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Review Article

The carcinogenic action of crystalline silica: A review of the evidence supporting secondary inflammation-driven genotoxicity as a principal mechanism

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Pages 756-770 | Received 14 Sep 2010, Accepted 24 Mar 2011, Published online: 17 Sep 2011

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Crossref
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Jeffrey S. Souris, Nai-Tzu Chen, Shih-Hsun Cheng, Chin-Tu Chen & Leu-Wei Lo. 2014. Cancer Theranostics. Cancer Theranostics 363 391 .
R.J. Southard, X. Li, E.A. Eisen & K.E. Pinkerton. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 266 269 .
Bernd FriedeMichelle Wyart-Remy. 2013. Silica and Associated Respirable Mineral Particles. Silica and Associated Respirable Mineral Particles 1 11 .
Peter Morfeld, Kenneth A. Mundt, Dirk Taeger, Karlheinz Guldner, Othmar Steinig & Brian G. Miller. (2013) Threshold Value Estimation for Respirable Quartz Dust Exposure and Silicosis Incidence Among Workers in the German Porcelain Industry. Journal of Occupational & Environmental Medicine 55:9, pages 1027-1034.
Crossref
Rasmus Foldbjerg, Jing Wang, Christiane Beer, Kasper Thorsen, Duncan S. Sutherland & Herman Autrup. (2013) Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines. Chemico-Biological Interactions 204:1, pages 28-38.
Crossref
Ken DonaldsonAnja SchinwaldFiona Murphy, Wan-Seob ChoRodger DuffinLang TranCraig Poland. (2012) The Biologically Effective Dose in Inhalation Nanotoxicology. Accounts of Chemical Research 46:3, pages 723-732.
Crossref
Magdiel Inggrid Setyawati, Wanru Fang, Sing Ling Chia & David Tai Leong. (2012) Nanotoxicology of common metal oxide based nanomaterials: their ROS‐y and non‐ROS‐y consequences. Asia-Pacific Journal of Chemical Engineering 8:2, pages 205-217.
Crossref
Susanne Rittinghausen, Bernd Bellmann, Otto Creutzenberg, Heinrich Ernst, Angelika Kolling, Inge Mangelsdorf, Rupert Kellner, Sascha Beneke & Christina Ziemann. (2013) Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs. Toxicology 303, pages 177-186.
Crossref
Marco Giovine, Sonia Scarfì, Marina Pozzolini, Antonella Penna & Carlo Cerrano. 2013. Biomedical Inorganic Polymers. Biomedical Inorganic Polymers 143 174 .
R. William Field & Brian L. Withers. (2012) Occupational and Environmental Causes of Lung Cancer. Clinics in Chest Medicine 33:4, pages 681-703.
Crossref
Hamsa Jaganathan & Biana Godin. (2012) Biocompatibility assessment of Si-based nano- and micro-particles. Advanced Drug Delivery Reviews 64:15, pages 1800-1819.
Crossref
Robert Landsiedel, Lan Ma-Hock, Hans-Juergen Haussmann, Ben van Ravenzwaay, Martin Kayser & Karin Wiench. (2012) Inhalation studies for the safety assessment of nanomaterials: status quo and the way forward. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 4:4, pages 399-413.
Crossref
Thomas R. Downs, Meredith E. Crosby, Ting Hu, Shyam Kumar, Ashley Sullivan, Katherine Sarlo, Bob Reeder, Matt Lynch, Matthew Wagner, Tim Mills & Stefan Pfuhler. (2012) Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 745:1-2, pages 38-50.
Crossref

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