmann, Jens Schrader & Dirk Holtmann. (2012) Immobilized redox mediators for electrochemical NAD(P)+ regeneration. Applied Microbiology and Biotechnology 93:6, pages 2251-2264.
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Fabian Rundbäck, Milica Fidanoska & Patrick Adlercreutz. (2012) Coupling of permeabilized cells of Gluconobacter oxydans and Ralstonia eutropha for asymmetric ketone reduction using H2 as reductant. Journal of Biotechnology 157:1, pages 154-158.
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Kurt FaberKurt Faber. 2011. Biotransformations in Organic Chemistry. Biotransformations in Organic Chemistry 315 390 .
Andreas Buthe, Songtao Wu & Ping Wang. 2011. Enzyme Stabilization and Immobilization. Enzyme Stabilization and Immobilization 37 48 .
Paul Thorey, Željko Knez & Maja Habulin. (2010) Alcohol dehydrogenase in non‐aqueous media using high‐pressure technologies: reaction set‐up and deactivation determination. Journal of Chemical Technology & Biotechnology 85:7, pages 1011-1016.
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Michael C. FlickingerLutz Hilterhaus, Andreas Liese & Udo Kragl. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology 1 14 .
Elton P. Hudson, Michael J. Liszka & Douglas S. Clark. 2010. Manual of Industrial Microbiology and Biotechnology. Manual of Industrial Microbiology and Biotechnology 509 523 .
Wei Zhang, Kevin O'Connor, Daniel I. C. Wang & Zhi Li. (2009) Bioreduction with Efficient Recycling of NADPH by Coupled Permeabilized Microorganisms. Applied and Environmental Microbiology 75:3, pages 687-694.
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Dirk Holtmann & Jens Schrader. 2007. Modern Biooxidation. Modern Biooxidation 265 290 .
Stephan Lütz. 2006. The Handbook of Homogeneous Hydrogenation. The Handbook of Homogeneous Hydrogenation 1470 1482 .
Reto Ruinatscha, Volker Höllrigl, Katja Otto & Andreas Schmid. (2006) Productivity of Selective Electroenzymatic Reduction and Oxidation Reactions: Theoretical and Practical Considerations. Advanced Synthesis & Catalysis 348:15, pages 2015-2026.
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Jie Zhang, Bernard Witholt & Zhi Li. (2006) Coupling of permeabilized microorganisms for efficient enantioselective reduction of ketone with cofactor recycling. Chem. Commun.:4, pages 398-400.
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Hidehiko Hirakawa, Noriho Kamiya, Yutaka Kawarabayashi & Teruyuki Nagamune. (2005) Log P effect of organic solvents on a thermophilic alcohol dehydrogenase. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1748:1, pages 94-99.
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Kurt FaberKurt Faber. 2004. Biotransformations in Organic Chemistry. Biotransformations in Organic Chemistry 334 418 .
Wilfred A van der Donk & Huimin Zhao. (2003) Recent developments in pyridine nucleotide regeneration. Current Opinion in Biotechnology 14:4, pages 421-426.
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Elena V. Kudryashova, Tatiana M. Artemova, Alexei A. Vinogradov, Alexander K. Gladilin, Vadim V. Mozhaev & Andrey V. Levashov. (2003) Stabilization and activation of α-chymotrypsin in water–organic solvent systems by complex formation with oligoamines. Protein Engineering, Design and Selection 16:4, pages 303-309.
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Thomas Schäfer, Ole Kirk, Torben Vedel Borchert, Claus Crone Fuglsang, Sven Pedersen, Sonja Salmon, Hans Sejr Olsen, Randy Deinhammer & Henrik Lund. 2005. Biopolymers Online. Biopolymers Online.
J Lutz, V.V Mozhaev, Yu.L Khmelnitsky, B Witholt & A Schmid. (2002) Preparative application of 2-hydroxybiphenyl 3-monooxygenase with enzymatic cofactor regeneration in organic-aqueous reaction media. Journal of Molecular Catalysis B: Enzymatic 19-20, pages 177-187.
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F Hollmann, B Witholt & A Schmid. (2002) [Cp∗Rh(bpy)(H2O)]2+: a versatile tool for efficient and non-enzymatic regeneration of nicotinamide and flavin coenzymes. Journal of Molecular Catalysis B: Enzymatic 19-20, pages 167-176.
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Manfred Biselli, Udo Kragl & Christian Wandrey. 2002. Enzyme Catalysis in Organic Synthesis. Enzyme Catalysis in Organic Synthesis 185 257 .
Andreas Schmid, Frank Hollmann & Bruno Bühler. 2002. Enzyme Catalysis in Organic Synthesis. Enzyme Catalysis in Organic Synthesis 1108 1170 .
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Andreas Schmid, Ingrid Vereyken, Martin Held & Bernard Witholt. (2001) Preparative regio- and chemoselective functionalization of hydrocarbons catalyzed by cell free preparations of 2-hydroxybiphenyl 3-monooxygenase. Journal of Molecular Catalysis B: Enzymatic 11:4-6, pages 455-462.
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Ursula Baminger, Roland Ludwig, Christiane Galhaup, Christian Leitner, Klaus D. Kulbe & Dietmar Haltrich. (2001) Continuous enzymatic regeneration of redox mediators used in biotransformation reactions employing flavoproteins. Journal of Molecular Catalysis B: Enzymatic 11:4-6, pages 541-550.
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Kurt FaberKurt Faber. 2000. Biotransformations in Organic Chemistry. Biotransformations in Organic Chemistry 334 418 .
PATRICK ADLERCREUTZ, MATS ANDERSSON & HANS HOLMBERG. (1998) Coenzyme-Dependent Oxidoreductions in Organic Media. Annals of the New York Academy of Sciences 864:1 ENZYME ENGINE, pages 180-182.
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Mats Andersson, Hans Holmberg & Patrick Adlercreutz. (1998) Evaluation ofAlcaligenes eutrophus cells as an NADH regenerating catalyst in organic-aqueous two-phase system. Biotechnology and Bioengineering 57:1, pages 79-86.
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S. Bielecki & R.I. Somiari. 1998. Stability and Stabilization of Biocatalysts, Proceedings of an International Symposium organized under auspices of the Working Party on Applied Biocatalysis of the European Federation of Biotechnology, the University of Cordoba, Spain, and the Spanish Society of Biotechnology. Stability and Stabilization of Biocatalysts, Proceedings of an International Symposium organized under auspices of the Working Party on Applied Biocatalysis of the European Federation of Biotechnology, the University of Cordoba, Spain, and the Spanish Society of Biotechnology 423 428 .

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