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Research Article

Fungal Plasma Membrane Proton Pumps as Promising New Antifungal Targets

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Pages 209-223 | Published online: 25 Sep 2008

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Blase Billack, Magdalena Piętka-Ottlik, Michelle Santoro, Stacia Nicholson, Jacek Młochowski & Cesar Lau-Cam. (2010) Evaluation of the antifungal and plasma membrane H+-ATPase inhibitory action of ebselen and two ebselen analogs in S. cerevisiae cultures. Journal of Enzyme Inhibition and Medicinal Chemistry 25:3, pages 312-317.
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Elizabeth A Wills, Matthew R Redinbo, John R Perfect & Maurizio Del Poeta. (2000) New potential targets for antifungal development. Emerging Therapeutic Targets 4:3, pages 265-296.
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T.J. Walsh, M. Kasai, A. Francesconi, D. Landsman & S.J. Chanock. (1997) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. Journal of Medical and Veterinary Mycology 35:2, pages 133-137.
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Marcus M. Teixeira, Rodrigo Almeida-Paes, Andréa R. Bernardes-Engemann, André M. Nicola, Priscila M. de Macedo, Antonio Carlos F. Valle, Maria Clara Gutierrez-Galhardo, Dayvison F.S. Freitas, Bridget M. Barker, Daniel R. Matute, Jason E. Stajich & Rosely M. Zancopé-Oliveira. (2022) Single nucleotide polymorphisms and chromosomal copy number variation may impact the Sporothrix brasiliensis antifungal susceptibility and sporotrichosis clinical outcomes. Fungal Genetics and Biology 163, pages 103743.
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Truong‐Thanh Tung & John Nielsen. (2022) Drug Discovery and Development on Pma1, Where Are We Now? A Critical Review from 1995 to 2022. ChemMedChem 17:19.
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Luis A. Bagatolli, Agustín Mangiarotti & Roberto P. Stock. (2021) Cellular metabolism and colloids: Realistically linking physiology and biological physical chemistry. Progress in Biophysics and Molecular Biology 162, pages 79-88.
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Lars F. Olsen, Roberto P. Stock & L.A. Bagatolli. (2020) Glycolytic oscillations and intracellular K+ concentration are strongly coupled in the yeast Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics 681, pages 108257.
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João Xavier da Silva Neto, Helen Paula Silva da Costa, Ilka Maria Vasconcelos, Mirella Leite Pereira, Jose Tadeu Abreu Oliveira, Tiago Deiveson Pereira Lopes, Lucas Pinheiro Dias, Nadine Monteiro Salgueiro Araújo, Luiz Francisco Wemmenson Gonçalves Moura, Mauricio Fraga Van Tilburg, Maria Izabel Florindo Guedes, Larissa Alves Lopes, Eva Gomes Morais & Daniele de Oliveira Bezerra de Sousa. (2020) Role of membrane sterol and redox system in the anti-candida activity reported for Mo-CBP2, a protein from Moringa oleifera seeds. International Journal of Biological Macromolecules 143, pages 814-824.
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Nadine M.S. Araújo, Lucas P. Dias, Helen P.S. Costa, Daniele O.B. Sousa, Ilka M. Vasconcelos, Glaucia A. de Morais & Jose T.A. Oliveira. (2019) ClTI, a Kunitz trypsin inhibitor purified from Cassia leiandra Benth. seeds, exerts a candidicidal effect on Candida albicans by inducing oxidative stress and necrosis. Biochimica et Biophysica Acta (BBA) - Biomembranes 1861:11, pages 183032.
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Xingxing Teng, Yuanyuan Wang, Jinhua Gu, Peiqi Shi, Zhibin Shen & Lianbao Ye. (2018) Antifungal Agents: Design, Synthesis, Antifungal Activity and Molecular Docking of Phloroglucinol Derivatives. Molecules 23:12, pages 3116.
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Truong-Thanh Tung, Trong T. Dao, Marta G. Junyent, Michael Palmgren, Thomas Günther-Pomorski, Anja T. Fuglsang, Søren B. Christensen & John Nielsen. (2018) LEGO-Inspired Drug Design: Unveiling a Class of Benzo[ d ]thiazoles Containing a 3,4-Dihydroxyphenyl Moiety as Plasma Membrane H + -ATPase Inhibitors . ChemMedChem 13:1, pages 37-47.
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Trong Tuan Dao, Pankaj Sehgal, Truong Thanh Tung, Jesper Vuust Møller, John Nielsen, Michael Palmgren, Søren Brøgger Christensen & Anja Thoe Fuglsang. (2016) Demethoxycurcumin Is A Potent Inhibitor of P-Type ATPases from Diverse Kingdoms of Life. PLOS ONE 11:9, pages e0163260.
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Sheikh Shreaz, Waseem A. Wani, Jawad M. Behbehani, Vaseem Raja, Md Irshad, Maribasappa Karched, Intzar Ali, Weqar A. Siddiqi & Lee Ting Hun. (2016) Cinnamaldehyde and its derivatives, a novel class of antifungal agents. Fitoterapia 112, pages 116-131.
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Nikhat Manzoor. 2016. Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Regulation of Ca2+-ATPases,V-ATPases and F-ATPases 519 530 .
Kenneth T. Kongstad, Sileshi G. Wubshet, Lasse Kjellerup, Anne-Marie Lund Winther & Dan Staerk. (2015) Fungal plasma membrane H+-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv.. Fitoterapia 105, pages 102-106.
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Clidia E.M. Pinto, Davi F. Farias, Ana F.U. Carvalho, José T.A. Oliveira, Mirella L. Pereira, Thalles B. Grangeiro, José E.C. Freire, Daniel A. Viana & Ilka M. Vasconcelos. (2015) Food safety assessment of an antifungal protein from Moringa oleifera seeds in an agricultural biotechnology perspective. Food and Chemical Toxicology 83, pages 1-9.
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Kenneth T. Kongstad, Sileshi G. Wubshet, Ane Johannesen, Lasse Kjellerup, Anne-Marie Lund Winther, Anna Katharina Jäger & Dan Staerk. (2014) High-Resolution Screening Combined with HPLC-HRMS-SPE-NMR for Identification of Fungal Plasma Membrane H + -ATPase Inhibitors from Plants . Journal of Agricultural and Food Chemistry 62:24, pages 5595-5602.
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Mikhail V. Keniya, Richard D. Cannon, ẤnBình Nguyễn, Joel D.A. Tyndall & Brian C. Monk. (2013) Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae . FEMS Yeast Research 13:3, pages 302-311.
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Azmat Ullah, Maria Inês Lopes, Stanley Brul & Gertien J. Smits. (2013) Intracellular pH homeostasis in Candida glabrata in infection-associated conditions. Microbiology 159:Pt_4, pages 803-813.
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Juliana M. Gifoni, José T. A. Oliveira, Hermogenes D. Oliveira, Adelina B. Batista, Mirella L. Pereira, Antoniella S. Gomes, Henrique P. Oliveira, Thalles B. Grangeiro & Ilka M. Vasconcelos. (2012) A novel chitin‐binding protein from Moringa oleifera seed with potential for plant disease control . Peptide Science 98:4, pages 406-415.
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Janne Keila S. Morais, Valdirene M. Gomes, José Tadeu A. Oliveira, Izabela S. Santos, Maura Da Cunha, Hermogenes D. Oliveira, Henrique P. Oliveira, Daniele O. B. Sousa & Ilka M. Vasconcelos. (2010) Soybean Toxin (SBTX), a Protein from Soybeans That Inhibits the Life Cycle of Plant and Human Pathogenic Fungi. Journal of Agricultural and Food Chemistry 58:19, pages 10356-10363.
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Blase BillackMichelle SantoroCesar Lau-Cam. (2009) Growth Inhibitory Action of Ebselen on Fluconazole-Resistant Candida albicans : Role of the Plasma Membrane H + -ATPase . Microbial Drug Resistance 15:2, pages 77-83.
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N.L. Tatsadjieu, P.M. Jazet Dongmo, M.B. Ngassoum, F-X. Etoa & C.M.F. Mbofung. (2009) Investigations on the essential oil of Lippia rugosa from Cameroon for its potential use as antifungal agent against Aspergillus flavus Link ex. Fries. Food Control 20:2, pages 161-166.
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Grace Chan, Diane Hardej, Michelle Santoro, Cesar Lau‐Cam & Blase Billack. (2007) Evaluation of the antimicrobial activity of ebselen: Role of the yeast plasma membrane H + ‐ATPase . Journal of Biochemical and Molecular Toxicology 21:5, pages 252-264.
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David S. Perlin. (2007) Resistance to echinocandin-class antifungal drugs. Drug Resistance Updates 10:3, pages 121-130.
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Shuhong Luo, Jianmin Fang & Roberto Docampo. (2006) Molecular Characterization of Trypanosoma brucei P-type H+-ATPases. Journal of Biological Chemistry 281:31, pages 21963-21973.
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Weixing Shan, Jun Liu & Adrienne R. Hardham. (2006) Phytophthora nicotianae PnPMA1 encodes an atypical plasma membrane H+-ATPase that is functional in yeast and developmentally regulated. Fungal Genetics and Biology 43:8, pages 583-592.
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Mauricio VieiraPeter RohloffShuhong LuoNarcisa L. Cunha-E-Silva, Wanderley De Souza & Roberto Docampo. (2005) Role for a P-type H+-ATPase in the acidification of the endocytic pathway of Trypanosoma cruzi . Biochemical Journal 392:3, pages 467-474.
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Vânia M.M. Melo, Ilka M. Vasconcelos, Valdirene M. Gomes, Maura Da Cunha, Arlete A. Soares & José T.A. Oliveira. (2005) A cotyledonary agglutinin from Luetzelburgia auriculata inhibits the fungal growth of Colletotrichum lindemuthianum, Fusarium solani and Aspergillus niger and impairs glucose-stimulated acidification of the incubation medium by Saccharomyces cerevisiae cells. Plant Science 169:3, pages 629-639.
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Kildare Miranda, Anibal E. Vercesi, Rosana Catisti, Wanderley De Souza, Claudia O. Rodrigues & Roberto Docampo. (2005) P-type Proton ATPases are Involved in Intracellular Calcium and Proton Uptake in the Plant Parasite Phytomonas francai. The Journal of Eukaryotic Microbiology 52:1, pages 55-60.
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Brian C Monk & David R K Harding. (2005) Peptide Motifs for Cell-Surface Intervention. BioDrugs 19:4, pages 261-278.
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Brian C. Monk, Kyoko Niimi, Susan Lin, Allison Knight, Thomas B. Kardos, Richard D. Cannon, Rekha Parshot, Amanda King, David Lun & David R. K. Harding. (2005) Surface-Active Fungicidal d -Peptide Inhibitors of the Plasma Membrane Proton Pump That Block Azole Resistance . Antimicrobial Agents and Chemotherapy 49:1, pages 57-70.
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Javier Afeltra, Roxana G. Vitale, Johan W. Mouton & Paul E. Verweij. (2004) Potent Synergistic In Vitro Interaction between Nonantimicrobial Membrane-Active Compounds and Itraconazole against Clinical Isolates of Aspergillus fumigatus Resistant to Itraconazole . Antimicrobial Agents and Chemotherapy 48:4, pages 1335-1343.
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Werner Kühlbrandt. (2004) Biology, structure and mechanism of P-type ATPases. Nature Reviews Molecular Cell Biology 5:4, pages 282-295.
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Shuhong Luo, David A. Scott & Roberto Docampo. (2002) Trypanosoma cruzi H+-ATPase 1 (TcHA1) and 2 (TcHA2) Genes Complement Yeast Mutants Defective in H+ Pumps and Encode Plasma Membrane P-type H+-ATPases with Different Enzymatic Properties. Journal of Biological Chemistry 277:46, pages 44497-44506.
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Henriette P. Burghoorn, Patricia Soteropoulos, Padmaja Paderu, Ryota Kashiwazaki & David S. Perlin. (2002) Molecular Evaluation of the Plasma Membrane Proton Pump from Aspergillus fumigatus . Antimicrobial Agents and Chemotherapy 46:3, pages 615-624.
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