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Research Article

Binding of Bilirubin to Albumin

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Pages 307-399 | Published online: 27 Sep 2008

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Christine Mölzer, Hedwig Huber, Andrea Steyrer, Gesa Ziesel, Anita Ertl, Admira Plavotic, Marlies Wallner, Andrew Cameron Bulmer & Karl-Heinz Wagner. (2012) In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrroles. Free Radical Research 46:11, pages 1369-1377.
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Smruti R. Sahoo, Sandy Huey-Jen Hsu, Dev-Aur Chou, Gou-Jen Wang & Cheng-Chung Chang. (2022) Surface plasmon-enhanced fluorescence and surface-enhanced Raman scattering dual-readout chip constructed with silver nanowires: Label-free clinical detection of direct-bilirubin. Biosensors and Bioelectronics 213, pages 114440.
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Libor Vítek. 2022. Carbon Monoxide in Drug Discovery. Carbon Monoxide in Drug Discovery 175 194 .
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Xiang Pan, Linhu Li, Hangduo Lin, Jiayi Tan, Haitao Wang, Mengling Liao, Caiju Chen, Beibei Shan, Yingfan Chen & Ming Li. (2019) A graphene oxide-gold nanostar hybrid based-paper biosensor for label-free SERS detection of serum bilirubin for diagnosis of jaundice. Biosensors and Bioelectronics 145, pages 111713.
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Allan W. Wolkoff  & Paul D. Berk. 2017. Schiff's Diseases of the Liver. Schiff's Diseases of the Liver 103 134 .
Karl-Heinz Wagner, Marlies Wallner, Christine Mölzer, Silvia Gazzin, Andrew Cameron Bulmer, Claudio Tiribelli & Libor Vitek. (2015) Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases. Clinical Science 129:1, pages 1-25.
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Jon F. Watchko & M. Jeffrey Maisels. (2014) The enigma of low bilirubin kernicterus in premature infants: Why does it still occur, and is it preventable?. Seminars in Perinatology 38:7, pages 397-406.
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Mónika Szabó, Zsuzsa Veres, Attila Bátai-Konczos, Orsolya Kékesi, Emese Kis, Kitti Szabó & Katalin Jemnitz. (2014) Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes. Toxicology in Vitro 28:6, pages 1136-1143.
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. (2014) Bilirubin-Induced Neurologic Damage. New England Journal of Medicine 370:10, pages 978-979.
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A. Bhogale, N. Patel, J. Mariam, P.M. Dongre, A. Miotello & D.C. Kothari. (2014) Comprehensive studies on the interaction of copper nanoparticles with bovine serum albumin using various spectroscopies. Colloids and Surfaces B: Biointerfaces 113, pages 276-284.
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Iryna Goncharova, Sergey Orlov & Marie Urbanová. (2013) The location of the high- and low-affinity bilirubin-binding sites on serum albumin: Ligand-competition analysis investigated by circular dichroism. Biophysical Chemistry 180-181, pages 55-65.
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Hiroyuki MoriyaKatsuhiko SaitoNuala HelsbyShigekazu SuginoMichiaki YamakageMasahiko TakasakiHidenori KatoNahoko Kurosawa. (2013) The Association Between Heterozygosity for UGT1A1*6 , UGT1A1*28 , and Variation in the Serum Total-Bilirubin Level in Healthy Young Japanese Adults . Genetic Testing and Molecular Biomarkers 17:6, pages 464-469.
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Iryna Goncharova, Sergey Orlov & Marie Urbanová. (2013) Chiroptical Properties of Bilirubin-Serum Albumin Binding Sites. Chirality 25:4, pages 257-263.
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M J Maisels, J F Watchko, V K Bhutani & D K Stevenson. (2012) An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation. Journal of Perinatology 32:9, pages 660-664.
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Allan W. Wolkoff & Paul D. Berk. 2011. Schiff's Diseases of the Liver. Schiff's Diseases of the Liver 120 151 .
Ai Minomo, Yu Ishima, Ulrich Kragh‐Hansen, Victor T. G. Chuang, Makiyo Uchida, Kazuaki Taguchi, Hiroshi Watanabe, Toru Maruyama, Hiroshi Morioka & Masaki Otagiri. (2011) Biological characteristics of two lysines on human serum albumin in the high‐affinity binding of 4 Z ,15 Z ‐bilirubin‐IXα revealed by phage display . The FEBS Journal 278:21, pages 4100-4111.
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Ali J. Ryan, Jamie Ghuman, Patricia A. Zunszain, Chun-wa Chung & Stephen Curry. (2011) Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin. Journal of Structural Biology 174:1, pages 84-91.
Crossref
Thor Willy Ruud-Hansen. 2011. Fetal and Neonatal Physiology. Fetal and Neonatal Physiology 1295 1306 .
Allison Przekop & Terence D. Sanger. 2011. Hyperkinetic Movement Disorders. Hyperkinetic Movement Disorders 387 395 .
Sanjiv B. Amin, Theresa Harte, Lori Scholer & Hongyue Wang. (2009) Intravenous Lipid and Bilirubin-Albumin Binding Variables in Premature Infants. Pediatrics 124:1, pages 211-217.
Crossref
Sandra M. Arriaga, Cecilia L. Basiglio, Aldo D. Mottino & Adriana M. Almará. (2009) Unconjugated bilirubin inhibits C1 esterase activity. Clinical Biochemistry 42:9, pages 919-921.
Crossref
Karl B. McCann, Yvonne Vucica, Sandy Famulari & Joseph Bertolini. (2009) Effect of processing methods on colouration of human serum albumin preparations. Biologicals 37:1, pages 32-36.
Crossref
Ann C Rice & Steven M Shapiro. (2008) A New Animal Model of Hemolytic Hyperbilirubinemia-Induced Bilirubin Encephalopathy (Kernicterus). Pediatric Research 64:3, pages 265-269.
Crossref
Patricia A. Zunszain, Jamie Ghuman, Antony F. McDonagh & Stephen Curry. (2008) Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-IXα. Journal of Molecular Biology 381:2, pages 394-406.
Crossref
Sanjiv B. Amin & Charles E. Ahlfors. (2008) Bilirubin-binding Capacity in Premature Infants. Pediatrics 121:4, pages 872-873.
Crossref
Cecilia L. Basiglio, Sandra M. Arriaga, Héctor F. Pelusa, Adriana M. Almará, Marcelo G. Roma & Aldo D. Mottino. (2007) Protective role of unconjugated bilirubin on complement-mediated hepatocytolysis. Biochimica et Biophysica Acta (BBA) - General Subjects 1770:7, pages 1003-1010.
Crossref
Mark F. McCarty. (2007) ‘‘Iatrogenic Gilbert syndrome’’– A strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. Medical Hypotheses 69:5, pages 974-994.
Crossref
Richard P. Wennberg, Charles E. Ahlfors, Vinod K. Bhutani, Lois H. Johnson & Steven M. Shapiro. (2006) Toward Understanding Kernicterus: A Challenge to Improve the Management of Jaundiced Newborns. Pediatrics 117:2, pages 474-485.
Crossref
Roland Stocker. (2004) Antioxidant Activities of Bile Pigments. Antioxidants & Redox Signaling 6:5, pages 841-849.
Crossref
Charles E. Ahlfors & Richard P. Wennberg. (2004) Bilirubin—albumin binding and neonatal jaundice. Seminars in Perinatology 28:5, pages 334-339.
Crossref
Michael Peake, Beryl Mazzachi, Andrew Fudge & Renze Bais. (2003) Spectrophotometric bilirubin measurement combined with blood gas analysis. Clinica Chimica Acta 329:1-2, pages 151-152.
Crossref
Thor Willy Ruud Hansen. (2002) Mechanisms of bilirubin toxicity: clinical implications. Clinics in Perinatology 29:4, pages 765-778.
Crossref
Erwin Kuntz & Hans-Dieter KuntzErwin Kuntz & Hans-Dieter Kuntz. 2002. Hepatology. Hepatology 25 62 .
John M. Seubert, Christopher D. Webb & John R. Bend. (2002) Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner . Journal of Biochemical and Molecular Toxicology 16:2, pages 96-106.
Crossref
TWR Hansen. (2007) Kernicterus in term and near‐term infants–the specter walks again. Acta Paediatrica 89:10, pages 1155-1157.
Crossref
Charles E. Petersen, Chung-Eun Ha, Krishna Harohalli, Jimmy B. Feix & Nadhipuram V. Bhagavan. (2000) A Dynamic Model for Bilirubin Binding to Human Serum Albumin. Journal of Biological Chemistry 275:28, pages 20985-20995.
Crossref
Thor Willy Ruud Hansen, Jeffrey W. Allen & Steve Tommarello. (1999) Oxidation of Bilirubin in the Brain—Further Characterization of a Potentially Protective Mechanism. Molecular Genetics and Metabolism 68:3, pages 404-409.
Crossref
Rui Silva, Lucinda R. Mata, Sérgio Gulbenkian, Maria A. Brito, Claudio Tiribelli & Dora Brites. (1999) Inhibition of Glutamate Uptake by Unconjugated Bilirubin in Cultured Cortical Rat Astrocytes: Role of Concentration and pH. Biochemical and Biophysical Research Communications 265:1, pages 67-72.
Crossref
Richard A. Weisiger. 1998. Whole Organ Approaches to Cellular Metabolism. Whole Organ Approaches to Cellular Metabolism 389 423 .
Miklós Simonyi. 1997. Advances in Drug Research Volume 30. Advances in Drug Research Volume 30 73 110 .
Laurence Chuniaud, Michèle Dessante, Françoise Chantoux, Jean-Paul Blondeau, Jacques Francon & François Trivin. (1996) Cytotoxicity of bilirubin for human fibroblasts and rat astrocytes in culture. Effect of the ratio of bilirubin to serum albumin. Clinica Chimica Acta 256:2, pages 103-114.
Crossref
Ida S. Owens & Joseph K. Ritter. 1995. 305 338 .
. 1995. All About Albumin. All About Albumin 319 413 .
Guangjin Cheng, Yi Yang & Shaojun Dong. (1994) In-situ UV-visible spectroelectrochemical and circular dichroic electrochemical study of bilirubin and bilirubin + human serum albumin complex. Bioelectrochemistry and Bioenergetics 34:2, pages 141-147.
Crossref
Weilin L. Shelver, Harry Rosenberg & William H. Shelver. (1994) Semiempirical molecular orbital calculations on the role of hydrogen bonding in the structure of bilirubin dianion. Journal of Molecular Structure: THEOCHEM 312:1, pages 1-9.
Crossref
Stylianos Tsakiris. (1993) Na+, K+-ATPase and acetylcholinesterase activities: Changes in postnatally developing rat brain induced by bilirubin. Pharmacology Biochemistry and Behavior 45:2, pages 363-368.
Crossref
Leonard J. Shore, William S. Mogilevsky, Philip B.W. Smith, Catherine Fenselau & Gerard B. Odell. (1991) In vitro formation of glutathione conjugates of the dimethylester of bilirubin. Biochemical Pharmacology 42:10, pages 1969-1976.
Crossref
John F. Ennever. 1991. Optronic Techniques in Diagnostic and Therapeutic Medicine. Optronic Techniques in Diagnostic and Therapeutic Medicine 177 190 .
Kathryn M. Ivanetlch, Alfred E.A. Thumser, Susan E. Phillips & Cynthia N.T. Sikakana. (1990) Reversible inhibition of rat hepatic glutathione s-transferase 1–2 by bilirubin. Biochemical Pharmacology 40:7, pages 1563-1568.
Crossref
Rena Vassilopoulou-Sellin, Norse Rey-Bear & Caroline O. Oyedeji. (2009) Bilirubin as an inhibitor of cartilage metabolism: Effect on avian chondrocyte proliferation in cell culture. Journal of Bone and Mineral Research 5:7, pages 769-774.
Crossref
P. MEISEL, D. JÄHRIG, E. BEYERSDORFF & K. JÄHRIG. (2008) Bilirubin Binding and Acid‐Base Equilibrium in Newborn Infants with Low Birthweight. Acta Paediatrica 77:4, pages 496-501.
Crossref
Claudy J. P. Million, Alexander M. Klibanov & Robert Langer. (2004) Kinetics of bilirubin oxidase and modeling of an immobilized bilirubin oxidase reactor for bilirubin detoxification. Biotechnology and Bioengineering 31:6, pages 536-546.
Crossref
Georg Löffler & Petro E. PetridesP. E. Petrides. 1988. Physiologische Chemie. Physiologische Chemie 523 538 .
Akira Kosaka, Chieko Yamamoto, Yoshitaka Morishita & Kiyoshi Nakane. (1987) Enzymatic determination of bilirubin fractions in serum. Clinical Biochemistry 20:6, pages 451-458.
Crossref
Kasturi Lahiri Puranam & P. Balaram. (1987) Spectroscopic studies on the interaction of bilirubin with symmetrical alkyl diamines. Journal of Biosciences 11:1-4, pages 485-493.
Crossref
Cynthia Sung, Arthur Lavin, Alexander M. Klibanov & Robert Langer. (2004) An immobilized enzyme reactor for the detoxification of bilirubin. Biotechnology and Bioengineering 28:10, pages 1531-1539.
Crossref
Miklós Simonyi, Ilona Fitos & Julia Visy. (1986) Chirality of bioactive agents in protein binding storage and transport processes. Trends in Pharmacological Sciences 7, pages 112-116.
Crossref
Kathy J. Dien Hillig & Michael D. Morris. (2005) Inverse Raman spectroscopy of bilirubin and its ditauride. Journal of Raman Spectroscopy 15:4, pages 288-292.
Crossref
Miklós Simonyi. (2006) On chiral drug action. Medicinal Research Reviews 4:3, pages 359-413.
Crossref
L. Okolicsanyi. 1983. Clinical Hepatology. Clinical Hepatology 70 77 .
V. Glushko, M. Thaler & M. Ros. (1982) The fluorescence of bilirubin upon interaction with human erythrocyte ghosts. Biochimica et Biophysica Acta (BBA) - General Subjects 719:1, pages 65-73.
Crossref
Richard G. Ryall & Michael J. Peake. (1982) Theoretical constraints in the measurement of serum bilirubin binding capacity. Clinical Biochemistry 15:3, pages 146-151.
Crossref
Charles E. Cornelius. (2005) The use of nonhuman primates in the study of bilirubin metabolism and bile secretion. American Journal of Primatology 2:4, pages 343-354.
Crossref
J. J. Lee & G. D. Gillispie. (2008) THE EFFECT OF pH ON THE FLUORESCENCE OF COMPLEXES OF HUMAN SERUM ALBUMIN AND BOVINE SERUM ALBUMIN WITH BILIRUBIN. Photochemistry and Photobiology 33:5, pages 757-760.
Crossref
Rolf Brodersen. (1980) Bilirubin transport in the newborn infant, reviewed with relation to kernicterus. The Journal of Pediatrics 96:3, pages 349-356.
Crossref

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