1,006
Views
74
CrossRef citations to date
0
Altmetric
Review Article

Generation of data on within-subject biological variation in laboratory medicine: An update

&
Pages 313-325 | Received 09 Oct 2015, Accepted 01 Feb 2016, Published online: 14 Mar 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Hayat Ozkanay, Fatma Demet Arslan, Figen Narin & Mehmet Hicri Koseoglu. (2023) Biological variation of plasma 25-Hydroxyvitamin D3, Serum vitamin B12, folate and ferritin in Turkish healthy subject. Scandinavian Journal of Clinical and Laboratory Investigation 83:7, pages 509-518.
Read now
Sander Bach, Birgit M.M. Wever, Mark A. van de Wiel, Joris D. Veltman, Sayed M.S. Hashemi, Geert Kazemier, Idris Bahce & Renske D.M. Steenbergen. (2022) Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients. Epigenetics 17:10, pages 1057-1069.
Read now
Paul R. Johnson, Shahram Shahangian & J. Rex Astles. (2021) Managing biological variation data: modern approaches for study design and clinical application. Critical Reviews in Clinical Laboratory Sciences 58:7, pages 493-512.
Read now
Morten Lindberg, Helle Borgstrøm Hager & Mette Brokner. (2019) Week-to-week biological variation of methylmalonic acid and homocysteine in healthy women. Scandinavian Journal of Clinical and Laboratory Investigation 79:4, pages 247-250.
Read now
Mette Brokner, Helle Borgstrøm Hager & Morten Lindberg. (2017) Biological variation of holotranscobalamin and cobalamin in healthy individuals. Scandinavian Journal of Clinical and Laboratory Investigation 77:6, pages 433-436.
Read now
Marek Kozinski, Magdalena Krintus, Jacek Kubica & Grazyna Sypniewska. (2017) High-sensitivity cardiac troponin assays: From improved analytical performance to enhanced risk stratification. Critical Reviews in Clinical Laboratory Sciences 54:3, pages 143-172.
Read now

Articles from other publishers (68)

Melnichnikova Olga, Zhilenkova Yuliya, Lukinov Vitaly, Zolotova Ekaterina, Pishchulov Konstantin, Evgina Svetlana, Simakova Maria & Vavilova Tatyana. (2023) Reference intervals and biological variation in parameters of the thrombin generation test in healthy individuals. International Journal of Laboratory Hematology.
Crossref
Anne Tranberg Madsen, Helle Pilgaard Kristiansen & Anne Winther-Larsen. (2023) Short-term biological variation of serum tryptase. Clinical Chemistry and Laboratory Medicine (CCLM) 0:0.
Crossref
Yakup Dülgeroğlu & Müjgan Ercan. (2023) Biological variation of serum neopterin concentrations in apparently healthy individuals. Clinical Chemistry and Laboratory Medicine (CCLM) 0:0.
Crossref
Hamit Hakan Alp. (2023) Re.: Louise Guillaume et al. Biological variation of CA 15-3, CA 125 and HE 4 on lithium heparinate plasma in apparently healthy Caucasian volunteers. Clin Chem Lab Med 2023;61(7):1319–1326; https://doi.org/10.1515/cclm-2022-0966. Clinical Chemistry and Laboratory Medicine (CCLM) 0:0.
Crossref
Louise Guillaume, Virginie Chapelle, Matthieu Deltombe, Arnaud Nevraumont, Antoine Mairesse, Diane Maisin & Damien Gruson. (2023) Biological variation of CA 15-3, CA 125 and HE 4 on lithium heparinate plasma in apparently healthy Caucasian volunteers. Clinical Chemistry and Laboratory Medicine (CCLM) 61:7, pages 1319-1326.
Crossref
Magdalena Krintus & Mauro Panteghini. (2023) Judging the clinical suitability of analytical performance of cardiac troponin assays. Clinical Chemistry and Laboratory Medicine (CCLM) 61:5, pages 801-810.
Crossref
Anne Winther-Larsen, Anne Tranberg Madsen, Peter H. Nissen, Elke Hoffmann-Lücke & Eva Greibe. (2023) Short-term biological variation of plasma uracil in a Caucasian healthy population. Clinical Chemistry and Laboratory Medicine (CCLM) 0:0.
Crossref
Gizem Yılmaz Çalık & Mehmet Şeneş. (2023) Biological variation estimates for spot urine analytes and analyte/creatinine ratios in 33 healthy subjects. Clinical Chemistry and Laboratory Medicine (CCLM) 0:0.
Crossref
Lennart J. van Winden, Mirthe Lanfermeijer, Vincent Dezentje, Andries M. Bergman, Henk G. van der Poel & Huub H. van Rossum. (2023) Predictive value of low testosterone concentrations during and prior to enzalutamide treatment in metastatic castration-resistant prostate cancer. Urologic Oncology: Seminars and Original Investigations 41:2, pages 104.e11-104.e17.
Crossref
Federica Braga, Sara Pasqualetti, Francesca Borrillo, Alessia Capoferri, Mariia Chibireva, Leila Rovegno & Mauro Panteghini. (2023) Definition and application of performance specifications for measurement uncertainty of 23 common laboratory tests: linking theory to daily practice. Clinical Chemistry and Laboratory Medicine (CCLM) 61:2, pages 213-223.
Crossref
S. Wang, M. Zhao, Z. Su & R. Mu. (2023) Annual biological variation and personalized reference intervals of clinical chemistry and hematology analytes. Laboratornaya sluzhba 12:2, pages 51.
Crossref
L. Wauthier, J. Favresse, M. Hardy, J. Douxfils, G. Le Gal, P.M. Roy, N. van Es, C. Ay, H. ten Cate, T. Lecompte, G. Lippi & F. Mullier. 2023. 151 223 .
David Morland, Elizabeth Katherine Anna Triumbari, Christopher Hoog, Ghali Sézin, Sébastien Dejust, Guillaume Cadiot, Pierre Paris & Dimitri Papathanassiou. (2022) Predicting subacute hematological toxicity of 177Lu-DOTATATE therapy using healthy organs’ uptake on post-treatment quantitative SPECT: A pilot study. Medicine 101:49, pages e32212.
Crossref
Silje Hovden Christensen, Claus Vinter Bødker Hviid, Anne Tranberg Madsen, Tina Parkner & Anne Winther-Larsen. (2022) Short-term biological variation of serum glial fibrillary acidic protein. Clinical Chemistry and Laboratory Medicine (CCLM) 60:11, pages 1813-1819.
Crossref
Stefanie Thöni, Felix Keller, Sara Denicolò, Lukas Buchwinkler & Gert Mayer. (2022) Biological variation and reference change value of the estimated glomerular filtration rate in humans: A systematic review and meta-analysis. Frontiers in Medicine 9.
Crossref
Liming Ma, Bin Zhang, Limei Luo, Rui Shi, Yonghua Wu & Yunshuang Liu. (2022) Biological variation estimates obtained from Chinese subjects for 32 biochemical measurands in serum. Clinical Chemistry and Laboratory Medicine (CCLM) 60:10, pages 1648-1660.
Crossref
Erica M Fatica, Sarah M Jenkins, Renee J Scott, Darci R Block, Jeffrey W Meeusen, Nikola A Baumann, Amy K Saenger & Leslie J Donato. (2022) Short- and Long-Term Biological Variability of Small Dense LDL, HDL3, and Triglyceride-Rich Lipoprotein Cholesterol. The Journal of Applied Laboratory Medicine 7:5, pages 1047-1061.
Crossref
Alice Brochier, Antoine Mairesse, Pascale Saussoy, Christel Gavard, Sandrine Desmet, Cédric Hermans, Damien Gruson & Marie-Astrid van Dievoet. (2022) Short-term biological variation study of plasma hemophilia and thrombophilia parameters in a population of apparently healthy Caucasian adults. Clinical Chemistry and Laboratory Medicine (CCLM) 60:9, pages 1409-1415.
Crossref
Mariangela Altilia, Federica Braga, Alessia Capoferri & Mauro Panteghini. (2022) Biological variation of serum cholinesterase catalytic concentrations. Clinical Chemistry and Laboratory Medicine (CCLM) 60:8, pages e177-e180.
Crossref
Wupu Osimanjiang, JuliAnne E. Allgood, Rae L. Van Sandt, Daniel T. Burns & Jared S. Bushman. (2022) Sexual Dimorphism in Lesion Size and Sensorimotor Responses Following Spinal Cord Injury. Frontiers in Neurology 13.
Crossref
Kristen R. Friedrichs, Asger Lundorff Jensen & Mads Kjelgaard‐Hansen. 2022. Schalm's Veterinary Hematology. Schalm's Veterinary Hematology 1273 1284 .
Huub H. van Rossum, Qing H. Meng, Lakshmi V. Ramanathan & Stefan Holdenrieder. (2022) A word of caution on using tumor biomarker reference change values to guide medical decisions and the need for alternatives. Clinical Chemistry and Laboratory Medicine (CCLM) 60:4, pages 553-555.
Crossref
Fernando Marques-Garcia, Beatriz Boned, Elisabet González-Lao, Federica Braga, Anna Carobene, Abdurrahman Coskun, Jorge Díaz-Garzón, Pilar Fernández-Calle, Maria Carmen Perich, Margarida Simon, Niels Jonker, Berna Aslan, William Alexander Bartlett, Sverre Sandberg & Aasne K. Aarsand. (2022) Critical review and meta-analysis of biological variation estimates for tumor markers. Clinical Chemistry and Laboratory Medicine (CCLM) 60:4, pages 494-504.
Crossref
Shuo Wang, Min Zhao, Zihan Su & Runqing Mu. (2022) Annual biological variation and personalized reference intervals of clinical chemistry and hematology analytes. Clinical Chemistry and Laboratory Medicine (CCLM) 60:4, pages 606-617.
Crossref
Claus Vinter Bødker Hviid, Anne Tranberg Madsen & Anne Winther-Larsen. (2022) Biological variation of serum neurofilament light chain. Clinical Chemistry and Laboratory Medicine (CCLM) 60:4, pages 569-575.
Crossref
Antonín Jabor, Tereza Vacková, Zdenek Kubíček, Jitka Komrsková, Marek Protuš & Janka Franeková. (2021) Biological variation of proprotein convertase subtilisin/kexin type 9 (PCSK9) in human serum. Clinica Chimica Acta 521, pages 59-63.
Crossref
Federica Braga & Mauro Panteghini. (2021) Performance specifications for measurement uncertainty of common biochemical measurands according to Milan models. Clinical Chemistry and Laboratory Medicine (CCLM) 59:8, pages 1362-1368.
Crossref
Antoine Mairesse, Jean‐Louis Bayart, Sandrine Desmet, Helder Lopes Dos Santos, Pascale Saussoy, Jean‐Philippe Defour, Stéphane Eeckhoudt & Marie‐Astrid Dievoet. (2020) Biological variation data and analytical specification goal estimates of the thrombin generation assay with and without thrombomodulin in healthy individuals. International Journal of Laboratory Hematology 43:3, pages 450-457.
Crossref
Antoine Mairesse, Loris Wauthier, Louisiane Courcelles, Urszula Luyten, Maria‐Cristina Burlacu, Diane Maisin, Julien Favresse, Marie‐Astrid Dievoet & Damien Gruson. (2021) Biological variation and analytical goals of four thyroid function biomarkers in healthy European volunteers. Clinical Endocrinology 94:5, pages 845-850.
Crossref
Hamza Anwer, Dominic Mason, Susanne Zajitschek, Daniel W.A. Noble, Daniel Hesselson, Margaret J. Morris, Malgorzata Lagisz & Shinichi Nakagawa. (2021) An efficient new assay for measuring zebrafish anxiety: Tall tanks that better characterize between-individual differences. Journal of Neuroscience Methods 356, pages 109138.
Crossref
Simona Ferraro, Marco Bussetti, Roberta Simona Rossi, Giacomo Piero Incarbone & Mauro Panteghini. (2021) Is pre-biopsy serum prostate specific antigen retesting always justified? A study of the influence of individual and analytical factors on decision making for biopsy referral. Clinica Chimica Acta 516, pages 77-82.
Crossref
Osman Oğuz, Hilal Mercan & F. Sinem Hocaoglu-Emre. (2021) Biological variation of glycated albumin, glucose and albumin in healthy Turkish subjects. Turkish Journal of Biochemistry 46:2, pages 197-203.
Crossref
Alexandra Jungert & Jan Frank. (2021) Intra-Individual Variation and Reliability of Biomarkers of the Antioxidant Defense System by Considering Dietary and Lifestyle Factors in Premenopausal Women. Antioxidants 10:3, pages 448.
Crossref
Unity Jeffery, Nick D. Jeffery, Kate E. Creevy, Rod Page & Melissa J. Simpson. (2021) Variation in biochemistry test results between annual wellness visits in apparently healthy Golden Retrievers. Journal of Veterinary Internal Medicine 35:2, pages 912-924.
Crossref
Selçuk Korkmaz, Gökmen Zarasız, Dinçer Göksülük, Mehmet Senes, Cem Sönmez & Dogan Yucel. (2020) BioVar: an online biological variation analysis tool. Turkish Journal of Biochemistry 45:5, pages 479-489.
Crossref
Jean-Louis Bayart, Antoine Mairesse, Damien Gruson & Marie-Astrid van Dievoet. (2020) Analytical performances and biological variation of PIVKA-II (des-y-carboxy-prothrombin) in European healthy adults. Clinica Chimica Acta 509, pages 264-267.
Crossref
Chenbin Li, Mingting Peng, Ji Wu, Zhongli Du, Hong Lu & Wenbin Zhou. (2020) Long-term biological variation estimates of 13 hematological parameters in healthy Chinese subjects. Clinical Chemistry and Laboratory Medicine (CCLM) 58:8, pages 1282-1290.
Crossref
Miriam Aceves, Valerie A. Dietz, Jennifer N. Dulin, Unity Jeffery & Nicholas D. Jeffery. (2020) An Analysis of Variability in “CatWalk” Locomotor Measurements to Aid Experimental Design and Interpretation. eneuro 7:4, pages ENEURO.0092-20.2020.
Crossref
Shuo Wang, Runqing Mu, Xin Zhang, Ke Yun, Hong Shang & Min Zhao. (2020) Biological variation in serum bone turnover markers. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 57:2, pages 144-150.
Crossref
Federica Braga, Simona Ferraro, Simona Borille & Mauro Panteghini. (2020) Biological variation of two serum markers for preeclampsia prediction. Clinical Chemistry and Laboratory Medicine (CCLM) 58:2, pages e27-e28.
Crossref
Erdem ÇOKLUK. (2019) Klinik biyokimyada biyolojik varyasyon: Referansdeğişim değeri ve bireysellik indeksiBiological variation in clinical biochemistry: Reference change value and ındividual ındex. Turkish Journal of Clinics and Laboratory 10:4, pages 526-532.
Crossref
Federica Braga, Elena Aloisio, Andrea Panzeri, Takahito Nakagawa & Mauro Panteghini. (2019) Analytical validation of a highly sensitive point-of-care system for cardiac troponin I determination. Clinical Chemistry and Laboratory Medicine (CCLM) 58:1, pages 138-145.
Crossref
Brooke M. Katzman, Amy M. Wockenfus, Renee J. Scott, Sandra C. Bryant, Allan S. Jaffe & Brad S. Karon. (2019) Estimating short- and long-term reference change values and index of individuality for tests of platelet function. Clinical Biochemistry 74, pages 54-59.
Crossref
Anne Tranberg Madsen, Johanne Andersen Hojbjerg, Boe Sandahl Sorensen & Anne Winther-Larsen. (2019) Day-to-day and within-day biological variation of cell-free DNA. eBioMedicine 49, pages 284-290.
Crossref
Elena Aloisio, Alberto Dolci & Mauro Panteghini. (2019) Procalcitonin: Between evidence and critical issues. Clinica Chimica Acta 496, pages 7-12.
Crossref
Simona Ferraro & Mauro Panteghini. (2019) Making new biomarkers a reality: the case of serum human epididymis protein 4. Clinical Chemistry and Laboratory Medicine (CCLM) 57:9, pages 1284-1294.
Crossref
Jia Wei, Yi-ning Wu, Yun Ling, Xiao-ting Chen, Qiong Zhu & Jian Xu. (2019) False decrease of high-sensitivity cardiac troponin T assay in pneumatic tube system samples. Clinica Chimica Acta 495, pages 507-511.
Crossref
Antonín Jabor, Zdenek Kubíček, Magda Labanczová & Janka Franeková. (2019) Presepsin: what is important for correct interpretation. Vnitřní lékařství 65:7-8, pages 490-496.
Crossref
Mesude Falay, Mehmet Senes, Selçuk Korkmaz, Gökmen Zararsız, Turan Turhan, Murat Okay, Çiğdem Yücel, Muhammed Fevzi Kılınckaya, Gulsum Ozet & Dogan Yucel. (2019) Biological variation of peripheral blood T-lymphocytes. Journal of Immunological Methods 470, pages 1-5.
Crossref
Magdalena Krintus, Federica Braga, Marek Kozinski, Simona Borille, Jacek Kubica, Grazyna Sypniewska & Mauro Panteghini. (2019) A study of biological and lifestyle factors, including within-subject variation, affecting concentrations of growth differentiation factor 15 in serum. Clinical Chemistry and Laboratory Medicine (CCLM) 57:7, pages 1035-1043.
Crossref
Antonín Jabor, Zdenek Kubíček, Jitka Komrsková, Tereza Vacková, Jiří Vymětalík & Janka Franeková. (2019) Biological variation of intact fibroblast growth factor 23 measured on a fully automated chemiluminescent platform. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 56:3, pages 381-386.
Crossref
M. E. Wright, E. L. Croser, S. Raidal, R. M. Baral, W. Robinson, J. Lievaart & K. P. Freeman. (2018) Biological variation of routine haematology and biochemistry measurands in the horse. Equine Veterinary Journal 51:3, pages 384-390.
Crossref
Shun Kubo, Masaki Iwasaki, Mari Horie, Ai Matsukane, Toshihide Hayashi, Yuri Tanaka, Hiroki Hase & Nobuhiko Joki. (2018) Biological variation of procalcitonin levels in hemodialysis patients. Clinical and Experimental Nephrology 23:3, pages 402-408.
Crossref
F. Ceriotti, P. Fernandez-Calle, G. G. Klee, G. Nordin, S. Sandberg, T. Streichert, J.-L. Vives-Corrons & M. Panteghini. (2019) Criteria for assigning laboratory measurands to models for analytical performance specifications defined in the 1st EFLM Strategic Conference. Laboratornaya sluzhba 8:1, pages 93.
Crossref
Matthew A. Kopke, Richard K. Burchell, Craig G. Ruaux, Stacey E. Burton, Nicolas Lopez-Villalobos & Arnon Gal. (2019) Response to letter to editor regarding Variability of symmetric dimethylarginine in apparently healthy dogs. Journal of Veterinary Internal Medicine 33:1, pages 9-10.
Crossref
Ian Farrance, Tony Badrick & Robert Frenkel. (2018) Uncertainty in measurement: A review of the procedures for determining uncertainty in measurement and its use in deriving the biological variation of the estimated glomerular filtration rate. Practical Laboratory Medicine 12, pages e00097.
Crossref
Rebecca Whittle, George Peat, John Belcher, Gary S. Collins & Richard D. Riley. (2018) Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported. Journal of Clinical Epidemiology 102, pages 38-49.
Crossref
Antonín Jabor, Zdenek Kubíček, Soňa Fraňková, Renáta Šenkeříková & Janka Franeková. (2018) Enhanced liver fibrosis (ELF) score: Reference ranges, biological variation in healthy subjects, and analytical considerations. Clinica Chimica Acta 483, pages 291-295.
Crossref
Nicoline H. J. Leenders, Frans J. van Ittersum, Tiny Hoekstra, Joost G. J. Hoenderop & Marc G. Vervloet. (2018) Routine hemodialysis induces a decline in plasma magnesium concentration in most patients: a prospective observational cohort study. Scientific Reports 8:1.
Crossref
Paola Lanuti, Pasquale Simeone, Gianluca Rotta, Camillo Almici, Giuseppe Avvisati, Rosa Azzaro, Giuseppina Bologna, Alfredo Budillon, Melania Di Cerbo, Elena Di Gennaro, Maria Luisa Di Martino, Annamaria Diodato, Paolo Doretto, Eva Ercolino, Alessandra Falda, Chiara Gregorj, Alessandra Leone, Francesca Losa, Natalia Malara, Mirella Marini, Pasquale Mastroroberto, Vincenzo Mollace, Michele Morelli, Emma Muggianu, Giuseppe Musolino, Arabella Neva, Laura Pierdomenico, Silvia Pinna, Giovanna Piovani, Maria Serena Roca, Domenico Russo, Lorenza Scotti, Maria Cristina Tirindelli, Valentina Trunzo, Roberta Venturella, Carlo Vitagliano, Fulvio Zullo, Marco Marchisio & Sebastiano Miscia. (2018) A standardized flow cytometry network study for the assessment of circulating endothelial cell physiological ranges. Scientific Reports 8:1.
Crossref
Dagan YangQian CaiXinglun QiYunxian Zhou. (2018) Postprandial Lipid Concentrations and Daytime Biological Variation of Lipids in a Healthy Chinese Population. Annals of Laboratory Medicine 38:5, pages 431.
Crossref
Sara Pasqualetti, Federica Braga & Mauro Panteghini. (2017) Pre-analytical and analytical aspects affecting clinical reliability of plasma glucose results. Clinical Biochemistry 50:10-11, pages 587-594.
Crossref
Sabrina Buoro, Michela Seghezzi, Barbara Manenti, Aurelio Pacioni, Anna Carobene, Ferruccio Ceriotti, Cosimo Ottomano & Giuseppe Lippi. (2017) Biological variation of platelet parameters determined by the Sysmex XN hematology analyzer. Clinica Chimica Acta 470, pages 125-132.
Crossref
D. Yang, Y. Zhou & C. Yang. (2016) Daytime biological variation of hematological parameters in a healthy Chinese population. International Journal of Laboratory Hematology 39:2.
Crossref
Ferruccio Ceriotti, Pilar Fernandez-Calle, George G. Klee, Gunnar Nordin, Sverre Sandberg, Thomas Streichert, Joan-Lluis Vives-Corrons & Mauro Panteghini. (2017) Criteria for assigning laboratory measurands to models for analytical performance specifications defined in the 1st EFLM Strategic Conference. Clinical Chemistry and Laboratory Medicine (CCLM) 55:2, pages 189-194.
Crossref
Simona Ferraro, Andrea Panzeri & Mauro Panteghini. (2017) Tackling serum folate test in European countries within the health technology assessment paradigm: request appropriateness, assays and health outcomes. Clinical Chemistry and Laboratory Medicine (CCLM) 55:9.
Crossref
Mauro Panteghini, Ferruccio Ceriotti, Graham Jones, Wytze Oosterhuis, Mario Plebani & Sverre Sandberg. (2017) Strategies to define performance specifications in laboratory medicine: 3 years on from the Milan Strategic Conference. Clinical Chemistry and Laboratory Medicine (CCLM) 55:12.
Crossref
Sabrina Coelli, Camila Bergonsi Farias, Ariana Aguiar Soares, Gabriele Martins Crescente, Vânia Naomi Hirakata, Luiza Barboza Souza, Mauro Antônio Czepielewski, Joíza Lins Camargo & Sandra Pinho Silveiro. (2017) Influence of age, gender and body mass index on late-night salivary cortisol in healthy adults. Clinical Chemistry and Laboratory Medicine (CCLM) 55:12.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.