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Review Article

Molecular malaria diagnostics: A systematic review and meta-analysis

, , &
Pages 87-105 | Received 12 Feb 2015, Accepted 04 Jul 2015, Published online: 17 Sep 2015

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Crossref
K.V. Ragavan, Sanni Kumar, Shiva Swaraj & Suresh Neethirajan. (2018) Advances in biosensors and optical assays for diagnosis and detection of malaria. Biosensors and Bioelectronics 105, pages 188-210.
Crossref
Sarah A. Budischak, Aprilianto E. Wiria, Firdaus Hamid, Linda J. Wammes, Maria M. M. Kaisar, Lisette van Lieshout, Erliyani Sartono, Taniawati Supali, Maria Yazdanbakhsh & Andrea L. Graham. (2018) Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections. Ecology Letters 21:4, pages 536-545.
Crossref
D. C. SIJBRANDA, B. D. GARTRELL, Z. L. GRANGE & L. HOWE. (2017) Use of a real-time PCR to explore the intensity of Plasmodium spp. infections in native, endemic and introduced New Zealand birds . Parasitology 144:13, pages 1743-1751.
Crossref
Manijeh Vafa Homann, S. Noushin Emami, Victor Yman, Christine Stenström, Klara Sondén, Hanna Ramström, Mattias Karlsson, Muhammad Asghar & Anna Färnert. (2017) Detection of Malaria Parasites After Treatment in Travelers: A 12-months Longitudinal Study and Statistical Modelling Analysis. EBioMedicine 25, pages 66-72.
Crossref
Nikhil Ranadive, Simon Kunene, Sarah Darteh, Nyasatu Ntshalintshali, Nomcebo Nhlabathi, Nomcebo Dlamini, Stanley Chitundu, Manik Saini, Maxwell Murphy, Adam Soble, Alanna Schwartz, Bryan Greenhouse & Michelle S. Hsiang. (2017) Limitations of Rapid Diagnostic Testing in Patients with Suspected Malaria: A Diagnostic Accuracy Evaluation from Swaziland, a Low-Endemicity Country Aiming for Malaria Elimination. Clinical Infectious Diseases 64:9, pages 1221-1227.
Crossref
Kenneth Gavina, Eliana Arango, Catalina Alvarez Larrotta, Amanda Maestre & Stephanie K. Yanow. (2017) A sensitive species-specific reverse transcription real-time PCR method for detection of Plasmodium falciparum and Plasmodium vivax. Parasite Epidemiology and Control 2:2, pages 70-76.
Crossref
T. Grossman, E. Schwartz, J. Vainer, V. Agmon, Y. Glazer, D. Goldmann & E. Marva. (2016) Contribution of real-time PCR to Plasmodium species identification and to clinical decisions: a nationwide study in a non-endemic setting. European Journal of Clinical Microbiology & Infectious Diseases 36:4, pages 671-675.
Crossref
Camille Ponce, Flora Kaczorowski, Thomas Perpoint, Patrick Miailhes, Alain Sigal, Etienne Javouhey, Yves Gillet, Laurent Jacquin, Marion Douplat, Karim Tazarourte, Véronique Potinet, Bruno Simon, Adeline Lavoignat, Guillaume Bonnot, Fatimata Sow, Anne-Lise Bienvenu & Stéphane Picot. (2017) Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for screening patients with imported malaria in a non-endemic setting. Parasite 24, pages 53.
Crossref
Catherine E. Majors, Chelsey A. Smith, Mary E. Natoli, Kathryn A. Kundrod & Rebecca Richards-Kortum. (2017) Point-of-care diagnostics to improve maternal and neonatal health in low-resource settings. Lab on a Chip 17:20, pages 3351-3387.
Crossref
Zhi Zheng & Zhibin Cheng. 2017. 155 192 .
Anofel, Françoise Botterel, M.-L. Dardé, A. Debourgogne, L. Delhaes, S. Houzé, F. Morio, C. Kauffmann-Lacroix & C. Roques. 2017. Parasitologie et Mycologie Médicales - Guide des Analyses et des Pratiques Diagnostiques. Parasitologie et Mycologie Médicales - Guide des Analyses et des Pratiques Diagnostiques 217 220 .
Sean C. Murphy. 2017. Encyclopedia of Malaria. Encyclopedia of Malaria 1 17 .
Sumudu Britton, Qin Cheng & James S. McCarthy. (2016) Novel molecular diagnostic tools for malaria elimination: a review of options from the point of view of high-throughput and applicability in resource limited settings. Malaria Journal 15:1.
Crossref

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