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Critical Reviews in Clinical Laboratory Sciences Volume 52, 2015 - Issue 2
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Review Article

Pseudohyperkalemia: A new twist on an old phenomenon

Qing H. MengDepartment of Laboratory Medicine, MD Anderson Cancer Center, The University of Texas, Houston, TX, USACorrespondence[email protected]
&
Elizabeth A. WagarDepartment of Laboratory Medicine, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA
Pages 45-55 | Received 06 Aug 2014, Accepted 15 Sep 2014, Published online: 16 Oct 2014

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Bridgit O. Crews, Julia C. Drees & Dina N. Greene. (2020) Data-driven quality assurance to prevent erroneous test results. Critical Reviews in Clinical Laboratory Sciences 57:3, pages 146-160.
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Aman Verma, Michael Mbughuni, Evan Mariash & Hector Mesa. (2019) Hyperleukocytosis increases risk of fatal hyperkalemia with new ibrutinib/venetoclax regimen for refractory mantle cell lymphoma. Journal of Chemotherapy 31:7-8, pages 428-431.
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Articles from other publishers (46)

Thai Lun Tan, Ahmad Eijas, Sharon Mei Wern Chang, Nurul Hidayah Hashim, Nur Aasyirah Zakariah, Elina Subramaniam & Sy Liang Yong. (2023) Pseudohyperkalaemia Associated with Southeast Asian Ovalocytosis—a Case Report. SN Comprehensive Clinical Medicine 5:1.
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Alon Bnaya, Chezi Ganzel & Linda Shavit. (2023) Pseudohyperkalemia in chronic lymphocytic leukemia: Prevalence, impact, and management challenges. The American Journal of the Medical Sciences 366:3, pages 167-175.
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Diane H. Brown & Neil J. Paloian. (2023) Hypokalemia/Hyperkalemia and Hyponatremia/Hypernatremia. Pediatrics in Review 44:7, pages 349-362.
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Lu‐Lu Zhang, Xi Chen, Ying‐Ying Huang, Chi‐Xiong Liang, Meng‐Yun Qiang, Zhuo‐Chen Cai, Ze‐Jiang Zhan, Ying Deng, Jia‐Yu Zhou, Hao‐Yang Huang, Xiang Guo & Xing Lv. (2023) Incidence, consequences, and predictors of serious chemotherapy‐induced thrombocytopenia in nasopharyngeal carcinoma. Cancer Medicine 12:13, pages 14084-14093.
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Emine Emektar. (2023) Acute hyperkalemia in adults. Turkish Journal of Emergency Medicine 23:2, pages 75.
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Naszrin Arani & Adriana H. Wechsler. (2023) Hyperkalemia in the setting of severe leukocytosis: Should you treat?. The American Journal of Emergency Medicine.
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Jenna Spring & Laveena Munshi. (2022) Hematology Emergencies in Adults With Critical Illness. Chest 162:1, pages 120-131.
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Jenna Spring & Laveena Munshi. (2022) Hematology Emergencies in Critically Ill Adults. Chest 161:5, pages 1285-1296.
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Kleber Goia-Nishide, Lucas Coregliano-Ring & Érika Bevilaqua Rangel. (2022) Hyperkalemia in Diabetes Mellitus Setting. Diseases 10:2, pages 20.
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Rahul Gujarathi, Venu Chippa, Narsimha Candula & Meet Kadakia. (2022) Pseudohyperkalemia in a Patient With Chronic Lymphocytic Leukemia. Cureus.
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Yung-Chieh Huang, Fang-Liang Huang, Shang-Feng Tsai, Sheng-Ling Jan & Lin-Shien Fu. (2022) Pseudohyperkalemia accompanying actual hyperphosphatemia and hypocalcemia in an adolescent with T-lymphoblastic lymphoma. Clinical Biochemistry 101, pages 5-8.
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Carsten Hafer. (2022) Kalium in der Intensivmedizin. Aktuelle Ernährungsmedizin 47:01, pages 35-56.
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Briana M. Domenegato, Etienne Côté, Deepmala Agarwal, M. Lynne O’Sullivan, Elaine D. Reveler, Elizabeth Dobbin & Ellen McMahon. (2022) Effects of handling and storage on potassium concentration in plasma and serum samples obtained from cats. Journal of the American Veterinary Medical Association 260:2, pages 187-193.
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Samuel I. McCash & Melissa S. Pessin. 2022. Cancer Biomarkers. Cancer Biomarkers 67 92 .
Shiyi Geng, Emily F. Green, Michael C. Kurz & Jessica V. Rivera. (2021) Sodium bicarbonate administration and subsequent potassium concentration in hyperkalemia treatment. The American Journal of Emergency Medicine 50, pages 132-135.
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Carsten Hafer. (2021) Kalium – was Intensivmediziner wissen sollten. Intensivmedizin up2date 17:03, pages 291-312.
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Alon Bnaya, Rosa Ruchlemer, Eyal Itzkowitz, Ezra Gabbay, Ari Mosenkis & Linda Shavit. (2021) Incidence, risk factors, and recognition of pseudohyperkalemia in patients with chronic lymphocytic leukemia. International Journal of Hematology 114:1, pages 102-108.
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Şerif Ercan, Bahri Ramadan & Ozan Gerenli. (2021) Order of draw of blood samples affect potassium results without K-EDTA contamination during routine workflow. Biochemia Medica 31:2.
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L. O. MiakinkovaO. M. Toronchenko. (2021) CLINICAL ASPECTS OF HYPERKALIEMIA IN MODERN CARDIOLOGICAL PRACTICE. Bulletin of Problems Biology and Medicine 4:1, pages 47.
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Thomas G Morris, Sushmita Lamba, Thomas Fitzgerald, Gary Roulston, Helen Johnstone & Mehdi Mirzazadeh. (2020) The potential role of the eGFR in differentiating between true and pseudohyperkalaemia. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 57:6, pages 444-455.
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Dominika Szoke, Simone Caruso, Sara Pasqualetti & Mauro Panteghini. (2020) Further improvement of the quality of tube transportation system is needed to prevent ‘seasonal’ pseudohyperkalaemia. Clinica Chimica Acta 510, pages 644-646.
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Hui Zhuan Tan & Jason Chon Jun Choo. (2020) Pseudohyperkalemia with concurrent tumor lysis syndrome in extreme leukocytosis: Diagnostic and management pitfalls. Journal of Onco-Nephrology 4:3, pages 117-120.
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Mahmoud Ibrahim, Christina Seto & Tracy MacIntosh. (2020) Hyperkalemic Emergency: When You Have Taken a Few Too Many KCl Tablets. Cureus.
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Robert C Benirschke & Thomas J Gniadek. (2020) Detection of Falsely Elevated Point-of-Care Potassium Results Due to Hemolysis Using Predictive Analytics. American Journal of Clinical Pathology 154:2, pages 242-247.
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João Pedro Ferreira, Javed Butler, Patrick Rossignol, Bertram Pitt, Stefan D. Anker, Mikhail Kosiborod, Lars H. Lund, George L. Bakris, Matthew R. Weir & Faiez Zannad. (2020) Abnormalities of Potassium in Heart Failure. Journal of the American College of Cardiology 75:22, pages 2836-2850.
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O. Barbance, D. De Bels, P.M. Honoré, D. Bargalzan, A. Tolwani, K. Ismaili, D. Biarent & S. Redant. (2020) Potassium disorders in pediatric emergency department: Clinical spectrum and management. Archives de Pédiatrie 27:3, pages 146-151.
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Ming-Che Liu, Feng-Yi Chou, Yi-An Chien, Yen-Ju Chen, Masaichi Abe, Koki Furusho & Shunji Matsuki. (2020) Comparative pharmacokinetics of maxacalcitol in healthy Taiwanese and Japanese subjects. Heliyon 6:3, pages e03538.
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Anna E. Merrill & Allison B. Chambliss. 2020. Contemporary Practice in Clinical Chemistry. Contemporary Practice in Clinical Chemistry 651 663 .
Alisha D. Ware. 2020. Contemporary Practice in Clinical Chemistry. Contemporary Practice in Clinical Chemistry 429 444 .
M. Pasquier, M. Blancher, S. Buse, B. Boussat, G. Debaty, M. Kirsch, M. de Riedmatten, P. Schoettker, T. Annecke & P. Bouzat. (2019) Intra-patient potassium variability after hypothermic cardiac arrest: a multicentre, prospective study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 27:1.
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Guillaume Grzych, Jean‐David Pekar, Patrice Maboudou & Giuseppe Lippi. (2019) Leucocytosis‐induced plasma hyperkalaemia in samples conveyed by a pneumatic transport system: tips and tricks. British Journal of Haematology 186:4.
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Ashlin Rampul, Dipak Nowrungsah, Savathree Madurai & Tahir S. Pillay. (2019) Big data analysis reveals the existence of seasonal pseudohyperkalaemia even in temperate climates. Clinica Chimica Acta.
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Dina N Greene & Paul O Collinson. (2019) A Few Steps Closer to Optimizing Pseudohyperkalemia Detection. The Journal of Applied Laboratory Medicine 3:6, pages 919-921.
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Ross M Valentine, Angelique Barkhuizen, Richard Roberts, Clare Ford & Rousseau Gama. (2019) Pseudohyperkalemia—Not Always Benign. The Journal of Applied Laboratory Medicine 3:6, pages 1049-1053.
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Luca Di Lullo, Claudio Ronco, Antonio Granata, Ernesto Paoletti, Vincenzo Barbera, Mario Cozzolino, Maura Ravera, Maria Fusaro & Antonio Bellasi. (2019) Chronic Hyperkalemia in Cardiorenal Patients: Risk Factors, Diagnosis, and New Treatment Options. Cardiorenal Medicine 9:1, pages 8-21.
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Tony Malek & Leon Chen. (2019) Spurious Laboratory Values in Patients With Leukocytosis. Critical Care Nursing Quarterly 42:1, pages 44-46.
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K. Struniawski, S. Pogorzelski, D. Wróblewski, Ł. Kuźma, G. Kobus & S. Dobrzycki. (2018) Pseudohyperkalemia: in vitro phenomenon or misdiagnosis. A case report. Progress in Health Sciences 8:2, pages 239-242.
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Rimda Wanchoo, Carolina Bernabe Ramirez, Jacqueline Barrientos & Kenar D Jhaveri. (2018) Renal involvement in chronic lymphocytic leukemia. Clinical Kidney Journal 11:5, pages 670-680.
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Brit Long, Justin R. Warix & Alex Koyfman. (2018) Controversies in Management of Hyperkalemia. The Journal of Emergency Medicine 55:2, pages 192-205.
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James A Mays, Dina N Greene, Anna E Merrill & Patrick C Mathias. (2018) Evidence-Based Validation of Hemolysis Index Thresholds by Use of Retrospective Clinical Data. The Journal of Applied Laboratory Medicine 3:1, pages 109-114.
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Olga Ciepiela, Agata Raniszewska, Aneta Manda-Handzlik, Iwona Kotuła & Urszula Demkow. (2017) Pseudohyperkalemia in capillary whole-blood samples – an occasional error or a significant problem in a pediatric hospital?. Clinical Chemistry and Laboratory Medicine (CCLM) 55:8, pages e159-e162.
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Pratistha Ranjitkar, Dina N. Greene, Geoffrey S. Baird, Andrew N. Hoofnagle & Patrick C. Mathias. (2017) Establishing evidence-based thresholds and laboratory practices to reduce inappropriate treatment of pseudohyperkalemia. Clinical Biochemistry.
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Jenna Khan, Joshua A. Lieberman & Christina M. Lockwood. (2017) Variability in, variability out: best practice recommendations to standardize pre-analytical variables in the detection of circulating and tissue microRNAs. Clinical Chemistry and Laboratory Medicine (CCLM) 55:5.
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Tsering Dhondup & Qi Qian. (2017) Electrolyte and Acid-Base Disorders in Chronic Kidney Disease and End-Stage Kidney Failure. Blood Purification 43:1-3, pages 179-188.
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Vincenzo Roccaforte, Massimo Daves, Adawiya Alfreijat, Monica Riva, Maria Leitner, Stefania Filippi, Giulio Angaroni, Franco Montani, Stefan Platzgummer & Giuseppe Lippi. (2016) Spurious elevation of serum potassium concentration measured in samples with thrombocytosis. Diagnosis 3:2, pages 71-74.
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Richard H. Sterns, Marvin Grieff & Paul L. Bernstein. (2016) Treatment of hyperkalemia: something old, something new. Kidney International 89:3, pages 546-554.
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