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Review Article

Nucleic acid-based biomarkers in body fluids of patients with urologic malignancies

, , , , &
Pages 200-231 | Received 15 Dec 2013, Accepted 10 Apr 2014, Published online: 30 May 2014

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Crossref
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Crossref
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Crossref
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Crossref
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Petros D. Grivas, Marilena Melas & Athanasios G. Papavassiliou. (2015) The biological complexity of urothelial carcinoma: Insights into carcinogenesis, targets and biomarkers of response to therapeutic approaches. Seminars in Cancer Biology 35, pages 125-132.
Crossref
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Crossref
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Crossref
Fanshuang Zhang, Xiaoyu Cheng, Yuan Yuan, Jianqiang Wu & Youhe Gao. (2015) Urinary microRNA can be concentrated, dried on membranes and stored at room temperature in vacuum bags. PeerJ 3, pages e1082.
Crossref
Yuxuan WangSimeon SpringerCarolyn L. MulveyNatalie SillimanJoy SchaeferMark SausenNathan JamesEleni M. RettigTheresa GuoCurtis R. PickeringJustin A. BishopChristine H. ChungJoseph A. CalifanoDavid W. EiseleCarole FakhryChristine G. GourinPatrick K. HaHyunseok KangAna KiessWayne M. KochJeffrey N. MyersHarry QuonJeremy D. RichmonDavid SidranskyRalph P. TufanoWilliam H. WestraChetan BettegowdaLuis A. DiazJr.Jr., Nickolas PapadopoulosKenneth W. KinzlerBert VogelsteinNishant Agrawal. (2015) Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Science Translational Medicine 7:293.
Crossref
Zhugen Yang, Marc Anglès d’Auriac, Sean Goggins, Barbara Kasprzyk-Hordern, Kevin V. Thomas, Christopher G. Frost & Pedro Estrela. (2015) A Novel DNA Biosensor Using a Ferrocenyl Intercalator Applied to the Potential Detection of Human Population Biomarkers in Wastewater. Environmental Science & Technology 49:9, pages 5609-5617.
Crossref
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Crossref
Carsten Stephan, Monika Jung, Silke Rabenhorst, Ergin Kilic & Klaus Jung. (2015) Urinary miR-183 and miR-205 do not surpass PCA3 in urine as predictive markers for prostate biopsy outcome despite their highly dysregulated expression in prostate cancer tissue. Clinical Chemistry and Laboratory Medicine (CCLM) 53:7.
Crossref
Eleonora Zonta, Philippe Nizard & Valérie Taly. 2015. 197 246 .
Siri Strand, Torben Orntoft & Karina Sorensen. (2014) Prognostic DNA Methylation Markers for Prostate Cancer. International Journal of Molecular Sciences 15:9, pages 16544-16576.
Crossref

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